PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SMAD1 RNF138 15761153 i2d exp G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G RNF138 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SLX4 RNF138 19596235 intact exp P P G G GP GP P P G P P G G GP GP P G P P P G P GP UBE2K RNF138 25416956,19549727,16714285 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 UBE2D4 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G PCBP4 RNF138 16713569 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFBR1 RNF138 15761153 i2d exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G C6orf165 RNF138 16189514 hprd,biogrid,mint,intact exp P P P P P P P P P P P P GP APP RNF138 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G MAPK14 RNF138 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G LNX2 RNF138 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G RNF138 LEF1 16714285 biogrid exp G G G G GP GP G GP G GP GP G G G GP G G G G G G G G G G RNF138 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G BZW1 RNF138 26186194 biogrid exp GP GP G G GP G G G GP G GP GP GP G G GP G G GP G G GP G G GP G GP GP G TAF9 RNF138 16713569 hprd,biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G XPO1 RNF138 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 COPS5 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 QKI 16713569 hprd,biogrid,mint,intact exp G G G G GP GP G G GP G GP G GP G G G GP G G G GP G G GP G G G GP G SMAD4 RNF138 15761153 i2d exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G RNF138 DVL3 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G COPS6 RNF138 21145461 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G ELAVL1 RNF138 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 UBE2W 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 TCF7L2 16714285 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF138 NAP1L5 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RNF138 TRPV5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G UBE2D2 RNF138 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G RYR1 RNF138 ortho P G GP G P G G GP GP G G UBE2C RNF138 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2D3 RNF138 23023127 pred GP G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G SMAD2 RNF138 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G TGFB1I1 RNF138 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G RNF138 INVS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G RNF138 HDAC2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2B RNF138 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNRPD1 RNF138 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RNF138 PTP4A1 25402006 pred G GP G G G G G G G G G G G G G GP G GP G G G G G G GP G GP G G UBE2D1 RNF138 23023127 pred GP G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WVD3 anti tag coimmunoprecipitation 19596235 association C 77 A0A0A6YY93 Q8WVD3 two hybrid array 16713569 physical association X 2 Q8WVD3 Q8IYR0 two hybrid pooling approach 16189514 physical association X 2 Q8WVD3 B3KSH4 two hybrid array 19549727 physical association X 2 Q8WVD3 P62837 two hybrid array 19549727 physical association X 2 Q8WVD3 Q9BZR9 two hybrid array 22493164 physical association X 2 Q96PU8 Q8WVD3 two hybrid array 16713569 physical association X 2 Q8WVD3 A0A024R320 two hybrid array 16713569 physical association X 2 Q8WVD3 Q96B02 two hybrid array 19549727 physical association X 2 Q8WVD3 P61086 two hybrid 19549727 physical association X 2 Q8WVD3 A0A024RA90 two hybrid array 19549727 physical association X 2 Q8WVD3 Q8N448 two hybrid array 22493164 physical association X 2 Q8WVD3 P61086 two hybrid prey pooling approach 25416956 physical association X 2 Q8WVD3 P61086 two hybrid array 25416956 physical association X 2 Q8WVD3 P61086 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B C6orf165 RNF138 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0468(hprd) MINT_67739|UniProt_152944|MINT_38525|BIOGRID_80101|HPRD_23661 prey|unspecified role|prey|prey|- bait|unspecified role|bait|bait|- TCF4 RNF138 MI:0096(pull down) 16714285 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124797 prey bait RNF138 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100980 prey bait TAF9 RNF138 MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0397(two hybrid array) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact) BIOGRID_215397|MINT_50725|MINT_83013|HPRD_25102|UniProt_85817 bait|bait|bait|-|prey prey|prey|prey|-|bait QKI RNF138 MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_50724|BIOGRID_215382|MINT_83012|UniProt_85807|HPRD_34276 bait|bait|bait|prey|- prey|prey|prey|bait|- APP RNF138 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229477 prey bait RNF138 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124029|UniProt_101153 prey|prey bait|bait ELAVL1 RNF138 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187670 bait prey LNX2 RNF138 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284021|UniProt_122552 