Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 19 39521937 39521937 + Nonsense_Mutation SNP G G A TCGA-OR-A5LB-01A-11D-A29I-10 TCGA-OR-A5LB-10A-01D-A29L-10 g.chr19:39521937G>A c.388C>T c.(388-390)Caa>Taa p.Q130* BLCA 19 39516069 39516069 + Silent SNP C C G TCGA-BT-A20W-01A-21D-A14W-08 TCGA-BT-A20W-11A-11D-A14W-08 g.chr19:39516069C>G c.834G>C c.(832-834)gtG>gtC p.V278V BLCA 19 39516075 39516075 + Silent SNP C C T TCGA-GV-A40E-01A-12D-A23M-08 TCGA-GV-A40E-10A-01D-A23K-08 g.chr19:39516075C>T c.828G>A c.(826-828)gtG>gtA p.V276V BLCA 19 39516171 39516171 + Missense_Mutation SNP G G C TCGA-GD-A3OQ-01A-32D-A21Z-08 TCGA-GD-A3OQ-10A-01D-A21Z-08 g.chr19:39516171G>C c.732C>G c.(730-732)atC>atG p.I244M BLCA 19 39517563 39517563 + Missense_Mutation SNP A A G TCGA-DK-A6AW-01A-11D-A30E-08 TCGA-DK-A6AW-10A-01D-A30H-08 g.chr19:39517563A>G c.655T>C c.(655-657)Ttc>Ctc p.F219L BLCA 19 39521746 39521746 + Missense_Mutation SNP C C G TCGA-DK-A3IK-01A-32D-A21A-08 TCGA-DK-A3IK-10A-01D-A21A-08 g.chr19:39521746C>G c.495G>C c.(493-495)caG>caC p.Q165H BLCA 19 39521863 39521863 + Silent SNP G G A TCGA-BT-A20J-01A-11D-A14W-08 TCGA-BT-A20J-11A-11D-A14W-08 g.chr19:39521863G>A c.462C>T c.(460-462)ttC>ttT p.F154F BLCA 19 39521874 39521874 + Nonsense_Mutation SNP G G A TCGA-KQ-A41R-01A-21D-A34U-08 TCGA-KQ-A41R-10G-01D-A34X-08 g.chr19:39521874G>A c.451C>T c.(451-453)Cag>Tag p.Q151* BLCA 19 39521925 39521925 + Missense_Mutation SNP C C A TCGA-XF-AAN2-01A-11D-A42E-08 TCGA-XF-AAN2-10A-01D-A42H-08 g.chr19:39521925C>A c.400G>T c.(400-402)Gac>Tac p.D134Y BRCA 19 39516186 39516186 + Silent SNP G G A TCGA-A8-A09Z-01A-11W-A019-09 TCGA-A8-A09Z-10A-01W-A021-09 g.chr19:39516186G>A c.717C>T c.(715-717)caC>caT p.H239H BRCA 19 39517580 39517580 + Missense_Mutation SNP T T C TCGA-AO-A0JM-01A-21W-A071-09 TCGA-AO-A0JM-10A-01W-A071-09 g.chr19:39517580T>C c.638A>G c.(637-639)cAg>cGg p.Q213R COAD 19 39516061 39516061 + Missense_Mutation SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr19:39516061C>T c.842G>A c.(841-843)cGt>cAt p.R281H COAD 19 39516067 39516067 + Missense_Mutation SNP C C T TCGA-AA-3524-01A-02W-0831-10 TCGA-AA-3524-10A-01W-0831-10 g.chr19:39516067C>T c.836G>A c.(835-837)cGa>cAa p.R279Q COAD 19 39516072 39516072 + Silent SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr19:39516072G>A c.831C>T c.(829-831)atC>atT p.I277I COAD 19 39516110 39516110 + Missense_Mutation SNP C C T TCGA-AA-A00E-01A-01W-A005-10 TCGA-AA-A00E-10A-01W-A005-10 g.chr19:39516110C>T c.793G>A c.(793-795)Ggc>Agc p.G265S COAD 19 39516148 39516148 + Missense_Mutation SNP G G T TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr19:39516148G>T c.755C>A c.