PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SAN1 MDN1 21211726 biogrid exp SAN1 CCT8 11805837 dip exp SSC1 SAN1 11805837 dip exp SSA2 SAN1 21211726 biogrid exp SAN1 CDC48 11805837 dip exp RPB3 SAN1 16554755 biogrid,i2d,mint,intact exp TDH1 SAN1 21211726 biogrid exp ILV2 SAN1 21211726 biogrid exp SAN1 RFC4 11805837 biogrid,mint,intact,dip exp SAN1 NAB2 19840948 biogrid exp SAN1 CMR1 22199229 biogrid exp VMA2 SAN1 11805837 dip exp SAN1 NIF3 21211726 biogrid exp SAN1 SPT8 21734642 intact exp SAN1 NOP58 21211726 biogrid exp SAN1 MCM4 11805837 biogrid,mint,intact,dip exp TEF1, TEF2 SAN1 21211726 biogrid exp SAN1 Putative methyltransferase YGR283C 16554755 intact exp SAN1 SGF73 21734642 biogrid,intact exp SAN1 HPF1 21211726 biogrid exp SSA1 SAN1 21211726 biogrid exp SSB1 SAN1 19536198 intact exp SAN1 VAM6 25026036 biogrid exp SAN1 DBP2 21211726 biogrid exp STE6 SAN1 23653356 biogrid exp RPL40A SAN1 11805837 intact,dip exp URA4 SAN1 21211726 biogrid exp PDC1 SAN1 21211726 biogrid exp SAN1 TOS1 21211726 biogrid exp GAL10 SAN1 11805837 dip exp ATP1 SAN1 11805837 dip exp SAN1 RRP5 21211726 biogrid exp SAN1 SPT16 21211726 biogrid exp SAN1 CNM67 21211726 biogrid exp SAN1 GCN5 21734642 intact exp SAN1 SPT7 21734642 biogrid,intact exp SAN1 ADA2 21734642 biogrid,intact exp TDH3 SAN1 21211726 biogrid exp SAN1 PRO3 21211726 biogrid exp TDH2 SAN1 21211726 biogrid exp SAN1 PNC1 21211726 biogrid exp CAP2 SAN1 21211726 biogrid exp UBI4 SAN1 15699485,11805837 biogrid,mint,intact exp SAN1 LYS21 21211726 biogrid exp SAN1 SED1 21211726,21551067 biogrid exp SAN1 SCW4 21211726 biogrid exp SAN1 NTF2 21211726 biogrid exp HOM2 SAN1 21211726 biogrid exp BGL2 SAN1 21211726 biogrid exp SAN1 Putative 2-hydroxyacid dehydrogenase YPL113C 11805837 biogrid,mint,intact,dip exp RPA135 SAN1 21211726,11805837 biogrid,mint,intact,dip exp TUB1 SAN1 11805837 dip exp LEU2 SAN1 11805837 dip exp RPB2 SAN1 11805837 dip exp SAN1 NUG1 21211726 biogrid exp SAN1 RRP12 21211726 biogrid exp HSP82 SAN1 21211726 biogrid exp SAN1 UPC2 21211726 biogrid exp SAN1 SSE1 21211726 biogrid exp SAN1 HSP104 21211726 biogrid exp SAN1 HEK2 18805955 biogrid exp SAN1 WHI3 18667435 biogrid exp SAN1 HHT1, HHT2 22199229 biogrid exp SAN1 SUB2 21211726 biogrid exp SAN1 ASC1 21211726 biogrid exp ATP2 SAN1 11805837 dip exp SIR4 SAN1 21211726,23363599 biogrid exp SAN1 SRP1 11805837 biogrid,mint,intact,dip exp DBP3 SAN1 21211726 biogrid exp SES1 SAN1 21211726 biogrid exp SAN1 ARP2 11805837 biogrid,mint,intact,dip exp SAN1 CDC13 21211726,23363599 biogrid exp SAN1 MOT2 21211726, 23023127 biogrid exp, pred SAN1 RXT2 20489023, 23023127 biogrid,mint,intact exp, pred SAN1 RAD16 21551067, 23023127 biogrid exp, pred SAN1 YDJ1 21211726, 23023127 biogrid exp, pred SAN1 RRI2 21289098, 23023127 biogrid exp, pred CDC42 SAN1 11805837, 23023127 biogrid,intact,dip exp, pred SAN1 Putative methyltransferase YMR310C 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SAN1 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P22470 - 11805837 - C 7 P22470 - 11805837 - C 3 P22470 - 11805837 - C 8 P10592 P22470 affinity chromatography technology 21211726 physical association X 2 Q05164 P22470 two hybrid 21211726 direct interaction X 2 Q05022 P22470 affinity chromatography technology 21211726 physical association X 2 P0CG63 P22470 affinity chromatography