PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ibtk Cul3 23086144 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Rps9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp10 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Histone-lysine N-methyltransferase, H3 lysine-79 specific Ibtk ortho Eif4a1 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpn Ibtk ortho P G G G G G Ibtk Rfc3 ortho GP G G G G G G G G G G G G G G G G G G B9d2 Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G Ibtk Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkd1 Ibtk ortho GP G G G G G G G G G G G G G G G G G Espl1 Ibtk ortho Ubc Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rgs2 Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcte1 Ibtk ortho G G G G G G G G Eif4a2 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Rpp25l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkce Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdcd4 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcg Ibtk ortho G G G G Adam19 Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G Rps8 Ibtk ortho P Cep135 Ibtk ortho P Lamtor3 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd81 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Pcm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Dhx30 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Cd2bp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Cep128 ortho Btk Ibtk ortho G G G G G Ibtk Igsf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Cand1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkca Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G Ncam1 Ibtk ortho G G G G G G G G G G G G G G G G G Ibtk Nat10 ortho P Ibtk Rpgrip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Rfc4 ortho GP G G G G G G G G G G G G G G G G G G G Signal recognition particle subunit SRP72 Ibtk ortho P Ibtk Rpl10 ortho P Ibtk Rpgrip1l ortho Ibtk Wdr74 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps3 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsr1 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcd Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Pop7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops3 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Odf2 Ibtk ortho G G G G Ibtk Cnot1 ortho P Ibtk Poc1a ortho Cep44 Ibtk ortho Rfc1 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Lactb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops4 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Nop56 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rplp0 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cenpj Ibtk ortho Plcg1 Ibtk ortho P Akt1 Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ibtk Cep120 ortho Ttk Ibtk ortho G G G G G G G G Ibtk Ddx21 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcb Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1ca Ibtk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itk Ibtk ortho G G G Msl1 Ibtk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZPR6 Q9JLV5 affinity chromatography technology 23086144 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ibtk Cul3 MI:0004(affinity chromatography technology) 23086144 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323386 prey bait

PPI - HINT Gene A Gene B PMID Method Quality IBTK CUL3 23086144 0004 LC