PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bsn Siah1 23403927 intact exp G G G Mapk8 Siah1 21336655 biogrid exp G G G Siah1 Pclo 23403927 intact exp Grm1 Siah1 10469171 biogrid exp G G G Gapdh Siah1 15951807 biogrid,i2d exp, ortho G G G Snca Siah1 18065497,19224863 biogrid exp, ortho G G G Sh3rf1 Siah1 16230351 intact exp, ortho Sncaip_predicted Siah1 14506261 biogrid exp, ortho Grm5 Siah1 10469171 biogrid exp, ortho Syp Siah1 11786535 biogrid exp, ortho G G G Mapre3 Siah1 ortho Arpc4_predicted Siah1 ortho G G G Pias3 Siah1 ortho G G G Dnajc15_predicted Siah1 ortho G G G Rapsn_predicted Siah1 ortho Klf10 Siah1 ortho G G G Zfyve21 Siah1 ortho G G G Kif5b Siah1 ortho Stat3 Siah1 ortho G G G Siah1 Sdcbp ortho G G G Runx1 Siah1 ortho RGD1311095_predicted Siah1 ortho Siah1 Khdrbs3 ortho G G G Ube2l6 Siah1 ortho G G G Kif22 Siah1 ortho Pygb Siah1 ortho G G G Ube2e3_predicted Siah1 ortho G G G Dld Siah1 ortho G G G Protein Ell2 Siah1 ortho G G G Siah1 Plce1 ortho G G G Slc9a3r2 Siah1 ortho G G G Ube2d1 Siah1 ortho G G G Numb Siah1 ortho G G G Mobkl2c_predicted Siah1 ortho Bag1 Siah1 ortho G G G Protein Rara, Retinoic acid receptor, alpha, Retinoic acid receptor, alpha, isoform CRA_b Siah1 ortho Znf148 Siah1 ortho G G G Protein Cdc34, RCG29282, isoform CRA_b Siah1 ortho G G G Hipk3 Siah1 ortho LOC312299 Siah1 ortho Protein Trim8 Siah1 ortho G G G Htt Siah1 ortho G G G Eef1d Siah1 ortho G G G Eif3j Siah1 ortho G G G Zbp1 Siah1 ortho Tnk2 Siah1 ortho G G G Protein Jsrp1, RCG29469, isoform CRA_c Siah1 ortho Siah1 Trib3 ortho Otub2_predicted Siah1 ortho Apc Siah1 ortho Ube2d3 Siah1 ortho Aff4_predicted Siah1 ortho G G G Cdk5r1 Siah1 ortho Protein LOC100294508 Siah1 ortho G G G Protein Mab21l1, RCG63671 Siah1 ortho Nol10 Siah1 ortho Prpf31_predicted Siah1 ortho Txn Siah1 ortho G G G Ttyh3_predicted Siah1 ortho G G G Protein Spata4, Spermatogenesis-associated 4 Siah1 ortho Tmem43 Siah1 ortho G G G Pias2 Siah1 ortho G G G Inha Siah1 ortho G G G Myd88 Siah1 ortho G G G Mapk12 Siah1 ortho G G G Hip2_predicted Siah1 ortho G G G Ube2i Siah1 ortho G G G Oprk1 Siah1 ortho G G G Pias1 Siah1 ortho Urkl1_predicted Siah1 ortho Rbbp8 Siah1 ortho Tollip Siah1 ortho G G G Rab33a_predicted Siah1 ortho Polyhomeotic-like 2 (Drosophila), Protein Phc2 Siah1 ortho G G G Tbc1d22b Siah1 ortho G G G Protein Cdc23 Siah1 ortho G G G COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Siah1 ortho G G G Ptch Siah1 ortho Rpl27a Siah1 ortho G G G Ptpmt1 Siah1 ortho DEAD (Asp-Glu-Ala-Asp) box polypeptide 41, Protein Ddx41, RCG24134 Siah1 ortho Cops7b_predicted Siah1 ortho Aqp1 Siah1 ortho Zmat3 Siah1 ortho G G G Siah2 Siah1 ortho LOC684274 protein, Protein Mtif3 Siah1 ortho Friend leukemia integration 1, Protein Fli1 Siah1 ortho G G G Wdyhv1 Siah1 ortho Aff1_predicted Siah1 ortho Hist1h4b, Hist1h4m, Hist4h4 Siah1 ortho Aasdhppt Siah1 ortho Sft2d1 Siah1 ortho G G G Katnal1 Siah1 ortho Dnali1 Siah1 ortho Siah1 Ube2n ortho G G G Pfkm Siah1 ortho G G G Bcl6_predicted Siah1 ortho Kif1b Siah1 ortho Poliovirus receptor-related 2, Protein Pvrl2 Siah1 ortho LOC100361515 Siah1 ortho LOC100365869 Siah1 ortho Trim27 Siah1 ortho G G G Whsc2 Siah1 ortho G G G Rnf2 Siah1 ortho Upp2_predicted Siah1 ortho G G G Protein Surf4, Surfeit 4, isoform CRA_a Siah1 ortho G G G Tfdp1 Siah1 ortho G G G Usp19 Siah1 ortho G G G Oprd1 Siah1 ortho Frizzled homolog 9 (Drosophila), Frizzled-9, Frizzled-like protein 9, Protein Fzd9 Siah1 ortho Rshl2 Siah1 ortho Sarm1_predicted Siah1 ortho Ube2v2 Siah1 ortho G G G Tuba8 Siah1 ortho G G G Tuba1a Siah1 ortho Kinesin-like protein Siah1 ortho Uxt Siah1 ortho G G G Protein Lipt1, RCG22417 Siah1 ortho Kcnj10 Siah1 ortho Mx3 Siah1 ortho Mapkbp1_predicted Siah1 ortho Dab1 Siah1 ortho Phc1_predicted Siah1 ortho G G G Psmc5 Siah1 ortho G G G Siah1 Siah1 ortho G G G Tbl1x_predicted Siah1 ortho G G G Oprm1 Siah1 ortho Kif28p Siah1 ortho Trim23 Siah1 ortho Ube2d2 Siah1 ortho G G G Lactb2 Siah1 ortho G G G Hipk1 Siah1 ortho Siah1 Pard3 ortho RGD1559673_predicted Siah1 ortho Protein Pkd1 Siah1 ortho Vav1 Siah1 ortho Numbl Siah1 ortho Siah1 Xiap ortho Protein Pou2af1, RCG57833 Siah1 ortho Protein Spatc1l, Putative uncharacterized protein LOC499418, Uncharacterized protein Siah1 ortho RGD1561416 Siah1 ortho RGD1565055_predicted Siah1 