prey|bait bait|prey UBE2W RNF138 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101481|BIOGRID_124262 bait|bait prey|prey COPS5 RNF138 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205460 bait prey UBE2K RNF138 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_100746|BIOGRID_124030 bait|bait prey|prey UBE2D2 RNF138 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124261|UniProt_101262 bait|bait prey|prey RNF138 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122551|BIOGRID_283991 prey|bait bait|prey COPS6 RNF138 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205726 bait prey PCBP4 RNF138 MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd) MINT_50723|MINT_83011|BIOGRID_215366|UniProt_85795|HPRD_34806 bait|bait|bait|prey|- prey|prey|prey|bait|-

PPI - HINT Gene A Gene B PMID Method Quality UBE2K RNF138 27173435,16714285 0676,0004 HT,LC MAPK14 RNF138 26186194 0004 HT BZW1 RNF138 26186194 0004 HT COPS6 RNF138 21145461 0004 HT RNF138 COPS5 21145461 0004 HT RNF138 NAP1L5 26186194 0004 HT RNF138 TRPV5 26186194 0004 HT UBE2K RNF138 27173435 0676 HT MAPK14 RNF138 26186194 0004 HT BZW1 RNF138 26186194 0004 HT COPS6 RNF138 21145461 0004 HT RNF138 COPS5 21145461 0004 HT RNF138 NAP1L5 26186194 0004 HT RNF138 TRPV5 26186194 0004 HT UBE2K RNF138 16714285 0004 LC HIP2 RNF138 19549727 0397 HT RAD51D RNF138 27161866,27161866 0018,0004 LC TGFBR1 RNF138 15761153 0019 HT PCBP4 RNF138 16713569,16713569 0397,0018 HT UBE2K RNF138 25416956,25416956,25416956,25416956,19549727 1112,0397,0018,1356,0018 HT UBE2D2 RNF138 19549727,19549727 0397,0018 HT SMAD4 RNF138 15761153 0019 HT SMAD1 RNF138 15761153 0019 HT TAF9 RNF138 16713569,16713569 0397,0018 HT C6ORF165 RNF138 16189514,16189514 0398,0018 HT LNX2 RNF138 22493164,22493164 0018,0397 HT Q8N771 RNF138 16189514 0018 HT RNF138 UBE2W 19549727,19549727 0397,0018 HT RNF138 QKI 16713569,16713569 0397,0018 HT RNF138 TRIM8 22493164,22493164 0018,0397 HT RNF138 SMURF1 15761153 0019 HT RNF138 TCF7L2 16714285,16714285 0415,0004 LC RNF138 LEF1 16714285,16714285 0415,0004 LC RNF138 UBE2D4 19549727,19549727 0397,0018 HT RNF138 AK6 16713569 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WVD3 B3KSH4 RNF138 HIP2 0.126 19549727 Q8WVD3 P57078 RNF138 RIPK4 0.126 26972000 Q8WVD3 O14980 RNF138 XPO1 0.126 26673895 Q9NQA5 Q8WVD3 TRPV5 RNF138 0.126 26186194 Q8WVD3 Q7L1Q6 RNF138 BZW1 0.126 26186194 Q8WVD3 Q7L5N1 RNF138 COPS6 0.126 21145461 Q8WVD3 Q6P5F9 RNF138 XPO1 0.126 26673895 Q8WVD3 O94888 RNF138 UBXN7 0.126 26389662 Q8WVD3 O75771 RNF138 RAD51D 0.702 27161866 Q8WVD3 O95967 RNF138 EFEMP2 0.236 unassigned1304 Q96HA8 Q8WVD3 WDYHV1 RNF138 0.236 unassigned1304 Q8WVD3 Q16594 RNF138 TAF9 0.286 16713569 Q8WVD3 P62837 RNF138 UBE2D2 0.286 19549727 Q8WVD3 P61086 RNF138 UBE2K 0.863 25416956,16714285,27173435,unassigned1312,19549727,unassigned1304 Q92905 Q8WVD3 COPS5 RNF138 0.126 21145461 Q8WVD3 P57723 RNF138 PCBP4 0.376 16713569 Q8WVD3 P05067 RNF138 APP 0.183 21832049 Q9BZR9 Q8WVD3 TRIM8 RNF138 0.286 22493164 Q8WVD3 Q8IYR0 RNF138 C6ORF165 0.286 16189514 Q8WVD3 Q8IY92 RNF138 SLX4 0.236 19596235 Q96PU8 Q8WVD3 QKI RNF138 0.286 16713569 Q8WVD3 Q8N448 RNF138 LNX2 0.286 22493164 Q96B02 Q8WVD3 UBE2W RNF138 0.376 19549727 Q9Y2X8 Q8WVD3 UBE2D4 RNF138 0.286 19549727 Q9NQB0 Q8WVD3 TCF7L2 RNF138 0.454 16714285 Q9UJU2 Q8WVD3 LEF1 RNF138 0.454 16714285 Q96NT1 Q8WVD3 NAP1L5 RNF138 0.126 26186194 Q8WVD3 Q15717 RNF138 ELAVL1 0.126 19322201 Q8WVD3 Q16539 RNF138 MAPK14 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database RAD51D RNF138 MI:0045 experimental interaction detection MI:0461 interaction database UBXN7 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database APP RNF138 MI:0045 experimental interaction detection MI:0461 interaction database TCF4 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database RYR1 RNF138 MI:0362 inference MI:0461 interaction database TGFBR1 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database PCBP4 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K RNF138 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database SMAD4 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database MAPK14 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database TAF9 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database CYHR1 RNF138 MI:0362 inference MI:0461 interaction database BZW1 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database SLX4 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database C6orf165 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database LNX2 RNF138 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF138 NAP1L5 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 QKI MI:0045 experimental interaction detection MI:0461 interaction database RNF138 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 TRPV5 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 TCF7L2 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 LEF1 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database