PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CASK TRIM22 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 CIC 16713569 hprd,biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 TAB2 23818111 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM22 USP7 16713569 hprd,biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 RERE 16713569 hprd,biogrid,mint,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CREB1 TRIM22 20211142 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TAF7 TRIM22 20211142 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ZZZ3 TRIM22 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EIF4E TRIM22 22509910 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 TRIM22 17156811, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SKI TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 TSG101 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HCLS1 TRIM22 25402006 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G G GP G G G MICB TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G UBE2L6 TRIM22 25402006, 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CASP8 TRIM22 23023127 pred GP GP G GP P GP GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP GP G TRIM22 CMYA5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G TRIM22 TRIM5 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G TRIM22 CHMP4B 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G RNF135 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PXN TRIM22 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP G GP G TRIM22 IFI44 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP G GP GP G GP G GP G CUL1 TRIM22 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G CCL5 TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP100 TRIM22 25402006, 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G TRAF2 TRIM22 23023127 pred P P P P P P P P P P P P P P P P P P P GP GP P TRIM25 TRIM22 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM22 PHF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 IRF7 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OASL TRIM22 23023127 pred GP G G G GP GP G G GP G G G GP GP G G GP G G G GP G G GP G G G GP G CXCL11 TRIM22 25402006 pred P P P P P P P P P P P P P GP P P P P P P P P OAS1 TRIM22 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G BTN3A2 TRIM22 25402006 pred GP GP G GP GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP P GP GP GP GP G DDX58 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G IFI16 TRIM22 25402006, 23023127 pred G G G G GP GP G G GP G GP G G GP G G GP GP G G G G G G G GP G G G TRIM28 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MX1 TRIM22 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM22 ALG2 21836163 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G XAF1 TRIM22 25402006 pred G GP G G GP GP G GP GP G GP GP G G G GP GP GP P G GP G GP G GP G GP GP G APOL3 TRIM22 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM22 LNX2 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G HLA-E TRIM22 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP G G GP GP GP GP G UBE2N TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2C TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 PVRL2 23023127 pred GP GP G G GP G G GP GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP GP GP GP G UBE2D3 TRIM22 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G IRF1 TRIM22 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G TRIM22 MALT1 23023127 pred G G GP G G G G G G GP G G G G G G G G G G G G GP G HLA-G TRIM22 25402006 pred G G G G G G G G G G G G G G G G G G G G GP G G G G G G G G ILK TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 TRIM31 23023127 pred P P G GP P GP P P P P P P P GP P P P P GP P P GP P TRIM22 TRIM31 23023127 pred P P G GP P GP P P P P P P P GP P P P P GP P P GP P IFIT3 TRIM22 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP G GP G GP GP G TNFRSF1A TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PLSCR1 TRIM22 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4A TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IRF9 TRIM22 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRIM22 TRIM52 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G MDM2 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2NL TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMB9 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TRIM22 DMBT1 23023127 pred G G G G G G G G GP G GP G GP G G GP G G G G G G GP G GP G GP G G TP53 TRIM22 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G IGFBP7 TRIM22 23023127 pred G G G G G G G G G G GP G G G G G G G GP G G G G G G G G GP G IFIT1 TRIM22 25402006 pred G GP G GP G GP GP G GP GP GP GP G GP GP G P G G GP GP GP GP G GP GP TRIM22 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P TRIM72 TRIM22 23023127 pred P P P GP G G P IFIT5 TRIM22 25402006 pred G G G G G GP G G G G G G G G G G GP G G G G G G G G GP G G TRIM22 SAMHD1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP GP GP GP G TRIM22 ISG20 23023127 pred G G G G G G G G G G G G G G G G G G G G G TGFB1 TRIM22 23023127 pred G G G G GP G G G G G G G G G G GP G G G G GP G G GP GP GP G G RAG1 