PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2D2 PDZRN3 17576800 biogrid exp GP G G GP G G GP G GP P GP GP G G GP GP P GP GP G GP G P GP GP G FAM13C PDZRN3 26186194 biogrid exp GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP LNX2 PDZRN3 22889411 biogrid exp GP GP G GP G GP GP G GP GP GP G GP GP G P GP GP GP GP GP P GP GP G OFD1 PDZRN3 26638075 biogrid,intact exp GP GP G GP G GP GP G GP GP G G GP GP GP P GP GP GP GP GP P GP GP G EFNB2 PDZRN3 15458844 hprd exp GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G OIP5 PDZRN3 26186194 biogrid exp GP G P GP P GP G P GP GP G GP GP GP BMPR2 PDZRN3 15188402, 25402006 hprd exp, ortho, pred G GP G GP G GP GP G GP P GP GP G GP GP GP P G GP G GP GP P GP GP G MUSK PDZRN3 17576800, 21836163 biogrid exp, pred G G G G G G LNX1 PDZRN3 22889411, 23023127 biogrid exp, pred GP G G GP G GP GP G GP P GP GP G GP GP G P GP GP GP G GP P GP GP PDZRN3 PDZRN3 10431247, 23023127 hprd exp, pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G SYNJ2BP PDZRN3 23023127 pred G GP G GP G GP GP G GP P GP G G GP GP GP P GP GP GP G GP GP GP G CNKSR3 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P G G G GP GP GP P GP GP GP G GP GP GP G TNFRSF10A PDZRN3 16082366 pred GP G G GP G GP GP G GP GP G G GP GP G GP G GP G GP GP GP G TNFRSF19 PDZRN3 16082366 pred GP GP P G GP GP G GP P GP GP G GP GP GP P P GP GP GP GP P GP GP G PDLIM2 PDZRN3 23023127 pred G G G GP G G GP G GP GP GP G GP GP G P GP G G GP GP P GP GP G GIPC2 PDZRN3 23023127 pred GP GP GP GP P G G GP G P P P GP P GP GP P G MPP4 PDZRN3 23023127 pred PPP1R9A PDZRN3 23023127 pred GP GP G GP G GP GP G GP GP GP G GP GP GP P GP GP GP GP GP P GP GP G RAPSN PDZRN3 25402006 pred P P P P P P P P P P P P P P GP GP P P P VSIG2 PDZRN3 21836163 pred P P P GP P P G GP P P GP GP G GP GP P CLMP PDZRN3 21836163 pred GP GP P G GP P P GP GP G G P GP P GP G GP P G RXRA PDZRN3 21836163 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G MAGI1 PDZRN3 23023127 pred G G G G G G GP G GP P GP G G GP G G P G G GP G GP GP G G PDZD7 PDZRN3 23023127 pred G G G G G G G G G G G G G G TJP3 PDZRN3 23023127 pred P P GP GP P GP G GP P P GP P GP GP GP GP PDZD4 PDZRN3 23023127 pred P G GP G P G P P P GP P P P P P P P G PDZRN3 GRIP1 23023127 pred P P G GP G P GP G GP P P P G P GP P GP GP GP P P P GP P TJP1 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G PDZK1P1, PDZK1P2 PDZRN3 23023127 pred RGS3 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G TJP2 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP GP GP G LRRC7 PDZRN3 23023127 pred P P G GP P G P P P P P GP P P P P P P P P P P PTPN4 PDZRN3 23023127 pred GP GP G GP G GP GP G GP GP GP G GP GP GP P GP GP GP GP GP GP GP G DLG2 PDZRN3 23023127 pred P GP G GP G G P P GP GP P P P P CADM2 PDZRN3 21836163 pred G GP G GP G P P P P GP P P P P P P P P FRMPD2B PDZRN3 23023127 pred CXADR PDZRN3 21836163 pred GP GP G GP G G GP G GP P GP G G GP GP GP P P GP GP GP GP GP GP G NR1I3 PDZRN3 21836163 pred P P P P GP P P P P P P GP P P GP G GRIP2 PDZRN3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G PDZD8 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP G G GP GP GP P GP GP GP G GP P GP GP G SYNE1 PDZRN3 25402006 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G MAGIX PDZRN3 23023127 pred G G G G G G G G G G G G G G G G G G G G