PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSP90AA1 FBXW8 21946088 biogrid exp P P P P P P P CCT3 FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P FBXW8 CCT6B 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P EP300 FBXW8 19297328 biogrid exp P P P P P P P P P P P P P P P P P P P P P ARF1 FBXW8 21572988 dip exp P P P P P P P P P P P P P P P P P P P P P MYC FBXW8 17314511 biogrid,i2d,intact exp P P P P P P P P P P P P P P P P P P P P P FBXW8 CCT7 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P XPO1 FBXW8 26673895 biogrid exp P P P P P P P P P P P P P P P P P P P P CASQ2 FBXW8 26186194 biogrid exp P P HSPA4 FBXW8 21946088 biogrid exp P P P P P P P P P P P P P P P P P P P P FBXW8 CCDC8 24711643,21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P CCT2 FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P TBC1D3 FBXW8 23029530 biogrid exp OBSL1 FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P UBE2D3 FBXW8 17205132 biogrid exp P P P P P P P P P P P P P P P P FBXW8 TTC29 26186194 biogrid exp NFKBIA FBXW8 20558726 biogrid exp P P P P P P P P P P P P P P P P P P TCP1 FBXW8 21946088 biogrid exp P P P P P P P P P P P P P P P P P P P P P CCND1 FBXW8 17205132,18650423 biogrid exp P P P P P P P P P P P P P P TRIP13 FBXW8 21572988 biogrid,dip exp P PDCD5 FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P REST FBXW8 18354482 biogrid exp P P P P P P P P P P P P P P P P P P P P P TP53 FBXW8 25609649,22653443 intact exp P P P P FBXW8 MAP4K1 24362026 biogrid exp P P P P P FBXW8 GORASP1 21572988 biogrid exp P P P P P P P P P P P P P P P P P P IRS1 FBXW8 23045529 biogrid exp P P P P P P P P P P P P P P P P P P P P VBP1 FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P CCT6A FBXW8 21572988 biogrid,dip exp P P P P P P P P P P P P P P P P P P P P P BCL3 FBXW8 20558726 biogrid exp P P P P P P P P MAPK14 FBXW8 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P CUL1 FBXW8 21946088,17205132,22268729,25515538,21145461,21572988, 25402006 biogrid,dip exp, ortho, pred P P P P P P P P P P P P P P P P P P SKP1 FBXW8 20596027,15070733,10531037,21946088,17205132,21572988,22388891,12481031, 25402006, 21836163 hprd,biogrid,intact,dip exp, ortho, pred P P P P P P P P P P P P P P P P P P P CUL7 FBXW8 23029530,16142236,10531037,21946088,17205132,17998335,21572988,12904573,23045529,12481031,17332328, 25402006, 21836163 innatedb,hprd,biogrid,dip exp, ortho, pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO4 21946088, 25402006 biogrid exp, pred SKP2 FBXW8 21946088, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P P P P FBXW8 FBXW2 21946088, 25402006, 16082366 biogrid exp, pred P P P P P P P P P P P P P P P P CUL2 FBXW8 21572988, 25402006 biogrid,dip exp, pred P P P P P P P P P P P P P P P CUL4A FBXW8 17079684, 25402006 biogrid exp, pred RBX1 FBXW8 10531037,17205132,12481031, 25402006, 21836163 hprd,biogrid exp, pred P P P P P P P P DDB1 FBXW8 17079684, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P P P P P P P FBXW8 BTRC 21946088, 25402006, 16082366 biogrid exp, pred P P P P P P P P P P P P P P P P P P P P FBXW8 PFDN5 21572988, 25402006 biogrid,dip exp, pred P P P P P P P P P P P P P P P P P P P P P FBXW8 NANOG ortho P P P P P P NEDD8 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 CUL5 25402006 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO2 25402006, 16082366 pred FBXO24 FBXW8 16082366 pred P P P P P P P P P P P P P P P FBXW8 BIRC6 23023127 pred FBXW8 MYO15A 23023127 pred P P P P P P P P P P P P FBXW8 FBXO34 25402006 pred P P P P P P VAV2 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P NCOA6 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P P ITGB8 FBXW8 23023127 pred P P P P P P P P P P P P P P P P FBXW8 FBXO22 16082366 pred MYCBP2 FBXW8 25402006 pred P P P P P P P P P P P P FBXW8 FBXL3 25402006, 16082366 pred P P SP1 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 CDCA3 25402006 pred P P P P P P P P P P P P P P P P P P FBXW8 FBXW11 25402006, 16082366 pred