TRIM22 23023127 pred IQGAP1 TRIM22 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G LGALS3BP TRIM22 25402006 pred GP G G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP G G GP G GP GP G TRIM22 UBE2D4 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G NMI TRIM22 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G HERPUD1 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GBP1 TRIM22 25402006 pred G G G G GP G G GP G GP G GP G G GP GP G G G G G G GP G G G GIMAP6 TRIM22 25402006 pred GP GP G G GP P GP GP G GP G GP GP G GP P P GP GP GP GP GP GP G GP P G TRIM73 TRIM22 23023127 pred GP G G G G GP G GP GP G GP GP G G G GP GP G P G P GP GP P GP G GP G G ISG15 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRAK1 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM22 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM22 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G TRIM22 RNASE6 25402006 pred G P G G G P GP G G G G G G HNRNPK TRIM22 23023127 pred P P P P P P P P P P P P P P P P P P P P P P HLA-DRA TRIM22 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G G G GP GP GP GP GP G G TRIM22 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G IFNGR2 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CXCL10 TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP5C TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NPC2 TRIM22 23023127 pred G GP G G GP G G G G G GP GP GP GP G G G G GP G GP GP GP G G GP GP GP G TRIM22 SP110 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM50 TRIM22 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP UBE2A TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZC3HAV1 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ALOX5AP TRIM22 23023127 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G G GP G G G PDLIM4 TRIM22 23023127 pred GP GP G P GP G GP GP G GP P GP G G GP GP G GP G G G GP G GP GP GP G G SKIL TRIM22 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G TRIM22 CD93 23023127 pred G G G G GP GP G G GP G GP G GP G G G GP G G G G G G G G GP G G G PTPRC TRIM22 25402006 pred G G G G GP G G G G G G G G GP G G G G G G G G G G GP G G LYN TRIM22 23023127 pred GP G G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP G G TRIM22 FYCO1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF3 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM22 CHMP1A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G MX2 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G TRIM22 TRIM54 23023127 pred P P P GP P P P P G P GP GP P P HLA-DPA1 TRIM22 25402006 pred G G G G G GP G G G G G G GP GP G G GP G G G G G G G G GP G GP G HLA-C TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HLA-A TRIM22 23023127 pred UBE2B TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FYB TRIM22 23023127 pred G G G GP G G G G G G G GP G G G G G G G G GP G IFI44L TRIM22 25402006 pred GP GP G G GP GP G GP GP G GP G G G G GP GP G P G P GP GP GP GP GP GP GP TRIM27 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 UBE2F 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM22 TRIM63 23023127 pred G G G G FGL2 TRIM22 25402006 pred G G G G GP GP G G GP G G G GP GP G G GP G G G G G G G G GP G G G RFPL4A TRIM22 23023127 pred P P P P P P P P P P P P P P P P P P P P P P HLA-F TRIM22 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM38 TRIM22 25402006, 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G LAP3 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G BIRC2 TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G TRIM22 CUL5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CFLAR TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 TRIM22 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 ERMAP 23023127 pred GP GP G GP P P P P GP P P G P P P G GP P GP P P GP GP P TRIM22 RSAD2 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G P GP GP GP G GP G G GP GP GP GP P G TRIM22 TRIM10 23023127 pred G G G G G G G G G G G G G G GP G GP G G G G G GP GP GP GP G TRIM22 PEX13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRAT1 TRIM22 21836163 pred P GP G PLCG2 TRIM22 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP G G GP G G GP GP GP GP GP G IFI35 TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EVI2B TRIM22 25402006 pred GP GP G G GP GP G GP GP G P GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P INSR TRIM22 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM74 TRIM22 23023127 pred NASP TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP GP GP G GP GP GP GP GP G GP GP G HLA-DPB1 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP GP G GP GP GP GP G DDX60 TRIM22 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP P G IRF8 TRIM22 25402006 pred G G G G GP G G G G G G G GP GP G G G G G G G G G G G GP G G G VPS4B TRIM22 21836163 pred GP G G G GP GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP GP GP GP G TRIM22 VPS25 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2S TRIM22 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G TRIM22 STUB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TNFSF10 TRIM22 25402006, 23023127 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G TRIM22 DTX3L 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP GP G FADD TRIM22 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G GP GP GP GP GP GP G BIRC3 TRIM22 23023127 pred GP G GP G G GP P GP G GP G GP G GP P G GP GP GP GP GP ARL6IP1 TRIM22 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G CASP1 TRIM22 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G BTN3A3 TRIM22 25402006, 23023127 pred GP GP G GP P G GP GP G GP GP GP GP G GP GP GP P G P GP P P GP GP GP P G UBE2D1 TRIM22 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G IFITM1 TRIM22 25402006 pred GP G G G GP GP G G GP G GP G G GP G G GP GP G G G G GP G G GP G G G TRIM22 WFDC12 23023127 pred UBE2I TRIM22 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PSMB8 TRIM22 25402006 pred GP GP G GP P G G GP GP GP GP GP G GP P G GP GP GP GP GP GP GP P G TRIM75P TRIM22 23023127 pred STAT1 TRIM22 25402006 pred G G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP G GP G TRIM22 CPVL 21836163 pred G G G G GP G G GP G G GP G GP G G G G G GP G GP G G G G GP G GP G UBE2D2 TRIM22 23023127, 21836163 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G TRIM22 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM22 TRIM34 23023127 pred CD74 TRIM22 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MICA TRIM22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IYM9 Q93009 two hybrid 16713569 - X 2 Q8IYM9 Q93009 two hybrid 16713569 - X 2 Q8IYM9 Q9P2R6-2 two hybrid 16713569 - X 2 Q8IYM9 Q9P2R6-2 two hybrid 16713569 - X 2 Q8IYM9 Q96RK0 two hybrid 16713569 - X 2 Q8IYM9 Q96RK0 two hybrid 16713569 - X 2 Q8IYM9 Q93009 two hybrid array 16713569 physical association X 2 Q8IYM9 Q5NF08 two hybrid pooling approach 20711500 physical association X 2 Q8IYM9 Q5NES5 two hybrid pooling approach 20711500 physical association X 2 Q8IYM9 Q81NI7 two hybrid pooling approach 20711500 physical association X 2 Q8IYM9 O14936 two hybrid array 21988832 physical association X 2 Q7CIT3 Q8IYM9 two hybrid pooling approach 20711500 physical association X 2 Q8IYM9 Q96RK0 two hybrid array 16713569 physical association X 2 Q8IYM9 A0A024R4E9 two hybrid array 16713569 physical association X 2 Q5NID2 Q8IYM9 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC TRIM22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19218198,21139048,21890473,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_149721|BIOGRID_174470|BIOGRID_170088|BIOGRID_268067 bait|bait|bait|bait prey|prey|prey|prey TRIM22 USP7 MI:0096(pull down)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint) MINT_82802|BIOGRID_215419|UniProt_85835|HPRD_27089|MINT_50514 prey|prey|bait|-|prey bait|bait|prey|-|bait CASK TRIM22 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285843|UniProt_117593 bait|unspecified role prey|unspecified role ZZZ3 TRIM22 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128841 prey bait TRIM22 RERE MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) UniProt_85811|BIOGRID_215388|MINT_82801|HPRD_27243|MINT_50513 bait|prey|prey|-|prey prey|bait|bait|-|bait TRIM22 TAB2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23818111 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_283264|BIOGRID_283263 prey|bait bait|prey CREB1 TRIM22 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128327 bait prey TRIM22 CIC MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) BIOGRID_215323|UniProt_85762|MINT_82800|HPRD_34513|MINT_50512 prey|bait|prey|-|prey bait|prey|bait|-|bait TAF7 TRIM22 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128691 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CASK TRIM22 21988832,21988832 0397,0018 HT CREB1 TRIM22 20211142 0018 HT TAF7 TRIM22 20211142 0018 HT ZZZ3 TRIM22 20211142 0018 HT TRIM22 USP7 16713569,16713569 0397,0018 HT TRIM22 CIC 16713569,16713569 0397,0018 HT TRIM22 RERE 16713569,16713569 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IYM9 O14936 TRIM22 CASK 0.286 21988832 Q8IYM9 Q5NES5 TRIM22 Q5NES5 0.126 20711500 Q8IYM9 Q5NF08 TRIM22 RHO 0.126 20711500 Q8IYM9 Q8IYM9 TRIM22 TRIM22 0.332 17156811 Q8IYM9 Q8IYH5 TRIM22 ZZZ3 0.183 20211142 Q8IYM9 Q7CIT3 TRIM22 GLCD3 0.126 20711500 Q8IYM9 P06730 TRIM22 EIF4E 0.376 22509910 Q8IYM9 Q5NID2 TRIM22 RPOB 0.126 20711500 Q9NYJ8 Q8IYM9 TAB2 TRIM22 0.376 23818111 Q8IYM9 P16220 TRIM22 CREB1 0.183 20211142 Q8IYM9 Q81NI7 TRIM22 Q81NI7 0.126 20711500 Q9H8W4 Q8IYM9 PLEKHF2 TRIM22 0.236 unassigned1304 Q9P2R6 Q8IYM9 RERE TRIM22 0.286 16713569 Q96RK0 Q8IYM9 CIC TRIM22 0.286 16713569 Q93009 Q8IYM9 USP7 TRIM22 0.286 16713569 Q8IYM9 Q15545 TRIM22 TAF7 0.183 20211142

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CASK TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database EIF4E TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database CREB1 TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database TAF7 TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database ZZZ3 TRIM22 MI:0045 experimental interaction detection MI:0461 interaction database TRIM22 USP7 MI:0045 experimental interaction detection MI:0461 interaction database TRIM22 CIC MI:0045 experimental interaction detection MI:0461 interaction database TRIM22 TAB2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM22 RERE MI:0045 experimental interaction detection MI:0461 interaction database