technology 23749301 physical association X 2 P0CG63 P22470 biochemical 23583075 association X 2 P0CG63 P22470 affinity chromatography technology 17644757 physical association X 2 P0CG63 P22470 affinity chromatography technology 23793018 physical association X 2 P0CG63 P22470 affinity chromatography technology 23363599 physical association X 2 P0CG63 P22470 affinity chromatography technology 12872131 physical association X 2 P0CG63 P22470 affinity chromatography technology 15699485 physical association X 2 P0CG63 P22470 affinity chromatography technology 11805837 physical association X 2 P0CG63 P22470 affinity chromatography technology 22106047 physical association X 2 P16370 P22470 affinity chromatography technology 16554755 physical association X 2 P13517 P22470 two hybrid 21211726 direct interaction X 2 P22470 P32797 two hybrid 23363599 direct interaction X 2 P22470 P38255 affinity chromatography technology 20489023 physical association X 2 P22470 Q12348 affinity chromatography technology 21289098 physical association X 2 P22470 P32797 two hybrid 21211726 direct interaction X 2 P22470 P40010 affinity chromatography technology 21211726 physical association X 2 P22470 P25491 affinity chromatography technology 21211726 physical association X 2 P22470 P53081 two hybrid 21211726 direct interaction X 2 P22470 P00359 two hybrid 21211726 direct interaction X 2 P22470 P53334 two hybrid 21211726 direct interaction X 2 P22470 P32263 two hybrid 21211726 direct interaction X 2 P22470 P38288 two hybrid 21211726 direct interaction X 2 P22470 P33331 two hybrid 21211726 direct interaction X 2 P22470 P34909 two hybrid 21211726 direct interaction X 2 P22470 Q12151 two hybrid 21211726 direct interaction X 2 P22470 P40339 affinity chromatography technology 11805837 physical association X 2 P22470 P32381 affinity chromatography technology 11805837 physical association X 2 P22470 Q02961 affinity chromatography technology 11805837 physical association X 2 P24783 P22470 affinity chromatography technology 21211726 physical association X 2 P53184 P22470 two hybrid 21211726 direct interaction X 2 P53865 P22470 two hybrid 21211726 direct interaction X 2 P31244 P22470 two hybrid 21551067 direct interaction X 2 Q12510 P22470 affinity chromatography technology 22199229 physical association X 2 P10591 P22470 affinity chromatography technology 21211726 physical association X 2 Q01589 P22470 two hybrid 21211726 direct interaction X 2 Q01589 P22470 two hybrid 21551067 direct interaction X 2 P32589 P22470 affinity chromatography technology 21211726 physical association X 2 P00358 P22470 two hybrid 21211726 direct interaction X 2 P20051 P22470 two hybrid 21211726 direct interaction X 2 P12866 P22470 affinity chromatography technology 23653356 physical association X 2 P00360 P22470 two hybrid 21211726 direct interaction X 2 P07342 P22470 two hybrid 21211726 direct interaction X 2 P15703 P22470 two hybrid 21211726 direct interaction X 2 P11978 P22470 two hybrid 23363599 direct interaction X 2 P11978 P22470 two hybrid 21211726 direct interaction X 2 P11978 P22470 affinity chromatography technology 21211726 physical association X 2 Q12499 P22470 affinity chromatography technology 21211726 physical association X 2 P22470 Q12122 affinity chromatography technology 21211726 physical association X 2 