PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM27 RNF213 25416956 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF213 MCRS1 17353931 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G CBX4 RNF213 21282530 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP P G TRIM23 RNF213 25416956 innatedb,biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G CBX2 RNF213 21282530 biogrid,intact exp P P GP P P G P G P P P GP G RNF213 RNF213 24658080 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G UBC RNF213 16196087 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNASEH2B RNF213 26496610 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP P G SCN2B RNF213 26186194 biogrid exp P P G P GP G G GP G P P P P P GP P P G P P P GP GP P P P PTPN1 RNF213 26496610 biogrid,intact exp GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP G GP GP GP P G HLA-C RNF213 17353931 intact exp RNF213 CD244 26186194 biogrid exp P P G GP P GP P GP P GP P P P GP G P P P P P GP P P CBX6 RNF213 21282530 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP P G GOLGA2 RNF213 25416956 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP P G TRIP6 RNF213 25416956 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G REL RNF213 25416956 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G GP GP GP GP G P GP GP G GP GP GP P G RNF213 MRPL50 26496610 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G IFI16 RNF213 25693804 biogrid exp G G G G GP GP G G GP G GP G G GP G G GP GP G G G G G G G GP G G PLAC9 RNF213 21988832 biogrid,intact exp GP GP P G G GP P P GP G G GP P P G G GP GP GP GP P G UBXN11 RNF213 25416956 biogrid,intact exp G GP G G G GP G G P G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP P G RNF213 KRT40 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P EGFR RNF213 23956138 biogrid exp GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP P G UBE2G2 RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP P G RNF213 BARD1 23023127 pred P G GP P GP P P P GP G GP P G P P GP P GP P GP GP P G UBE2D2 RNF213 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP P G UBE2C RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF213 PTCD3 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF213 CABIN1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G UBE2I RNF213 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP P G RNF213 UBE2R2 23023127 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP GP G UBE2K RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G UBE2M RNF213 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP P G RNF213 UBE2F 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G RNF213 TTC14 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP P G RNF213 STUB1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G UBE2D3 RNF213 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP P G RNF213 UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P P G RNF213 UBE2D4 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP P G UBE2NL RNF213 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 RNF213 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP P G UBE2L6 RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP P G NASP RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP GP GP G GP GP GP GP GP G GP P G UBE2N RNF213 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q63HN8 anti tag coimmunoprecipitation 22190034 association C 35 Q63HN8 pull down 22190034 association C 32 Q63HN8 P30504 anti bait coimmunoprecipitation 17353931 physical association X 2 Q63HN8 Q96EZ8 anti bait coimmunoprecipitation 17353931 physical association X 2 Q63HN8 tandem affinity purification 21282530 association C 25 Q63HN8 Q5JTB6 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CBX6 RNF213 MI:0004(affinity chromatography technology) 21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_262996 bait prey RNF213 MCRS1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_150805 prey bait CBX4 RNF213 MI:0004(affinity chromatography technology) 21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_262954 bait prey EGFR RNF213 MI:0004(affinity chromatography technology) 23956138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_285066 bait prey PLAC9 RNF213 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118491|BIOGRID_285585 unspecified role|bait unspecified role|prey UBC RNF213 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,21139048,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_143181|BIOGRID_179955|BIOGRID_224717|BIOGRID_170729 bait|bait|bait|bait prey|prey|prey|prey CBX2 RNF213 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_262928|UniProt_111844 bait|bait prey|prey HLA-C RNF213 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_148700 bait prey

