PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NAE1 DCPS 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MSN NAE1 22863883 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP GP G G GP G GP G CAPN2 NAE1 22863883 biogrid exp GP GP G G GP GP G G G G GP GP GP G G G GP G GP G G GP GP G G G GP GP G NAE1 EXOC6 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP NAE1 MCTS1 22863883 biogrid exp G G G G G GP G G G G GP G GP G G G GP G G G GP G G G G G G G G PAFAH1B2 NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NAE1 UBQLN4 16169070 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NAE1 FBXO11 17098746 intact exp G G G G G GP G G G G G GP GP G G GP GP G G G GP G G G GP G G G G APEX1 NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TUFM NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPP1R2 NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PAPSS1 NAE1 22863883 biogrid exp GP G G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G GP GP GP G GP GP G NAE1 ALG8 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 UBE2F 19250909 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NAE1 NUDCD3 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PDIA4 NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 NSFL1C 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NAE1 TRIP12 18627766 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NUCB2 NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G G G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NAE1 TP53BP2 12694406,8626687 hprd,biogrid,i2d,bci exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 CAMK1D 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 ZBTB44 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 PCYT2 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PLOD1 NAE1 26344197 biogrid exp G G G G G GP G G GP G GP G GP G G GP GP G G G GP G G G GP G GP G G NAE1 TATDN1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NTRK1 NAE1 25921289 biogrid exp P P P G P P P P P P P P P P P P P P P XRCC6 NAE1 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 TXNRD1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 UIMC1 19615732 biogrid,intact exp G G G G GP G G GP GP G GP GP GP G G GP G GP G G GP G G G GP G GP GP G NAE1 PINK1 22388932 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATIC NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PROSC NAE1 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SREBF2 NAE1 21988832 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP G GP GP GP GP GP GP G RAP1GDS1 NAE1 22863883 biogrid exp GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP GP GP GP G APP NAE1 8626687 hprd,biogrid,i2d,bci exp, ortho G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G NAE1 UBA3 26344197,22939629,12646924,10207026,17220875,15361859,22863883,12740388,18264111,9694792,10722740, 25402006, 23023127, 21836163 hprd,biogrid,i2d,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 NEDD8 14690597,18274552,16620772,18264111,16503656,21145461,17220875, 25402006, 23023127, 21836163 innatedb,hprd,biogrid,i2d,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2M NAE1 18652489,19250909,17220875,17353931, 25402006, 21836163 biogrid,intact,bci exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G XPO1 NAE1 22863883, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP53 NAE1 25402006 bci exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G NAE1 UBA5 26344197, 23023127 biogrid exp, pred GP GP G G G GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP GP GP G GP GP G YWHAE NAE1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDK2 NAE1 ortho GP GP G G GP GP G GP GP G GP G G GP G GP GP G G G GP GP G G GP G GP GP G ALAS2 NAE1 ortho P P G GP P P P P P P P G P P P SNRPD2 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 AK6 21836163 pred PPP1CC NAE1 25402006, 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G NAE1 SENP8 25402006 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP NAE1 NUB1 25402006 pred GP GP G G GP G G GP GP G GP GP GP GP G GP G GP GP G GP GP G GP GP GP GP GP G NAE1 KARS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NDUFS5 NAE1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAP1L1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IPO7 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBA6 