PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SOCS2 MET 24728074 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 BMI1 21988832 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P SOCS2 ERG 20478527 intact exp G GP G GP P GP GP GP GP GP GP G GP P G G G G G GP GP GP GP P G SOCS2 ARFIP2 21988832 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G SOCS2 CCNC 18508766 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS2 RNF7 21980433 biogrid exp GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP G G GP GP GP GP G SOCS2 RYBP 20543098 biogrid exp GP G G G G G G G G G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G SOCS2 PLA2G1B 21988832 biogrid,intact exp G G G GP G G SOCS2 PTK2B 20543098 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G P GP G G GP G GP GP G SOCS2 TPD52 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 FLT3 23548639 biogrid exp, ortho GP P G G GP GP G GP GP G GP GP P GP P GP GP GP G GP P GP GP GP P P GP G SOCS2 CUL5 23897481,23098073,21980433,21145461 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 KIT 24728074 intact exp, ortho G G G G GP GP G G G G G GP G G G GP GP G G G G G G G G G G SOCS2 SOCS3 16199887, 25402006, 23023127, 21836163 innatedb,hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G SOCS2 SOCS1 17898043, 25402006, 23023127 biogrid exp, ortho, pred GP GP P P GP GP GP GP GP GP G GP P GP GP G GP P GP P GP GP GP GP G SOCS2 TCEB1 19159283,21980433,23333304,16643902, 25402006 biogrid,mint,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 GHR 12135564,16675548,10585430,21980433, 25402006, 21836163 innatedb,hprd,biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 TCEB2 21980433,23333304, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 PTK2 16189514, 25402006, 21836163 hprd,biogrid,mint exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 IGF1R 9727029, 25402006, 21836163 hprd,biogrid,i2d exp, pred GP GP G G G G G GP GP G GP GP GP GP G GP G G GP G GP GP GP G GP GP GP GP G SOCS2 PRLR 10455112,9202403, 25402006, 21836163 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G SOCS2 INSR 10453981, 25402006, 23023127 hprd exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 LCK 21234523, 23023127 biogrid exp, pred G G GP G G G G G G GP G G G G G GP G SOCS2 EPOR 16961462,15644415,11781573, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 CSHL1 ortho G G GP SOCS2 LEPR 25402006 ortho, pred GP GP G G GP G G GP G G GP G GP G G GP G G G G GP GP GP GP GP G GP G SOCS2 CISH 25402006, 23023127 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 SOCS2 23023127 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 EPO 25402006 pred GP P G G G G GP P P G P G G G G G G P SOCS2 INPP5D 25402006, 23023127 pred G GP G G GP GP G GP G G GP G G GP G G GP GP G G G G GP GP G GP G G G SOCS2 PIK3CA 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G P GP GP GP G P GP GP GP GP GP GP GP SOCS2 SGTA 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS2 TRIM16 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 TNFAIP1 23023127 pred G G G G G G G G GP G GP G G G G GP G G GP G G G GP G GP G GP G G SOCS2 EPHA2 23023127 pred GP GP G P P G GP GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP GP GP G SOCS2 PRL 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 GRAP 25402006, 23023127 pred P P P GP P GP GP G P GP P P P P P GP P P SOCS2 DGCR8 23023127 pred P P P P P P P P P P P P P P P P P P P P P P SOCS2 GH1 25402006 pred G G G G G G GP GP SOCS2 PTPN1 25402006 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP G GP GP GP GP G SOCS2 PARP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 SHC3 23023127 pred P GP G GP P GP G P P P G P GP P P P P GP P GP P P SOCS2 PTPN3 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP GP G SOCS2 ESR1 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 LIMK1 23023127 pred P GP P GP G P P G P P P P P GP P GP G P P P P P P P SOCS2 EGFR 25402006 pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G SOCS2 IGF1 21836163 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G GP G SOCS2 SPSB1 25402006 pred GP GP G G GP GP G GP G G GP GP GP G G G GP G GP G GP GP G GP G GP GP G SOCS2 FEM1B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS2 GRAP2 25402006, 23023127 pred P P P P P P P P P P P P P P P PIK3R2 SOCS2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 KLHL14 23023127 pred P P G GP P P P GP P P GP P P P P P P P P P GP P P SOCS2 TRIM25 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS2 KBTBD4 23023127 pred GP GP GP G P G GP P P G GP GP G GP G P GP GP G GP G P GP SOCS2 MYNN 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 BLNK 25402006, 23023127 pred GP P G G GP GP