PTM - CPLM Gene Name UniProt ID Type Position Code TRIM5; RNF88 Q9C035 Ubiquitination 324 K TRIM5; RNF88 Q9C035 Ubiquitination 282 K TRIM5; RNF88 Q9C035 Ubiquitination 481 K TRIM5; RNF88 Q9C035 Ubiquitination 50 K TRIM5; RNF88 Q9C035 Ubiquitination 171 K TRIM5; RNF88 Q9C035 Ubiquitination 84 K TRIM5; RNF88 Q9C035 Ubiquitination 79 K TRIM5; RNF88 Q9C035 Ubiquitination 264 K TRIM5; RNF88 Q9C035 Ubiquitination 45 K TRIM5; RNF88 Q9C035 Ubiquitination 270 K TRIM5; RNF88 Q9C035 Ubiquitination 255 K TRIM5; RNF88 Q9C035 Ubiquitination 91 K TRIM5; RNF88 Q9C035 Ubiquitination 152 K TRIM5; RNF88 Q9C035 Ubiquitination 263 K TRIM5; RNF88 Q9C035 Ubiquitination 178 K TRIM5; RNF88 Q9C035 Ubiquitination 212 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TRIM5; RNF88 Q9C035 176 Y Homo sapiens(Human) TRIM5; RNF88 Q9C035 197 S Homo sapiens(Human) TRIM5; RNF88 Q9C035 329 Y Homo sapiens(Human) TRIM5; RNF88 Q9C035 416 S Homo sapiens(Human) TRIM5; RNF88 Q9C035 490 S Homo sapiens(Human) TRIM5; RNF88 Q9C035 492 S Homo sapiens(Human) TRIM5; RNF88 Q9C035 493 S Homo sapiens(Human) TRIM5; RNF88 Q9C035 86 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9C035 S3-p Phosphorylation _____MAsGILVNVk Q9C035 S86-p Phosphorylation kLREVkLsPEGQkVD Q9C035 Y176-p Phosphorylation SWKTQIQyDkTNVLA Q9C035 S197-p Phosphorylation DILDWEEsNELQNLE Q9C035 Y329-p Phosphorylation SPkPQIIyGARGTRY Q9C035 S416-p Phosphorylation KCSAFQDsSFHTPSV Q9C035 S490-p Phosphorylation GVPMTLCsPss____ Q9C035 S492-p Phosphorylation PMTLCsPss______ Q9C035 S493-p Phosphorylation MTLCsPss_______ Q9C035 K10-sm Sumoylation sGILVNVkEEVTCPI Q9C035 K45-ub Ubiquitination CLTANHKkSMLDkGE Q9C035 K50-ub Ubiquitination HKkSMLDkGESSCPV Q9C035 K79-ub Ubiquitination HVANIVEkLREVkLs Q9C035 K84-ub Ubiquitination VEkLREVkLsPEGQk Q9C035 K91-ub Ubiquitination kLsPEGQkVDHCARH Q9C035 K178-ub Ubiquitination KTQIQyDkTNVLADF Q9C035 K212-ub Ubiquitination KEEEDILkSLTNSET Q9C035 K255-ub Ubiquitination QGVDGVIkRTENVTL Q9C035 K282-ub Ubiquitination VFRAPDLkGMLEVFR Q9C035 K324-ub Ubiquitination KRQVSSPkPQIIyGA

PTM - dbPTM UniProt ID Position Code Type Resources References Q9C035 86 S Phosphorylation Swiss-Prot 1010711 18691976 Q9C035 178 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9C035 212 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9C035 255 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9C035 282 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9C035 324 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9C035 86 S Phosphorylation Phosphositeplus.1010730 18691976 Q9C035 86 S Phosphorylation HPRD 9.0 18691976

PTM - HPRD Symbol Position Code Type References TRIM5 86 S Phosphorylation 18691976

PTM - UniProt UniProt ID Position Type PMIDs Q9C035 2 N-acetylalanine 22223895 Q9C035 86 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TRIM5 IPI00394971 S 86 LREVKLpSPEGQKV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 85363 124491 - K Ubiquitination 18312418 85363 124491 - K Ubiquitination 21139048 85363 124491 - K Ubiquitination 21890473 85363 124491 - K Ubiquitination 21906983 85363 124491 - K Ubiquitination 18799573 85363 124491 - K Ubiquitination 22505724 85363 124491 - K Ubiquitination 21963094 85363 124491 - K Ubiquitination 23000965 85363 124491 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TRIM5 Homo sapiens (Human) 324 "324,RQVSSPKPQIIYG" 324:21890473 TRIM5 Homo sapiens (Human) 324; 178; 212; 282 "324,RQVSSPKPQIIYG; 178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 324:21890473; 178:21906983; 212:21906983; 282:21906983 TRIM5 Homo sapiens (Human) 178; 212; 283 "178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 283,FRAPDLKGMLEVF" 178:21906983; 212:21906983; 283:21906983 TRIM5 Homo sapiens (Human) 178 "178,TQIQYDKTNVLAD" 178:21906983 TRIM5 Homo sapiens (Human) 255; 324; 178; 212; 282 "255,GVDGVIKRTENVT; 324,RQVSSPKPQIIYG; 178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 255:21906983; 324:21890473; 178:21906983; 212:21906983; 282:21906983 TRIM5 Homo sapiens (Human) 255; 178; 212; 282 "255,GVDGVIKRTENVT; 178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 255:21906983; 178:21906983; 212:21906983; 282:21906983 TRIM5 Homo sapiens (Human) 255; 324; 178; 212; 282 "255,GVDGVIKRTENVT; 324,RQVSSPKPQIIYG; 178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 255:21906983; 324:21890473; 178:21906983; 212:21906983; 282:21906983 TRIM5 Homo sapiens (Human) 178; 212 "178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE" 178:21906983; 212:21906983 TRIM5 Homo sapiens (Human) 255; 178; 212; 282 "255,GVDGVIKRTENVT; 178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 255:21906983; 178:21906983; 212:21906983; 282:21906983 TRIM5 Homo sapiens (Human) 178; 212; 282 "178,TQIQYDKTNVLAD; 212,EEEDILKSLTNSE; 282,FRAPDLKGMLEVF" 178:21906983; 212:21906983; 282:21906983