(754-756)tCt>tAt p.S252Y COAD 19 39517630 39517630 + Silent SNP G G A TCGA-AA-3679-01A-02W-0900-09 TCGA-AA-3679-10A-01W-0900-09 g.chr19:39517630G>A c.588C>T c.(586-588)caC>caT p.H196H COAD 19 39517630 39517630 + Silent SNP G G A TCGA-D5-6540-01A-11D-1719-10 TCGA-D5-6540-10A-01D-1719-10 g.chr19:39517630G>A c.588C>T c.(586-588)caC>caT p.H196H COAD 19 39521863 39521863 + Silent SNP G G A TCGA-AA-A00E-01A-01W-A005-10 TCGA-AA-A00E-10A-01W-A005-10 g.chr19:39521863G>A c.462C>T c.(460-462)ttC>ttT p.F154F COAD 19 39521869 39521869 + Silent SNP C C T TCGA-AA-3516-01A-02W-0833-10 TCGA-AA-3516-10A-01W-0833-10 g.chr19:39521869C>T c.456G>A c.(454-456)acG>acA p.T152T COADREAD 19 39516061 39516061 + Missense_Mutation SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr19:39516061C>T c.842G>A c.(841-843)cGt>cAt p.R281H COADREAD 19 39516067 39516067 + Missense_Mutation SNP C C T TCGA-AA-3524-01A-02W-0831-10 TCGA-AA-3524-10A-01W-0831-10 g.chr19:39516067C>T c.836G>A c.(835-837)cGa>cAa p.R279Q COADREAD 19 39516072 39516072 + Silent SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr19:39516072G>A c.831C>T c.(829-831)atC>atT p.I277I COADREAD 19 39516110 39516110 + Missense_Mutation SNP C C T TCGA-AA-A00E-01A-01W-A005-10 TCGA-AA-A00E-10A-01W-A005-10 g.chr19:39516110C>T c.793G>A c.(793-795)Ggc>Agc p.G265S COADREAD 19 39516148 39516148 + Missense_Mutation SNP G G T TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr19:39516148G>T c.755C>A c.(754-756)tCt>tAt p.S252Y COADREAD 19 39517630 39517630 + Silent SNP G G A TCGA-AA-3679-01A-02W-0900-09 TCGA-AA-3679-10A-01W-0900-09 g.chr19:39517630G>A c.588C>T c.(586-588)caC>caT p.H196H COADREAD 19 39517630 39517630 + Silent SNP G G A TCGA-D5-6540-01A-11D-1719-10 TCGA-D5-6540-10A-01D-1719-10 g.chr19:39517630G>A c.588C>T c.(586-588)caC>caT p.H196H COADREAD 19 39521863 39521863 + Silent SNP G G A TCGA-AA-A00E-01A-01W-A005-10 TCGA-AA-A00E-10A-01W-A005-10 g.chr19:39521863G>A c.462C>T c.(460-462)ttC>ttT p.F154F COADREAD 19 39521869 39521869 + Silent SNP C C T TCGA-AA-3516-01A-02W-0833-10 TCGA-AA-3516-10A-01W-0833-10 g.chr19:39521869C>T c.456G>A c.(454-456)acG>acA p.T152T ESCA 19 39516071 39516071 + Missense_Mutation SNP C C T TCGA-R6-A6KZ-01A-11D-A31U-09 TCGA-R6-A6KZ-10A-01D-A31U-09 g.chr19:39516071C>T c.832G>A c.(832-834)Gtg>Atg p.V278M GBMLGG 19 39517588 39517588 + Silent SNP G G A TCGA-S9-A6WO-01A-21D-A34A-08 TCGA-S9-A6WO-10A-01D-A34A-08 g.chr19:39517588G>A c.630C>T c.(628-630)gaC>gaT p.D210D HNSC 19 39517548 39517548 + Missense_Mutation SNP C C G TCGA-CV-A6JM-01A-11D-A31L-08 TCGA-CV-A6JM-10A-01D-A31J-08 g.chr19:39517548C>G c.670G>C c.