G P GP G GP G G GP G GP GP GP GP G GP G G GP GP GP P G SOCS2 SRC 25402006, 23023127 pred GP GP G GP GP G G GP G G G G GP GP G G G GP GP G GP GP GP GP G SOCS2 ABL1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 VSIG10 25402006 pred G GP G G GP GP G GP GP G GP G GP G G G GP G GP G G G G GP G G GP GP G SOCS2 RASA1 23023127 pred GP G G G GP GP G G G G G G G G G G GP G G G GP G G G G G GP G G SOCS2 NACC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS2 PIK3R3 25402006, 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP G GP G GP GP GP GP G SOCS2 SH2D3C 23023127, 16082366 pred GP G G G GP G G GP G G GP G G GP G G G G G GP G G G G GP GP GP G SOCS2 KEAP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G SOCS2 RASGRP1 16082366 pred G G G G G G G G G G G G G G G G G G G SOCS2 PTPRH 25402006 pred P P P P P P P P P P P P SH2B2 SOCS2 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G SOCS2 LCP2 23023127 pred G G G GP G G G GP GP G G G G G G GP G SOCS2 ING5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G AGRN SOCS2 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP GP GP GP G SOCS2 PTPN11 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS2 GRB14 23023127 pred P GP P P G GP GP GP G P GP P P G GP GP P P GP P P GP SOCS2 RASGRF2 16082366 pred GP GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G SOCS2 ZMAT3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 BLK 23023127 pred GP P P P P P P P GP P P P P P GP P P SOCS2 FGFR3 23023127 pred G P G P GP GP G G GP G GP GP G G GP G GP G G GP SOCS2 PDGFRA 25402006, 23023127 pred G G G G GP GP G 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ZBTB48 23023127 pred G GP G G GP P P GP GP GP G GP G G P GP G P G GP P G GP G GP G SOCS2 SPSB4 25402006 pred G SOCS2 RGL2 16082366 pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP G GP GP G GP GP G SOCS2 RALGDS 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 VAV3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SOCS2 LZTR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 RAB40C 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G GP G G G G GP GP G GP GP G SOCS2 BTBD7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SOCS2 VAV1 25402006, 23023127 pred GP GP G GP GP G P P G P GP GP GP G GP GP G GP G GP G GP P P GP GP GP G SOCS2 SOS2 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 LRP1 23023127 pred G G G G G GP G G G G G GP GP G G G GP GP G G GP G G G G G G GP G SOCS2 KAZALD1 23023127 pred G P G GP P G GP GP P P P GP G GP P P GP G P GP GP GP GP GP GP P G SOCS2 SOCS5 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS2 Fos39347_1 25402006 pred SOCS2 CSF3R 21836163 pred G G G G GP GP G GP G G G G GP G G G GP G G GP G G G G G G GP G SOCS2 ERBB4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP GP G SOCS2 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G SOCS2 SORBS1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS2 PTPN9 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 F7 23023127 pred P GP G G GP GP G GP GP G GP GP GP GP G P GP G GP G GP P GP GP GP G GP GP G SOCS2 F2 23023127 pred P P P P GP P SOCS2 ZAP70 23023127 pred G G GP G G G GP G G GP G SOCS2 LYN 25402006, 23023127 pred GP G G G GP GP G G GP G G G 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GP GP GP GP G SOCS2 LIMS1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 ALK 23023127 pred GP GP G P GP G GP GP G P G GP GP G GP GP GP GP G GP P GP GP GP P GP GP G SOCS2 TGFB1I1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G SOCS2 LRRC41 25402006 pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G SOCS2 STAP1 25402006 pred P G GP P P GP GP P GP P P P P P GP GP P SOCS2 IRS2 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 SH2D1A 23023127 pred G G SOCS2 GRB10 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 ROR1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 VAV2 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP G SOCS2 ROBO2 23023127 pred P P G P GP G P P G P P GP P P GP GP GP G P P P P P GP P P SOCS2 STAT5B 25402006, 23023127, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G SOCS2 SQSTM1 23023127 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP GP GP GP G SOCS2 RASGEF1C 16082366 pred P P G P GP P P G P P P P P GP P GP P P P P P P GP SOCS2 GRB2 25402006, 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 KLHL38 23023127 pred P P P P P P P P P P P P P P P P P P P P P SOCS2 IGFBP2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 GRB7 23023127 pred GP GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP GP G SOCS2 ZNF354A 23023127 pred GP GP G G G GP GP GP GP P G G P GP G P G G P P GP G GP GP G SOCS2 DUSP7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 