PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RAD53 CAC2 i2d exp YAP3 CAC2 17634282 biogrid exp SPT10 CAC2 25228766 biogrid exp ECM15 CAC2 17634282 biogrid exp CAC2 RTT109 21256037 dip exp SSB1 CAC2 19536198 intact exp GAL10 CAC2 11805837 dip exp CAC2 LUC7 17634282 biogrid exp RNR4 CAC2 11805837 dip exp LEE1 CAC2 17634282 biogrid exp CAC2 HSP42 19536198 intact exp GIS2 CAC2 21232131 biogrid exp CAC2 BTB/POZ domain-containing protein YLR108C 17634282 biogrid exp VPS75 CAC2 21256037 dip exp SSB2 CAC2 23332755 biogrid exp TSA1 CAC2 11805837 dip exp TKL2 CAC2 17634282 biogrid exp CRM1 CAC2 26673895 biogrid exp FET5 CAC2 16554755 biogrid,i2d,mint,intact exp SSE1 CAC2 19536198 intact exp ASF1 CAC2 23034810 biogrid,i2d exp SSA1 CAC2 19536198 intact exp CAC2 BUG1 11283351 i2d,mint,intact,dip exp RAD27 CAC2 i2d exp STM1 CAC2 16554755, 23023127 biogrid,i2d,mint,intact exp, pred HHT1, HHT2 CAC2 20188666,21256037,21444721,24209620,24573675,23034810,18662540, 23023127 biogrid,intact,dip exp, pred HHF1, HHF2 CAC2 21256037,21444721,24209620,23034810, 23023127 biogrid,intact,dip exp, pred NET1 CAC2 20489023, 23023127 biogrid,mint,intact exp, pred SBA1 CAC2 21777812, 23023127 biogrid exp, pred MSI1 CAC2 16429126,8743889,16554755,18662540, 23023127 biogrid,i2d,mint,intact,dip exp, pred POL30 CAC2 16157874, 23023127 biogrid exp, pred RTT106 CAC2 19683497,16157874,21179020,21444721, 23023127 biogrid,intact exp, pred SLD3 CAC2 17634282, 23023127 biogrid exp, pred CAC2 RLF2 16429126,17321547,21179020,11283351,16554755,11805837,11731480,8743889,17634282,18662540, 23023127 biogrid,i2d,mint,intact,dip exp, pred CSE4 CAC2 23023127 pred UME1 CAC2 23023127 pred CDC5 CAC2 23023127 pred CTF4 CAC2 23023127 pred SKI8 CAC2 23023127 pred CAC2 ESA1 23023127 pred GPA1 CAC2 23023127 pred SPT8 CAC2 23023127 pred CDC40 CAC2 23023127 pred HTA2 CAC2 23023127 pred NHP6A CAC2 23023127 pred HTB1 CAC2 23023127 pred PRP4 CAC2 23023127 pred NHP6B CAC2 23023127 pred SST2 CAC2 23023127 pred HAT2 CAC2 23023127 pred NAP1 CAC2 23023127 pred HTA1 CAC2 23023127 pred CDH1 CAC2 23023127 pred TUP1 CAC2 23023127 pred HIR1 CAC2 23023127 pred HTB2 CAC2 23023127 pred HHO1 CAC2 23023127 pred CAC2 HTZ1 23023127 pred SLA1 CAC2 23023127 pred CDC20 CAC2 23023127 pred TAF5 CAC2 23023127 pred GSP1 CAC2 23023127 pred UBC7 CAC2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04199 - 15044803 - C 3 P32447 Q04199 - 11756556 - X 2 Q12191 Q04199 - 11283351 - X 2 Q12495 Q04199 - 11805837 - X 2 Q12495 Q04199 - 11283351 - X 2 P35195 Q04199 two hybrid 17634282 direct interaction X 2 P43561 Q04199 affinity chromatography technology 16554755 physical association X 2 P40161 Q04199 affinity chromatography technology 16157874 physical association X 2 P40161 Q04199 affinity chromatography technology 19683497 physical association X 2 P40161 Q04199 affinity chromatography technology 21444721 physical association X 2 Q02799 Q04199 two hybrid 17634282 direct interaction X 2 P32447 Q04199 pull down 23034810 direct interaction X 2 P0CG63 Q04199 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q04199 biochemical 23583075 association X 2 P53135 Q04199 two hybrid 17634282 direct interaction X 2 P35208 Q04199 affinity chromatography technology 25228766 physical association X 2 Q07508 Q04199 two hybrid 17634282 direct interaction X 2 P15873 Q04199 affinity chromatography technology 16157874 physical association X 2 P61830 Q04199 pull down 23034810 direct interaction X 2 P61830 Q04199 affinity chromatography technology 18662540 physical association X 2 P61830 Q04199 affinity chromatography technology 18662540 physical association X 2 P61830 Q04199 affinity chromatography technology 20188666 physical association X 2 P61830 Q04199 affinity chromatography technology 20188666 physical association X 2 P61830 Q04199 affinity chromatography technology 21256037 physical association X 2 P61830 Q04199 affinity chromatography technology 21256037 physical association X 2 P61830 Q04199 affinity chromatography technology 21444721 physical association X 2 P61830 Q04199 affinity chromatography technology 21444721 physical association X 2 P33315 Q04199 two hybrid 17634282 direct interaction X 2 P39015 Q04199 affinity chromatography technology 16554755 physical association X 2 P28707 Q04199 two hybrid 21777812 direct interaction X 2 Q04199 P47035 affinity chromatography technology 