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GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBA3 UHRF2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPH2 UBA3 25402006 pred P P P P P P P P P P P P P P P P P P P P P P UBA3 EID1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBA3 STOML2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL2 UBA3 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G UBA3 SMC3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CBX3 UBA3 25402006 pred ADRM1 UBA3 25402006, 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RPN1 UBA3 21836163 pred G GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2L3 UBA3 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G UBA7 UBA3 23023127 pred P P P P P P P P P P P P P P P P P P RAB11A UBA3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAP UBA3 25402006 pred G GP G G G GP G GP G G G G GP G G G GP G G G G G G G G G GP GP G UBE2E1 UBA3 25402006, 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G PSMC3 UBA3 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VAMP7 UBA3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RBX1 UBA3 25402006, 23023127 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8TBC4 - 14690597 - X 2 Q8TBC4 - 14690597 - X 2 Q8TBC4 Q13564 - 14690597 - X 2 Q8TBC4 Q13564 - 12646924 - X 2 Q8TBC4 Q13564 - 14690597 - X 2 Q8TBC4 A0A024R4T4 enzymatic study 15361859 direct interaction X 2 Q8TBC4 P0CG48 pull down 18652489 direct interaction X 2 Q8TBC4 A0A024R4T4 pull down 18652489 direct interaction X 2 Q8TBC4 A0A024R4T4 x-ray crystallography 15694336 association X 2 Q8TBC4 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q8TBC4 Q9Y3C8 biochemical 22939629 colocalization X 2 Q8TBC4 P60981-2 biochemical 22939629 colocalization X 2 Q8TBC4 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q8TBC4 Q9BWD1 biochemical 22863883 colocalization X 2 Q8TBC4 P23526-2 biochemical 22863883 colocalization X 2 Q8TBC4 P17655 biochemical 22863883 colocalization X 2 Q8TBC4 Q96C86 biochemical 22863883 colocalization X 2 Q8TBC4 B3KSC8 biochemical 22863883 colocalization X 2 Q8TBC4 O14980 biochemical 22863883 colocalization X 2 Q8TBC4 P0CG48 affinity chromatography technology 24816145 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 25015289 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q8TBC4 O14732 two hybrid 25416956 direct interaction X 2 Q8TBC4 Q8TBC4 two hybrid 25416956 direct interaction X 2 Q8TBC4 A0A024R4T4 enzymatic study 19250909 direct interaction X 2 Q8TBC4 Q8TBC4 enzymatic study 10207026 direct interaction X 2 Q8TBC4 A0A024R4T4 enzymatic study 10207026 direct interaction X 2 Q8TBC4 A0A024R4T4 affinity chromatography technology 17353931 physical association X 2 Q8TBC4 A0A024R7R0 affinity chromatography technology 19615732 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q8TBC4 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q8TBC4 Q15843 affinity chromatography technology 16503656 physical association X 2 Q8TBC4 Q13564-4 x-ray crystallography 18264111 association X 2 Q8TBC4 Q13564-4 x-ray crystallography 17220875 association X 2 Q8TBC4 Q13564-4 x-ray crystallography 12646924 association X 2 Q8TBC4 Q13564-4 biochemical 12740388 association X 2 Q8TBC4 Q15843 pull down 18652489 direct interaction X 2 Q8TBC4 Q15843 affinity chromatography technology 21145461 physical association X 2 Q8TBC4 Q13564-4 pull down 9694792 direct interaction X 2 Q8TBC4 Q13564-4 biochemical 22939629 colocalization X 2 Q8TBC4 Q9GZS3 biochemical 22939629 colocalization X 2 Q8TBC4 P32119 biochemical 22939629 colocalization X 2 Q8TBC4 biochemical 22939629 colocalization X 2 Q8TBC4 Q12792-3 biochemical 22939629 colocalization X 2 Q8TBC4 