PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG12024, isoform A, GH08896p CG3529, isoform B, GH05942p 22036573 biogrid exp G G G G G G G G G G Trio, isoform A, Trio, isoform C CG3529, isoform B, GH05942p 14605208 i2d,intact exp G G G CG9795-RD CG3529, isoform B, GH05942p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G CG3529, isoform B, GH05942p NC2-alpha 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G CG3529, isoform B, GH05942p trio 14605208 mint exp CG12428, isoform A, CG12428, isoform B, CG12428, isoform D, CG12428, isoform E, SD09912p CG3529, isoform B, GH05942p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G MED8 CG3529, isoform B, GH05942p 14605208 biogrid,i2d,intact exp G G G G G G G G G G CG5081-PA, isoform A, LD23667p, Syntaxin 7, isoform A CG3529, isoform B, GH05942p 14605208 biogrid,intact exp G G G G G G G G G G CG3529, isoform B, GH05942p Wbp2 ortholog, isoform E 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Ubi-p63E CG3529, isoform B, GH05942p ortho G G G G G G G G G G Sin3A CG3529, isoform B, GH05942p ortho G G G G G G G G G G CG32850-PA, RE41137p CG3529, isoform B, GH05942p ortho G G G G G G G G G jar CG3529, isoform B, GH05942p ortho G G G G G G G G G G LD22577p, Smt3 activating enzyme 2 CG3529, isoform B, GH05942p ortho G G G G G G G G G G emb CG3529, isoform B, GH05942p ortho G G G G G G G G G G Chc CG3529, isoform B, GH05942p ortho G G G G G G G G G G 14-3-3epsilon CG3529, isoform B, GH05942p ortho G G G G G G G G G G Ahcy13 CG3529, isoform B, GH05942p ortho G G G G G G G G G G CG3529, isoform B, GH05942p CG9485, isoform B ortho G G G G G G G G G CG3529, isoform B, GH05942p Putative sulfiredoxin ortho G G G G G G G G LD07294p, Two A-associated protein of 42kDa CG3529, isoform B, GH05942p ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q95RI8 Q9VSZ1 - 14605208 - X 2 A1ZBT5 Q9VSZ1 - 14605208 - X 2 Q8IRI4 Q9VSZ1 - 14605208 - X 2 Q7K0X9 Q9VSZ1 - 14605208 - X 2 Q9VSZ1 Q8MLV5 - 14605208 - X 2 Q9VSZ1 - 14605208 - X 2 Q9VB02 Q9VSZ1 - 14605208 - X 2 Q9VSZ1 Q8IRG7 affinity chromatography technology 22036573 physical association X 2 A1ZBT5 Q9VSZ1 two hybrid 14605208 direct interaction X 2 Q9W2E3 Q9VSZ1 two hybrid 14605208 direct interaction X 2 Q7K0X9 Q9VSZ1 two hybrid 14605208 direct interaction X 2 Q59E01 Q9VSZ1 two hybrid 14605208 direct interaction X 2 Q9VSZ1 M9PFH0 two hybrid 14605208 direct interaction X 2 Q9VB02 Q9VSZ1 two hybrid 14605208 direct interaction X 2 Q9VSZ1 two hybrid 14605208 physical association X 2 A1ZBT5 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9W2E3 Q9VSZ1 two hybrid 14605208 physical association X 2 Q7K0X9 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9VU19 Q9VSZ1 two hybrid 14605208 physical association X 2 Q7KVD1 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9VB02 Q9VSZ1 two hybrid 14605208 physical association X 2 A1ZBT5 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9W2E3 Q9VSZ1 two hybrid 14605208 physical association X 2 Q7K0X9 Q9VSZ1 two hybrid 14605208 physical association X 2 Q86BB1 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9VU19 Q9VSZ1 two hybrid 14605208 physical association X 2 Q7KVD1 Q9VSZ1 two hybrid 14605208 physical association X 2 Q9VB02 Q9VSZ1 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG3529 CG11009 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_23325|BIOGRID_30212|UniProt_54075 prey|prey|prey bait|bait|bait CG3529 MED8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_31364|UniProt_47006|DIP_13690 prey|bait|- bait|prey|- CG9795 CG3529 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_49627|MINT_14235 prey|prey bait|bait NC2alpha CG3529 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_58454|MINT_30774 prey|prey bait|bait NC2alpha CG3529 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_6378|BIOGRID_34578 -|bait -|prey trio CG3529 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_10778 prey bait Q8MLK2 CG3529 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_28649 prey bait CG12024 CG3529 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64650 bait prey CG9795 CG3529 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_33066 prey bait trio CG3529 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_56552 prey bait trio CG3529 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_18626 - - CG12428 CG3529 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_30843|MINT_18203|UniProt_65135 bait|null|prey prey|bait|bait Syx7 CG3529 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_49626|DIP_22428|BIOGRID_33065 prey|-|prey bait|-|bait Q9VP33 CG3529 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_14234 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VSZ1 Q7KVD1 Q9VSZ1 TRIO 0.183 14605208 Q9VSZ1 Q86BB1 Q9VSZ1 Q86BB1 0.183 14605208 Q9VSZ1 Q9VB02 Q9VSZ1 Q9VB02 0.183 14605208 Q9VSZ1 Q7K0X9 Q9VSZ1 SYX7 0.183 14605208 Q9VU19 Q9VSZ1 WBP2 Q9VSZ1 0.183 14605208 Q9W2E3 Q9VSZ1 NC2ALPHA Q9VSZ1 0.183 14605208 Q9VSZ1 A1ZBT5 Q9VSZ1 MED8 0.183 14605208