PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ctbp1 Kdm2b 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Cbx8 17296600 biogrid,intact exp G G G G G G G G G G G Csnk2a2 Kdm2b 17296600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctbp2 Kdm2b 17296600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx3 Kdm2b 17296600 biogrid,intact exp G G G G Rbbp4 Kdm2b 17296600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Rybp 23395003 biogrid exp Csnk2a1 Kdm2b 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Kdm1a 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Kdm2b 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr5 Kdm2b 17296600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmi1 Kdm2b 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Kdm2b 17296600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Yaf2 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Rnf2 17296600,23395003,22496869 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Pcgf1 17296600,23395003 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Kdm2b Bcor 17296600 biogrid,intact exp, ortho Kdm2b Skp1 17296600 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Acbd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Kdm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Cebpe ortho Kdm2b Lztr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sin3a Kdm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Kdm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Kdm2b ortho G G G G Kdm2b Ecm29 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jun Kdm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ezh2 Kdm2b ortho G G G G G G G G G G G G G G G G G G G G G G G Kdm2b PcgF3 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6P1G2 anti bait coimmunoprecipitation 17296600 association C 7 Q6P1G2 pull down 17296600 association C 10 Q6P1G2 pull down 17296600 association C 52 Q6P1G2 Q9CQJ4 pull down 17296600 physical association X 2 Q6P1G2 pull down 17296600 association C 9 Q6P1G2 pull down 17296600 association C 11

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Wdr5 Kdm2b MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315752 prey bait Ring1 Kdm2b MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315750|BIOGRID_315764|UniProt_166513 prey|prey|prey|prey bait|bait|bait|bait Ctbp1 Kdm2b MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_166520|UniProt_166513|BIOGRID_315763|BIOGRID_315755 prey|prey|prey|prey bait|bait|bait|bait Kdm2b Kdm2b MI:0870(demethylase assay)|MI:0870(demethylase assay)|MI:0870(demethylase assay) 18836456,19202064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|-|- MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_849|DIP_616|DIP_848 -|-|- -|-|- Kdm2b Pcgf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600,23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_329741|BIOGRID_329735|BIOGRID_315749 prey|bait|bait bait|prey|prey Kdm2b Yaf2 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_166520|BIOGRID_315758|BIOGRID_315754 bait|bait|bait prey|prey|prey Kdm2b Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331807 prey bait Ctbp2 Kdm2b MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315756 prey bait Cbx3 Kdm2b MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315744|BIOGRID_315765|UniProt_166513 prey|prey|prey|prey bait|bait|bait|bait Rbbp4 Kdm2b MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315747 prey bait Hspa8 Kdm2b MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315745 prey bait Kdm2b Bcor MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315741|BIOGRID_315757|UniProt_166513 bait|bait|bait|bait prey|prey|prey|prey Kdm2b Hist3h2a MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_315770 bait prey Kdm2b Cbx8 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_166520|UniProt_166513|BIOGRID_315761|BIOGRID_315748 bait|bait|bait|bait prey|prey|prey|prey Kdm2b Kdm1a MI:0096(pull down)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_166520|BIOGRID_315766 bait|bait prey|prey Kdm2b Skp1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315760|BIOGRID_315746|UniProt_166513 bait|bait|bait|bait prey|prey|prey|prey Csnk2a2 Kdm2b MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315751 prey bait Bmi1 Kdm2b MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315753|BIOGRID_315762|UniProt_166513 prey|prey|prey|prey bait|bait|bait|bait Kdm2b Rybp MI:0004(affinity chromatography technology) 23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329736 bait prey Csnk2a1 Kdm2b MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315759|BIOGRID_315743 prey|prey bait|bait Kdm2b Rnf2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600,22496869,23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_166512|UniProt_166514|UniProt_166511|UniProt_166519|BIOGRID_329734|BIOGRID_315742|BIOGRID_315730|BIOGRID_329737|BIOGRID_320484|BIOGRID_315767|BIOGRID_315736 prey|prey|prey|prey|bait|bait|prey|prey|prey|bait|prey bait|bait|prey|bait|prey|prey|bait|bait|bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality KDM2B HIST3H2A 17296600 0415 LC RING1 KDM2B 17296600,17296600 0096,0004 LC CSNK2A2 KDM2B 17296600 0004 LC CTBP1 KDM2B 17296600,17296600 0096,0004 LC CBX3 KDM2B 17296600,17296600 0096,0004 LC BMI1 KDM2B 17296600,17296600 0096,0004 LC CTBP2 KDM2B 17296600 0004 LC WDR5 KDM2B 17296600 0004 LC HSPA8 KDM2B 17296600 0004 LC CSNK2A1 KDM2B 17296600 0004 LC RBBP4 KDM2B 17296600 0004 LC Q61177 KDM2B 17296600 0096 LC KDM2B KDM1A 17296600,17296600 0096,0004 LC KDM2B RYBP 23395003 0004 LC KDM2B BCOR 17296600,17296600 0096,0004 LC KDM2B PCGF1 23395003,17296600 0004,0004 LC KDM2B EED 24457600 0004 LC KDM2B YAF2 17296600,17296600 0096,0004 LC KDM2B RNF2 17296600,23395003,17296600,17296600,22496869 0096,0004,0004,0006,0004 LC KDM2B CBX8 17296600,17296600 0096,0004 LC KDM2B SKP1 17296600,17296600 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8R023 Q6P1G2 PCGF1 KDM2B 0.454 23395003,17296600 Q6P1G2 P63017 KDM2B HSPA8 0.126 17296600 Q6P1G2 P61965 KDM2B WDR5 0.126 17296600 Q6P1G2 P56546 KDM2B CTBP2 0.126 17296600 Q6P1G2 P23198 KDM2B CBX3 0.126 17296600 Q6P1G2 O54833 KDM2B CSNK2A2 0.126 17296600 Q6P1G2 Q60972 KDM2B RBBP4 0.126 17296600 Q6P1G2 Q60737 KDM2B CSNK2A1 0.126 17296600 Q8CCI5 Q6P1G2 RYBP KDM2B 0.21 23395003 Q6P1G2 Q61177 KDM2B CSNK2A1 0.126 17296600 Q6P1G2 O35730 KDM2B RING1 0.236 17296600 Q6P1G2 O88712 KDM2B CTBP1 0.236 17296600 Q6P1G2 P25916 KDM2B BMI1 0.236 17296600 Q6ZQ88 Q6P1G2 KDM1A KDM2B 0.236 17296600 Q8CGN4 Q6P1G2 BCOR KDM2B 0.236 17296600 Q99LW6 Q6P1G2 YAF2 KDM2B 0.236 17296600 Q9QXV1 Q6P1G2 CBX8 KDM2B 0.236 17296600 Q9WTX5 Q6P1G2 SKP1 KDM2B 0.236 17296600 Q9CQJ4 Q6P1G2 RNF2 KDM2B 0.772 22496869,17296600,23395003 Q921E6 Q6P1G2 EED KDM2B 0.126 24457600