Q8WVJ2 biochemical 22939629 colocalization X 2 Q8TBC4 biochemical 22939629 colocalization X 2 Q8TBC4 Q5TFE4 biochemical 22939629 colocalization X 2 Q8TBC4 O60341 two hybrid 23455924 direct interaction X 2 Q8TBC4 Q13564-4 biochemical 22863883 colocalization X 2 Q8TBC4 biochemical 22863883 colocalization X 2 Q8TBC4 O43252 biochemical 22863883 colocalization X 2 Q8TBC4 Q8IU85 biochemical 22863883 colocalization X 2 Q8TBC4 Q15843 affinity chromatography technology 24654937 physical association X 2 Q8TBC4 Q96FN4 two hybrid 25416956 direct interaction X 2 Q8TBC4 Q13564-4 pull down 15361859 direct interaction X 2 Q8TBC4 Q969M7 enzymatic study 19250909 direct interaction X 2 Q8TBC4 Q13564-4 pull down 10207026 direct interaction X 2 Q8TBC4 B3KWV4 two hybrid 16169070 direct interaction X 2 Q8TBC4 Q13564-4 two hybrid 10722740 direct interaction X 2 Q8TBC4 Q13564-4 affinity chromatography technology 10722740 physical association X 2 Q8TBC4 Q15843 affinity chromatography technology 16620772 physical association X 2 Q9BRA2 Q8TBC4 biochemical 22939629 colocalization X 2 Q8TBC4 Q13564 x-ray crystallography 12646924 association X 2 Q8TBC4 enzymatic study 18805092 neddylation reaction C 4 Q8TBC4 enzymatic study 18805092 neddylation reaction C 4 Q8TBC4 A0A024R4T4 x-ray crystallography 15694336 direct interaction X 2 Q8TBC4 P54727 pull down 16712842 physical association X 2 Q8TBC4 A0A024R7G8 pull down 16712842 physical association X 2 Q8TBC4 P54727 pull down 16712842 physical association X 2 Q8TBC4 A0A024R4T4 anti bait coimmunoprecipitation 17353931 physical association X 2 Q8TBC4 A0A024R4T4 two hybrid 19549727 physical association X 2 Q8TBC4 Q8TBC4 two hybrid array 25416956 physical association X 2 Q8TBC4 O14732 two hybrid prey pooling approach 25416956 physical association X 2 Q8TBC4 O14732 two hybrid array 25416956 physical association X 2 Q8TBC4 O14732 validated two hybrid 25416956 physical association X 2 Q9WMX2 Q8TBC4 two hybrid prey pooling approach 18985028 physical association X 2 Q8TBC4 enzymatic study 17098746 neddylation reaction C 6 Q8TBC4 x-ray crystallography 14690597 physical association C 3 Q8TBC4 x-ray crystallography 14690597 physical association C 3 Q8TBC4 anti tag coimmunoprecipitation 19615732 physical association C 33 Q8TBC4 Q12873 two hybrid pooling approach 16169070 physical association X 2 Q8TBC4 Q969M7 two hybrid 19549727 physical association X 2 Q8TBC4 O60341 two hybrid 23455924 physical association X 2 Q8TBC4 Q96FN4 two hybrid prey pooling approach 25416956 physical association X 2 Q8TBC4 Q96FN4 two hybrid array 25416956 physical association X 2 Q8TBC4 Q96FN4 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBA3 WDR61 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239034 bait prey CHD3 UBA3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint) MINT_64295|BIOGRID_94914|UniProt_155858|HPRD_29779|MINT_35293 prey|prey|prey|-|prey bait|bait|bait|-|bait TWF1 UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240330 bait prey VCL UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241240 prey bait UBA3 UIMC1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120003|UniProt_100723 prey|prey bait|bait PRDX2 UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239166 bait prey RAD23B UBA3 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16712842 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint) MINT_49530|MINT_49532|UniProt_167486|MINT_81738|UniProt_167484|UniProt_200129|UniProt_84983|UniProt_200127|UniProt_84985|MINT_81740 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey UBE2M UBA3 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0114(x-ray crystallography) 