NAE1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G FBL NAE1 21836163 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMA3 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G PLRG1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G NAE1 ZC3H15 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MRPL3 NAE1 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G EIF3E NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G STAU1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMB5 NAE1 21836163 pred G GP G G G GP G G GP G GP G G G G G GP G GP G G G GP G G G GP GP G NAE1 CUL5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBA7 NAE1 23023127 pred P P P P P P P P P P P P P P P P P P PSMA6 NAE1 21836163 pred P P P P P P P P P P P P P P P P P P P P CCT6A NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBX3 NAE1 25402006 pred SET NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOD1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 DCAF13 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SUB1 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMA4 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 CUL1 25402006 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 COPS5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SEC11A NAE1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NAE1 CUL2 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G NDUFAB1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NAE1 NAE1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRKAR1A NAE1 25402006 pred GP GP G G G GP G GP GP G GP G G GP G GP GP GP G G G G GP G GP GP GP GP G UQCRH NAE1 21836163 pred P P P P P P P P P P P P P P P P P P P P VBP1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UCHL3 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G DNAJA1 NAE1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SRP19 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G EIF3H NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBX1 NAE1 25402006, 23023127 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G BCL2 NAE1 25402006 pred G G G G GP GP G G GP G GP G G GP G G GP GP G G GP GP G G G GP G G G NAE1 COPS3 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP1 NAE1 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G G G GP G GP GP GP GP GP GP G NAE1 UBA2 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G NAE1 PUM1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G YAP1 NAE1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GLO1 NAE1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G G GP G G GP GP GP GP G NAE1 TAF9 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LSM3 NAE1 21836163 pred GP GP G G G GP G G G G GP G G GP G G GP G GP G GP G G GP G GP GP GP G EEF1B2 NAE1 21836163 pred P P P P P P P P P P P P P P P P P P P P BUB3 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO1 NAE1 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NDUFB5 NAE1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMD14 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G G GP GP G GP GP G SNRPB2 NAE1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NAE1 CUL4B 25402006 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP GP GP GP G RAD17 NAE1 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAD23B NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 AP3S1 21836163 pred GP G G G G GP G GP G G GP G GP G G G GP G G G G G GP G G G G GP G NAE1 SNW1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NAE1 SAE1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBX3 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MSH2 NAE1 25402006 pred GP P G G GP GP G GP GP G GP P P P G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPA2B1 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CCT2 NAE1 25402006, 21836163 pred GP GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G NAE1 PWP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DPM1 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TCERG1 NAE1 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G LAMTOR5 NAE1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SSBP1 NAE1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RPL24 NAE1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8TBC4 Q13564 - 14690597 - X 2 Q8TBC4 