FBXW8 LRR1 25402006 pred FBXW8 FBXL6 16082366 pred FBXW8 DCUN1D1 25402006 pred P P P P P P P P P P P P P P P P P P CYR61 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P FBXW4 FBXW8 16082366 pred P P P P P P P FBXW8 FEM1B 25402006 pred P P P P P P P P P P P P P P P P P P P MYO1E FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P CUL4B FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO25 16082366 pred FBXW8 SUGT1 25402006 pred P P P P P P P P P FBXW8 FBXO7 16082366 pred P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO5 16082366 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO3 16082366 pred VHL FBXW8 25402006 pred P P P P P P P BCR FBXW8 16082366 pred FBXW8 FAF1 25402006 pred P P P P P P P P P P P P P P P P P P P P CRKL FBXW8 23023127 pred P P P P P P P P P P P P P P FBXO46 FBXW8 25402006 pred P P P P P P P P P FBXW8 FBXO10 16082366 pred P P P P P P P FBXW8 FBXO44 25402006 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO6 25402006, 16082366 pred P P P P P P P P P P P P P P P P P P P P GRB2 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P BIRC2 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO17 25402006 pred FBXW9 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P FBXW8 FOXD3 23023127 pred P P P P P P P P P P P P P P P P P P P P P GDNF FBXW8 23023127 pred P P P P P P P P P P P P P P P P P FBXW8 FBXW7 25402006 pred P P P P P P P P P P P P P P P P P P P P P SP3 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P FBXW8 FBXW5 25402006, 21836163 pred P P P P P P P P P P P P P P P P P P P FBXW8 VAV3 23023127 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXL2 25402006 pred PLG FBXW8 23023127 pred P P P P P P FBXW8 RBM15 23023127 pred P P P P P P P P P P P P P P P P P P P P P PBRM1 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P FBXW8 FBXL8 25402006 pred P P P P P P P P P P P P P P P P FBXW8 FBXL5 16082366 pred FBXO31 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P CUL3 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P P SOCS3 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P FBXW8 GLMN 21836163 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXL21 16082366 pred FBXW8 EGLN1 23023127 pred P P P P P P P P P P P P P P P P P P P P P CDC34 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P P P P AKT1 FBXW8 23023127 pred P P P P P P P P P P P P P P P P P P P P P FBXW8 FBXO18 25402006 pred P P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P20749 Q8N3Y1 affinity chromatography technology 20558726 physical association X 2 P24385 Q8N3Y1 affinity chromatography technology 18650423 physical association X 2 P24385 Q8N3Y1 enzymatic study 17205132 direct interaction X 2 P24385 Q8N3Y1 affinity chromatography technology 17205132 physical association X 2 Q09472 Q8N3Y1 affinity chromatography technology 19297328 physical association X 2 O14737 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8IZP1-2 Q8N3Y1 affinity chromatography technology 23029530 physical association X 2 Q8IZP1-2 Q8N3Y1 affinity chromatography technology 23029530 physical association X 2 P01106 Q8N3Y1 affinity chromatography technology 17314511 physical association X 2 P01106 Q8N3Y1 affinity chromatography technology 17314511 physical association X 2 P01106 Q8N3Y1 two hybrid 17314511 direct interaction X 2 Q9UKT8 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 Q92918 Q8N3Y1 affinity chromatography technology 24362026 physical association X 2 Q92918 Q8N3Y1 affinity chromatography technology 24362026 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 22388891 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 15070733 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 12481031 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 17205132 physical association X 2 P63208 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 affinity chromatography technology 17332328 physical association X 2 Q8N3Y1 affinity chromatography technology 17332328 physical association X 2 Q8N3Y1 