PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus cgh-1 K08E3.7a 18692475,unassigned701 biogrid,mint,intact exp G Y53H1A.2b K08E3.7a 14704431 biogrid exp nhr-111 K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp Y39E4A.2b K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp G F39H11.5 K08E3.7a 18692475,unassigned701 biogrid,mint,intact exp G Y39B6A.19a K08E3.7a i2d exp tbb-2 K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp G Y53H1A.5a K08E3.7a i2d exp T14G10.4 K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp zyg-8 K08E3.7a 18692475,unassigned701 biogrid,mint,intact exp Y39B6A.1 K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp G K08E3.7a rpl-8 14704431 biogrid,i2d,mint,intact,dip exp, ortho G rps-8 K08E3.7a 14704431 biogrid,i2d,mint,intact,dip exp, ortho G pas-7 K08E3.7a ortho G Uncharacterized protein C30C11.4 K08E3.7a ortho G W02B12.15b K08E3.7a ortho G Malate dehydrogenase K08E3.7a ortho G F27C1.7b K08E3.7a ortho G Cell division protein kinase 5, T27E9.3 K08E3.7a ortho G Putative DEAD-box RNA helicase, Y71H2AM.19b K08E3.7a ortho G rps-6 K08E3.7a ortho G D2030.2a K08E3.7a ortho G arr-1 K08E3.7a ortho G rpn-11 K08E3.7a ortho G rpl-7 K08E3.7a ortho G Mitochondrial Rho GTPase, Miro K08E3.7a ortho F55A12.9a K08E3.7a ortho G Y105E8A.16 K08E3.7a ortho G Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCase subunit beta K08E3.7a ortho G mrps-7 K08E3.7a ortho Calumenin-like protein, M03F4.7a K08E3.7a ortho G hsp-60 K08E3.7a ortho G ogt-1 K08E3.7a ortho G F39B2.2 K08E3.7a ortho G T22D1.9 K08E3.7a ortho G W09C5.2 K08E3.7a ortho RNA-binding protein 8A K08E3.7a ortho G F40G9.17 K08E3.7a ortho C27H6.2 K08E3.7a ortho G Y39E4B.1 K08E3.7a ortho G Y47D3A.4 K08E3.7a ortho T-complex protein 1 subunit gamma K08E3.7a ortho lev-11 K08E3.7a ortho G mlc-4 K08E3.7a ortho G rpl-6 K08E3.7a ortho G spr-2 K08E3.7a ortho G K04G7.4a K08E3.7a ortho G rpn-3 K08E3.7a ortho G F44G4.4c K08E3.7a ortho G fzo-1 K08E3.7a ortho G B0205.3 K08E3.7a ortho G ubq-2 K08E3.7a ortho G cct-2 K08E3.7a ortho G rpl-4 K08E3.7a ortho G Putative ATP-dependent RNA helicase T26G10.1 K08E3.7a ortho G mpk-1 K08E3.7a ortho G Hexokinase K08E3.7a ortho G Y54G2A.31 K08E3.7a ortho G C14A4.14 K08E3.7a ortho G C14A4.2 K08E3.7a ortho G K08E3.7a Proteasome subunit beta type ortho G Phosphoinositide phospholipase C K08E3.7a ortho G tag-320 K08E3.7a ortho G vdac-1 K08E3.7a ortho G T07F12.1 K08E3.7a ortho smo-1 K08E3.7a ortho G pdi-2 K08E3.7a ortho G atx-3 K08E3.7a ortho enpl-1 K08E3.7a ortho G D2013.5 K08E3.7a ortho G rpa-0 K08E3.7a ortho G Y39G10AR.9b K08E3.7a ortho G Y56A3A.32a K08E3.7a ortho G hsp-6 K08E3.7a ortho G T12E12.4b K08E3.7a ortho G Y57G11C.22a K08E3.7a ortho G rpt-2 K08E3.7a ortho G Y59A8B.6 K08E3.7a ortho G rps-16 K08E3.7a ortho G pbs-6 K08E3.7a ortho G Y37E3.11b K08E3.7a ortho G pgam-5 K08E3.7a ortho G Y110A2AM.3 K08E3.7a ortho apl-1 K08E3.7a ortho G pink-1 K08E3.7a ortho cct-1 K08E3.7a ortho G rpt-4 K08E3.7a ortho G W09D10.3 K08E3.7a ortho G rpt-3 K08E3.7a ortho G hmp-2 K08E3.7a ortho G 1G758 K08E3.7a ortho G K08E3.7a F58E10.3a ortho G Alpha-amylase K08E3.7a ortho Probable protein disulfide-isomerase A4 K08E3.7a ortho G pbs-4 K08E3.7a ortho G ZK1307.8 K08E3.7a ortho G rpn-12 