ASAP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS2 IL2RG 25402006 pred G G G G GP GP G G GP G G G G G G G GP G G G G G G G G GP GP G G SOCS2 CRK 25402006, 23023127 pred GP G G G G G G GP GP G GP GP G G G GP G G GP G GP GP GP GP GP G GP G G SOCS2 SH3GLB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 EPHB2 23023127 pred P GP G G GP GP G GP GP G GP P GP P GP GP GP GP G GP P GP GP GP P P GP G SOCS2 KLHL4 23023127 pred P GP G P GP P G P P P G P GP G P P P P P SOCS2 TP53 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G SOCS2 LDLR 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G GP G G GP GP G GP GP G SOCS2 NEDD9 23023127 pred GP GP G G GP GP G GP GP GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 PDGFC 23023127 pred GP G G G G GP G G GP G GP G GP G G G GP G GP G G G G G G G GP GP G SOCS2 BCAR3 23023127, 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP G SOCS2 HCLS1 23023127 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G G GP 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GP P GP GP P G SH2D7 SOCS2 23023127 pred P P P P P P P P P SOCS2 IGFBP5 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SOCS2 CRKL 25402006, 23023127 pred GP G G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP G G GP GP GP G G SOCS2 SHC4 23023127 pred G G G G G G G G G SOCS2 SOCS6 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP GP G SOCS2 IRS4 25402006 pred GP GP G G G GP G GP GP G GP P P GP G GP GP G GP G GP P GP GP GP GP GP GP G SOCS2 JAK2 25402006, 23023127, 21836163 pred G GP G G GP GP G GP GP G GP P GP GP G P GP GP P P G GP G GP GP GP GP SOCS2 IRS1 25402006 pred GP GP G P GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G SOCS2 BAIAP2 23023127 pred P P G G GP GP G GP P G GP GP GP GP P GP GP GP G GP GP P P P P GP GP G SOCS2 RASGRP2 23023127, 16082366 pred G GP G G GP GP GP GP G GP GP GP GP G GP GP P GP G P GP GP GP GP P G SOCS2 CAMK2D 23023127 pred G GP G G G GP G GP GP G GP G G GP G GP GP G GP G G GP GP GP GP G GP GP G SOCS2 IGFBP7 23023127 pred G G G G G G G G G G GP G G G G G G G GP G G G G G G G G GP G SOCS2 TEC 25402006 pred P P P P P P P P P P P P P P P P P P P SOCS2 SYK 23023127 pred GP G G G GP GP G GP G GP G GP GP G GP GP GP G G G G G GP GP GP GP G SOCS2 PTPRJ 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 NCK2 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 CCDC85B 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G SOCS2 ABTB2 23023127 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G SOCS2 SOCS7 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 EGR1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 CSK 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP G GP G GP G G G GP GP GP GP G SOCS2 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 ERBB2 25402006 pred GP G G G G G G G GP G GP G G G G GP G G G G GP GP G G GP G G G G SOCS2 PDGFRB 25402006 pred G G G G G GP G G G G GP G G G G G GP GP G G GP GP G G G G GP GP G SOCS2 FYN 23023127 pred G GP G G GP GP G G GP G GP GP G GP G G GP G G G G G G G G GP G G G SOCS2 STAT3 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 YWHAG 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 MMP14 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SOCS2 RAPGEFL1 16082366 pred G G GP P G P P P GP GP P P P P P P SOCS2 KDR 25402006 pred GP GP G G G G G G GP G GP G GP G G G G G G G G G G G G G G GP G SOCS2 NOTCH1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 EGR2 23023127 pred G G G G G G G G G G G G G G G G G G G G G SOCS2 YWHAE 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 PTPN6 25402006 pred G G G G GP G G G G G G G GP GP G G G G G G GP G G G G GP G G G SOCS2 KLHL40 23023127 pred GP G SOCS2 BCAR1 23023127 pred GP GP G P GP G GP GP G GP GP GP GP GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 EPHB4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G SOCS2 NCK1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS2 SHC1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS2 EBF1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 F3 23023127 pred GP GP G P GP G G G G GP P GP GP G GP GP G GP G GP GP G G GP GP GP GP G SOCS2 KCTD14 23023127 pred P P P P P P P P P P P P SOCS2 MAPK8IP1 23023127 pred P P G P GP G P P G P P P P P GP P G P P P P P P P GP SOCS2 TNN 16082366 pred GP G G G G GP G G GP G P GP GP G G GP GP GP GP G P P G GP GP GP GP P G SOCS2 NTRK1 23023127 pred P P P G P P P P P P P P P P P P P P P SOCS2 PTPRB 25402006 pred G GP G GP G GP G G GP GP GP GP G GP GP G GP G G GP G G GP GP GP P G SOCS2 RALGPS2 16082366 pred GP GP G GP P G P GP GP GP P GP G GP P GP P GP P P GP GP GP GP SOCS2 SPSB2 25402006 pred GP GP G G G