G TNFRSF10B PDZRN3 16082366 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G PARD3B PDZRN3 23023127 pred G GP G GP G G GP G GP P GP G G GP GP G P GP GP GP GP GP GP G G LMO7 PDZRN3 23023127 pred GP GP G GP G GP GP GP P GP GP G GP GP G P GP GP GP G GP GP GP PSMD9 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G PDZD11 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP GP G GP GP GP P GP GP GP GP GP P GP GP G PARD3 PDZRN3 23023127 pred G G G GP G G GP G GP P GP G G GP GP G P GP G GP G GP P GP GP G DOK7 PDZRN3 25402006 pred GP P G GP GP GP G GP P G G G GP GP GP P GP GP GP GP GP GP GP G TRIM13 PDZRN3 23023127 pred GP GP G GP G G GP G G P GP G G GP GP G G GP G GP GP GP GP G MPP7 PDZRN3 23023127 pred GP P GP P GP GP P GP GP G GP P P P GP GP GP GP GP P GP P G FRMPD1 PDZRN3 23023127 pred P G GP G GP P P P P P P GP P P P GP GP P P P GP MAST4 PDZRN3 23023127 pred GP GP G GP G G G G G G G G GP GP G P GP GP GP G GP GP GP G SYNPO2L PDZRN3 23023127 pred GP P P P G GP GP P PDZRN3 MAST1 23023127 pred P P G GP G P G P P P P GP P P P P P P INADL PDZRN3 23023127 pred G G G G G G G G G G G G G G G G G G G G PTPN13 PDZRN3 23023127 pred GP GP G GP G G GP G GP GP GP G GP GP GP P P GP GP GP P GP GP G PDLIM4 PDZRN3 23023127 pred GP GP G GP G GP GP G GP P GP G G GP GP G P G G GP G GP P GP G G AHNAK2 PDZRN3 23023127 pred GP G GP G G GP G P G G G G GP G GP G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UPQ7 Q8TBB1 two hybrid 22889411 direct interaction X 2 Q9UPQ7 Q8N448 two hybrid 22889411 direct interaction X 2 Q9UPQ7 affinity chromatography technology 17576800 physical association X 2 Q9UPQ7 affinity chromatography technology 17576800 physical association X 2 Q9UPQ7 P62837 pull down 17576800 direct interaction X 2 P31016 Q9UPQ7 two hybrid 17118964 direct interaction X 2 Q9UPQ7 P52799 two hybrid 15458844 - X 2 Q9UPQ7 Q9UPQ7 in vitro 10431247 - X 2 Q9UPQ7 P52799 two hybrid 15458844 - X 2 Q9UPQ7 Q13873-2 in vitro 15188402 - X 2 Q9UPQ7 Q13873-2 in vitro 15188402 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EFNB2 PDZRN3 MI:0018(two hybrid) 15458844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24192 - - MUSK PDZRN3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17576800 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_119175|BIOGRID_119174 bait|prey prey|bait LNX1 PDZRN3 MI:0018(two hybrid) 22889411 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_208606 bait prey BMPR2 PDZRN3 MI:0492(in vitro) 15188402 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_7767 - - UBE2D2 PDZRN3 MI:0004(affinity chromatography technology) 17576800 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_119176 prey bait LNX2 PDZRN3 MI:0018(two hybrid) 22889411 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_208611 bait prey PDZRN3 PDZRN3 MI:0492(in vitro) 10431247 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_16100 - -

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UPQ7 O43482 PDZRN3 OIP5 0.126 26186194 Q9UPQ7 Q8N448 PDZRN3 LNX2 0.183 22889411 Q9UPQ7 Q9H6Z9 PDZRN3 EGLN3 0.126 26972000 Q9UPQ7 Q8NE31 PDZRN3 FAM13C 0.126 26186194 Q9UPQ7 Q8TBB1 PDZRN3 LNX1 0.183 22889411 Q9UPQ7 O75665 PDZRN3 OFD1 0.236 26638075 Q9UPQ7 P31016 PDZRN3 DLG4 0.309 17118964 Q9UPQ7 O15146 PDZRN3 MUSK 0.376 17576800 Q9UPQ7 P62837 PDZRN3 UBE2D2 0.309 17576800