PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GIS2 CUE4 21277287 biogrid exp HSC82 CUE4 15766533 i2d,intact exp SRO9 CUE4 22271760 biogrid exp RAD18 CUE4 16554755 intact exp CUE4 Uncharacterized ABC transporter ATP-binding protein/permease YOL075C 23831759 biogrid exp CUE4 GET3 11283351,18719252 biogrid,i2d,mint,intact,dip exp MUB1 CUE4 16554755 intact exp HSP82 CUE4 15766533 biogrid,i2d exp NAB2 CUE4 19840948 biogrid exp RAD6 CUE4 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SSB1 CUE4 19536198, 23023127 intact exp, pred ILM1 CUE4 18467557, 23023127 biogrid,i2d,mint,intact exp, pred VPS25 CUE4 11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBX4 CUE4 23023127 pred SHP1 CUE4 23023127 pred UBI4 CUE4 23023127 pred UBX7 CUE4 23023127 pred DSK2 CUE4 23023127 pred CUE4 MDY2 23023127 pred CUE4 HUB1 23023127 pred RAD23 CUE4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P15108 Q04201 - 15766533 - X 2 P47142 Q04201 - 11283351 - X 2 Q04201 Q12154 - 11283351 - X 2 P0CG63 Q04201 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q04201 biochemical 23583075 association X 2 P0CG63 Q04201 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q04201 affinity chromatography technology 22106047 physical association X 2 Q08234 Q04201 protein complementation assay 23831759 direct interaction X 2 P47142 Q04201 two hybrid 11283351 direct interaction X 2 P06104 Q04201 affinity chromatography technology 16554755 physical association X 2 P02829 Q04201 affinity chromatography technology 15766533 physical association X 2 Q04201 Q12154 two hybrid 11283351 direct interaction X 2 Q04201 Q12154 two hybrid 18719252 direct interaction X 2 Q04201 P53849 affinity chromatography technology 21277287 physical association X 2 P47155 Q04201 protein complementation assay 18467557 direct interaction X 2 P47142 Q04201 two hybrid pooling approach 11283351 physical association X 2 Q04201 Q12154 two hybrid pooling approach 11283351 physical association X 2 Q04201 inferred by author 16554755 association C 4 P11484 Q04201 tandem affinity purification 19536198 association X 2 P15108 Q04201 affinity chromatography technology 15766533 physical association X 2 P47142 Q04201 two hybrid fragment pooling approach 11283351 physical association X 2 P06104 Q04201 tandem affinity purification 16554755 physical association X 2 Q04201 Q12154 two hybrid fragment pooling approach 11283351 physical association X 2 Q04201 Q12154 two hybrid 18719252 physical association X 2 P47155 Q04201 dihydrofolate reductase reconstruction 18467557 physical association X 2 P47155 Q04201 dihydrofolate reductase reconstruction 18467557 physical association X 2 P47142 Q04201 two hybrid 11283351 - X 2 Q04201 Q12154 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality VPS25 CUE4 11283351,11283351,11283351 0018,0399,0398 HT ILM1 CUE4 18467557,18467557 0090,0111 HT CUE4 Q08234 23831759 0090 HT CUE4 GET3 11283351,18719252,11283351,11283351 0018,0018,0399,0398 HT HSP82 CUE4 15766533 0004 LC RAD6 CUE4 16554755,16554755,16554755 0363,0676,0004 HT UBI4 CUE4 22106047 0004 LC RAD18 CUE4 16554755 0363 HT SSB1 CUE4 19536198 0676 HT HSC82 CUE4 15766533 0004 LC NAB2 CUE4 19840948 0004 LC GIS2 CUE4 21277287 0004 LC MUB1 CUE4 16554755 0363 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04201 O43765 CUE4 SGTA 0.332 27107014 Q12154 Q04201 GET3 CUE4 0.554 11283351,18719252 Q04201 P25567 CUE4 SRO9 0.126 22271760 Q04201 P02829 CUE4 HSP82 0.126 15766533 Q04201 P06104 CUE4 RAD6 0.332 16554755 Q04201 P32505 CUE4 NAB2 0.126 19840948 Q9UMX0 Q04201 UBQLN1 CUE4 0.332 27107014 Q04201 P47142 CUE4 VPS25 0.354 11283351 Q04201 P53849 CUE4 GIS2 0.126 21277287 Q04201 P10862 CUE4 RAD18 0.126 16554755 Q04201 Q03162 CUE4 MUB1 0.126 16554755 Q04201 P15108 CUE4 HSC82 0.126 15766533 Q04201 P11484 CUE4 SSB1 0.126 19536198 Q04201 P47155 CUE4 ILM1 0.376 18467557