PTM - CPLM Gene Name UniProt ID Type Position Code USP22; KIAA1063; USP3L Q9UPT9 Acetylation 129 K USP22; KIAA1063; USP3L Q9UPT9 Acetylation 417 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 144 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 493 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 505 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 417 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 137 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 152 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 166 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 159 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 382 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 35 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 501 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 394 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 380 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 442 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 410 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 462 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 488 K USP22; KIAA1063; USP3L Q9UPT9 Ubiquitination 59 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP22; KIAA1063; USP3L Q9UPT9 146 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 147 T Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 151 T Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 232 Y Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 233 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 237 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 342 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 345 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 423 T Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 444 S Homo sapiens(Human) USP22; KIAA1063; USP3L Q9UPT9 450 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9UPT9 K129-ac Acetylation KDMEIIAkEEQRKAW Q9UPT9 K166-ac Acetylation kHNPKRRkITSNCTI Q9UPT9 K417-ac Acetylation KRFEHSAkLRRKItT Q9UPT9 R208-m1 Methylation RDFFLSDrHRCEMQS Q9UPT9 R485-m1 Methylation GHYTSFIrQHKDQWF Q9UPT9 S146-p Phosphorylation QGVGEkFstWEPtkR Q9UPT9 T147-p Phosphorylation GVGEkFstWEPtkRE Q9UPT9 T151-p Phosphorylation kFstWEPtkRELELL Q9UPT9 Y232-p Phosphorylation SSLFQEFySGHRsPH Q9UPT9 S237-p Phosphorylation EFySGHRsPHIPYKL Q9UPT9 T423-p Phosphorylation AkLRRKItTYVSFPL Q9UPT9 S444-p Phosphorylation FMASSKEsRMNGQyQ Q9UPT9 Y450-p Phosphorylation EsRMNGQyQQPTDSL Q9UPT9 K129-sm Sumoylation KDMEIIAkEEQRKAW Q9UPT9 K137-sm Sumoylation EEQRKAWkMQGVGEk Q9UPT9 K152-sm Sumoylation FstWEPtkRELELLk Q9UPT9 K382-sm Sumoylation LGSSAKIkCSGCHSY Q9UPT9 K417-sm Sumoylation KRFEHSAkLRRKItT Q9UPT9 K35-ub Ubiquitination SFKVDNWkQNLRAIY Q9UPT9 K59-ub Ubiquitination EARKRKAkSCICHVC Q9UPT9 K129-ub Ubiquitination KDMEIIAkEEQRKAW Q9UPT9 K137-ub Ubiquitination EEQRKAWkMQGVGEk Q9UPT9 K144-ub Ubiquitination kMQGVGEkFstWEPt Q9UPT9 K152-ub Ubiquitination FstWEPtkRELELLk Q9UPT9 K159-ub Ubiquitination kRELELLkHNPKRRk Q9UPT9 K166-ub Ubiquitination kHNPKRRkITSNCTI Q9UPT9 K382-ub Ubiquitination LGSSAKIkCSGCHSY Q9UPT9 K394-ub Ubiquitination HSYQESTkQLTMKKL Q9UPT9 K417-ub Ubiquitination KRFEHSAkLRRKItT Q9UPT9 K493-ub Ubiquitination QHKDQWFkCDDAIIT Q9UPT9 K501-ub Ubiquitination CDDAIITkASIkDVL Q9UPT9 K505-ub Ubiquitination IITkASIkDVLDSEG

PTM - dbPTM UniProt ID Position Code Type Resources References Q9UPT9 129 K Acetylation Swiss-Prot 1010711 19608861 Q9UPT9 129 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UPT9 137 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UPT9 144 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9UPT9 152 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UPT9 159 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UPT9 35 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UPT9 493 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9UPT9 129 K Acetylation Phosphositeplus.1010730 19608861 Q9UPT9 129 K Acetylation HPRD 9.0 19608861 Q9UPT9 237 S Phosphorylation HPRD 9.0 19651622

PTM - HPRD Symbol Position Code Type References USP22 129 K Acetylation 19608861 USP22 237 S Phosphorylation 19651622

PTM - UniProt UniProt ID Position Type PMIDs Q9UPT9 129 N6-acetyllysine 19608861

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP22 IPI00010365 K 404 DMEIIAaKEEQRKA acetylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23326 116914 - K Ubiquitination 22118674 23326 116914 - K Ubiquitination 21139048 23326 116914 - K Ubiquitination 21890473 23326 116914 - K Ubiquitination 21906983 23326 116914 - K Ubiquitination 22505724 23326 116914 - K Ubiquitination 21963094 23326 116914 - K Ubiquitination 22053931 23326 116914 - K Ubiquitination 21987572 23326 116914 - K Ubiquitination 23000965 23326 116914 - K Ubiquitination 24654937 23326 116914 - K Sumoylation 24654937 23326 116914 - K Ubiquitination 25147182 23326 116914 - K Sumoylation 25391492

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP22 Homo sapiens (Human) 493; 505; 144 "493,HKDQWFKCDDAII; 505,ITKASIKDVLDSE; 144,MQGVGEKFSTWEP" 493:21890473; 505:21890473; 144:21890473 USP22 Homo sapiens (Human) 137; 152; 493; 35; 505; 159; 129; 144 "137,EQRKAWKMQGVGE; 152,STWEPTKRELELL; 493,HKDQWFKCDDAII; 35,FKVDNWKQNLRAI; 505,ITKASIKDVLDSE; 159,RELELLKHNPKRR; 129,DMEIIAKEEQRKA; 144,MQGVGEKFSTWEP" 137:21906983; 152:21906983; 493:21890473; 35:21906983; 505:21890473; 159:21906983; 129:21906983; 144:21890473 USP22 Homo sapiens (Human) 493; 117; 140; 125; 147; 481; 132 "493,ITKASIKDVLDSE; 117,DMEIIAKEEQRKA; 140,STWEPTKRELELL; 125,EQRKAWKMQGVGE; 147,RELELLKHNPKRR; 481,HKDQWFKCDDAII; 132,MQGVGEKFSTWEP" 493:21890473; 117:21906983; 140:21906983; 125:21906983; 147:21906983; 481:21890473; 132:21890473