(670-672)Gat>Cat p.D224H HNSC 19 39517588 39517588 + Silent SNP G G A TCGA-BA-A6DJ-01A-11D-A30E-08 TCGA-BA-A6DJ-10A-01D-A30H-08 g.chr19:39517588G>A c.630C>T c.(628-630)gaC>gaT p.D210D HNSC 19 39521762 39521762 + Nonsense_Mutation SNP C C T TCGA-IQ-7630-01A-11D-2078-08 TCGA-IQ-7630-10A-01D-2078-08 g.chr19:39521762C>T c.479G>A c.(478-480)tGg>tAg p.W160* HNSC 19 39521925 39521925 + Missense_Mutation SNP C C T TCGA-CV-A6JY-01A-11D-A31L-08 TCGA-CV-A6JY-10A-01D-A31J-08 g.chr19:39521925C>T c.400G>A c.(400-402)Gac>Aac p.D134N KIPAN 19 39517640 39517640 + Missense_Mutation SNP C C T TCGA-AK-3425-01A-02D-1361-10 TCGA-AK-3425-10A-01D-1361-10 g.chr19:39517640C>T c.578G>A c.(577-579)gGa>gAa p.G193E KIPAN 19 39521925 39521925 + Missense_Mutation SNP C C T TCGA-B4-5377-01A-01D-1501-10 TCGA-B4-5377-10A-01D-1501-10 g.chr19:39521925C>T c.400G>A c.(400-402)Gac>Aac p.D134N KIRC 19 39517640 39517640 + Missense_Mutation SNP C C T TCGA-AK-3425-01A-02D-1361-10 TCGA-AK-3425-10A-01D-1361-10 g.chr19:39517640C>T c.578G>A c.(577-579)gGa>gAa p.G193E KIRC 19 39521925 39521925 + Missense_Mutation SNP C C T TCGA-B4-5377-01A-01D-1501-10 TCGA-B4-5377-10A-01D-1501-10 g.chr19:39521925C>T c.400G>A c.(400-402)Gac>Aac p.D134N LGG 19 39517588 39517588 + Silent SNP G G A TCGA-S9-A6WO-01A-21D-A34A-08 TCGA-S9-A6WO-10A-01D-A34A-08 g.chr19:39517588G>A c.630C>T c.(628-630)gaC>gaT p.D210D LIHC 19 39517611 39517611 + Nonsense_Mutation SNP T T A TCGA-UB-A7MB-01A-11D-A33Q-10 TCGA-UB-A7MB-10A-01D-A33Q-10 g.chr19:39517611T>A c.607A>T c.(607-609)Aga>Tga p.R203* LUAD 19 39517531 39517531 + Nonsense_Mutation SNP C C T TCGA-55-8506-01A-11D-2393-08 TCGA-55-8506-10A-01D-2393-08 g.chr19:39517531C>T c.687G>A c.(685-687)tgG>tgA p.W229* LUAD 19 39517606 39517606 + Silent SNP G G A TCGA-69-7980-01A-11D-2184-08 TCGA-69-7980-10A-01D-2184-08 g.chr19:39517606G>A c.612C>T c.(610-612)ctC>ctT p.L204L LUAD 19 39522510 39522510 + Missense_Mutation SNP C C A TCGA-05-4249-01A-01D-1105-08 TCGA-05-4249-10A-01D-1105-08 g.chr19:39522510C>A c.358G>T c.(358-360)Ggc>Tgc p.G120C LUSC 19 39516090 39516090 + Silent SNP C C T TCGA-22-1012-01A-01D-1521-08 TCGA-22-1012-11A-01D-1521-08 g.chr19:39516090C>T c.813G>A c.(811-813)gtG>gtA p.V271V LUSC 19 39521733 39521733 + Missense_Mutation SNP C C T TCGA-60-2698-01A-01D-1522-08 TCGA-60-2698-11A-01D-1522-08 g.chr19:39521733C>T c.508G>A c.(508-510)Gag>Aag p.E170K LUSC 19 39521752 39521752 + Missense_Mutation SNP C C G TCGA-18-3410-01A-01D-0983-08 TCGA-18-3410-11A-01D-0983-08 g.chr19:39521752C>G c.489G>C c.(487-489)aaG>aaC p.K163N OV 19 39517637 39517637 + Missense_Mutation SNP G G T TCGA-59-2348-01A-01W-0799-08 TCGA-59-2348-11A-01W-0800-08 g.chr19:39517637G>T c.581C>A c.