GP G G P G GP GP GP G GP GP G GP G GP GP G GP GP GP GP G SOCS2 GAB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 CUL2 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G SOCS2 CBL 23023127 pred G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SOCS2 TPD52 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119309|BIOGRID_287839 unspecified role|bait unspecified role|prey SOCS2 RNF7 MI:0004(affinity chromatography technology) 21980433 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_147062 bait prey SOCS2 UBC MI:0004(affinity chromatography technology) 23567159 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272942 prey bait SOCS2 RYBP MI:0018(two hybrid) 20543098 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_153778 bait prey SOCS2 CCNC MI:0004(affinity chromatography technology) 18508766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_210338 bait prey SOCS2 EPOR MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0231(mammalian protein protein interaction trap)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0090(protein complementation assay)|MI:0231(mammalian protein protein interaction trap)|MI:0090(protein complementation assay)|MI:0231(mammalian protein protein interaction trap)|MI:0231(mammalian protein protein interaction trap) 11781573,15644415,16961462 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(intact)|(intact) BIOGRID_98325|BIOGRID_98324|BIOGRID_135849|UniProt_161404|MINT_80191|MINT_48204|HPRD_33729|BIOGRID_135061|UniProt_71200|BIOGRID_135060|UniProt_71199|UniProt_71201 prey|prey|prey|prey|unspecified role|unspecified role|-|prey|prey|prey|prey|prey bait|bait|bait|bait|unspecified role|unspecified role|-|bait|bait|bait|bait|bait SOCS2 PTK2B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 20543098 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_153780|BIOGRID_153779|BIOGRID_153777 prey|bait|bait bait|prey|prey SOCS2 ARFIP2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119680|BIOGRID_288238 unspecified role|prey unspecified role|bait SOCS2 GHR MI:0004(affinity chromatography technology)|MI:0065(isothermal titration calorimetry)|MI:0004(affinity chromatography technology)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0493(in vivo)|MI:0096(pull down) 10585430,12135564,16675548,21980433 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|-|MI:0407(direct interaction) (biogrid)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0468(hprd)|(biogrid) BIOGRID_101894|MINT_79608|BIOGRID_147063|UniProt_84663|MINT_47705|HPRD_8036|BIOGRID_210144 prey|unspecified role|bait|unspecified role|unspecified role|-|prey bait|unspecified role|prey|unspecified role|unspecified role|-|bait SOCS2 PTK2 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_78841|HPRD_21555 prey|- bait|- SOCS2 MET MI:0053(fluorescence polarization spectroscopy) 24728074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_133093 neutral component neutral component SOCS2 KIT MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy) 24728074 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact) UniProt_132909|UniProt_132739|UniProt_132931|UniProt_132846 neutral component|neutral component|neutral component|neutral component neutral component|neutral component|neutral component|neutral component SOCS2 BMI1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285825|UniProt_116852 prey|unspecified role bait|unspecified role SOCS2 IGF1R MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 9727029 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_107288|BIOGRID_107290|BIOGRID_107289|HPRD_36303 bait|bait|bait|- prey|prey|prey|- SOCS2 DKFZp666O0110 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_36897|MINT_66057 prey|prey bait|bait SOCS2 FLT3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23548639 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272870|BIOGRID_272869 bait|prey prey|bait SOCS2 TCEB1 MI:0018(two hybrid)|MI:0231(mammalian protein protein interaction trap)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16643902,19159283,21980433 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|(intact) BIOGRID_197007|UniProt_98781|BIOGRID_197019|MINT_49822|BIOGRID_147060|UniProt_85143|MINT_82041|UniProt_167601 prey|bait|bait|bait|bait|bait|bait|bait bait|prey|prey|prey|prey|prey|prey|prey SOCS2 TCEB2 MI:0004(affinity chromatography technology) 21980433 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_147059 bait prey SOCS2 INSR MI:0018(two hybrid) 10453981 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24732 - - SOCS2 LCK MI:0004(affinity chromatography technology) 21234523 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_214638 