PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBC1 JID1 19536198 intact exp UBC1 UBP14 i2d exp UBC1 SRO9 22271760 biogrid exp RPL40B UBC1 i2d exp ADK1 UBC1 11805837 biogrid,mint,intact,dip exp UBC1 SPT21 25228766 biogrid exp UBC1 NAB2 19840948 biogrid exp UBC1 PXA1 23831759 biogrid exp UBC1 SPT10 25228766 biogrid exp UBC1 SSB2 23332755 biogrid exp UBI4 UBC1 2265617,19620964,15328341,18662542,2065660 biogrid,i2d exp UBC1 HRD1 11146622 biogrid exp UBC1 CCT7 19536198 intact exp UBC1 KAR9 20598539 biogrid exp UBC1 UBA4 9388185 biogrid exp RPS31 UBC1 i2d exp UBC1 VMA10 i2d exp RPL40A UBC1 18662542,16007098 i2d,intact,dip exp SSA1 UBC1 23217712 intact exp UBC1 APC11 17632060,23751495 biogrid exp, ortho UBC1 CDH1 22072716, 23023127 biogrid exp, ortho, pred UBC1 RSP5 19364824,17719829,23443663,22307975,17289586,24820415,15933713,18953286, 23023127 biogrid exp, ortho, pred UBC1 UBA1 2265617,17632060,18662542,11591345,22072716, 23023127 biogrid exp, ortho, pred UBC1 UBC1 11805826,14747994, 23023127 biogrid,mint,intact exp, ortho, pred UBC1 KKQ8 20489023, 23023127 biogrid,mint,intact exp, pred UBC1 BEM1 19841731, 23023127 mint,intact exp, pred UBC1 ASR1 18719252, 23023127 biogrid,intact exp, pred UBC1 PRE1 10848595, 23023127 biogrid exp, pred UBC1 PRE2 8628401, 23023127 biogrid exp, pred UBC1 SMI1 16362369, 23023127 biogrid,intact exp, pred UBC5 UBC1 23023127 i2d exp, pred UBC1 AKR1 ortho UBC1 RPN10 ortho UBC1 MEX67 ortho CDC21 UBC1 ortho UBC1 CLB3 ortho YPT1 UBC1 ortho UBC1 ESS1 ortho UBC1 TPD3 ortho UBC1 TRX3 ortho UBC1 AIP1 ortho UBC4 UBC1 23023127 ortho, pred UBC1 UBC9 23023127 ortho, pred UBC1 RUB1 23023127 ortho, pred UBC1 UFD4 23023127 pred UBC1 UBC7 23023127 pred UBC1 ATG1 23023127 pred UBC1 UBI4 23023127 pred UBC1 URM1 23023127 pred UBC1 ELC1 23023127 pred UBC1 APS2 23023127 pred UBC1 END3 23023127 pred UBC1 PUP2 23023127 pred UBC1 UBX4 23023127 pred UBC1 RPN12 23023127 pred UBC1 CDC53 23023127 pred CDC33 UBC1 23023127 pred RAD6 UBC1 23023127 pred UBC1 MPE1 23023127 pred UBC1 UBC8 23023127 pred UBC1 YRB1 23023127 pred UBC1 MMS2 23023127 pred UBC1 SNC2 23023127 pred UBC1 MCK1 23023127 pred UBC1 HUB1 23023127 pred UBC1 UBX6 23023127 pred UBC1 AOS1 23023127 pred UBC1 BUL1 23023127 pred RAD18 UBC1 23023127 pred UBC1 YCK1 23023127 pred UBC1 APS1 23023127 pred UBC1 SHP1 23023127 pred UBC1 YPT53 23023127 pred UBC1 RAD23 23023127 pred UBC1 UBP6 23023127 pred UBC1 PRE3 23023127 pred CDC23 UBC1 23023127 pred UBC1 YAP1802 23023127 pred UBC1 UBX3 23023127 pred UBC1 APM1 23023127 pred UBC1 DSK2 23023127 pred UBC1 YDJ1 23023127 pred UBC1 YPT31 23023127 pred UBC1 UBC6 23023127 pred UBC1 DMA1 23023127 pred UBC1 RPN7 23023127 pred UBC1 TUL1 23023127 pred UBC1 SEC8 23023127 pred UBC1 ATG8 23023127 pred UBC1 UBA2 23023127 pred UBC1 PRE7 23023127 pred CDC24 UBC1 23023127 pred UBC1 YCK2 23023127 pred UBC1 HRT3 23023127 pred UBC1 SLA1 23023127 pred UBC1 TLG2 23023127 pred UBC1 SMT3 23023127 pred GCN2 UBC1 23023127 pred UBC1 ARL3 23023127 pred UBC1 CDC20 23023127 pred UBC1 MYO3 23023127 pred UBC1 HRT1 23023127 pred UBC1 SNF7 23023127 pred UBC1 RPN11 23023127 pred UBC1 RPN8 23023127 pred UBC1 ATG5 23023127 pred UBC1 UBX7 23023127 pred UBC1 ATG12 23023127 pred UBC1 PRP19 23023127 pred UBC1 CDC48 23023127 pred SEC4 UBC1 23023127 pred UBC1 UBC13 23023127 pred UBC1 PRE4 23023127 pred UBC1 UFE1 23023127 pred UBC1 BUL2 23023127 pred UBC1 NYV1 23023127 pred UBC1 MOT2 23023127 pred UBC1 UBC12 23023127 pred UBC1 ATG3 23023127 pred UBC1 UBX5 23023127 pred CDC34 UBC1 