PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RBX1 ABTB2 18429817 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G GP G XPO1 ABTB2 26673895 biogrid exp GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G ABTB2 COPS5 21145461 biogrid exp GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G EEF1A1 ABTB2 18459963 hprd,biogrid exp GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G CUL3 ABTB2 18459963,18429817, 25402006 hprd,biogrid exp, pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G DNTT ABTB2 18429817, 25402006 hprd,biogrid exp, pred GP G G G G G G G G G P G G G G G P G P P G G GP NCAM1 ABTB2 ortho G GP G G G GP G GP G G G G G G G G GP G G G G G G G GP GP G ALKBH6 ABTB2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G ABTB2 PRPF19 25402006 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G KCTD11 ABTB2 25402006 pred GP GP G P GP G GP G G GP G GP G G GP GP G GP G GP GP GP P GP P GP P G KLHL12 ABTB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G VARS ABTB2 25402006 pred G GP G G G GP G G G G GP G GP G G GP GP G GP G GP GP GP G GP P GP GP G ABTB2 SOCS4 23023127 pred GP GP G G GP GP G G G G GP G GP G G GP GP G G G GP GP GP GP GP P GP GP G RAD23A ABTB2 25402006 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G KEAP1 ABTB2 25402006 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G NOTCH1 ABTB2 23023127 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G SOCS5 ABTB2 23023127 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP G TSPY1 ABTB2 25402006 pred P G P P CCNE1 ABTB2 25402006 pred P GP G G GP GP G GP G G P P G GP GP P GP P P P GP P GP GP PSMD10 ABTB2 23023127 pred GP G G G G GP G G G G G G GP G G GP GP G GP G GP GP GP G GP GP GP G NOTCH2 ABTB2 23023127 pred G GP G G G G G G G G G G G G G G G G G G G G G G G GP G G ZBTB16 ABTB2 25402006 pred G GP G G G GP G G G G G G GP G G GP GP G GP G G GP GP G GP G GP G BCL6 ABTB2 23023127 pred G G G G GP G G G G G G G G G G G G G G G GP G G G G P G G G SOCS3 ABTB2 23023127 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP G GP GP GP GP GP G SOCS2 ABTB2 23023127 pred GP GP G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP GP P GP GP G DNTTIP2 ABTB2 25402006 pred GP G G G G GP G GP G G GP G G G G GP GP G GP G GP G G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N961 P68104 pull down 18459963 direct interaction X 2 Q8N961 P68104 affinity chromatography technology 18459963 physical association X 2 Q8N961 P68104 affinity chromatography technology 18459963 physical association X 2 Q8N961 A0A024R475 pull down 18429817 direct interaction X 2 Q8N961 A0A024R475 affinity chromatography technology 18429817 physical association X 2 Q8N961 P04053-2 pull down 18429817 direct interaction X 2 Q8N961 P04053-2 pull down 18429817 direct interaction X 2 Q8N961 P04053-2 affinity chromatography technology 18429817 physical association X 2 Q8N961 P04053-2 affinity chromatography technology 18429817 physical association X 2 Q8N961 P04053-2 two hybrid 18429817 direct interaction X 2 Q8N961 P04053-2 two hybrid 18429817 direct interaction X 2 Q8N961 A0A024R475 affinity chromatography technology 18429817 physical association X 2 A0A024R7W9 Q8N961 affinity chromatography technology 21145461 physical association X 2 Q8N961 P62877 affinity chromatography technology 18429817 physical association X 2 P0CG48 Q8N961 affinity chromatography technology 18429817 physical association X 2 P0CG48 Q8N961 affinity chromatography technology 21906983 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 ABTB2 MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down) 18429817,18459963 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) HPRD_40064|BIOGRID_117136|BIOGRID_117127|HPRD_33184|BIOGRID_117128 -|bait|bait|-|prey -|prey|prey|-|bait RBX1 ABTB2 MI:0493(in vivo)|MI:0096(pull down) 18429817 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_40064|BIOGRID_117129 -|prey -|bait UBC ABTB2 MI:0004(affinity chromatography technology)|MI:0096(pull down) 18429817,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_181048|BIOGRID_117140 bait|prey prey|bait ABTB2 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205032 prey bait DNTT ABTB2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 18429817 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_117134|BIOGRID_117135|BIOGRID_117132|BIOGRID_117133|BIOGRID_117130|BIOGRID_117131|HPRD_33325 prey|bait|prey|bait|bait|prey|- bait|prey|bait|prey|prey|bait|- EEF1A1 ABTB2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 18459963 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_117077|BIOGRID_117075|BIOGRID_117076|HPRD_33183 prey|bait|bait|- bait|prey|prey|-

PPI - HINT Gene A Gene B PMID Method Quality ABTB2 COPS5 21145461 0004 HT ABTB2 COPS5 21145461 0004 HT DNTT ABTB2 18429817,18429817,18429817 0096,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N961 P62877 ABTB2 RBX1 0.21 18429817 Q8N961 P68104 ABTB2 EEF1A1 0.569 18459963 Q8N961 Q13618 ABTB2 CUL3 0.569 18429817 Q8N961 Q6P5F9 ABTB2 XPO1 0.126 26673895 Q8N961 P04053 ABTB2 DNTT 0.858 18429817 Q92905 Q8N961 COPS5 ABTB2 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database DNTT ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database UBC ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database EEF1A1 ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 ABTB2 MI:0045 experimental interaction detection MI:0461 interaction database ABTB2 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database