PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MCK1 UBX7 16319894 biogrid,i2d exp UBX7 BFA1 16554755 intact exp UBX7 SSB2 23332755 biogrid exp YAK1 UBX7 16319894 biogrid,i2d exp CDC48 UBX7 14755638,21211725,15258615,16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBX7 DFM1 18407841,18719252, 23023127 biogrid,mint,intact exp, pred UBX7 KSP1 16319894, 23023127 biogrid,i2d exp, pred HSP82 UBX7 15879519, 23023127 biogrid,i2d,intact exp, pred HSL1 UBX7 16319894, 23023127 biogrid,i2d exp, pred UBX7 UBX7 14755638, 23023127 biogrid exp, pred UBX7 NUP116 11283351, 23023127 i2d,mint,intact,dip exp, pred UBX7 RIM11 16319894, 23023127 biogrid,i2d exp, pred DOA1 UBX7 14755638, 23023127 biogrid exp, pred UBX7 UFD2 18719252, 23023127 biogrid,intact exp, pred UBX7 UBX6 14755638, 23023127 biogrid exp, pred UBX7 STE20 16319894, 23023127 biogrid,i2d exp, pred UBX7 UBC13 23023127 pred SLA1 UBX7 23023127 pred UBX7 CUE5 23023127 pred ATG12 UBX7 23023127 pred UBX7 RUP1 23023127 pred UBX7 UBX5 23023127 pred UBX7 UBI4 23023127 pred UBX7 OTU1 23023127 pred UBX7 UBX3 23023127 pred UBX7 CUE3 23023127 pred SHP1 UBX7 23023127 pred RAD23 UBX7 23023127 pred CUE2 UBX7 23023127 pred UBX7 SMT3 23023127 pred UBX7 GGA1 23023127 pred UBX7 UBC11 23023127 pred RAD6 UBX7 23023127 pred UBX7 UBC12 23023127 pred UBX7 EPS1 23023127 pred UBX7 VPS20 23023127 pred UBX7 DSK2 23023127 pred YSC84 UBX7 23023127 pred CDC34 UBX7 23023127 pred UBX7 LSB3 23023127 pred UBX7 UBP7 23023127 pred UBX7 SNF7 23023127 pred UBX7 SRN2 23023127 pred EDE1 UBX7 23023127 pred UBC4 UBX7 23023127 pred PEX4 UBX7 23023127 pred UBX7 UBC7 23023127 pred UBX7 GGA2 23023127 pred UBX7 UBP6 23023127 pred UBX7 UBP5 23023127 pred UBX7 CUE4 23023127 pred UBX7 CUE1 23023127 pred UBC1 UBX7 23023127 pred UBA1 UBX7 23023127 pred MYO3 UBX7 23023127 pred UBC6 UBX7 23023127 pred UBX7 UBP16 23023127 pred BEM1 UBX7 23023127 pred UBX7 UBP15 23023127 pred CDC25 UBX7 23023127 pred UBC5 UBX7 23023127 pred UBC8 UBX7 23023127 pred FUS1 UBX7 23023127 pred DOA4 UBX7 23023127 pred UBX7 UBX4 23023127 pred ATG8 UBX7 23023127 pred UBX7 DDI1 23023127 pred UBX7 HUB1 23023127 pred UBX7 MMS2 23023127 pred UBP14 UBX7 23023127 pred UBX7 VPS9 23023127 pred UBP11 UBX7 23023127 pred YUH1 UBX7 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38349 P02829 - 15879519 - X 2 P38349 Q02630 - 11283351 - X 2 P0CG63 P38349 affinity chromatography technology 23749301 physical association X 2 P0CG63 P38349 affinity chromatography technology 17644757 physical association X 2 P0CG63 P38349 affinity chromatography technology 23793018 physical association X 2 P0CG63 P38349 affinity chromatography technology 12872131 physical association X 2 P0CG63 P38349 affinity chromatography technology 22106047 physical association X 2 P38349 P36037 two hybrid 14755638 direct interaction X 2 P38349 P02829 two hybrid 15879519 direct interaction X 2 P38349 P34244 enzymatic study 16319894 direct interaction X 2 P38349 P21965 enzymatic study 16319894 direct interaction X 2 P38349 P38615 enzymatic study 16319894 direct interaction X 2 P38349 Q03497 enzymatic study 16319894 direct interaction X 2 P38349 P54860 two hybrid 18719252 direct interaction X 2 P47049 P38349 two hybrid 14755638 direct interaction X 2 P38349 P38349 two hybrid 14755638 direct interaction X 2 P38349 P25694 two hybrid 14755638 direct interaction X 2 P38349 P25694 affinity chromatography technology 