PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB18 FBXL17 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYC ZBTB18 21150319 i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G TSN ZBTB18 9756912 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAK1 ZBTB18 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 ZBTB18 19322201 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTBP2 ZBTB18 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DNMT1 ZBTB18 bci exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTBP1 ZBTB18 24722188 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G POMGNT1 ZBTB18 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 DNMT3B 11350943, 25402006 hprd exp, pred G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 DNMT3A 15616584,11350943, 21836163 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TCEB2 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UHRF1 ZBTB18 25402006 pred G G G G G G G G G G G G G G G VHL ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 ZBTB32 23023127 pred G SOCS3 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW7 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB44 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2I ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS2 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 DNMT3L 25402006 pred G G KLHL23 ZBTB18 23023127 pred G G G G G G G G G G G G G EZH2 ZBTB18 25402006 pred G G G G G G G G G G G G ZBTB18 BCL11B 21836163 pred G G G G G G G G G G G G G G G G G G G G G G PIAS1 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPRC1 ZBTB18 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 MBD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 KLHL3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NRIP1 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KBTBD11 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G BTBD6 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL1 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB14 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 KLHL11 23023127 pred G CENPI ZBTB18 21836163 pred G G G G CHAF1A ZBTB18 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HDAC1 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BACH1 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SETDB1 ZBTB18 25402006, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NACC1 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 BTRC 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H3F3A, H3F3B ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB7A ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCOR1 ZBTB18 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNTA1 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 CENPH 21836163 pred G G G G G G ZBTB16 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIC2 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB18 FEZ1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99592 Q9UBC3-3 in vitro 11350943 - X 2 Q99592 Q9UBC3-3 in vitro 11350943 - X 2 Q9Y6K1-3 Q99592 two hybrid 11350943 - X 2 Q9Y6K1-3 Q99592 in vitro 11350943 - X 2 Q9Y6K1-3 Q99592 in vivo 11350943 - X 2 Q9Y6K1-3 Q99592 two hybrid 11350943 - X 2 Q9Y6K1-3 Q99592 in vivo 11350943 - X 2 Q9Y6K1-3 Q99592 in vitro 11350943 - X 2 Q99592 Q8IY44 two hybrid prey pooling approach 25416956 physical association X 2 Q99592 Q8IY44 two hybrid array 25416956 physical association X 2 Q99592 Q8IY44 validated two hybrid 25416956 physical association X 2 A0A024R5P0 Q99592 two hybrid pooling approach 20936779 physical association X 2 Q8WZA1 Q99592 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZNF238 DNMT3A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro) 11350943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_91679|BIOGRID_91678|BIOGRID_91682|HPRD_11515 prey|bait|bait|- bait|prey|prey|- ELAVL1 ZNF238 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187619 bait prey UBC ZNF238 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_169582 bait prey ZNF238 DNMT3B MI:0492(in vitro) 11350943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_11700 - - ZNF238 FBXL17 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289811 prey bait PAK1 ZNF238 MI:0096(pull down)|MI:0018(two hybrid) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110649|BIOGRID_126992 bait|bait prey|prey ZNF238 POMGNT1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285936|UniProt_118214 prey|unspecified role bait|unspecified role TSN ZNF238 MI:0018(two hybrid) 9756912 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214005 bait prey

PPI - HINT Gene A Gene B PMID Method Quality ZBTB18 DNMT3A 11350943,11350943,15616584,11350943 0018,0004,0096,0096 LC ZBTB18 DNMT3A 11350943,11350943,15616584,11350943 0018,0004,0096,0096 LC CTBP2 ZBTB18 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PAK1 ZBTB18 20936779,20936779 0398,0018 HT CTBP1 ZBTB18 24722188 0018 HT TSN ZBTB18 9756912 0018 LC POMGNT1 ZBTB18 21988832,21988832 0397,0018 HT ZBTB18 DNMT3A 11350943,11350943,11350943 0018,0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y6K1 Q99592 DNMT3A ZBTB18 0.74 11350943,15616584 Q99592 P01106 ZBTB18 MYC 0.126 21150319 Q99592 Q8WY64 ZBTB18 MYLIP 0.236 unassigned1304 Q99592 Q92569 ZBTB18 PIK3R3 0.236 unassigned1304 Q99592 Q5SQP8 ZBTB18 CTBP2 {ECO:0000313|ENSEMBL:ENSP00000357816} 0.236 unassigned1304 Q99592 Q8N680 ZBTB18 ZBTB2 0.236 unassigned1304 Q99592 Q8IY44 ZBTB18 CTBP2 {ECO:0000313|EMBL:AAH37900.1} 0.332 25416956 Q99592 Q8WZA1 ZBTB18 POMGNT1 0.286 21988832 Q99592 Q13153 ZBTB18 PAK1 0.286 20936779 Q9UF56 Q99592 FBXL17 ZBTB18 0.21 24035498 Q99592 Q13363 ZBTB18 CTBP1 0.183 24722188 Q99592 Q15631 ZBTB18 TSN 0.309 9756912 Q99592 Q15717 ZBTB18 ELAVL1 0.126 19322201 Q99592 P56545 ZBTB18 CTBP2 0.183 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYC ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database CTBP2 ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database PAK1 ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database CTBP1 ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database TSN ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database POMGNT1 ZBTB18 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB18 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB18 DNMT3A MI:0045 experimental interaction detection MI:0461 interaction database