PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Cbll1 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbll1 Cbll1 22252131,doi:10.1038/emboj.2011.496 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cttn Cbll1 22252131,doi:10.1038/emboj.2011.496 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdh1 Cbll1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G Dok1 Cbll1 ortho G G G G G G G G G G G G G G G G G G G G Wtap Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Src Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sfpq Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kif26b Cbll1 ortho Rnf2 Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Cbll1 ortho G G G G G Kiaa1429 Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JIY2 anti tag coimmunoprecipitation 22252131 association C 23 Q60598 Q9JIY2 anti tag coimmunoprecipitation 22252131 physical association X 2 Q60598 Q9JIY2 anti tag coimmunoprecipitation 22252131 physical association X 2 Q60598 Q9JIY2 anti tag coimmunoprecipitation 22252131 physical association X 2 Q60598 Q9JIY2 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 nuclear magnetic resonance 22252131 direct interaction X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q99704 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q9JIY2 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q14247 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 Q9JIY2 molecular sieving 22252131 direct interaction Y 1 Q9JIY2 Q9JIY2 molecular sieving 22252131 direct interaction Y 1 Q9JIY2 Q9JIY2 molecular sieving 22252131 direct interaction Y 1 Q9JIY2 Q9JIY2 molecular sieving 22252131 direct interaction Y 1 Q9JIY2 Q9JIY2 x-ray crystallography 22252131 direct interaction Y 1 Q9JIY2 P12830 anti tag coimmunoprecipitation 22252131 physical association X 2 Q9JIY2 P12830 pull down 22252131 physical association X 2 Q9JIY2 Q9JIY2 dynamic light scattering 22252131 direct interaction Y 1 Q9JIY2 P12830 isothermal titration calorimetry 22252131 direct interaction X 2 Q9JIY2 Q99704 competition binding 22252131 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cttn Cbll1 MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16615898,22252131 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_167133|UniProt_175632|UniProt_175633|UniProt_122131|UniProt_122132|UniProt_122133|UniProt_122134|UniProt_175635|UniProt_175634 neutral component|prey|prey|prey|prey|prey|prey|prey|prey neutral component|bait|bait|bait|bait|bait|bait|bait|bait Cbll1 Cbll1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 22252131 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_175607|UniProt_175610|UniProt_175611|UniProt_175613|UniProt_122118|UniProt_175612|UniProt_175609|UniProt_175619 neutral component|neutral component|neutral component|neutral component|prey|neutral component|neutral component|bait neutral component|neutral component|neutral component|neutral component|prey|neutral component|neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality CDH1 CBLL1 11836526,11836526 0007,0018 LC YWHAE CBLL1 16615898 0027 LC CBLL1 CBLL1 22252131,22252131,22252131,22252131 0114,0071,0007,0038 LC CDH1 CBLL1 11836526,11836526 0007,0018 LC CTTN CBLL1 22252131 0007 LC CBLL1 CBLL1 22252131,22252131,22252131,22252131 0114,0071,0007,0038 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JIY2 P62259 CBLL1 YWHAE 0.081 16615898 Q9JIY2 O14654 CBLL1 IRS4 0.21 22252131 Q9JIY2 O14974 CBLL1 PPP1R12A 0.21 22252131 Q9JIY2 O75150 CBLL1 RNF40 0.21 22252131 Q9JIY2 O75688 CBLL1 PPM1B 0.21 22252131 Q9JIY2 P10644 CBLL1 PRKAR1A 0.21 22252131 Q9JIY2 P23458 CBLL1 JAK1 0.21 22252131 Q9JIY2 P35813 CBLL1 PPM1A 0.21 22252131 Q9JIY2 P41743 CBLL1 PRKCI 0.21 22252131 Q9JIY2 P42356 CBLL1 PI4KA 0.21 22252131 Q9JIY2 P48730 CBLL1 CSNK1D 0.21 22252131 Q9JIY2 P49674 CBLL1 CSNK1E 0.21 22252131 Q9JIY2 P50395 CBLL1 GDI2 0.21 22252131 Q9JIY2 P51617 CBLL1 IRAK1 0.21 22252131 Q9JIY2 P60228 CBLL1 EIF3E 0.21 22252131 Q9JIY2 Q05655 CBLL1 PRKCD 0.21 22252131 Q9JIY2 Q12905 CBLL1 ILF2 0.21 22252131 Q9JIY2 Q5T5U3 CBLL1 ARHGAP21 0.21 22252131 Q9JIY2 Q5VTR2 CBLL1 RNF20 0.21 22252131 Q9JIY2 Q60598 CBLL1 CTTN 0.21 22252131 Q9JIY2 Q99570 CBLL1 PIK3R4 0.21 22252131 Q9UGP4 Q9JIY2 LIMD1 CBLL1 0.21 22252131 Q9Y2A7 Q9JIY2 NCKAP1 CBLL1 0.21 22252131 Q9JIY2 Q75N03 CBLL1 CBLL1 0.309 22252131 Q9JIY2 Q99704 CBLL1 DOK1 0.376 22252131 Q9JIY2 Q14247 CBLL1 CTTN 0.376 22252131 Q9JIY2 Q9JIY2 CBLL1 CBLL1 0.772 22252131 Q9JIY2 P12830 CBLL1 CDH1 0.702 22252131