Q13127-3 affinity chromatography technology 18354482 physical association X 2 Q8N3Y1 affinity chromatography technology 17998335 physical association X 2 Q8N3Y1 affinity chromatography technology 23029530 physical association X 2 Q8N3Y1 affinity chromatography technology 23045529 physical association X 2 Q8N3Y1 affinity chromatography technology 12481031 physical association X 2 Q8N3Y1 affinity chromatography technology 16142236 physical association X 2 Q8N3Y1 affinity chromatography technology 16142236 physical association X 2 Q8N3Y1 affinity chromatography technology 17205132 physical association X 2 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 P07900-2 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 Q9UKT5 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 Q13617 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 E7EQR6 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 P25963 Q8N3Y1 affinity chromatography technology 20558726 physical association X 2 P34932 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 A0A090N7U0 Q8N3Y1 affinity chromatography technology 21145461 physical association X 2 A0A090N7U0 Q8N3Y1 affinity chromatography technology 22268729 physical association X 2 A0A090N7U0 Q8N3Y1 affinity chromatography technology 17205132 physical association X 2 A0A090N7U0 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 A0A090N7U0 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 P78371 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 P0CG48 Q8N3Y1 affinity chromatography technology 21890473 physical association X 2 Q9H0W5 Q8N3Y1 affinity chromatography technology 24711643 physical association X 2 Q9H0W5 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 B2RBV7 affinity chromatography technology 17079684 physical association X 2 Q8N3Y1 Q16531 affinity chromatography technology 17079684 physical association X 2 Q8N3Y1 A0A024R499 pull down 23045529 direct interaction X 2 Q8N3Y1 P61077-3 pull down 17205132 direct interaction X 2 Q8N3Y1 P62877 affinity chromatography technology 12481031 physical association X 2 Q8N3Y1 P62877 affinity chromatography technology 17205132 physical association X 2 Q8N3Y1 Q8N3Y1 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 Q13309-2 affinity chromatography technology 21946088 physical association X 2 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 Q99832-4 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 Q59H77 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 Q99471-2 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 P40227-2 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 Q15645-2 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 A0A024R2U5 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 A0A024R2U5 affinity chromatography technology 21572988 physical association X 2 Q8N3Y1 coimmunoprecipitation 12904573 association C 4 Q8N3Y1 affinity chromatography technology 12481031 association C 4 Q8N3Y1 anti tag coimmunoprecipitation 21572988 - C 17 O14737 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q14999 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 P63208 Q8N3Y1 anti tag coimmunoprecipitation 20596027 physical association X 2 P63208 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q99471 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 B1WBR1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 B1WBR1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 Q15645 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 Q13617 anti tag coimmunoprecipitation 21572988 physical association X 2 P49368 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 O75147 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 A0A090N7U0 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 P78371 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q92526 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q9H0W5 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 A0A024RDL1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 