15361859,15694336,17353931,18652489,19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(intact)|(biogrid) BIOGRID_200035|BIOGRID_82496|HPRD_32522|UniProt_100880|UniProt_80450|BIOGRID_203107|UniProt_147101|BIOGRID_205029 prey|bait|-|bait|neutral component|prey|bait|bait bait|prey|-|prey|neutral component|bait|prey|prey UBE2H UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240249 prey bait XPO1 UBA3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_305077 prey bait UBA3 TXNDC17 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239570 prey bait CAMK1D UBA3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304734 bait prey UBA3 ACAT2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298224 bait prey UBA3 PCYT2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301801 bait prey UBA3 NUDCD2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240583 prey bait RAD23A UBA3 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16712842 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact) MINT_49531|MINT_81739|UniProt_84984|UniProt_167485|UniProt_200128 bait|bait|bait|bait|bait prey|prey|prey|prey|prey KDM1A UBA3 MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 23455924 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_297760|UniProt_129737 prey|bait bait|prey PAPSS1 UBA3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301758 prey bait UBA3 NSFL1C MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301499 bait prey AHCY UBA3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298343 prey bait DSTN UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242533 bait prey UBA3 UBE2F MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100958 prey bait UBA3 DCPS MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299249 bait prey NT5DC1 UBA3 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243329 bait prey CAPN2 UBA3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298878 prey bait NEDD8 UBA3 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0096(pull down) 10207026,14690597,16503656,16620772,18652489,21145461,9694792 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction) (intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) UniProt_73963|UniProt_73964|HPRD_39551|BIOGRID_115756|BIOGRID_206910|BIOGRID_209541|BIOGRID_115755|BIOGRID_194570|HPRD_12107|BIOGRID_123870|BIOGRID_197486|BIOGRID_203103 neutral component|neutral component|-|bait|bait|bait|prey|bait|-|bait|bait|prey neutral component|neutral component|-|prey|prey|prey|bait|prey|-|prey|prey|bait UBC UBA3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 18652489,21139048,21890473,21906983,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_166249|BIOGRID_181316|BIOGRID_172222|BIOGRID_225444|BIOGRID_175942|BIOGRID_268675|BIOGRID_203105 bait|bait|bait|bait|bait|bait|prey prey|prey|prey|prey|prey|prey|bait NAE1 UBA3 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0493(in vivo) 10722740,12646924,12740388,14690597,16503656,17220875,18264111,22863883,22939629,9694792 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|- (intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_73963|UniProt_73964|HPRD_39551|BIOGRID_201342|BIOGRID_209542|BIOGRID_115752|BIOGRID_231251|BIOGRID_115751|BIOGRID_199079|BIOGRID_199077|BIOGRID_301268|BIOGRID_201633|HPRD_12113 neutral component|neutral component|-|bait|bait|prey|prey|bait|bait|bait|prey|bait|- neutral component|neutral component|-|prey|prey|bait|bait|prey|prey|prey|bait|prey|- UBA3 UFC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238451 bait prey