K08E3.7a ortho G mdh-2 K08E3.7a ortho G Mitochondrial import receptor subunit TOM40 homolog K08E3.7a ortho G F01G4.2a K08E3.7a ortho G F52E4.1a K08E3.7a ortho G hpr-1 K08E3.7a ortho F16D3.1 K08E3.7a ortho pas-6 K08E3.7a ortho G F13B9.8b K08E3.7a ortho G pcn-1 K08E3.7a ortho D1022.1a K08E3.7a ortho G hda-6 K08E3.7a ortho G H14N18.1a K08E3.7a ortho G lin-2 K08E3.7a ortho G Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial K08E3.7a ortho G Uncharacterized protein B0303.3 K08E3.7a ortho G Putative U5 small nuclear ribonucleoprotein 200 kDa helicase K08E3.7a ortho G Elongation factor Tu homologue, Y71H2AM.23 K08E3.7a ortho G Y48E1C.3 K08E3.7a ortho pas-5 K08E3.7a ortho G rsp-3 K08E3.7a ortho G ZK973.10 K08E3.7a ortho G rpl-12 K08E3.7a ortho G Y73B6BL.33a K08E3.7a ortho G daf-21 K08E3.7a ortho G pas-2 K08E3.7a ortho G atad-3 K08E3.7a ortho G cri-3 K08E3.7a ortho G W02D3.11a K08E3.7a ortho G T22D1.10 K08E3.7a ortho G F30A10.5a, F30A10.5b K08E3.7a ortho G Y66D12A.9 K08E3.7a ortho G Phosphatidylinositol 3-kinase K08E3.7a ortho G crt-1 K08E3.7a ortho G rpt-1 K08E3.7a ortho G let-70 K08E3.7a ortho G T19E7.3a K08E3.7a ortho G ads-1 K08E3.7a ortho G lmn-1 K08E3.7a ortho G Probable glycerol-3-phosphate dehydrogenase, mitochondrial, GPD-M, GPDH-M K08E3.7a ortho G pdcd-2 K08E3.7a ortho G mig-22 K08E3.7a ortho K08E3.7a DNA helicase ortho G rps-14 K08E3.7a ortho G rpn-7 K08E3.7a ortho G ZK20.3 K08E3.7a ortho G rps-25 K08E3.7a ortho G K08E3.7a K08E3.7a ortho G pcca-1 K08E3.7a ortho G F56H1.4 K08E3.7a ortho G R12E2.3 K08E3.7a ortho G pbs-3 K08E3.7a ortho G pas-3 K08E3.7a ortho G F10G7.8 K08E3.7a ortho G rpl-22 K08E3.7a ortho G Y87G2A.9 K08E3.7a ortho G cul-1 K08E3.7a ortho G rpn-6.1 K08E3.7a ortho G pas-1 K08E3.7a ortho G W03F11.6a K08E3.7a ortho Y69A2AR.18b K08E3.7a ortho G tbb-4 K08E3.7a ortho G pas-4 K08E3.7a ortho G K08E3.7a ATP synthase subunit alpha, mitochondrial ortho G T04D1.3d K08E3.7a ortho G T06D8.8 K08E3.7a ortho G rps-2 K08E3.7a ortho G hsp-1 K08E3.7a ortho G rpl-13 K08E3.7a ortho G T10E9.7a K08E3.7a ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XUS3 - 14704431 - X 2 Q9XUS3 Q22499 - 14704431 - X 2 Q9XUS3 Q9XVF7 - 14704431 - X 2 Q9XUS3 O45922 - 14704431 - X 2 Q9XUS3 - 14704431 - X 2 Q9XUS3 P48156 - 14704431 - X 2 Q9XUS3 - 14704431 - X 2 P52275 Q9XUS3 two hybrid 14704431 direct interaction X 2 Q9XUS3 Q9XVF7 two hybrid 14704431 direct interaction X 2 Q9XUS3 B1V8K4 two hybrid 14704431 direct interaction X 2 Q9XUS3 Q22499 two hybrid 14704431 direct interaction X 2 Q95YF3 Q9XUS3 two hybrid 18692475 direct interaction X 2 Q9XUS3 P90868 two hybrid 18692475 direct interaction X 2 Q9XUS3 O45521 two hybrid 14704431 direct interaction X 2 Q9XUS3 P48156 two hybrid 14704431 direct interaction X 2 Q9XUS3 O45923 two hybrid 14704431 direct interaction X 2 Q95QC4 Q9XUS3 two hybrid 18692475 direct interaction X 2 Q9NES7 Q9XUS3 two hybrid 14704431 direct interaction X 2 P52275 Q9XUS3 two hybrid 14704431 physical association X 2 Q9XUS3 two hybrid 14704431 physical association X 2 Q9XUS3 Q9XVF7 two hybrid 14704431 physical association X 2 Q9XUS3 O45922 two hybrid 14704431 physical association X 2 Q9XUS3 Q22499 two hybrid 14704431 physical association X 2 Q9XUS3 P48156 two hybrid 