A0A024R3Q3 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 Q99832 anti tag coimmunoprecipitation 21572988 physical association X 2 Q8N3Y1 tandem affinity purification 17314511 association C 222 Q8N3Y1 anti tag coimmunoprecipitation 22653443 association C 51 P01106 Q8N3Y1 anti tag coimmunoprecipitation 17314511 physical association X 2 P01106 Q8N3Y1 two hybrid 17314511 physical association X 2 P63208 Q8N3Y1 anti tag coimmunoprecipitation 15070733 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL1 FBXW8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17205132,21145461,21572988,21946088,22268729 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_141280|BIOGRID_204513|BIOGRID_153664|BIOGRID_162579|BIOGRID_292046 prey|bait|prey|prey|prey bait|prey|bait|bait|bait FBXW8 CCDC8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162588 bait prey RBX1 FBXW8 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12481031,17205132 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_39254|BIOGRID_141282|BIOGRID_101981|HPRD_14454 -|prey|prey|- -|bait|bait|- FBXW8 CCT7 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162582 bait prey FBXW8 PFDN5 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162585 bait prey REST FBXW8 MI:0004(affinity chromatography technology) 18354482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201068 prey bait FBXW8 GORASP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_162594|BIOGRID_162595 bait|prey prey|bait UBC FBXW8 MI:0004(affinity chromatography technology) 21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_173401 bait prey UBE2D3 FBXW8 MI:0004(affinity chromatography technology) 17205132 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225933 prey bait DDB1 FBXW8 MI:0401(biochemical) 17079684 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200200 bait prey CCND1 FBXW8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17205132,18650423 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_210777|BIOGRID_141278|BIOGRID_141277 bait|prey|prey prey|bait|bait TBC1D3 FBXW8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23029530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_217205|BIOGRID_217207 bait|prey prey|bait SKP1 FBXW8 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 10531037,12481031,15070733,17205132,21572988,22388891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_9125|BIOGRID_219151|BIOGRID_101980|BIOGRID_141279|UniProt_77058|BIOGRID_197527|BIOGRID_162578|HPRD_39254 -|prey|prey|prey|prey|prey|prey|- -|bait|bait|bait|bait|bait|bait|- TRIP13 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162589 prey bait FBXW8 CCT6B MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162581 bait prey CCT6A FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162586 prey bait OBSL1 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162590 prey bait MYC FBXW8 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 17314511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) UniProt_89764|BIOGRID_144381|BIOGRID_144190|UniProt_89759|BIOGRID_144383|UniProt_89753 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey HSP90AA1 FBXW8 MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153675 prey bait PDCD5 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162591 prey bait MAPK14 FBXW8 MI:0004(affinity chromatography technology) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_278713 bait prey CUL7 FBXW8 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 10531037,12481031,16142236,17205132,17332328,17998335,21572988,21946088,23029530,23045529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_15427|BIOGRID_214147|BIOGRID_141281|BIOGRID_200964|BIOGRID_218465|BIOGRID_217206|BIOGRID_126454|BIOGRID_162577|BIOGRID_126453|BIOGRID_200966|BIOGRID_101979|BIOGRID_153665|HPRD_39254 -|bait|prey|bait|bait|prey|bait|prey|prey|prey|prey|prey|- -|prey|bait|prey|prey|bait|prey|bait|bait|bait|bait|bait|- SKP2 FBXW8 MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153679 prey bait HSPA4 FBXW8 MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153674 prey bait FBXW8 BTRC MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153677 bait prey EP300 FBXW8 MI:0004(affinity chromatography technology) 19297328 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124832 bait prey CCT2 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162584 prey bait CCT3 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162583 prey bait VBP1 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162587 prey bait CUL4A FBXW8 MI:0401(biochemical) 17079684 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200198 bait prey NFKBIA FBXW8 MI:0004(affinity chromatography technology) 20558726 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_164028 bait prey IRS1 FBXW8 MI:0096(pull down) 23045529 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218461 bait prey CUL2 FBXW8 MI:0004(affinity chromatography technology) 21572988 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_162580 prey bait FBXW8 FBXW2 MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153678 bait prey FBXW8 FBXO4 MI:0004(affinity chromatography technology) 21946088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153680 bait prey BCL3 FBXW8 MI:0004(affinity chromatography technology) 20558726 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_164029 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CASQ2 FBXW8 26186194 0004 HT TP53 FBXW8 22653443,25609649 0007,0676 LC,HT CCND1 FBXW8 17205132,17205132,18650423 0415,0004,0004 LC RBX1 FBXW8 12481031,12481031,17205132 0004,0018,0004 LC SKP1 FBXW8 12481031,12481031,20596027,26087183,22388891,15070733,17205132,15070733,21572988,15070733,21572988,21946088 0004,0018,0007,0004,0004,0019,0004,0007,0007,0004,0004,0004 LC CUL1 FBXW8 21946088,21145461,17205132,25515538,21572988,22268729,21572988 0004,0004,0004,0004,0007,0004,0004 LC,HT CUL7 FBXW8 12481031,23045529,21946088,17332328,12904573,17205132,17998335,21572988,16142236,23029530,21572988 0004,0004,0004,0004,0007,0004,0004,0007,0004,0004,0004 LC MAPK14 FBXW8 26186194 0004 HT Q53GA5 FBXW8 25609649 0004 HT FBXW8 TTC29 26186194 0004 HT FBXW8 CCDC8 21572988,24711643,21572988 0007,0004,0004 LC CASQ2 FBXW8 26186194 0004 HT TP53 FBXW8 25609649 0676 HT CUL1 FBXW8 21145461 0004 HT MAPK14 FBXW8 26186194 0004 HT Q53GA5 FBXW8 25609649 0004 HT FBXW8 TTC29 26186194 0004 HT TP53 FBXW8 22653443 0007 LC CCND1 FBXW8 17205132,17205132,18650423 0415,0004,0004 LC RBX1 FBXW8 12481031,12481031,17205132 0004,0018,0004 LC SKP1 FBXW8 12481031,12481031,20596027,26087183,22388891,15070733,17205132,15070733,21572988,15070733,21572988,21946088 0004,0018,0007,0004,0004,0019,0004,0007,0007,0004,0004,0004 LC CUL1 FBXW8 21946088,17205132,25515538,21572988,22268729,21572988 0004,0004,0004,0007,0004,0004 LC CUL7 FBXW8 12481031,23045529,21946088,17332328,12904573,17205132,17998335,21572988,16142236,23029530,21572988 0004,0004,0004,0004,0007,0004,0004,0007,0004,0004,0004 LC FBXW8 CCDC8 21572988,24711643,21572988 0007,0004,0004 LC MYC FBXW8 17314511,17314511,17314511,17314511 0007,0018,0004,0676 LC CCND1 FBXW8 17205132,17205132 0415,0004 LC RBX1 FBXW8 12481031,12481031,10531037 0004,0018,0018 LC SKP1 FBXW8 12481031,12481031,15070733,15070733,10531037,15070733 0004,0018,0019,0007,0018,0004 LC CUL7 FBXW8 10531037 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N3Y1 O14958 FBXW8 CASQ2 0.126 26186194 Q8N3Y1 O14980 FBXW8 XPO1 0.126 26673895 Q8N3Y1 Q8IZP1 FBXW8 TBC1D3 0.376 23029530 Q8N3Y1 P24385 FBXW8 CCND1 0.569 17205132,18650423 Q8N3Y1 O14737 FBXW8 PDCD5 0.21 21572988 Q8N3Y1 O75147 FBXW8 OBSL1 0.21 21572988 Q8N3Y1 P01106 FBXW8 MYC 0.554 17314511 Q8N3Y1 P07900 FBXW8 HSP90AA1 0.21 21946088 Q8N3Y1 P34932 FBXW8 HSPA4 0.21 21946088 Q8N3Y1 P40227 FBXW8 CCT6A 0.21 21572988 Q8N3Y1 P49368 FBXW8 CCT3 0.21 21572988 Q8N3Y1 P61758 FBXW8 VBP1 0.21 21572988 Q8N3Y1 P78371 FBXW8 CCT2 0.21 21572988 Q8N3Y1 Q09472 FBXW8 EP300 0.21 