PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PJA1 ATXN3L 22626734 biogrid exp P P G GP P G P P P P P P P GP P P GP GP P P GP G RFFL ATXN3L 22626734 biogrid exp P P G GP P G P P P P P P P P P P P GP GP P P GP G TRIM63 ATXN3L 22626734 biogrid exp G G TRIM54 ATXN3L 22626734 biogrid exp P P P P P P P P GP P P P UBC ATXN3L 21118805 biogrid exp P P G GP P G P P P P P P P P GP P P GP GP P P GP G TRIM55 ATXN3L 22626734 biogrid exp P P P P P P P P P P P GP P P GP USP28 ATXN3L 22626734 biogrid exp P P G GP P G P P P P P P P P GP P P GP GP P P GP G KLF5 ATXN3L 26079537 biogrid exp P P G GP P G P P P P P P P GP P P GP GP P P GP G ATXN3L UBQLN1 25402006 pred P P G GP P G P P P P P P P P GP P P GP GP P P GP G ATXN3L UBQLN4 25402006 pred G G G G G G G G UBQLN3 ATXN3L 25402006 pred G G G G G GP G ATXN3L UBQLN2 25402006 pred P P G GP P G P P P P P P P P GP P P GP GP P P GP G VCP ATXN3L 25402006 pred P P G GP P G P P P P P P P P GP P P GP GP P P GP G UBQLNL ATXN3L 25402006 pred P P P P P P P G P P P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H3M9 Q9BYV2 enzymatic study 22626734 direct interaction X 2 Q9H3M9 Q96RU2 enzymatic study 22626734 direct interaction X 2 P0CG48 Q9H3M9 enzymatic study 21118805 direct interaction X 2 P0CG48 Q9H3M9 x-ray crystallography 21118805 association X 2 Q9H3M9 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q9H3M9 Q8NG27 enzymatic study 22626734 direct interaction X 2 Q9H3M9 Q969Q1 enzymatic study 22626734 direct interaction X 2 Q9H3M9 Q9BYV6-4 enzymatic study 22626734 direct interaction X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H3M9 Q8NG27 ATXN3L PJA1 0.183 22626734 Q9H3M9 P0CG48 ATXN3L UBC 0.523 21118805 Q9H3M9 Q969Q1 ATXN3L TRIM63 0.183 22626734 Q9H3M9 Q8WZ73 ATXN3L RFFL 0.183 22626734 Q9H3M9 Q96RU2 ATXN3L USP28 0.183 22626734 Q9H3M9 Q9BYV2 ATXN3L TRIM54 0.183 22626734 Q9H3M9 Q9BYV6 ATXN3L TRIM55 0.183 22626734 Q9H3M9 Q13887 ATXN3L KLF5 0.702 26079537

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD ATXN3L MI:0362 inference MI:0461 interaction database PARK2 ATXN3L MI:0362 inference MI:0461 interaction database UBE4B ATXN3L MI:0362 inference MI:0461 interaction database HLA-B ATXN3L MI:0362 inference MI:0461 interaction database TUBB4A ATXN3L MI:0362 inference MI:0461 interaction database HLA-A ATXN3L MI:0362 inference MI:0461 interaction database ITGA5 ATXN3L MI:0362 inference MI:0461 interaction database UBB ATXN3L MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC ATXN3L MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HSPA1A ATXN3L MI:0362 inference MI:0461 interaction database HSPA1B ATXN3L MI:0362 inference MI:0461 interaction database MAP2 ATXN3L MI:0362 inference MI:0461 interaction database HSPA8 ATXN3L MI:0362 inference MI:0461 interaction database HSPA6 ATXN3L MI:0362 inference MI:0461 interaction database HLA-G ATXN3L MI:0362 inference MI:0461 interaction database DNAJB1 ATXN3L MI:0362 inference MI:0461 interaction database CNTFR ATXN3L MI:0362 inference MI:0461 interaction database HLA-F ATXN3L MI:0362 inference MI:0461 interaction database DNAJA1 ATXN3L MI:0362 inference MI:0461 interaction database HAAO ATXN3L MI:0362 inference MI:0461 interaction database ATXN3 ATXN3L MI:0362 inference MI:0461 interaction database HSPA2 ATXN3L MI:0362 inference MI:0461 interaction database VCP ATXN3L MI:0362 inference MI:0461 interaction database RPS27A ATXN3L MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 ATXN3L MI:0362 inference MI:0461,MI:1106 interaction database,pathways database ACTC1 ATXN3L MI:0362 inference MI:0461 interaction database TUBA1B ATXN3L MI:0362 inference MI:0461 interaction database TUBA4A ATXN3L MI:0362 inference MI:0461 interaction database TUBB4B ATXN3L MI:0362 inference MI:0461 interaction database UBE3A ATXN3L MI:0362 inference MI:0461 interaction database MAP3K1 ATXN3L MI:0362 inference MI:0461 interaction database TUBA3C ATXN3L MI:0362 inference MI:0461 interaction database TUBB2A ATXN3L MI:0362 inference MI:0461 interaction database KLF5 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database HLA-B ATXN3L MI:0362 inference MI:0461 interaction database TUBA3E ATXN3L MI:0362 inference MI:0461 interaction database TUBA1A ATXN3L MI:0362 inference MI:0461 interaction database PJA1 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database RFFL ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database TRIM63 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database USP28 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database TUBB2B ATXN3L MI:0362 inference MI:0461 interaction database TRIM54 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database ATXN3L SACS MI:0362 inference MI:0461 interaction database ATXN3L STUB1 MI:0362 inference MI:0461 interaction database