Q13564 - 12646924 - X 2 Q8TBC4 Q13564 - 14690597 - X 2 P05067 Q13564 - 8626687 - X 2 Q8TBC4-2 Q13564 - 15361859 - X 2 Q8TBC4-2 Q13564 - 12646924 - X 2 Q13564 - 14690597 - X 2 Q13564 - 14690597 - X 2 Q13564 Q13625-2 - 12694406,8626687 - X 2 Q13564 - 10722740 - X 2 Q8TBC4 Q13564 x-ray crystallography 12646924 association X 2 A0A024R5K5 Q13564 two hybrid array 21988832 physical association X 2 Q13564 enzymatic study 17098746 neddylation reaction C 6 Q13564 tandem affinity purification 18274552 association C 75 Q13564 x-ray crystallography 14690597 physical association C 3 Q13564 x-ray crystallography 14690597 physical association C 3 Q13564 anti tag coimmunoprecipitation 19615732 physical association C 33 Q9NRR5 Q13564 two hybrid pooling approach 16169070 physical association X 2 Q13564 A0A024R4T4 anti bait coimmunoprecipitation 17353931 physical association X 2 Q13564 A0A024R1Q0 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NAE1 TATDN1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301266 prey bait NAE1 CAMK1D MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301260 prey bait RAP1GDS1 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301265 bait prey NAE1 NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294857 prey bait APEX1 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298490 prey bait NAE1 ALG8 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118164|BIOGRID_285583 unspecified role|prey unspecified role|bait NAE1 PCYT2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301798 bait prey NAE1 MCTS1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301097 bait prey NAE1 TXNRD1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304708 bait prey NAE1 NSFL1C MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301494 bait prey PAFAH1B2 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301262 bait prey XPO1 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_305070 prey bait SREBF2 NAE1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117485|BIOGRID_285608 unspecified role|prey unspecified role|bait APP NAE1 MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down) 8626687 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_37689|BIOGRID_109458|BIOGRID_109459 -|bait|prey -|prey|bait ATIC NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301259 bait prey PDIA4 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301263 bait prey PROSC NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301264 bait prey PAPSS1 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301753 prey bait TUFM NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301267 bait prey NAE1 DCPS MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299245 bait prey NAE1 TRIP12 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18627766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_116799|BIOGRID_116798 prey|prey bait|bait NAE1 UBQLN4 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0468(hprd) BIOGRID_93414|UniProt_155978|HPRD_29274 prey|prey|- bait|bait|- NAE1 UIMC1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119985|UniProt_100723 prey|prey bait|bait NAE1 NEDD8 MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 14690597,16503656,16620772,17220875,18264111,18274552,18652489,21145461,23824602,23936405,9694792 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0471(mint) UniProt_96281|UniProt_73963|UniProt_73964|HPRD_39551|MINT_65006|BIOGRID_194569|BIOGRID_199080|BIOGRID_203102|BIOGRID_284612|BIOGRID_206844|BIOGRID_209540|BIOGRID_199078|BIOGRID_148954|BIOGRID_282684|HPRD_2903|BIOGRID_123871|MINT_35952 prey|neutral component|neutral component|-|prey|prey|bait|bait|prey|prey|prey|bait|prey|bait|-|prey|prey bait|neutral component|neutral component|-|bait|bait|prey|prey|bait|bait|bait|prey|bait|prey|-|bait|bait UBE2M NAE1 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down) 17220875,17353931,18652489 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_199081|BIOGRID_82023|UniProt_145975|BIOGRID_203106 prey|bait|bait|prey bait|prey|prey|bait PPP1R2 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302115 prey bait NAE1 UBQLN4 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_63715|MINT_34745 prey|prey bait|bait MSN NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301165 prey bait CAPN2 