19297328 Q8N3Y1 Q13127 FBXW8 REST 0.21 18354482 Q8N3Y1 Q13309 FBXW8 SKP2 0.21 21946088 Q8N3Y1 Q13617 FBXW8 CUL2 0.21 21572988 Q8N3Y1 Q15645 FBXW8 TRIP13 0.21 21572988 Q8N3Y1 Q6IPX1 FBXW8 TBC1D3C 0.376 23029530 Q92526 Q8N3Y1 CCT6B FBXW8 0.21 21572988 Q99471 Q8N3Y1 PFDN5 FBXW8 0.21 21572988 Q99832 Q8N3Y1 CCT7 FBXW8 0.21 21572988 Q9H0W5 Q8N3Y1 CCDC8 FBXW8 0.21 21572988 Q9UKT5 Q8N3Y1 FBXO4 FBXW8 0.21 21946088 Q9UKT8 Q8N3Y1 FBXW2 FBXW8 0.21 21946088 Q9Y297 Q8N3Y1 BTRC FBXW8 0.21 21946088 Q8NA56 Q8N3Y1 TTC29 FBXW8 0.126 26186194 Q8N3Y1 Q6P5F9 FBXW8 XPO1 0.126 26673895 Q8N3Y1 P62877 FBXW8 RBX1 0.376 12481031,17205132 Q8N3Y1 P04637 FBXW8 TP53 0.332 22653443,25609649 Q8N3Y1 Q14999 FBXW8 CUL7 0.925 17205132,21946088,17332328,12481031,17998335,16142236,23029530,23045529,21572988 Q92918 Q8N3Y1 MAP4K1 FBXW8 0.376 24362026 Q8N3Y1 P25963 FBXW8 NFKBIA 0.21 20558726 Q9BQQ3 Q8N3Y1 GORASP1 FBXW8 0.376 21572988 Q8N3Y1 P35568 FBXW8 IRS1 0.309 23045529 Q8N3Y1 Q13616 FBXW8 CUL1 0.671 17205132,22268729,21145461,21946088,21572988,25515538 Q8N3Y1 Q13619 FBXW8 CUL4A 0.21 17079684 Q8N3Y1 P63208 FBXW8 SKP1 0.832 27705803,17205132,26087183,22388891,21572988,12481031,15070733 Q8N3Y1 Q16531 FBXW8 DDB1 0.21 17079684 Q8N3Y1 Q16539 FBXW8 MAPK14 0.126 26186194 Q8N3Y1 P20749 FBXW8 BCL3 0.21 20558726

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PDCD5 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database CASQ2 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXW8 MI:0362 inference MI:1106 pathways database OBSL1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXW8 MI:0362 inference MI:1106 pathways database MYC FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database TP53 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXW8 MI:0362 inference MI:1106 pathways database UBC FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TCP1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW8 MI:0362 inference MI:1106 pathways database BCL3 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database CCND1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database NFKBIA FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database HSPA4 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database IRS1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database CCT6A FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXW8 MI:0362 inference MI:1106 pathways database CCT3 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A FBXW8 MI:0362 inference MI:1106 pathways database FBXW4 FBXW8 MI:0362 inference MI:1106 pathways database UBE2D3 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database VBP1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXW8 MI:0362 inference MI:1106 pathways database UBA52 FBXW8 MI:0362 inference MI:1106 pathways database SKP1 FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CCT2 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database ARF1 FBXW8 MI:0362 inference MI:0461 interaction database EP300 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database REST FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL1 FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL2 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXW8 MI:0362 inference MI:1106 pathways database CUL7 FBXW8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP13 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database MAPK14 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXW8 MI:0362 inference MI:1106 pathways database HECTD2 FBXW8 MI:0362 inference MI:1106 pathways database FBXO31 FBXW8 MI:0362 inference MI:1106 pathways database FBXW9 FBXW8 MI:0362 inference MI:1106 pathways database FBXW10 FBXW8 MI:0362 inference MI:1106 pathways database RNF213 FBXW8 MI:0362 inference MI:1106 pathways database TBC1D3C FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database FBXL22 FBXW8 MI:0362 inference MI:1106 pathways database FBXL19 FBXW8 MI:0362 inference MI:1106 pathways database FBXW12 FBXW8 MI:0362 