PPI - HINT Gene A Gene B PMID Method Quality XPO1 UBA3 22863883 0401 HT PAPSS1 UBA3 22863883 0401 HT ATG7 UBA3 26344197 0401 HT AHCY UBA3 22863883 0401 HT UBE2M UBA3 18652489,18652489,17353931,17353931 0096,0415,0006,0004 LC,HT UBE2H UBA3 22939629 0401 HT TWF1 UBA3 22939629 0401 HT NAE1 UBA3 26344197,12740388,9694792,10722740,12740388,10207026,10722740,15361859,22863883,22939629,15361859 0401,0018,0096,0004,0401,0096,0018,0096,0401,0401,0114 HT,LC NEDD8 UBA3 10207026,21145461,16620772,16503656,10207026 0415,0004,0004,0004,0096 LC,HT Q59EF6 UBA3 22863883 0401 HT NT5DC1 UBA3 22939629 0401 HT CAMK1D UBA3 22863883 0401 HT ZBTB44 UBA3 26186194 0004 HT UBA3 NUDCD2 22939629 0401 HT UBA3 DCPS 22863883 0401 HT UBA3 APIP 26186194 0004 HT UBA3 UIMC1 19615732,19615732 0004,0007 HT UBA3 PCYT2 22863883 0401 HT UBA3 TXNDC17 22939629 0401 HT UBA3 ACAT2 22863883 0401 HT UBA3 WDR61 22939629 0401 HT UBA3 NSFL1C 22863883 0401 HT UBA3 UFC1 22939629 0401 HT UBA3 HEL-S-2A 22939629 0401 HT UBA3 HEL32 22939629 0401 HT UBA3 HEL114 22939629 0401 HT XPO1 UBA3 22863883 0401 HT PAPSS1 UBA3 22863883 0401 HT ATG7 UBA3 26344197 0401 HT AHCY UBA3 22863883 0401 HT UBE2M UBA3 17353931,17353931 0006,0004 HT UBE2H UBA3 22939629 0401 HT TWF1 UBA3 22939629 0401 HT NAE1 UBA3 26344197,22863883,22939629 0401,0401,0401 HT NEDD8 UBA3 21145461 0004 HT Q59EF6 UBA3 22863883 0401 HT NT5DC1 UBA3 22939629 0401 HT CAMK1D UBA3 22863883 0401 HT ZBTB44 UBA3 26186194 0004 HT UBA3 NUDCD2 22939629 0401 HT UBA3 DCPS 22863883 0401 HT UBA3 APIP 26186194 0004 HT UBA3 UIMC1 19615732,19615732 0004,0007 HT UBA3 PCYT2 22863883 0401 HT UBA3 TXNDC17 22939629 0401 HT UBA3 ACAT2 22863883 0401 HT UBA3 WDR61 22939629 0401 HT UBA3 NSFL1C 22863883 0401 HT UBA3 UFC1 22939629 0401 HT UBA3 HEL-S-2A 22939629 0401 HT UBA3 HEL32 22939629 0401 HT UBA3 HEL114 22939629 0401 HT UBE2M UBA3 18652489,18652489 0096,0415 LC NAE1 UBA3 12740388,9694792,10722740,12740388,10207026,10722740,15361859,15361859 0018,0096,0004,0401,0096,0018,0096,0114 LC NEDD8 UBA3 10207026,16620772,16503656,10207026 0415,0004,0004,0096 LC IMPA2 UBA3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT XPO1 UBA3 22863883 0401 LC PAPSS1 UBA3 22863883 0401 LC KDM1A UBA3 23455924 0018 HT ATG7 UBA3 26344197 0401 LC AHCY UBA3 22863883 0401 LC UBE2M UBA3 18652489,15694336,10207026,17220875,19250909,19549727,18652489,15361859 0096,0114,0415,0114,0415,0018,0415,0415 LC,HT UBE2H UBA3 22939629 0401 LC TWF1 UBA3 22939629 0401 LC CHD3 UBA3 16169070,16169070 0018,0398 HT NAE1 UBA3 26344197,17220875,18264111,12740388,12646924,10722740,12740388,14690597,10722740,15361859,22863883,22939629,15361859 0401,0114,0114,0018,0114,0004,0401,0114,0018,0096,0401,0401,0114 LC CUL1 UBA3 18805092 0415 LC NEDD8 UBA3 10207026,17220875,10207026,14690597 0415,0114,0096,0114 LC Q59EF6 UBA3 22863883 0401 LC NT5DC1 UBA3 22939629 0401 LC FBXO11 UBA3 17098746 0415 LC CAMK1D UBA3 22863883 0401 LC UBA3 UBA3 10207026,12646924,25416956,25416956 0415,0114,0397,0018 LC,HT UBA3 NUDCD2 22939629 0401 LC UBA3 CUL5 18805092 0415 LC UBA3 UBE2F 19250909,19549727,19250909 0114,0018,0415 LC,HT UBA3 DCPS 22863883 0401 LC UBA3 CPNE2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBA3 PCYT2 22863883 0401 LC UBA3 TXNDC17 22939629 0401 LC UBA3 ACAT2 22863883 0401 LC UBA3 WDR61 22939629 0401 LC UBA3 NSFL1C 22863883 0401 LC UBA3 UFC1 22939629 0401 LC UBA3 HEL-S-2A 22939629 0401 LC UBA3 HEL32 22939629 0401 LC UBA3 HEL114 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8TBC4 P60981 UBA3 DSTN 0.081 Q8TBC4 Q5TFE4 UBA3 NT5DC1 0.081 22939629 Q8TBC4 Q8NCP5 UBA3 ZBTB44 0.126 26186194 Q8TBC4 O14732 UBA3 IMPA2 0.583 25416956,unassigned1304 Q8TBC4 O14980 UBA3 XPO1 0.081 22863883 Q8TBC4 O43252 UBA3 PAPSS1 0.081 22863883 Q8TBC4 O95352 UBA3 ATG7 0.081 26344197 Q8TBC4 P17655 UBA3 CAPN2 0.081 22863883 Q8TBC4 P18206 UBA3 VCL 0.081 22939629 Q8TBC4 P23526 UBA3 AHCY 0.081 22863883 Q8TBC4 P62256 