(580-582)gCc>gAc p.A194D PAAD 19 39516062 39516062 + Missense_Mutation SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr19:39516062G>A c.841C>T c.(841-843)Cgt>Tgt p.R281C PAAD 19 39517624 39517624 + Silent SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr19:39517624G>A c.594C>T c.(592-594)agC>agT p.S198S PCPG 19 39522616 39522616 + Silent SNP G G A TCGA-RW-A68B-01A-11D-A35D-08 TCGA-RW-A68B-10A-01D-A35B-08 g.chr19:39522616G>A c.252C>T c.(250-252)caC>caT p.H84H PRAD 19 39521716 39521716 + Nonsense_Mutation SNP C C T TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr19:39521716C>T c.525G>A c.(523-525)tgG>tgA p.W175* SKCM 19 39516062 39516062 + Missense_Mutation SNP G G A TCGA-GF-A6C9-06A-11D-A30X-08 TCGA-GF-A6C9-10A-01D-A30X-08 g.chr19:39516062G>A c.841C>T c.(841-843)Cgt>Tgt p.R281C SKCM 19 39516072 39516072 + Silent SNP G G A TCGA-DA-A3F5-06A-11D-A20D-08 TCGA-DA-A3F5-10A-01D-A20D-08 g.chr19:39516072G>A c.831C>T c.(829-831)atC>atT p.I277I SKCM 19 39516072 39516072 + Silent SNP G G A TCGA-EE-A29M-06A-11D-A196-08 TCGA-EE-A29M-10A-01D-A198-08 g.chr19:39516072G>A c.831C>T c.(829-831)atC>atT p.I277I SKCM 19 39517545 39517545 + Missense_Mutation SNP G G A TCGA-GN-A266-06A-11D-A197-08 TCGA-GN-A266-10A-01D-A199-08 g.chr19:39517545G>A c.673C>T c.(673-675)Ccc>Tcc p.P225S SKCM 19 39517561 39517561 + Missense_Mutation SNP G G C TCGA-ER-A3EV-06A-11D-A20D-08 TCGA-ER-A3EV-10A-01D-A20D-08 g.chr19:39517561G>C c.657C>G c.(655-657)ttC>ttG p.F219L SKCM 19 39517561 39517561 + Silent SNP G G A TCGA-EE-A180-06A-11D-A21A-08 TCGA-EE-A180-10B-01D-A21A-08 g.chr19:39517561G>A c.657C>T c.(655-657)ttC>ttT p.F219F SKCM 19 39517597 39517597 + Silent SNP T T C TCGA-DA-A1IA-06A-11D-A196-08 TCGA-DA-A1IA-10A-01D-A198-08 g.chr19:39517597T>C c.621A>G c.(619-621)caA>caG p.Q207Q

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand BN17 COSM1612212 c.774G>T p.Q258H Substitution - Missense 19:39025489-39025489 - TCGA-DA-A3F5-06 COSM281094 c.831C>T p.I277I Substitution - coding silent 19:39025432-39025432 - S00943 COSM311128 c.410T>G p.V137G Substitution - Missense 19:39031275-39031275 - SWE-22 COSM1179125 c.630C>T p.D210D Substitution - coding silent 19:39026948-39026948 - CSCC-27-T COSM281094 c.831C>T p.I277I Substitution - coding silent 19:39025432-39025432 - TCGA-EE-A3AG-06 COSM311128 c.410T>G p.V137G Substitution - Missense 19:39031275-39031275 - TCGA-EA-A1QT-01 COSM311128 c.410T>G p.V137G Substitution - Missense 19:39031275-39031275 - TCGA-HJ-7597-01 COSM4077899 c.616G>A p.V206I Substitution - Missense 