PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhah Ubxn1 21311561 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ngly1 16709668 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Ubxn1 16709668 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Amfr 16709668 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Nsfl1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa2 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ube2v2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Ubxn1 ortho G G G Cdk4 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd81 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Asf1b ortho G G G G G G G G G G G G G G G G Ubxn1 Smurf1 ortho Btbd9 Ubxn1 ortho Ubxn1 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Cse1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tufm Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hif1a Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sssca1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v1a Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clns1a Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Unc45a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Igbp1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Plaa Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vamp2 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps27a Ubxn1 ortho P Ubxn1 Klhl22 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Ubxn1 ortho G G G G G G G G G G G G Fkbp14 Ubxn1 ortho Pja2 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Acvr1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Rpa3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pafah1b1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dbnl Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Txnrd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttc1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufm1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Twf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txndc5 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc3 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Huwe1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp47 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp34 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Ubxn1 ortho G G G G G G G G G G G G G Ubxn1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Homer2 ortho P G G G G G G G G G G G G G G G G G G G G G Ero1lb Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Btbd2 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capn2 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pex5 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Mid2 ortho G G G G G G G G G G G G G G G G G G G G G G G Ubr5 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl12 Ubxn1 ortho Ubxn1 Cul2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btbd1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mavs Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam189a2 Ubxn1 ortho Ubxn1 Dnajb11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Zfyve19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Babam1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam115a, Kiaa0738 Ubxn1 ortho Ubxn1 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb2a Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk1a1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp4 Ubxn1 ortho G G G G G G G G G G G G G Ubxn1 Denr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps4b Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Prosc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shkbp1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kctd10 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 March7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcc Ubxn1 ortho Usp39 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG14935, isoform CRA_a, WD repeat-containing protein 20 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctnnb1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Twf1 Ubxn1 ortho P Kiaa1598 Ubxn1 ortho P Ubxn1 Mcts1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc3 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ubqln1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec22b Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Vta1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Iap Ubxn1 ortho G G Ubr2 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G E2f1 Ubxn1 ortho G G G G G Usp9x Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctps1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG9018, Protein Kbtbd7 Ubxn1 ortho Ubiquitin carboxyl-terminal hydrolase Ubxn1 ortho P Basp1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Ubxn1 ortho P Tgfbr1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Protein S100a16, S100 calcium binding protein A16, S100 calcium binding protein A16, isoform CRA_a, S100F ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Spdl1 ortho G G G G G G G G G G G Trnt1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Unk Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hk1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr4 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sprtn Ubxn1 ortho Ubxn1 Prpf19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Tagln3 ortho P G G G G G G G Dvl1 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zpr1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bard1 Ubxn1 ortho Ubxn1 Ufc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Stk26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Rlim ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Taf9 Ubxn1 ortho Ube3a Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcpip1 Ubxn1 ortho Ahcyl1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pla2g4a Ubxn1 ortho G G G G G G G G G G G G G G G G G G G Ubxn1 Ube2c ortho G G G G G G G G G G G G G G G G G G Ubxn1 Trim39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q922Y1 pull down 16709668 association C 3 Q922Y1 pull down 16709668 association C 3 Q922Y1 Q15797 anti tag coimmunoprecipitation 15761153 physical association X 2 O00238 Q922Y1 anti tag coimmunoprecipitation 15761153 physical association X 2 Q922Y1 pull down 16709668 association C 5 Q922Y1 D3DPA4 anti tag coimmunoprecipitation 15761153 physical association X 2 Q922Y1 P36897 anti tag coimmunoprecipitation 15761153 physical association X 2 Q922Y1 Q9JI78 two hybrid 16709668 physical association X 2 Q922Y1 Q01853 pull down 16709668 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vcp Ubxn1 MI:0018(two hybrid) 16709668 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (intact) UniProt_165852 prey bait Ubxn1 Ngly1 MI:0018(two hybrid)|MI:0018(two hybrid) 16709668 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(intact) UniProt_165856|UniProt_165847 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality YWHAH UBXN1 21311561 0030 LC UBXN1 NGLY1 16709668,16709668 0096,0018 LC VCP UBXN1 16709668 0096 LC UBXN1 NGLY1 16709668,16709668 0096,0018 LC UBXN1 AMFR 16709668 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q922Y1 Q15797 UBXN1 SMAD1 0.126 15761153 Q922Y1 Q04771 UBXN1 ACVR1 0.126 15761153 Q922Y1 P36897 UBXN1 TGFBR1 0.126 15761153 Q922Y1 O00238 UBXN1 BMPR1B 0.126 15761153 Q922Y1 P68510 UBXN1 YWHAH 0.126 21311561