ortho G G G Siah1 SUP ortho G G G Cul4b_predicted Siah1 ortho Npm1 Siah1 ortho Capg Siah1 ortho Hif1an_predicted Siah1 ortho Siah1 Ctnnb1 ortho G G G Hipk2_predicted Siah1 ortho G G G Cacybp Siah1 ortho Dcc Siah1 ortho Ube2d2b Siah1 ortho Tuba4a Siah1 ortho G G G Protein Rad51ap1, RAD51 associated protein 1 Siah1 ortho Terf2_predicted Siah1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P04797 Q920M9 two hybrid 15951807 direct interaction X 2 P04797 Q920M9 pull down 15951807 direct interaction X 2 P04797 Q920M9 affinity chromatography technology 15951807 physical association X 2 Q920M9 P31424-2 two hybrid 10469171 direct interaction X 2 Q920M9 P49185 affinity chromatography technology 21336655 physical association X 2 Q920M9 P07825 two hybrid 11786535 direct interaction X 2 Q920M9 P07825 pull down 11786535 direct interaction X 2 Q920M9 P07825 affinity chromatography technology 11786535 physical association X 2 Q920M9 P07825 imaging technique 11786535 colocalization X 2 Q920M9 D3ZWQ5 affinity chromatography technology 14506261 physical association X 2 Q920M9 Q9WTJ1 affinity chromatography technology 10469171 physical association X 2 Q920M9 P37377 affinity chromatography technology 18065497 physical association X 2 Q920M9 P37377 affinity chromatography technology 19224863 physical association X 2 Q920M9 Q71F54 anti bait coimmunoprecipitation 16230351 physical association X 2 Q920M9 Q71F54 anti bait coimmunoprecipitation 16230351 physical association X 2 Q920M9 Q9JKS6 anti tag coimmunoprecipitation 23403927 physical association X 2 Q920M9 Q9JKS6 anti tag coimmunoprecipitation 23403927 physical association X 2 O88778 Q920M9 anti tag coimmunoprecipitation 23403927 physical association X 2 O88778 Q920M9 anti tag coimmunoprecipitation 23403927 physical association X 2 O88778 Q920M9 anti tag coimmunoprecipitation 23403927 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Grm1 Siah1 MI:0018(two hybrid) 10469171 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335172 bait prey Grm5 Siah1 MI:0018(two hybrid) 10469171 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335171 bait prey Gapdh Siah1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15951807 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335166|BIOGRID_335165|BIOGRID_335167 prey|bait|prey bait|prey|bait Siah1 Pclo MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23403927 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_186022|UniProt_186023 bait|bait prey|prey Sh3rf1 Siah1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16230351 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_182885|UniProt_182886 prey|bait bait|prey Bsn Siah1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23403927 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_186020|UniProt_186021|UniProt_186024 prey|prey|prey bait|bait|bait Siah1 Sncaip MI:0004(affinity chromatography technology) 14506261 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333801 bait prey Mapk8 Siah1 MI:0004(affinity chromatography technology) 21336655 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336922 prey bait Snca Siah1 MI:0096(pull down)|MI:0096(pull down) 18065497,19224863 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_333987|BIOGRID_333983 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality GAPDH SIAH1 15951807,15951807,15951807,15951807,15951807 0019,0096,0045,0018,0004 LC SYP SIAH1 11786535,11786535,11786535,11786535 0018,0428,0004,0096 LC GRM5 SIAH1 10469171 0018 LC SNCAIP SIAH1 14506261 0004 LC BSN SIAH1 23403927 0007 LC GAPDH SIAH1 15951807,15951807,15951807,15951807,15951807 0019,0096,0045,0018,0004 LC SYP SIAH1 11786535,11786535,11786535,11786535 0018,0428,0004,0096 LC GRM1 SIAH1 10469171 0004 LC SNCA SIAH1 19224863,18065497 0004,0004 LC MAPK8 SIAH1 21336655 0004 LC SH3RF1 SIAH1 16230351 0006 LC SIAH1 PCLO 23403927 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q920M9 P23385 SIAH1 GRM1 0.21 10469171 Q9JKS6 Q920M9 PCLO SIAH1 0.21 23403927 Q920M9 P04797 SIAH1 GAPDH 0.623 15951807 Q920M9 P07825 SIAH1 SYP 0.671 11786535 Q920M9 P37377 SIAH1 SNCA 0.376 18065497,19224863 Q920M9 P31424 SIAH1 GRM5 0.309 10469171 Q920M9 Q71F54 SIAH1 SH3RF1 0.21 16230351 Q920M9 P49185 SIAH1 MAPK8 0.21 21336655 Q920M9 O88778 SIAH1 BSN 0.376 23403927