P22470 Q12754 affinity chromatography technology 21211726 physical association X 2 P22470 Q07478 affinity chromatography technology 21211726 physical association X 2 P22470 P31539 affinity chromatography technology 21211726 physical association X 2 P22470 P06169 two hybrid 21211726 direct interaction X 2 P22470 P38011 two hybrid 21211726 direct interaction X 2 P22470 P02994 two hybrid 21211726 direct interaction X 2 P22470 P35177 affinity chromatography technology 21734642 physical association X 2 P22470 Q02336 affinity chromatography technology 21734642 physical association X 2 P22470 P53165 affinity chromatography technology 21734642 physical association X 2 P22470 P61830 affinity chromatography technology 22199229 physical association X 2 P22470 P61830 affinity chromatography technology 22199229 physical association X 2 P20447 P22470 affinity chromatography technology 21211726 physical association X 2 P02829 P22470 affinity chromatography technology 21211726 physical association X 2 Q04867 P22470 affinity chromatography technology 16554755 physical association X 2 P19073 P22470 affinity chromatography technology 11805837 physical association X 2 P07284 P22470 two hybrid 21211726 direct interaction X 2 P32558 P22470 two hybrid 21211726 direct interaction X 2 P22138 P22470 affinity chromatography technology 21211726 physical association X 2 P22138 P22470 affinity chromatography technology 11805837 physical association X 2 P13663 P22470 two hybrid 21211726 direct interaction X 2 Q02821 P22470 affinity chromatography technology 11805837 physical association X 2 P30665 P22470 affinity chromatography technology 11805837 physical association X 2 Q12019 P22470 affinity chromatography technology 21211726 physical association X 2 P22470 anti tag coimmunoprecipitation 11805837 - C 4 P22470 anti tag coimmunoprecipitation 11805837 - C 17 P22470 anti tag coimmunoprecipitation 11805837 - C 8 P22470 anti tag coimmunoprecipitation 11805837 - C 13 P22470 anti tag coimmunoprecipitation 11805837 - C 22 P22470 P07251 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P00830 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P47079 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P25694 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P40339 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P32381 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 Q02961 anti tag coimmunoprecipitation 11805837 physical association X 2 P04397 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 anti tag coimmunoprecipitation 11805837 - C 7 P08518 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P09733 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 P16140 anti tag coimmunoprecipitation 11805837 physical association X 2 P19073 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P04173 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P22138 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02821 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P30665 P22470 anti tag coimmunoprecipitation 11805837 physical association X 2 P22470 tandem affinity purification 21734642 association C 124 P22470 anti tag coimmunoprecipitation 20489023 association C 7 P22470 tandem affinity purification 21734642 association C 83 P22470 anti tag coimmunoprecipitation 11805837 