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298872 prey bait UBC NAE1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 18652489,21139048,21890473,21906983,21963094,22505724,23000965,23936405 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_170905|BIOGRID_263810|BIOGRID_174118|BIOGRID_225419|BIOGRID_180129|BIOGRID_284609|BIOGRID_203104|BIOGRID_267466 bait|bait|bait|bait|bait|bait|prey|bait prey|prey|prey|prey|prey|prey|bait|prey NUCB2 NAE1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301261 bait prey NAE1 UBA3 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0493(in vivo) 10722740,12646924,12740388,14690597,16503656,17220875,18264111,22863883,22939629,9694792 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|- (intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_73963|UniProt_73964|HPRD_39551|BIOGRID_201342|BIOGRID_209542|BIOGRID_115752|BIOGRID_231251|BIOGRID_115751|BIOGRID_199079|BIOGRID_199077|BIOGRID_301268|BIOGRID_201633|HPRD_12113 neutral component|neutral component|-|bait|bait|prey|prey|bait|bait|bait|prey|bait|- neutral component|neutral component|-|prey|prey|bait|bait|prey|prey|prey|bait|prey|- NAE1 TP53BP2 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12694406 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_18401|BIOGRID_200938 -|prey -|bait

PPI - HINT Gene A Gene B PMID Method Quality XPO1 NAE1 22863883 0401 HT PAPSS1 NAE1 22863883 0401 HT PROSC NAE1 22863883 0401 HT XRCC6 NAE1 26344197 0401 HT PDIA4 NAE1 22863883 0401 HT APEX1 NAE1 22863883 0401 HT PPP1R2 NAE1 22863883 0401 HT TUFM NAE1 22863883 0401 HT UBE2M NAE1 18652489,17353931,17353931 0096,0006,0004 LC,HT NUCB2 NAE1 22863883 0401 HT PLOD1 NAE1 26344197 0401 HT NAE1 NEDD8 21145461,18274552,18274552,16620772,16503656 0004,0676,0004,0004,0004 HT,LC NAE1 TXNRD1 22863883 0401 HT NAE1 Q59EF6 22863883 0401 HT NAE1 TATDN1 22863883 0401 HT NAE1 Q6U7G8 22863883 0401 HT NAE1 CAMK1D 22863883 0401 HT NAE1 NUDCD3 26344197 0401 HT NAE1 ZBTB44 26186194 0004 HT NAE1 EXOC6 26344197 0401 HT NAE1 UBA3 26344197,12740388,9694792,10722740,12740388,10207026,10722740,15361859,22863883,22939629,15361859 0401,0018,0096,0004,0401,0096,0018,0096,0401,0401,0114 HT,LC NAE1 DCPS 22863883 0401 HT NAE1 UIMC1 19615732,19615732 0004,0007 HT NAE1 PCYT2 22863883 0401 HT NAE1 UBA5 26344197 0401 HT NAE1 MCTS1 22863883 0401 HT NAE1 NSFL1C 22863883 0401 HT NAE1 HEL-S-303 22863883 0401 HT NAE1 HEL70 22863883 0401 HT NAE1 HEL-S-70P 22863883 0401 HT XPO1 NAE1 22863883 0401 HT PAPSS1 NAE1 22863883 0401 HT PROSC NAE1 22863883 0401 HT XRCC6 NAE1 26344197 0401 HT PDIA4 NAE1 22863883 0401 HT APEX1 NAE1 22863883 0401 HT PPP1R2 NAE1 22863883 0401 HT TUFM NAE1 22863883 0401 HT UBE2M NAE1 17353931,17353931 0006,0004 HT NUCB2 NAE1 22863883 0401 HT PLOD1 NAE1 26344197 0401 HT NAE1 NEDD8 21145461 0004 HT NAE1 TXNRD1 22863883 0401 HT NAE1 Q59EF6 22863883 0401 HT NAE1 TATDN1 22863883 0401 HT NAE1 Q6U7G8 22863883 0401 HT NAE1 CAMK1D 22863883 0401 HT NAE1 NUDCD3 26344197 0401 HT NAE1 ZBTB44 26186194 0004 HT NAE1 EXOC6 26344197 0401 HT NAE1 UBA3 26344197,22863883,22939629 0401,0401,0401 HT NAE1 DCPS 22863883 0401 HT NAE1 UIMC1 19615732,19615732 0004,0007 HT NAE1 PCYT2 22863883 0401 HT NAE1 UBA5 26344197 0401 HT NAE1 MCTS1 22863883 0401 HT NAE1 NSFL1C 22863883 0401 HT NAE1 HEL-S-303 22863883 0401 HT NAE1 HEL70 22863883 0401 HT NAE1 HEL-S-70P 22863883 0401 HT UBE2M NAE1 18652489 0096 LC NAE1 NEDD8 18274552,18274552,16620772,16503656 0676,0004,0004,0004 LC NAE1 UBA3 12740388,9694792,10722740,12740388,10207026,10722740,15361859,15361859 0018,0096,0004,0401,0096,0018,0096,0114 LC XPO1 NAE1 22863883 0401 LC PAPSS1 NAE1 22863883 0401 LC PROSC NAE1 22863883 0401 LC APP NAE1 8626687,8626687,8626687,8626687,8626687 0405,0084,0096,0019,0004 LC XRCC6 NAE1 26344197 0401 LC PDIA4 NAE1 22863883 0401 LC APEX1 NAE1 22863883 0401 LC PPP1R2 NAE1 22863883 0401 LC TUFM NAE1 22863883 0401 LC UBE2M NAE1 17220875,19250909 0114,0415 LC NUCB2 NAE1 22863883 0401 LC PLOD1 NAE1 26344197 0401 LC SREBF2 NAE1 21988832,21988832 0397,0018 HT NAE1 TP53BP2 12694406,12694406,12694406 0019,0004,0045 LC NAE1 TRIP12 18627766,18627766 0004,0415 LC NAE1 NEDD8 17220875,18264111,14690597 0114,0114,0114 LC NAE1 TXNRD1 22863883 0401 LC NAE1 Q59EF6 22863883 0401 LC NAE1 TATDN1 22863883 0401 LC NAE1 Q6U7G8 22863883 0401 LC NAE1 FBXO11 17098746 