19:39026962-39026962 - TCGA-AK-3425-01 COSM3223302 c.578G>A p.G193E Substitution - Missense 19:39027000-39027000 - TCGA-BR-4184-01 COSM4077898 c.747C>T p.R249R Substitution - coding silent 19:39025516-39025516 - TCGA-EE-A29M-06 COSM281094 c.831C>T p.I277I Substitution - coding silent 19:39025432-39025432 - TCGA-ER-A3EV-06 COSM3892502 c.657C>G p.F219L Substitution - Missense 19:39026921-39026921 - TCGA-18-3410-01 COSM711525 c.489G>C p.K163N Substitution - Missense 19:39031112-39031112 - S0024 COSM5883110 c.650A>G p.D217G Substitution - Missense 19:39026928-39026928 - TCGA-A8-A09Z-01 COSM3823001 c.717C>T p.H239H Substitution - coding silent 19:39025546-39025546 - TCGA-DA-A1IA-06 COSM3533614 c.621A>G p.Q207Q Substitution - coding silent 19:39026957-39026957 - PT52 COSM5940853 c.518G>A p.G173D Substitution - Missense 19:39031083-39031083 - TCGA-B4-5377-01 COSM3362845 c.400G>A p.D134N Substitution - Missense 19:39031285-39031285 - TCGA-12-0656 COSM1179125 c.630C>T p.D210D Substitution - coding silent 19:39026948-39026948 - PT52 COSM5940854 c.517G>A p.G173S Substitution - Missense 19:39031084-39031084 - TCGA-GD-A3OQ-01 COSM1304533 c.732C>G p.I244M Substitution - Missense 19:39025531-39025531 - SNUH_G22_S1 COSM4000719 c.550A>G p.I184V Substitution - Missense 19:39031051-39031051 - T3454 COSM4683949 c.566_567delCT p.S189fs*1 Deletion - Frameshift 19:39031034-39031035 - TCGA-GF-A6C9-06 COSM4901903 c.841C>T p.R281C Substitution - Missense 19:39025422-39025422 - pfg181T COSM4753278 c.760G>A p.E254K Substitution - Missense 19:39025503-39025503 - HCC129T COSM5817036 c.824G>A p.S275N Substitution - Missense 19:39025439-39025439 - TCGA-22-1012-01 COSM711527 c.813G>A p.V271V Substitution - coding silent 19:39025450-39025450 - HX20T COSM3746490 c.386T>G p.V129G Substitution - Missense 19:39031299-39031299 - TCGA-AO-A0JM-01 COSM439454 c.638A>G p.Q213R Substitution - Missense 19:39026940-39026940 - SNUH_G15_S1 COSM311128 c.410T>G p.V137G Substitution - Missense 19:39031275-39031275 - TCGA-AY-6197-01 COSM3692743 c.293C>A p.P98H Substitution - Missense 19:39031935-39031935 - T3225 COSM4683950 c.359G>A p.G120D Substitution - Missense 19:39031869-39031869 - YUKAT COSM5389695 c.476G>T p.S159I Substitution - Missense 19:39031209-39031209 - TCGA-GN-A266-06 COSM3533612 c.673C>T p.P225S Substitution - Missense 19:39026905-39026905 - TCGA-GV-A40E-01 COSM3797054 c.828G>A p.V276V Substitution - coding silent 19:39025435-39025435 - PASFXA COSM5005956 c.797A>G p.H266R Substitution - Missense 19:39025466-39025466 - 587376 COSM1206822 c.665T>G p.V222G Substitution - Missense 19:39026913-39026913 - TCGA-EE-A180-06 COSM3533613 c.657C>T p.F219F Substitution - coding silent 19:39026921-39026921 - TCGA-DK-A3IK-01 COSM1304534 c.495G>C p.Q165H Substitution - Missense 19:39031106-39031106 - In-5 COSM144811 c.809G>A p.R270H Substitution - Missense 19:39025454-39025454 - pfg181T COSM3223301 c.631G>A p.A211T Substitution - Missense 19:39026947-39026947 - TCGA-BT-A20W-01 COSM418271 c.834G>C p.V278V Substitution - coding silent 19:39025429-39025429 - TCGA-BT-A20J-01 COSM188938 c.462C>T p.F154F Substitution - coding silent 19:39031223-39031223 - T684 COSM4077899 c.616G>A p.V206I Substitution - Missense 19:39026962-39026962 - TCGA-D5-6540-01 COSM292949 c.588C>T p.H196H Substitution - coding silent 19:39026990-39026990 - TCGA-UB-A7MB-01 COSM4931203 c.607A>T p.R203* Substitution - Nonsense 19:39026971-39026971 - BN17T COSM1612212 c.774G>T p.Q258H Substitution - Missense 19:39025489-39025489 - TCGA-59-2348-01 COSM70754 c.581C>A p.A194D Substitution - Missense 19:39026997-39026997 - TCGA-AA-3510-01 COSM1393494 c.755C>A p.S252Y Substitution - Missense 19:39025508-39025508 - TCGA-60-2698-01 COSM711526 c.508G>A p.E170K Substitution - Missense 19:39031093-39031093 - TCGA-AA-3679-01 COSM292949 c.588C>T p.H196H Substitution - coding silent 19:39026990-39026990 - TCGA-AA-A010-01 COSM281094 c.831C>T p.I277I Substitution - coding silent 19:39025432-39025432 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.187461 19q13.2 609099 2487348|CGAP|BC030060|A/G|non-coding||1568|Validated; 2487349|CGAP|BC030060|A/G|non-coding||1569|Candidate; 1183219|dbSNP|BC014527|C/G|non-coding||1587|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.F253V c.757T>G 19 39516146 BRCA A C Missense p.V137G c.410T>G 19 39521915 SCLC C A Missense p.G120C c.358G>T 19 39522510 LUAD C G Missense p.K163N c.489G>C 19 39521752 LUSC C G Missense p.Q165H c.495G>C 19 39521746 BLCA C G Synonymous p.V278V c.834G>C 19 39516069 BLCA C T Missense p.D134N c.400G>A 19 39521925 RCCC C T Missense p.G193E c.578G>A 19 39517640 RCCC C T Missense p.R279Q c.836G>A 19 39516067 COREAD C T Nonsense p.W160* c.479G>A 19 39521762 HNSC C T Synonymous p.V271V c.813G>A 19 39516090 LUSC G A Synonymous p.F154F c.462C>T 19 39521863 BLCA G A Synonymous p.F219F c.657C>T 19 39517561 CM G A Synonymous p.H196H c.588C>T 19 39517630 COREAD G A Synonymous p.I277I c.831C>T 19 39516072 CM G C Missense p.F219L c.657C>G 19 39517561 CM G C Missense p.F253L c.759C>G 19 39516144 LUAD G C Missense p.I244M c.732C>G 19 39516171 BLCA G T Missense p.A194D c.581C>A 19 39517637 OV T C Missense p.Q213R c.638A>G 19 39517580 BRCA T C Synonymous p.Q207Q c.621A>G 19 39517597 CM