association C 3 P22470 tandem affinity purification 21734642 association C 156 P22470 inferred by author 16554755 association C 3 P22470 anti tag coimmunoprecipitation 11805837 association C 14 P0CG63 P22470 affinity chromatography technology 15699485 covalent binding X 2 P16370 P22470 tandem affinity purification 16554755 physical association X 2 P22470 anti tag coimmunoprecipitation 11805837 association C 7 P22470 tandem affinity purification 21734642 association C 49 P22470 tandem affinity purification 21734642 association C 93 P11484 P22470 tandem affinity purification 19536198 association X 2 Q04867 P22470 tandem affinity purification 16554755 physical association X 2 P22470 mass spectrometry studies of complexes 11805837 - C 9 P22470 mass spectrometry studies of complexes 11805837 - C 5 P22470 mass spectrometry studies of complexes 11805837 - C 8 P22470 mass spectrometry studies of complexes 11805837 - C 8

PPI - HINT Gene A Gene B PMID Method Quality TDH2 SAN1 21211726 0018 LC TDH3 SAN1 21211726 0018 LC TDH1 SAN1 21211726 0018 LC TEF1|TEF2 SAN1 21211726 0018 LC PDC1 SAN1 21211726 0018 LC SES1 SAN1 21211726 0018 LC ILV2 SAN1 21211726 0018 LC SIR4 SAN1 23363599,21211726,21211726 0018,0018,0004 LC CAP2 SAN1 21211726 0018 LC HOM2 SAN1 21211726 0018 LC BGL2 SAN1 21211726 0018 LC URA4 SAN1 21211726 0018 LC SAN1 RAD16 21551067 0018 LC SAN1 PRO3 21211726 0018 LC SAN1 SPT16 21211726 0018 LC SAN1 CDC13 23363599,21211726 0018,0018 LC SAN1 NTF2 21211726 0018 LC SAN1 MOT2 21211726 0018 LC SAN1 ASC1 21211726 0018 LC SAN1 TOS1 21211726 0018 LC SAN1 NIF3 21211726 0018 LC SAN1 PNC1 21211726 0018 LC SAN1 SCW4 21211726 0018 LC SAN1 CNM67 21211726 0018 LC SAN1 SED1 21211726,21551067 0018,0018 LC SAN1 HPF1 21211726 0018 LC SAN1 UPC2 21211726 0018 LC ATP2 SAN1 11805837 0007 HT HSP82 SAN1 21211726 0004 LC LEU2 SAN1 11805837 0007 HT GAL10 SAN1 11805837 0007 HT RPS31 SAN1 11805837 0007 HT ATP1 SAN1 11805837 0007 HT RPB2 SAN1 11805837 0007 HT TUB1 SAN1 11805837 0007 HT UBI4 SAN1 11805837,15699485,22106047,11805837 0004,0004,0004,0007 HT,LC RPL40B SAN1 11805837 0007 HT SSC1 SAN1 11805837 0007 HT SSA1 SAN1 21211726 0004 LC SSA2 SAN1 21211726 0004 LC SSB1 SAN1 19536198 0676 HT SIR4 SAN1 21211726,21211726 0018,0004 LC STE6 SAN1 23653356 0004 LC VMA2 SAN1 11805837 0007 HT RPB3 SAN1 16554755,16554755 0676,0004 HT CDC42 SAN1 11805837,11805837 0004,0007 HT DBP3 SAN1 21211726 0004 LC RPA135 SAN1 11805837,11805837,21211726 0004,0007,0004 HT,LC SAN1 DBP2 21211726 0004 LC SAN1 YDJ1 21211726 0004 LC SAN1 CDC48 11805837 0007 HT SAN1 MCM4 11805837,11805837 0004,0007 HT SAN1 HSP104 21211726 0004 LC SAN1 ARP2 11805837,11805837 0004,0007 HT SAN1 NAB2 19840948 0004 LC SAN1 SSE1 21211726 0004 LC SAN1 SPT7 21734642,21734642 0676,0004 LC SAN1 RXT2 20489023,20489023 0007,0004 HT SAN1 SPT8 21734642 0676 LC SAN1 NUG1 21211726 0004 LC SAN1 RFC4 11805837,11805837 0004,0007 HT SAN1 CCT8 11805837 0007 HT SAN1 INO80 26656161 0004 LC SAN1 SGF73 21734642,21734642 0676,0004 LC SAN1 P53336 16554755 0363 HT SAN1 HHT1|HHT2 22199229 0004 HT SAN1 ADA2 21734642,21734642 0676,0004 LC SAN1 SRP1 11805837,11805837 0004,0007 HT SAN1 Q02961 11805837,11805837 0004,0007 HT SAN1 GCN5 21734642 0676 LC SAN1 Q04867 16554755,16554755,16554755 0363,0676,0004 HT SAN1 RRP5 21211726 0004 LC SAN1 SUB2 21211726 0004 LC SAN1 MDN1 21211726 0004 