PPI - HINT Gene A Gene B PMID Method Quality SCN2B RNF213 26186194 0004 HT PTPN1 RNF213 26496610,26496610 0007,0004 HT MCM2 RNF213 25963833 0004 HT HLA-C RNF213 17353931 0006 HT RNASEH2B RNF213 26496610,26496610 0007,0004 HT RNF213 MRPL50 26496610,26496610 0007,0004 HT RNF213 MCRS1 17353931 0006 HT RNF213 CD244 26186194 0004 HT SCN2B RNF213 26186194 0004 HT PTPN1 RNF213 26496610,26496610 0007,0004 HT MCM2 RNF213 25963833 0004 HT HLA-C RNF213 17353931 0006 HT RNASEH2B RNF213 26496610,26496610 0007,0004 HT RNF213 MRPL50 26496610,26496610 0007,0004 HT RNF213 MCRS1 17353931 0006 HT RNF213 CD244 26186194 0004 HT TRIM27 RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM23 RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT REL RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT GOLGA2 RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIP6 RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PLAC9 RNF213 21988832,21988832 0397,0018 HT UBXN11 RNF213 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF213 KRT40 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63HN8 Q5JTB6 RNF213 PLAC9 0.286 21988832 Q63HN8 O60939 RNF213 SCN2B 0.126 26186194 Q9H2C0 Q63HN8 GAN RNF213 0.126 26460568 Q63HN8 Q63HN8 RNF213 RNF213 0.236 24658080 Q63HN8 Q5T124 RNF213 UBXN11 0.454 25416956 Q63HN8 P30504 RNF213 HLA-C 0.126 17353931 Q63HN8 P14373 RNF213 TRIM27 0.454 25416956 Q63HN8 P36406 RNF213 TRIM23 0.454 25416956 Q63HN8 Q15654 RNF213 TRIP6 0.454 25416956 Q6A162 Q63HN8 KRT40 RNF213 0.454 25416956 Q63HN8 P0CG48 RNF213 UBC 0.126 16196087 Q63HN8 P00533 RNF213 EGFR 0.126 23956138 Q63HN8 O95503 RNF213 CBX6 0.126 21282530 Q63HN8 P04608 RNF213 TAT 0.183 19454010 Q8N5N7 Q63HN8 MRPL50 RNF213 0.236 26496610 Q63HN8 P05919 RNF213 VPU 0.236 22190034 Q63HN8 P18031 RNF213 PTPN1 0.236 26496610 Q63HN8 Q08379 RNF213 GOLGA2 0.454 25416956 Q63HN8 Q5TBB1 RNF213 RNASEH2B 0.236 26496610 Q6ZWV7 Q63HN8 RPL35 RNF213 0.236 26496610 Q63HN8 P33174 RNF213 KIF4 0.236 26496610 Q63HN8 P61087 RNF213 UBE2K 0.236 26496610 Q63HN8 Q04864 RNF213 REL 0.454 25416956 Q96EZ8 Q63HN8 MCRS1 RNF213 0.236 17353931 Q9BZW8 Q63HN8 CD244 RNF213 0.126 26186194 Q63HN8 P49736 RNF213 MCM2 0.126 25963833 Q63HN8 Q14781 RNF213 CBX2 0.126 21282530 Q63HN8 O00257 RNF213 CBX4 0.126 21282530 Q63HN8 Q16666 RNF213 IFI16 0.126 25693804

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CBX4 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 RNF213 MI:0362 inference MI:1106 pathways database SCN2B RNF213 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 RNF213 MI:0362 inference MI:1106 pathways database KIF4A RNF213 MI:0362 inference MI:0461 interaction database CBX6 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database EGFR RNF213 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF213 MI:0362 inference MI:1106 pathways database UBC RNF213 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM27 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database PTPN1 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 RNF213 MI:0362 inference MI:1106 pathways database HLA-C RNF213 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database CCNF RNF213 MI:0362 inference MI:1106 pathways database RPL35 RNF213 MI:0362 inference MI:0461 interaction database UBE2A RNF213 MI:0362 inference MI:1106 pathways database MCM2 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RNF213 MI:0362 inference MI:1106 pathways database UBE2K RNF213 MI:0362 inference MI:0461 interaction database RBX1 RNF213 MI:0362 inference MI:1106 pathways database RPS27A RNF213 MI:0362 inference MI:1106 pathways database UBA52 RNF213 MI:0362 inference MI:1106 pathways database SKP1 RNF213 MI:0362 inference MI:1106 pathways database REL RNF213 MI:0045 experimental interaction detection MI:0461 interaction database GOLGA2 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 RNF213 MI:0362 inference MI:1106 pathways database CUL1 RNF213 MI:0362 inference MI:1106 pathways database TRIP12 RNF213 MI:0362 inference MI:1106 pathways database CBX2 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database TRIP6 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database IFI16 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 RNF213 MI:0362 inference MI:1106 pathways database KIF4B RNF213 MI:0362 inference MI:0461 interaction