23023127 pred UBC1 PEX10 23023127 pred UBC1 UBC11 23023127 pred UBC1 ARL1 23023127 pred UBC1 VPS24 23023127 pred UBC1 VPS9 23023127 pred UBC1 SKP1 23023127 pred UBC1 RVS161 23023127 pred UBC1 YPT52 23023127 pred UBC1 MYO5 23023127 pred UBC1 PEX4 23023127 pred UBC1 MUB1 23023127 pred CDC4 UBC1 23023127 pred UBC1 VPS21 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P21734 P07170 - 11805837 - X 2 P21734 P0CH08 - 11591345 - X 2 P21734 P0CH08 - 11591345 - X 2 P0CG63 P21734 affinity chromatography technology 23749301 physical association X 2 P0CG63 P21734 enzymatic study 2265617 direct interaction X 2 P0CG63 P21734 pull down 2065660 direct interaction X 2 P0CG63 P21734 affinity chromatography technology 23793018 physical association X 2 P0CG63 P21734 pull down 15328341 direct interaction X 2 P0CG63 P21734 pull down 18662542 direct interaction X 2 P0CG63 P21734 pull down 19620964 direct interaction X 2 P0CG63 P21734 affinity chromatography technology 21427232 physical association X 2 P0CG63 P21734 affinity chromatography technology 22106047 physical association X 2 P35208 P21734 affinity chromatography technology 25228766 physical association X 2 P21734 enzymatic study 1651925 direct interaction X 2 P21734 Q08109 pull down 11146622 direct interaction X 2 P21734 P39940 pull down 15933713 direct interaction X 2 P21734 P39940 pull down 17719829 direct interaction X 2 P21734 P39940 pull down 18953286 direct interaction X 2 P21734 P39940 pull down 22307975 direct interaction X 2 P21734 P39940 pull down 17289586 direct interaction X 2 P21734 Q08109 affinity chromatography technology 11146622 physical association X 2 P21734 P30656 biochemical 8628401 association X 2 P21734 P39940 pull down 24820415 direct interaction X 2 P21734 Q5E9F8 enzymatic study 1651925 direct interaction X 2 P21734 P21734 enzymatic study 14747994 direct interaction X 2 P21734 P38820 pull down 9388185 direct interaction X 2 P21734 Q12157 pull down 17632060 direct interaction X 2 P21734 Q12157 pull down 23751495 direct interaction X 2 P21734 P39940 pull down 23443663 direct interaction X 2 P21734 P39940 pull down 19364824 direct interaction X 2 P21734 P40150 biochemical 23332755 association X 2 P21734 P36004 affinity chromatography technology 20489023 physical association X 2 P21734 P32526 two hybrid 20598539 direct interaction X 2 P21734 P07170 affinity chromatography technology 11805837 physical association X 2 P21734 P22141 affinity chromatography technology 10848595 physical association X 2 P21734 P22515 enzymatic study 22072716 direct interaction X 2 P21734 P22515 enzymatic study 2265617 direct interaction X 2 P21734 P41909 protein complementation assay 23831759 direct interaction X 2 P21734 enzymatic study 1651925 direct interaction X 2 P21734 P62803 enzymatic study 1651925 direct interaction X 2 P21734 P35209 affinity chromatography technology 25228766 physical association X 2 P21734 P22515 enzymatic study 18662542 direct interaction X 2 P21734 P22515 enzymatic study 11591345 direct interaction X 2 P21734 P22515 enzymatic study 17632060 direct interaction X 2 P21734 P32566 affinity chromatography technology 16362369 physical association X 2 P21734 Q06834 two hybrid 18719252 direct interaction X 2 P21734 P22515 pull down 18662542 direct interaction X 2 P53197 P21734 pull down 22072716 direct interaction X 2 P21734 P07170 anti tag coimmunoprecipitation 11805837 physical association X 2 P21734 P05759 pull down 16007098 direct interaction X 2 P21734 pull down 23217712 