inference MI:1106 pathways database RNF19B FBXW8 MI:0362 inference MI:1106 pathways database RNF144B FBXW8 MI:0362 inference MI:1106 pathways database RBBP6 FBXW8 MI:0362 inference MI:1106 pathways database HUWE1 FBXW8 MI:0362 inference MI:1106 pathways database TRIM69 FBXW8 MI:0362 inference MI:1106 pathways database SIAH1 FBXW8 MI:0362 inference MI:1106 pathways database HERC6 FBXW8 MI:0362 inference MI:1106 pathways database UBR2 FBXW8 MI:0362 inference MI:1106 pathways database TBC1D3 FBXW8 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 FBXW8 MI:0362 inference MI:1106 pathways database FBXW8 FBXL16 MI:0362 inference MI:1106 pathways database FBXW8 TTC29 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 FBXO15 MI:0362 inference MI:1106 pathways database FBXW8 ZNRF1 MI:0362 inference MI:1106 pathways database FBXW8 FBXL13 MI:0362 inference MI:1106 pathways database FBXW8 FBXO22 MI:0362 inference MI:1106 pathways database FBXW8 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW8 FBXO27 MI:0362 inference MI:1106 pathways database FBXW8 FBXO30 MI:0362 inference MI:1106 pathways database FBXW8 RNF217 MI:0362 inference MI:1106 pathways database FBXW8 DTX3L MI:0362 inference MI:1106 pathways database FBXW8 FBXO41 MI:0362 inference MI:1106 pathways database FBXW8 LMO7 MI:0362 inference MI:1106 pathways database FBXW8 MYLIP MI:0362 inference MI:1106 pathways database FBXW8 CCT6B MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 MAP4K1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 FBXW7 MI:0362 inference MI:1106 pathways database FBXW8 FBXO32 MI:0362 inference MI:1106 pathways database FBXW8 FBXW5 MI:0362 inference MI:1106 pathways database FBXW8 MIB2 MI:0362 inference MI:1106 pathways database FBXW8 SPSB1 MI:0362 inference MI:1106 pathways database FBXW8 FBXL8 MI:0362 inference MI:1106 pathways database FBXW8 FBXO17 MI:0362 inference MI:1106 pathways database FBXW8 FBXL20 MI:0362 inference MI:1106 pathways database FBXW8 FBXL18 MI:0362 inference MI:1106 pathways database FBXW8 NEDD4L MI:0362 inference MI:1106 pathways database FBXW8 PFDN5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 CCT7 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 GORASP1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 RBCK1 MI:0362 inference MI:1106 pathways database FBXW8 CCDC8 MI:0045 experimental interaction detection MI:0461 interaction database FBXW8 FBXL15 MI:0362 inference MI:1106 pathways database FBXW8 FBXO44 MI:0362 inference MI:1106 pathways database FBXW8 UNKL MI:0362 inference MI:1106 pathways database FBXW8 NANOG MI:0362 inference MI:0461 interaction database FBXW8 SMURF2 MI:0362 inference MI:1106 pathways database FBXW8 TRIM36 MI:0362 inference MI:1106 pathways database FBXW8 FBXO6 MI:0362 inference MI:1106 pathways database FBXW8 RNF19A MI:0362 inference MI:1106 pathways database FBXW8 RLIM MI:0362 inference MI:1106 pathways database FBXW8 FBXL12 MI:0362 inference MI:1106 pathways database FBXW8 FBXO40 MI:0362 inference MI:1106 pathways database FBXW8 HERC5 MI:0362 inference MI:1106 pathways database FBXW8 FBXL7 MI:0362 inference MI:1106 pathways database FBXW8 FBXO2 MI:0362 inference MI:1106 pathways database FBXW8 FBXO10 MI:0362 inference MI:1106 pathways database FBXW8 FBXO9 MI:0362 inference MI:1106 pathways database FBXW8 FBXL5 MI:0362 inference MI:1106 pathways database FBXW8 FBXL4 MI:0362 inference MI:1106 pathways database FBXW8 FBXW11 MI:0362 inference MI:1106 pathways database FBXW8 FBXO4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXW8 FBXL21 MI:0362 inference MI:1106 pathways database FBXW8 FBXL3 MI:0362 inference MI:1106 pathways database FBXW8 FBXW2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXW8 BTRC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXW8 FBXO7 MI:0362 inference MI:1106 pathways database FBXW8 RNF115 MI:0362 inference MI:1106 pathways database FBXW8 RNF114 MI:0362 inference MI:1106 pathways database FBXW8 WSB1 MI:0362 inference MI:1106 pathways database