PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nup62 Stau2 15970630 biogrid exp G G G G G G G Nup62 Nup93 9348540 biogrid exp, ortho G G G G G G G G Nup62 Nup54 24574455 biogrid exp, ortho G G G G G G G Nup62 Ogt ortho G G G G G G G G Nup62 Cul5 ortho Pck1 Nup62 ortho G G G G G G G G RGD1309400_predicted Nup62 ortho G G G G G G G G Protein Ccdc121 Nup62 ortho Kinesin-like protein Nup62 ortho G Protein Klhl32 Nup62 ortho Nup62 Nup85 ortho G G G G G G G Nup62 Kpnb1 ortho G G G G G G G G Nup62 Bfsp1 ortho G G Nup62 Nup98 ortho G G G G G G G G Nup62 Cenpu ortho Nup62 Cep57l1 ortho Irak1_predicted Nup62 ortho G G G G G G G G Nup62 Adam15 ortho G G G G G G G G Nup62 Nup153 ortho G G G G G G G G Nup62 Ik ortho G G G G G G G G Nup62 hsf2 ortho G G G G G G Nup62 Ctnnb1 ortho G G G G G G G G Protein Heatr5a Nup62 ortho G G G G G G G Nup62 Bloc1s6 ortho G G G G G G G G Nup62 Vcp ortho G G G G G G G G Obsl1 Nup62 ortho Nup62 Nup35 ortho Nup62 Protein Hikeshi ortho G G G G G G G G Ncl Nup62 ortho G G G G G G G G Nup62 Nutf2 ortho Protein Ccdc150 Nup62 ortho Nup62 Nupl1 ortho G G G G G G G G RGD1309562_predicted Nup62 ortho G G G G G G G G Protein Ipo5 Nup62 ortho G G G G G G G G Hspb11 protein, Protein Hspb11, RCG50296, isoform CRA_a Nup62 ortho G G G G G G G Nup62 Gorasp2 ortho G G G G G G G G Protein G3bp1 Nup62 ortho G G G G G G G G Nup62 Interferon regulatory factor 3, Interferon regulatory factor 3, isoform CRA_c, Protein Irf3 ortho G G G G G G G G Arfgef1 Nup62 ortho G G G G G G G G Nup62 Sp1 ortho G G G G G G G G Nup62 Cchcr1 ortho Traf3_predicted Nup62 ortho G G G G G G G G Npm1 Nup62 ortho Nxf1 Nup62 ortho G G G G G G G G Nup62 Nup107 ortho Abi2 Nup62 ortho G G G G G G G G Protein Snapc5, RCG58206 Nup62 ortho Protein Ccdc53, RCG48807, isoform CRA_a Nup62 ortho G G G G G G G G Protein Txlna, Txlna protein Nup62 ortho G G G G G G G G Protein Gtf2e2 Nup62 ortho G G G G G G G G Nup62 Dtnb ortho G G G G G Nup62 Ccdc146 ortho Nup62 Ywhae ortho G G G G G G G G Nup62 Thap1 ortho Nup62 Fubp3 ortho Nxt1_predicted Nup62 ortho G G G G G G G G Cul3 Nup62 ortho G G G G G G G G Nup62 Nup62 ortho G G G G G G G G Nup88 Nup62 ortho G G G G G G G G Nup62 LIM domain only 2, Protein Lmo2 ortho Nup62 Clic1 ortho G G G G G G G G Nup62 Smarce1 ortho G G G G G G G G RGD1565772_predicted Nup62 ortho G G G G Xpo6 Nup62 ortho G G G G G G G G Traf2_predicted Nup62 ortho Protein Tnpo3, Transportin 3 Nup62 ortho G G G G G G G G Protein Lrrk2 Nup62 ortho Nup62 Kpna6 ortho G G G G G G G G Eef2 Nup62 ortho G G G G G G G G Traf6 Nup62 ortho Mogs Nup62 ortho G G G G G G G G PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Nup62 ortho G G G G G G G G Nup62 Chm ortho Nup62 Xpo1 ortho G G G G G G G G Nup62 Krt20 ortho G Acox1 Nup62 ortho Protein Ahctf1 Nup62 ortho Nup62 Ccdc153 ortho RGD1565406_predicted Nup62 ortho Hspa5 Nup62 ortho G G G G G G G G Nup62 Ddx19b ortho Nup62 Pre-B-cell leukemia transcription factor 2, Protein Pbx2 ortho G G G G G G G G Nup62 Eif4a3 ortho G G G G G G G G Nup62 Myd88 ortho G G G G G G G G Nup62 Rae1 ortho Nup62 Ikbip ortho G G G G Nup62 Interferon activated gene 204, Protein Mnda ortho Fabp3 Nup62 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P17955 Q68SB1-3 affinity chromatography technology 15970630 physical association X 2 P17955 Q68SB1-3 affinity chromatography technology 15970630 physical association X 2 P17955 Q66HC5 biochemical 9348540 colocalization X 2 P17955 P70582 pull down 24574455 direct interaction X 2 P17955 O15294-3 enzymatic study 17882263 direct interaction X 2 P17955 cosedimentation in solution 12196509 association C 28 P17955 mass spectrometry studies of complexes 12196509 association C 28 P17955 P70168 atomic force microscopy 18845677 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nup62 Nup54 MI:0096(pull down) 24574455 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_337631 bait prey Nup62 Nup93 MI:0004(affinity chromatography technology) 9348540 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_337344 prey bait

PPI - HINT Gene A Gene B PMID Method Quality NUP62 NUP62 22036567 0114 LC NUP62 NUP54 22036567 0114 LC NUP62 NUP93 9348540 0401 LC NUP62 NUP54 24574455 0096 LC NUP62 NUP93 9348540 0401 LC NUP62 STAU2 15970630 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P17955 O15294 NUP62 OGT 0.309 17882263 Q66HC5 P17955 NUP93 NUP62 0.126 9348540 P70168 P17955 KPNB1 NUP62 0.309 18845677 P70582 P17955 NUP54 NUP62 0.309 24574455 Q68SB1 P17955 STAU2 NUP62 0.376 15970630