0415 LC NAE1 CAMK1D 22863883 0401 LC NAE1 NUDCD3 26344197 0401 LC NAE1 EXOC6 26344197 0401 LC NAE1 UBA3 26344197,17220875,18264111,12740388,12646924,10722740,12740388,14690597,10722740,15361859,22863883,22939629,15361859 0401,0114,0114,0018,0114,0004,0401,0114,0018,0096,0401,0401,0114 LC NAE1 UBE2F 19250909 0415 LC NAE1 DCPS 22863883 0401 LC NAE1 PCYT2 22863883 0401 LC NAE1 ALG8 21988832,21988832 0397,0018 HT NAE1 UBA5 26344197 0401 LC NAE1 UBQLN4 16169070,16169070 0018,0398 HT NAE1 MCTS1 22863883 0401 LC NAE1 NSFL1C 22863883 0401 LC NAE1 HEL-S-303 22863883 0401 LC NAE1 HEL70 22863883 0401 LC NAE1 HEL-S-70P 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q13564 P61081 NAE1 UBE2M 0.748 17220875,18652489,17353931,19250909 Q8NCP5 Q13564 ZBTB44 NAE1 0.126 26186194 Q8TAG9 Q13564 EXOC6 NAE1 0.081 26344197 Q8IU85 Q13564 CAMK1D NAE1 0.081 22863883 Q8IVD9 Q13564 NUDCD3 NAE1 0.081 26344197 Q13564 O94903 NAE1 PROSC 0.081 22863883 Q86XK2 Q13564 FBXO11 NAE1 0.033 17098746 Q6P1N9 Q13564 TATDN1 NAE1 0.081 22863883 Q13564 P13667 NAE1 PDIA4 0.081 22863883 Q13564 P04629 NAE1 NTRK1 0.126 25921289 Q96RL1 Q13564 UIMC1 NAE1 0.236 19615732 Q15843 Q13564 NEDD8 NAE1 0.82 21145461,18264111,14690597,16503656,17220875,16620772,18274552 Q14669 Q13564 TRIP12 NAE1 0.454 18627766 Q9BVK2 Q13564 ALG8 NAE1 0.286 21988832 Q8TBC4 Q13564 UBA3 NAE1 0.97 12646924,15361859,10207026,17220875,9694792,22863883,unassigned1304,26344197,12740388,18264111,10722740 Q13564 P31939 NAE1 ATIC 0.081 22863883 Q9BXM7 Q13564 PINK1 NAE1 0.21 22388932 Q13564 O14980 NAE1 XPO1 0.081 22863883 Q13564 O43252 NAE1 PAPSS1 0.081 22863883 Q13564 P05067 NAE1 APP 0.454 8626687 Q13564 P12956 NAE1 XRCC6 0.081 26344197 Q13564 P17655 NAE1 CAPN2 0.081 22863883 Q13564 P26038 NAE1 MSN 0.081 22863883 Q13564 P27695 NAE1 APEX1 0.081 22863883 Q13564 P41236 NAE1 PPP1R2 0.081 22863883 Q13564 Q02809 NAE1 PLOD1 0.081 26344197 Q13564 Q12772 NAE1 SREBF2 0.286 21988832 Q16881 Q13564 TXNRD1 NAE1 0.081 22863883 Q6IAX6 Q13564 PAPSS1 NAE1 0.081 Q969M7 Q13564 UBE2F NAE1 0.309 19250909 Q96C86 Q13564 DCPS NAE1 0.081 22863883 Q99447 Q13564 PCYT2 NAE1 0.081 22863883 Q9GZZ9 Q13564 UBA5 NAE1 0.081 26344197 Q9NRR5 Q13564 UBQLN4 NAE1 0.286 16169070 Q9ULC4 Q13564 MCTS1 NAE1 0.081 22863883 Q9UNZ2 Q13564 NSFL1C NAE1 0.081 22863883 Q13564 P80303 NAE1 NUCB2 0.081 22863883 Q13625 Q13564 TP53BP2 NAE1 0.21 12694406 Q13564 P49411 NAE1 TUFM 0.081 22863883 Q13564 P68402 NAE1 PAFAH1B2 0.081 22863883 Q13564 P52306 NAE1 RAP1GDS1 0.081 22863883

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYO1F NAE1 MI:0362 inference MI:0461 interaction database NTRK1 NAE1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 NAE1 MI:0362 inference MI:0461 interaction database APP NAE1 MI:0045 experimental interaction detection MI:0461 interaction database UBC NAE1 MI:0045 experimental interaction detection MI:0461 interaction database ALAS1 NAE1 MI:0362 inference MI:0461 interaction database TAF1 NAE1 MI:0045 experimental interaction detection MI:0461 interaction database ALAS2 NAE1 MI:0362 inference MI:0461 interaction database CDK2 NAE1 MI:0362 inference MI:0461 interaction database UBE2M NAE1 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 NAE1 MI:0362 inference MI:0461 interaction database SKP1 NAE1 MI:0362 inference MI:0461 interaction database CDK3 NAE1 MI:0362 inference MI:0461 interaction database SREBF2 NAE1 MI:0045 experimental interaction detection MI:0461 interaction database MYO1E NAE1 MI:0362 inference MI:0461 interaction database NAE1 CUL1 MI:0362 inference MI:0461 interaction database NAE1 TP53BP2 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 TRIP12 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 NEDD8 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 FBXO11 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 ZBTB44 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 UBA3 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 UBE2F MI:0045 experimental interaction detection MI:0461 interaction database NAE1 UIMC1 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 ALG8 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 PINK1 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 UBQLN4 MI:0045 experimental interaction detection MI:0461 interaction database NAE1 PAK1IP1 MI:0362 inference MI:0461 interaction database