PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL4A BRWD1 21145461,16964240 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G MYC BRWD1 21150319 i2d,intact exp GP P P P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP P P GP G STAT3 BRWD1 25814554 biogrid,intact exp GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G UBXN7 BRWD1 18775313 biogrid,intact exp GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G APP BRWD1 21832049 innatedb,biogrid exp G P G P GP G G GP G G G G G G GP GP G GP G GP GP G G GP GP G MYO5C BRWD1 26496610 biogrid,intact exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP P P GP G CALM1, CALM2, CALM3 BRWD1 15840729 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G MMGT1 BRWD1 26496610 biogrid,intact exp GP P G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP G CUL3 BRWD1 25011449 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G RDX BRWD1 26344197 biogrid exp G P G GP G G G G GP GP G GP G G GP GP GP G GP GP GP G G P GP G COPS5 BRWD1 21145461 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G BRWD1 APPL1 25814554 biogrid,intact exp GP P G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP P P GP G CBX6 BRWD1 21282530 intact exp GP P G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP P GP G SMARCA4 BRWD1 12889071, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G DDB1 BRWD1 26344197,16964240, 25402006 biogrid exp, pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G POU5F1 BRWD1 ortho P P P P P P P P P P P P P P P P P P P P P P KLHL12 BRWD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G CREBBP BRWD1 25402006 pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G BRWD1 ZMYND8 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P P GP G WDFY3 BRWD1 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G BRWD1 BAZ2B 25402006 pred GP P G GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP P P GP G BRWD1 PLAA 25402006 pred GP P G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP P P GP G WDR26 BRWD1 25402006 pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP G KLHL22 BRWD1 25402006 pred G P G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP P GP G BRWD1 TRIM33 23023127 pred GP P G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP P P GP G SEPT6 BRWD1 21836163 pred G P G P GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP P P GP G BRWD1 ATAD2B 25402006 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP P P GP G BPTF BRWD1 25402006 pred G P G GP G G GP G GP GP GP G G GP GP GP G G GP G GP G GP P GP G CUL4B BRWD1 25402006 pred GP P G P GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP P P GP G UBR4 BRWD1 25402006 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP G DNM1 BRWD1 21836163 pred G G GP G G GP G G GP GP G G G GP G G G G G G G G WDR11 BRWD1 25402006 pred GP P G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP G BRWD1 KLHDC2 25402006 pred GP P G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP P P GP G SMARCA2 BRWD1 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P P GP G UBR1 BRWD1 25402006 pred GP P G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP P GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NSI6 anti tag coimmunoprecipitation 18775313 association C 23 Q9NSI6 anti tag coimmunoprecipitation 18775313 association C 22 Q9NSI6 tandem affinity purification 21282530 association C 54 Q9NSI6 Q7CGH3 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBXN7 BRWD1 18775313,18775313,26389662 0007,0004,0004 LC RDX BRWD1 26344197 0401 HT CUL4A BRWD1 16964240,21145461 0004,0004 LC,HT DDB1 BRWD1 16964240,26344197 0004,0401 LC,HT MMGT1 BRWD1 26496610,26496610 0007,0004 HT COPS5 BRWD1 21145461 0004 HT MYO5C BRWD1 26496610,26496610 0007,0004 HT RDX BRWD1 26344197 0401 HT CUL4A BRWD1 21145461 0004 HT DDB1 BRWD1 26344197 0401 HT MMGT1 BRWD1 26496610,26496610 0007,0004 HT COPS5 BRWD1 21145461 0004 HT MYO5C BRWD1 26496610,26496610 0007,0004 HT UBXN7 BRWD1 18775313,18775313,26389662 0007,0004,0004 LC CUL4A BRWD1 16964240 0004 LC DDB1 BRWD1 16964240 0004 LC RDX BRWD1 26344197 0401 LC STAT3 BRWD1 25814554,25814554,25814554 0397,0018,1356 HT DDB1 BRWD1 26344197 0401 LC BRWD1 APPL1 25814554,25814554,25814554 0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NSI6 P62158 BRWD1 CALM3 0.183 15840729 Q9NSI6 P05067 BRWD1 APP 0.183 21832049 Q9NSI6 P40763 BRWD1 STAT3 0.376 25814554 Q9NSI6 P51532 BRWD1 SMARCA4 0.21 12889071 Q9NSI6 Q7CGH3 BRWD1 MUTT7 0.126 20711500 Q9NSI6 P01106 BRWD1 MYC 0.126 21150319 Q9NSI6 Q9NQX4 BRWD1 MYO5C 0.236 26496610 Q9NSI6 Q8K3Y3 BRWD1 LIN28A 0.236 26496610 Q9NSI6 Q8N4V1 BRWD1 MMGT1 0.236 26496610 Q9NSI6 Q13619 BRWD1 CUL4A 0.236 16964240,21145461 Q9NSI6 Q16531 BRWD1 DDB1 0.196 26344197,16964240 Q9NSI6 P83917 BRWD1 CBX1 0.236 26496610 Q9NSI6 Q3TCH7 BRWD1 CUL4A 0.236 26496610 Q9NSI6 Q61687 BRWD1 ATRX 0.236 26496610 Q9NSI6 A2AHJ4 BRWD1 BRWD3 0.236 26496610 Q9NSI6 P60229 BRWD1 EIF3E 0.236 26496610 Q9NSI6 O94888 BRWD1 UBXN7 0.332 18775313,26389662 Q9UKG1 Q9NSI6 APPL1 BRWD1 0.376 25814554 Q9NSI6 Q92905 BRWD1 COPS5 0.126 21145461 Q9NSI6 P35241 BRWD1 RDX 0.081 26344197 Q9NSI6 Q13618 BRWD1 CUL3 0.21 25011449

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBXN7 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CBX6 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database MYC BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database APP BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database UBC BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database POLR2A BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database STAT3 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ATRX BRWD1 MI:0362 inference MI:0461 interaction database SMARCA4 BRWD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EIF3E BRWD1 MI:0362 inference MI:0461 interaction database SUMO2 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CALM1 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H3A BRWD1 MI:0362 inference MI:1106 pathways database CBX1 BRWD1 MI:0362 inference MI:0461 interaction database POU5F1 BRWD1 MI:0362 inference MI:0461 interaction database POU5F1B BRWD1 MI:0362 inference MI:0461 interaction database CUL3 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database BRWD3 BRWD1 MI:0362 inference MI:0461 interaction database LIN28B BRWD1 MI:0362 inference MI:0461 interaction database HIST2H3A BRWD1 MI:0362 inference MI:1106 pathways database MMGT1 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database LIN28A BRWD1 MI:0362 inference MI:0461 interaction database MYO5C BRWD1 MI:0045 experimental interaction detection MI:0461 interaction database BRWD1 APPL1 MI:0045 experimental interaction detection MI:0461 interaction database