UBA3 UBE2H 0.081 22939629 Q8TBC4 Q6IAX6 UBA3 PAPSS1 0.081 Q96C86 Q8TBC4 DCPS UBA3 0.081 22863883 Q96FN4 Q8TBC4 CPNE2 UBA3 0.583 25416956,unassigned1304 Q99447 Q8TBC4 PCYT2 UBA3 0.081 22863883 Q9BWD1 Q8TBC4 ACAT2 UBA3 0.081 22863883 Q9GZS3 Q8TBC4 WDR61 UBA3 0.081 22939629 Q9UNZ2 Q8TBC4 NSFL1C UBA3 0.081 22863883 Q9Y3C8 Q8TBC4 UFC1 UBA3 0.081 22939629 Q8TBC4 Q8IU85 UBA3 CAMK1D 0.081 22863883 Q8TBC4 Q86XK2 UBA3 FBXO11 0.033 17098746 Q8TBC4 Q12873 UBA3 CHD3 0.286 16169070 Q8TBC4 O60341 UBA3 KDM1A 0.332 23455924 Q96RL1 Q8TBC4 UIMC1 UBA3 0.236 19615732 Q9BVJ7 Q8TBC4 DUSP23 UBA3 0.236 unassigned1304 Q8TBC4 P61081 UBA3 UBE2M 0.932 17353931,19250909,10207026,15694336,19549727,18652489 Q8TBC4 Q13564 UBA3 NAE1 0.97 12646924,15361859,10207026,17220875,9694792,22863883,unassigned1304,26344197,12740388,18264111,10722740 Q8TBC4 Q15843 UBA3 NEDD8 0.569 16620772,21145461,14690597,16503656 Q8TBC4 Q8TBC4 UBA3 UBA3 0.681 25416956,unassigned1304,10207026 Q93034 Q8TBC4 CUL5 UBA3 0.033 18805092 Q8WVJ2 Q8TBC4 NUDCD2 UBA3 0.081 22939629 Q969M7 Q8TBC4 UBE2F UBA3 0.539 19549727,19250909 Q8TBC4 P35240 UBA3 NF2 0.126 26549023 Q96GX9 Q8TBC4 APIP UBA3 0.126 26186194 Q8TBC4 P32119 UBA3 PRDX2 0.081 22939629 Q9BRA2 Q8TBC4 TXNDC17 UBA3 0.081 22939629 Q8TBC4 Q13616 UBA3 CUL1 0.033 18805092 Q8TBC4 Q12792 UBA3 TWF1 0.081 22939629 Q8TBC4 P54725 UBA3 RAD23A 0.126 16712842 Q8TBC4 P54727 UBA3 RAD23B 0.236 16712842

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IMPA2 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database KDM1A UBA3 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A12 UBA3 MI:0362 inference MI:0461 interaction database HSPA4L UBA3 MI:0362 inference MI:0461 interaction database ESR1 UBA3 MI:0362 inference MI:0461 interaction database TP53 UBA3 MI:0362 inference MI:0461 interaction database UBC UBA3 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A UBA3 MI:0362 inference MI:0461 interaction database HSPA1B UBA3 MI:0362 inference MI:0461 interaction database HSPA8 UBA3 MI:0362 inference MI:0461 interaction database HSPA6 UBA3 MI:0362 inference MI:0461 interaction database HSPA1L UBA3 MI:0362 inference MI:0461 interaction database HSPA4 UBA3 MI:0362 inference MI:0461 interaction database NF2 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database CDC34 UBA3 MI:0362 inference MI:0461 interaction database HSPA2 UBA3 MI:0362 inference MI:0461 interaction database RAD23A UBA3 MI:0045 experimental interaction detection MI:0461 interaction database RAD23B UBA3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2M UBA3 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 UBA3 MI:0362 inference MI:0461 interaction database SKP1 UBA3 MI:0362 inference MI:0461 interaction database GTF2B UBA3 MI:0362 inference MI:0461 interaction database CHD3 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 UBA3 MI:0362 inference MI:0461 interaction database NEDD8 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2R2 UBA3 MI:0362 inference MI:0461 interaction database FBXO11 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB44 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database UBA3 HSPH1 MI:0362 inference MI:0461 interaction database UBA3 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database UBA3 UBE2F MI:0045 experimental interaction detection MI:0461 interaction database UBA3 CPNE2 MI:0045 experimental interaction detection MI:0461 interaction database UBA3 APIP MI:0045 experimental interaction detection MI:0461 interaction database UBA3 TBATA MI:0362 inference MI:0461 interaction database UBA3 UIMC1 MI:0045 experimental interaction detection MI:0461 interaction database UBA3 AMOTL2 MI:0362 inference MI:0461 interaction database