LC SAN1 LYS21 21211726 0004 LC SAN1 RRI2 21289098 0004 LC SAN1 NOP58 21211726 0004 LC SAN1 CMR1 22199229 0004 HT SAN1 RRP12 21211726 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P22470 P00358 SAN1 TDH2 0.309 21211726 P22470 P00359 SAN1 TDH3 0.309 21211726 P22470 P00360 SAN1 TDH1 0.309 21211726 P22470 P00830 SAN1 ATP2 0.126 11805837 P22470 P02829 SAN1 HSP82 0.21 21211726 P22470 P02994 SAN1 TEF2 0.309 21211726 P22470 P04173 SAN1 LEU2 0.126 11805837 P22470 P04397 SAN1 GAL10 0.126 11805837 P22470 P06169 SAN1 PDC1 0.309 21211726 P22470 P07284 SAN1 SES1 0.309 21211726 P22470 P07342 SAN1 ILV2 0.309 21211726 P22470 P09733 SAN1 TUB1 0.126 11805837 P22470 P0CG63 SAN1 UBI4 0.155 11805837,15699485 P22470 P10591 SAN1 SSA1 0.21 21211726 P22470 P10592 SAN1 SSA2 0.21 21211726 P22470 P11484 SAN1 SSB1 0.126 19536198 P22470 P12398 SAN1 SSC1 0.126 11805837 P22470 P13517 SAN1 CAP2 0.309 21211726 P22470 P13663 SAN1 HOM2 0.309 21211726 P22470 P15703 SAN1 BGL2 0.309 21211726 P22470 P16140 SAN1 VMA2 0.126 11805837 P22470 P20051 SAN1 URA4 0.309 21211726 P22470 P20447 SAN1 DBP3 0.21 21211726 P22470 P22138 SAN1 RPA135 0.416 11805837,21211726 P24783 P22470 DBP2 SAN1 0.21 21211726 P25491 P22470 YDJ1 SAN1 0.21 21211726 P30665 P22470 MCM4 SAN1 0.286 11805837 P31244 P22470 RAD16 SAN1 0.309 21551067 P31539 P22470 HSP104 SAN1 0.21 21211726 P32263 P22470 PRO3 SAN1 0.309 21211726 P32381 P22470 ARP2 SAN1 0.286 11805837 P32558 P22470 SPT16 SAN1 0.309 21211726 P32589 P22470 SSE1 SAN1 0.21 21211726 P33331 P22470 NTF2 SAN1 0.309 21211726 P34909 P22470 MOT2 SAN1 0.309 21211726 P38011 P22470 ASC1 SAN1 0.309 21211726 P38288 P22470 TOS1 SAN1 0.309 21211726 P40010 P22470 NUG1 SAN1 0.21 21211726 P47079 P22470 CCT8 SAN1 0.126 11805837 P53081 P22470 NIF3 SAN1 0.309 21211726 P53184 P22470 PNC1 SAN1 0.309 21211726 P53334 P22470 SCW4 SAN1 0.309 21211726 P53336 P22470 P53336 SAN1 0.126 16554755 P53865 P22470 CNM67 SAN1 0.309 21211726 P61864 P22470 RPL40A SAN1 0.236 11805837 Q02821 P22470 SRP1 SAN1 0.286 11805837 Q04867 P22470 Q04867 SAN1 0.332 16554755 Q05022 P22470 RRP5 SAN1 0.21 21211726 Q05164 P22470 HPF1 SAN1 0.309 21211726 Q07478 P22470 SUB2 SAN1 0.21 21211726 Q12019 P22470 MDN1 SAN1 0.21 21211726 Q12122 P22470 LYS21 SAN1 0.21 21211726 Q12151 P22470 UPC2 SAN1 0.309 21211726 Q12499 P22470 NOP58 SAN1 0.21 21211726 Q12754 P22470 RRP12 SAN1 0.21 21211726 P53115 P22470 INO80 SAN1 0.21 26656161 Q12221 P22470 PUF2 SAN1 0.126 26668354 Q12348 P22470 RRI2 SAN1 0.126 21289098 P25694 P22470 CDC48 SAN1 0.126 11805837 P22470 P08518 SAN1 RPB2 0.126 11805837 P22470 P12866 SAN1 STE6 0.21 23653356 P22470 P07251 SAN1 ATP1 0.126 11805837 P22470 P16370 SAN1 RPB3 0.236 16554755 Q01589 P22470 SED1 SAN1 0.523 21551067,21211726 P32797 P22470 CDC13 SAN1 0.523 21211726,23363599 P53165 P22470 SGF73 SAN1 0.236 21734642 P35177 P22470 SPT7 SAN1 0.236 21734642 P22470 P11978 SAN1 SIR4 0.623 21211726,23363599 P38199 P22470 HEK2 SAN1 0.126 18805955 P38255 P22470 RXT2 SAN1 0.286 20489023 P32505 P22470 NAB2 SAN1 0.126 19840948 P38915 P22470 SPT8 SAN1 0.126 21734642 P34761 P22470 WHI3 SAN1 0.183 18667435 P40339 P22470 RFC4 SAN1 0.21 11805837 P22470 P19073 SAN1 CDC42 0.236 11805837 Q02336 P22470 ADA2 SAN1 0.126 21734642 Q02961 P22470 Q02961 SAN1 0.332 11805837 Q03330 P22470 GCN5 SAN1 0.126 21734642 Q07468 P22470 VAM6 SAN1 0.126 25026036