14704431 physical association X 2 Q9XUS3 two hybrid 14704431 physical association X 2 Q9NES7 Q9XUS3 two hybrid 14704431 physical association X 2 P52275 Q9XUS3 two hybrid pooling approach 14704431 physical association X 2 Q9XUS3 Q9XVF7 two hybrid pooling approach 14704431 physical association X 2 Q9XUS3 Q22499 two hybrid pooling approach 14704431 physical association X 2 Q95YF3 Q9XUS3 two hybrid - physical association X 2 Q9XUS3 O45521 two hybrid pooling approach 14704431 physical association X 2 Q9XUS3 P48156 two hybrid pooling approach 14704431 physical association X 2 Q9XUS3 O45923 two hybrid pooling approach 14704431 physical association X 2 Q9XUS3 P90868 two hybrid - physical association X 2 Q95QC4 Q9XUS3 two hybrid - physical association X 2 Q9NES7 Q9XUS3 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B cgh-1 pdr-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_4007|MINT_4006|BIOGRID_28919|UniProt_24976 bait|bait|bait|bait prey|prey|prey|prey tbb-2 pdr-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_1247|MINT_6471|DIP_2811|BIOGRID_23280|UniProt_31199 prey|prey|-|prey|prey bait|bait|-|bait|bait Q9U251 pdr-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_1251|UniProt_31202 prey|prey bait|bait ttr-54 pdr-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0465(dip)|(intact) BIOGRID_24111|MINT_2101|DIP_3618|UniProt_28006 bait|bait|-|bait prey|prey|-|prey nhr-111 pdr-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0465(dip) MINT_822|BIOGRID_22862|UniProt_30823|DIP_2437 bait|bait|bait|- prey|prey|prey|- ttm-1 pdr-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_1250|UniProt_31200 prey|prey bait|bait zyg-8 pdr-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) BIOGRID_28837|UniProt_24978|MINT_6290|MINT_6291 bait|bait|bait|bait prey|prey|prey|prey ttm-1 pdr-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_2814|BIOGRID_23283 -|prey -|bait pdr-1 Y53H1A.2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_2815 - - pdr-1 Y53H1A.2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23284 bait prey pdr-1 rpl-8 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_1246|BIOGRID_23279|DIP_2810|UniProt_31196 bait|bait|-|bait prey|prey|-|prey rps-8 pdr-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_1248|DIP_2812|BIOGRID_23281|UniProt_31198 prey|-|prey|prey bait|-|bait|bait Y39B6A.1 pdr-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_2813|MINT_1249|BIOGRID_23282|UniProt_31197 -|prey|prey|prey -|bait|bait|bait pbs-7 pdr-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) MINT_4841|MINT_4842|UniProt_24977|BIOGRID_29147 bait|bait|bait|bait prey|prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XUS3 O45521 PDR-1 NHR-111 0.155 14704431 Q9XUS3 O45923 PDR-1 TTM-1 0.126 14704431 Q9XVF7 Q9XUS3 RPL-8 PDR-1 0.155 14704431 Q9XUS3 O45922 PDR-1 TTM-1 0.033 14704431 Q9XUS3 Q9NES7 PDR-1 Q9NES7 0.155 14704431 Q9XUS3 P90868 PDR-1 PBS-7 0.332 unassigned701,18692475 Q9XUS3 Q95QC4 PDR-1 ZYG-8 0.332 unassigned701,18692475 Q9XUS3 Q95YF3 PDR-1 CGH-1 0.332 unassigned701,18692475 Q9XUS3 P48156 PDR-1 RPS-8 0.155 14704431 Q9XUS3 Q9U251 PDR-1 Q9U251 0.033 14704431 Q9XUS3 P52275 PDR-1 TBB-2 0.155 14704431 Q9XUS3 Q22499 PDR-1 TTR-54 0.155 14704431