association C 317 P21734 P0CG48 x-ray crystallography 11591345 direct interaction X 2 P21734 P21734 tandem affinity purification 11805826 physical association X 2 P21734 P07170 anti tag coimmunoprecipitation 11805837 physical association X 2 P21734 Q12350 tandem affinity purification 19536198 association X 2 P21734 P29366 inferred by author 19841731 direct interaction X 2 P21734 P36004 anti tag coimmunoprecipitation 20489023 association X 2 P21734 affinity chromatography technology 16362369 association C 11 P21734 P05759 comigration in non denaturing gel electrophoresis 18662542 direct interaction X 2 P21734 Q06834 two hybrid 18719252 physical association X 2 P21734 P42943 tandem affinity purification 19536198 association X 2 P21734 P15732 interaction detection method - - X 2 P21734 mass spectrometry studies of complexes 11805837 - C 3 P21734 mass spectrometry studies of complexes 11805837 - C 3 P21734 P15731 interaction detection method - - X 2

PPI - HINT Gene A Gene B PMID Method Quality RPS31 UBC1 18662542 0404 LC UBI4 UBC1 2265617 0415 LC RPL40A UBC1 11591345 0114 LC RPL40B UBC1 18662542 0404 LC UBC1 UBC1 11591345,14747994 0114,0415 LC UBC1 UBA1 2265617,22072716,17632060,18662542,18662542,11591345 0415,0415,0415,0415,0096,0415 LC UBC1 PRE2 8628401 0401 LC UBC1 KAR9 20598539 0018 LC UBC1 SSB2 23332755 0401 LC UBC1 PXA1 23831759 0090 HT UBC1 ASR1 18719252 0018 HT ADK1 UBC1 11805837,11805837 0004,0007 HT UBI4 UBC1 19620964,2065660,18662542,15328341,22106047 0096,0096,0096,0096,0004 LC SSA1 UBC1 23217712 0096 LC UBC1 UBC1 11805826,11805826 0676,0007 HT UBC1 PRE1 10848595 0004 LC UBC1 UBA1 18662542,18662542 0415,0096 LC UBC1 BEM1 19841731 0363 LC UBC1 PRE2 8628401 0401 LC UBC1 NAB2 19840948 0004 LC UBC1 SMI1 16362369 0004 LC UBC1 SPT10 25228766 0004 HT UBC1 SPT21 25228766 0004 HT UBC1 KKQ8 20489023,20489023 0007,0004 HT UBC1 UBA4 9388185 0096 LC UBC1 RSP5 17289586,19364824,23443663,24820415,22307975,15933713,17719829,18953286 0096,0096,0096,0096,0096,0096,0096,0096 LC UBC1 SSB2 23332755 0401 LC UBC1 CCT7 19536198 0676 HT UBC1 CDH1 22072716 0096 LC UBC1 HRD1 11146622,11146622 0096,0004 LC UBC1 APC11 17632060,26306044,23751495 0096,0096,0096 LC UBC1 JID1 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53197 P21734 CDH1 UBC1 0.309 22072716 Q12350 P21734 JID1 UBC1 0.126 19536198 P25567 P21734 SRO9 UBC1 0.126 22271760 P21734 P10591 UBC1 SSA1 0.126 23217712 P21734 O95376 UBC1 ARIH2 0.332 27107014 Q08109 P21734 HRD1 UBC1 0.454 11146622 P21734 P21734 UBC1 UBC1 0.436 11805826,14747994 P32566 P21734 SMI1 UBC1 0.376 16362369 Q12157 P21734 APC11 UBC1 0.671 17632060,26306044,23751495 P22515 P21734 UBA1 UBC1 0.891 18662542,22072716,17632060,11591345,2265617 P21734 P0CG63 UBC1 UBI4 0.843 15328341,18662542,2065660,19620964,2265617 P39940 P21734 RSP5 UBC1 0.948 15933713,17719829,18953286,22307975,19364824,24820415,17289586,23443663 P35209 P21734 SPT21 UBC1 0.126 25228766 P32505 P21734 NAB2 UBC1 0.126 19840948 P38820 P21734 UBA4 UBC1 0.309 9388185 P32526 P21734 KAR9 UBC1 0.309 20598539 Q9C040 P21734 TRIM2 UBC1 0.332 27107014 P36004 P21734 KKQ8 UBC1 0.236 20489023 P40150 P21734 SSB2 UBC1 0.126 23332755 P42943 P21734 CCT7 UBC1 0.126 19536198 Q06834 P21734 ASR1 UBC1 0.332 18719252 P21734 P07170 UBC1 ADK1 0.236 11805837 P21734 P0CG48 UBC1 UBC 0.309 11591345 P29366 P21734 BEM1 UBC1 0.183 19841731 P61864 P21734 RPL40A UBC1 0.309 18662542 P62803 P21734 P62803 UBC1 0.309 1651925 Q5E9F8 P21734 H3F3B UBC1 0.309 1651925 Q9HCM9 P21734 TRIM39 UBC1 0.332 27107014