prey bait SOCS2 CUL5 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 21145461,21980433,23098073,23897481 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_283827|BIOGRID_147061|BIOGRID_273647|BIOGRID_203655 bait|bait|prey|prey prey|prey|bait|bait SOCS2 PRLR MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10455112 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_1338|BIOGRID_109442 -|bait -|prey SOCS2 SOCS3 MI:0004(affinity chromatography technology)|MI:0492(in vitro) 16199887 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_211608|HPRD_25720 prey|- bait|- SOCS2 SOCS2 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 17997974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) MI:0465(dip)|MI:0465(dip) DIP_53794|DIP_53795 -|- -|- SOCS2 SOCS1 MI:0004(affinity chromatography technology) 17898043 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_117875 bait prey SOCS2 PLA2G1B MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117366|BIOGRID_287686 unspecified role|prey unspecified role|bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS2 GHR 12135564,12135564,12135564,10585430 0096,0059,0405,0096 LC SOCS2 EPOR 11781573,11781573,11781573,16961462,16961462 0018,0231,0004,0096,0090 LC SOCS2 TCEB1 21980433,19159283,19159283,23333304,19159283 0004,0004,0007,0401,0018 LC SOCS2 TCEB2 23333304,21980433 0401,0004 LC SOCS2 CUL5 23098073,21145461,21980433 0096,0004,0004 LC,HT SOCS2 CUL5 21145461 0004 HT SOCS2 GHR 12135564,12135564,12135564,10585430 0096,0059,0405,0096 LC SOCS2 EPOR 11781573,11781573,11781573,16961462,16961462 0018,0231,0004,0096,0090 LC SOCS2 TCEB1 21980433,19159283,19159283,23333304,19159283 0004,0004,0007,0401,0018 LC SOCS2 TCEB2 23333304,21980433 0401,0004 LC SOCS2 CUL5 23098073,21980433 0096,0004 LC SOCS2 SOCS3 16199887,16199887 0004,0061 LC SOCS2 PLA2G1B 21988832,21988832 0397,0018 HT SOCS2 INSR 10453981 0018 LC SOCS2 IGF1R 9727029,9727029,9727029,9727029 0018,0019,0004,0096 LC SOCS2 MET 24728074 0053 HT SOCS2 KIT 24728074 0053 HT SOCS2 GHR 21980433,12135564,12135564,12135564,16675548 0415,0096,0059,0405,0065 LC SOCS2 EPOR 11781573,11781573,15644415,11781573,15644415,16961462,16961462 0018,0231,0018,0004,0090,0096,0090 LC SOCS2 BMI1 21988832,21988832 0397,0018 HT SOCS2 ARFIP2 21988832 0018 HT SOCS2 TPD52 21988832 0018 HT SOCS2 PTK2 16189514 0018 HT SOCS2 PTK2B 20543098,20543098 0018,0004 LC SOCS2 TCEB1 19159283,19159283,23333304,19159283,16675548,16643902 0004,0007,0401,0018,0114,0397 LC SOCS2 TCEB2 23333304,16675548 0401,0114 LC SOCS2 DKFZP666O0110 16189514 0018 HT SOCS2 RYBP 20543098 0018 LC SOCS2 CUL5 23897481 0114 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SOCS2 SOCS3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SOCS2 SOCS1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 JAK2 MI:0362 inference MI:1106 pathways database SOCS2 GH1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SOCS2 GH2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SOCS2 PLA2G1B MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 NTRK1 MI:0362 inference MI:0461 interaction database SOCS2 LCK MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 IGF1R MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 MET MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 UBC MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 CSH2 MI:0362 inference MI:0461 interaction database SOCS2 KIT MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 GHR MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SOCS2 ERG MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 PRLR MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 EPOR MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 CCNC MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 BMI1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 FLT3 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 LEPR MI:0362 inference MI:0461 interaction database SOCS2 ARFIP2 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 TPD52 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 PTK2 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 PTK2B MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 CSHL1 MI:0362 inference MI:0461 interaction database SOCS2 TCEB1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 TCEB2 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 NTRK3 MI:0362 inference MI:0461 interaction database SOCS2 NTRK2 MI:0362 inference MI:0461 interaction database SOCS2 RYBP MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database SOCS2 CISH MI:0362 inference MI:0461 interaction database SOCS2 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database