PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Otub1 Dcn 22279542 biogrid exp G G G G G G G Otub1 Ubc 22871113 biogrid exp Otub1 Smad3 ortho G G Ube2g2_predicted Otub1 ortho G G G G G G G Otub1 Rnaseh2b ortho G G G G G G G Otub1 Ube2d2 ortho G G G G G G G Otub1 Dlg4 ortho G G G G G Otub1 Ywhae ortho G G G G G G G Otub1 Ndn ortho G G G G Otub1 Ywhah ortho G G G G G G G Otub1 Eed_predicted ortho G G G G G G G Otub1 Protein Klhl8, RCG37870, isoform CRA_a ortho G G G G G G G Otub1 Smad2 ortho G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RYG6 Q01129 affinity chromatography technology 22279542 physical association X 2 B2RYG6 Q01129 affinity chromatography technology 22279542 physical association X 2 B2RYG6 Q63429 affinity chromatography technology 22871113 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality OTUB1 DCN 22279542 0004 LC