14755638 physical association X 2 P38349 P25694 two hybrid 15258615 direct interaction X 2 P38349 P25694 pull down 14755638 direct interaction X 2 P38349 P25694 two hybrid 15258615 direct interaction X 2 P38349 P25694 affinity chromatography technology 15258615 physical association X 2 P38349 P25694 pull down 15258615 direct interaction X 2 P38349 P40150 biochemical 23332755 association X 2 P38349 P25694 affinity chromatography technology 16554755 physical association X 2 P38349 P38691 enzymatic study 16319894 direct interaction X 2 P38349 P14680 enzymatic study 16319894 direct interaction X 2 P38349 Q12743 two hybrid 18719252 direct interaction X 2 P38349 Q12743 affinity chromatography technology 18407841 physical association X 2 P38349 P25694 affinity chromatography technology 21211725 physical association X 2 P38349 Q02630 two hybrid pooling approach 11283351 physical association X 2 P38349 anti tag coimmunoprecipitation 18407841 association C 11 P38349 inferred by author 16554755 association C 22 P38349 Q02630 two hybrid fragment pooling approach 11283351 physical association X 2 P38349 P02829 two hybrid array 15879519 physical association X 2 P38349 P54860 two hybrid 18719252 physical association X 2 P38349 P25694 two hybrid 15258615 physical association X 2 P38349 P25694 two hybrid 15258615 physical association X 2 P38349 P25694 anti tag coimmunoprecipitation 15258615 physical association X 2 P38349 P25694 pull down 15258615 physical association X 2 P38349 P25694 tandem affinity purification 16554755 physical association X 2 P38349 P25694 tandem affinity purification 16554755 physical association X 2 P38349 Q12743 anti tag coimmunoprecipitation 18407841 physical association X 2 P38349 Q12743 two hybrid 18719252 physical association X 2 P38349 Q02630 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP82 UBX7 15879519,15879519 0018,0397 HT YAK1 UBX7 16319894 0415 LC MCK1 UBX7 16319894 0415 LC CDC48 UBX7 14755638,15258615,14755638,15258615,15258615,15258615,14755638 0018,0096,0004,0018,0004,0007,0096 LC HSL1 UBX7 16319894 0415 LC DOA1 UBX7 14755638 0018 LC UBX7 UBX7 14755638 0018 LC UBX7 RIM11 16319894 0415 LC UBX7 KSP1 16319894 0415 LC UBX7 SSB2 23332755 0401 LC UBX7 UBX6 14755638 0018 LC UBX7 UFD2 18719252 0018 HT UBX7 NUP116 11283351,11283351,11283351 0018,0399,0398 HT UBX7 STE20 16319894 0415 LC UBX7 DFM1 18719252 0018 HT UBI4 UBX7 22106047 0004 LC CDC48 UBX7 14755638,21211725,16554755,15258615,14755638,15258615,15258615,15258615,14755638,16554755 0018,0004,0676,0096,0004,0018,0004,0007,0096,0004 LC,HT UBX7 SSB2 23332755 0401 LC UBX7 BFA1 16554755 0363 HT UBX7 INO80 26656161 0004 LC UBX7 ARP5 26656161 0004 LC UBX7 DFM1 18407841,18407841 0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53115 P38349 INO80 UBX7 0.21 26656161 Q12743 P38349 DFM1 UBX7 0.583 18719252,18407841 P38349 P25694 UBX7 CDC48 0.941 14755638,15258615,21211725,16554755 P38349 P02829 UBX7 HSP82 0.286 15879519 P38349 P38349 UBX7 UBX7 0.332 14755638 P47049 P38349 UBX6 UBX7 0.309 14755638 P53946 P38349 ARP5 UBX7 0.21 26656161 P54860 P38349 UFD2 UBX7 0.332 18719252 Q02630 P38349 NUP116 UBX7 0.21 11283351 P38691 P38349 KSP1 UBX7 0.183 16319894 P38349 P34244 UBX7 HSL1 0.183 16319894 P38349 P36037 UBX7 DOA1 0.309 14755638 P47113 P38349 BFA1 UBX7 0.126 16554755 P38349 P14680 UBX7 YAK1 0.183 16319894 Q03497 P38349 STE20 UBX7 0.183 16319894 P38349 P21965 UBX7 MCK1 0.183 16319894