database PLAC9 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database UBXN11 RNF213 MI:0045 experimental interaction detection MI:0461 interaction database RNASEH2B RNF213 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 RNF213 MI:0362 inference MI:1106 pathways database FBXO31 RNF213 MI:0362 inference MI:1106 pathways database FBXW9 RNF213 MI:0362 inference MI:1106 pathways database FBXW10 RNF213 MI:0362 inference MI:1106 pathways database RNF213 KRT40 MI:0045 experimental interaction detection MI:0461 interaction database RNF213 FBXL22 MI:0362 inference MI:1106 pathways database RNF213 FBXL19 MI:0362 inference MI:1106 pathways database RNF213 FBXW12 MI:0362 inference MI:1106 pathways database RNF213 RNF19B MI:0362 inference MI:1106 pathways database RNF213 RNF144B MI:0362 inference MI:1106 pathways database RNF213 RBBP6 MI:0362 inference MI:1106 pathways database RNF213 HUWE1 MI:0362 inference MI:1106 pathways database RNF213 TRIM69 MI:0362 inference MI:1106 pathways database RNF213 SIAH1 MI:0362 inference MI:1106 pathways database RNF213 HERC6 MI:0362 inference MI:1106 pathways database RNF213 UBR2 MI:0362 inference MI:1106 pathways database RNF213 FBXL14 MI:0362 inference MI:1106 pathways database RNF213 FBXW8 MI:0362 inference MI:1106 pathways database RNF213 FBXL16 MI:0362 inference MI:1106 pathways database RNF213 MRPL50 MI:0045 experimental interaction detection MI:0461 interaction database RNF213 FBXO15 MI:0362 inference MI:1106 pathways database RNF213 ZNRF1 MI:0362 inference MI:1106 pathways database RNF213 FBXL13 MI:0362 inference MI:1106 pathways database RNF213 FBXO22 MI:0362 inference MI:1106 pathways database RNF213 ZNRF2 MI:0362 inference MI:1106 pathways database RNF213 FBXO27 MI:0362 inference MI:1106 pathways database RNF213 FBXO30 MI:0362 inference MI:1106 pathways database RNF213 RNF217 MI:0362 inference MI:1106 pathways database RNF213 DTX3L MI:0362 inference MI:1106 pathways database RNF213 FBXO41 MI:0362 inference MI:1106 pathways database RNF213 LMO7 MI:0362 inference MI:1106 pathways database RNF213 MYLIP MI:0362 inference MI:1106 pathways database RNF213 FBXW7 MI:0362 inference MI:1106 pathways database RNF213 FBXO32 MI:0362 inference MI:1106 pathways database RNF213 FBXW5 MI:0362 inference MI:1106 pathways database RNF213 MIB2 MI:0362 inference MI:1106 pathways database RNF213 SPSB1 MI:0362 inference MI:1106 pathways database RNF213 FBXL8 MI:0362 inference MI:1106 pathways database RNF213 FBXO17 MI:0362 inference MI:1106 pathways database RNF213 MCRS1 MI:0045 experimental interaction detection MI:0461 interaction database RNF213 FBXL20 MI:0362 inference MI:1106 pathways database RNF213 FBXL18 MI:0362 inference MI:1106 pathways database RNF213 NEDD4L MI:0362 inference MI:1106 pathways database RNF213 RBCK1 MI:0362 inference MI:1106 pathways database RNF213 CD244 MI:0045 experimental interaction detection MI:0461 interaction database RNF213 GAN MI:0045 experimental interaction detection MI:0461 interaction database RNF213 FBXL15 MI:0362 inference MI:1106 pathways database RNF213 FBXO44 MI:0362 inference MI:1106 pathways database RNF213 UNKL MI:0362 inference MI:1106 pathways database RNF213 SMURF2 MI:0362 inference MI:1106 pathways database RNF213 TRIM36 MI:0362 inference MI:1106 pathways database RNF213 FBXO6 MI:0362 inference MI:1106 pathways database RNF213 RNF19A MI:0362 inference MI:1106 pathways database RNF213 RLIM MI:0362 inference MI:1106 pathways database RNF213 FBXL12 MI:0362 inference MI:1106 pathways database RNF213 FBXO40 MI:0362 inference MI:1106 pathways database RNF213 HERC5 MI:0362 inference MI:1106 pathways database RNF213 FBXL7 MI:0362 inference MI:1106 pathways database RNF213 FBXO2 MI:0362 inference MI:1106 pathways database RNF213 FBXO10 MI:0362 inference MI:1106 pathways database RNF213 FBXO9 MI:0362 inference MI:1106 pathways database RNF213 FBXL5 MI:0362 inference MI:1106 pathways database RNF213 FBXL4 MI:0362 inference MI:1106 pathways database RNF213 FBXW11 MI:0362 inference MI:1106 pathways database RNF213 FBXO4 MI:0362 inference MI:1106 pathways database RNF213 FBXL21 MI:0362 inference MI:1106 pathways database RNF213 FBXL3 MI:0362 inference MI:1106 pathways database RNF213 FBXW2 MI:0362 inference MI:1106 pathways database RNF213 BTRC MI:0362 inference MI:1106 pathways database RNF213 FBXO7 MI:0362 inference MI:1106 pathways database RNF213 RNF115 MI:0362 inference MI:1106 pathways database RNF213 RNF114 MI:0362 inference MI:1106 pathways database RNF213 WSB1 MI:0362 inference MI:1106 pathways database