20489023 physical association X 2 P38749 Q04199 two hybrid 17634282 direct interaction X 2 Q9Y294 Q04199 affinity chromatography technology 16980972 physical association X 2 Q12495 Q04199 affinity chromatography technology 11731480 physical association X 2 Q12495 Q04199 affinity chromatography technology 16554755 physical association X 2 Q12495 Q04199 affinity chromatography technology 17200106 physical association X 2 Q12495 Q04199 two hybrid 17321547 direct interaction X 2 Q12495 Q04199 two hybrid 17634282 direct interaction X 2 Q12495 Q04199 two hybrid 17634282 direct interaction X 2 Q12495 Q04199 affinity chromatography technology 18662540 physical association X 2 Q12495 Q04199 affinity chromatography technology 11805837 physical association X 2 Q12259 Q04199 two hybrid 17634282 direct interaction X 2 P13712 Q04199 affinity chromatography technology 16554755 physical association X 2 P13712 Q04199 affinity chromatography technology 16429126 physical association X 2 P13712 Q04199 affinity chromatography technology 17200106 physical association X 2 P13712 Q04199 affinity chromatography technology 18662540 physical association X 2 P40150 Q04199 biochemical 23332755 association X 2 P02309 Q04199 pull down 23034810 direct interaction X 2 P02309 Q04199 affinity chromatography technology 21256037 physical association X 2 P02309 Q04199 affinity chromatography technology 21256037 physical association X 2 P02309 Q04199 affinity chromatography technology 21444721 physical association X 2 P02309 Q04199 affinity chromatography technology 21444721 physical association X 2 P53853 Q04199 tandem affinity purification 21256037 physical association X 2 P53853 Q04199 tandem affinity purification 21256037 physical association X 2 P04397 Q04199 anti tag coimmunoprecipitation 11805837 physical association X 2 P34760 Q04199 anti tag coimmunoprecipitation 11805837 physical association X 2 P61830 Q04199 tandem affinity purification 21256037 physical association X 2 P61830 Q04199 tandem affinity purification 21256037 physical association X 2 Q04199 anti tag coimmunoprecipitation 11805837 - C 5 Q04199 tandem affinity purification 21256037 - C 7 Q04199 tandem affinity purification 21256037 - C 7 Q9Y294 Q04199 pull down 16980972 direct interaction X 2 Q12191 Q04199 two hybrid pooling approach 11283351 physical association X 2 P49723 Q04199 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12495 Q04199 experimental interaction detection 8743889 physical association X 2 Q12495 Q04199 two hybrid pooling approach 11283351 physical association X 2 Q12495 Q04199 tandem affinity purification 21256037 physical association X 2 Q12495 Q04199 tandem affinity purification 21256037 physical association X 2 Q12495 Q04199 coimmunoprecipitation 11731480 physical association X 2 Q12495 Q04199 anti tag coimmunoprecipitation 11805837 physical association X 2 Q07794 Q04199 tandem affinity purification 21256037 physical association X 2 Q07794 Q04199 tandem affinity purification 21256037 physical association X 2 P13712 Q04199 tandem affinity purification 21256037 physical association X 2 P13712 Q04199 tandem affinity purification 21256037 physical association X 2 P13712 Q04199 experimental interaction detection 8743889 physical association X 2 P02309 Q04199 tandem affinity purification 21256037 physical association X 2 P02309 Q04199 tandem affinity purification 21256037 physical association X 2 Q04199 tandem affinity purification 21179020 association C 140 Q04199 tandem affinity purification 21179020 association C 45 Q04199 anti tag coimmunoprecipitation 24209620 association C 3 Q04199 inferred by author 16554755 association C 4 Q04199 tandem affinity purification 16429126 association C 5 P43561 Q04199 tandem affinity purification 16554755 physical association X 2 P11484 Q04199 tandem affinity purification 19536198 association X 2 Q12329 Q04199 tandem affinity purification 19536198 association X 2 P39015 Q04199 tandem affinity purification 16554755 physical association X 2 P10591 Q04199 tandem affinity purification 19536198 association X 2 Q04199 anti tag coimmunoprecipitation 20489023 association C 6 Q04199 tandem affinity purification 21179020 association C 16 Q04199 tandem affinity purification 21179020 association C 40 P32589 Q04199 tandem affinity purification 19536198 association X 2 Q12191 Q04199 two hybrid fragment pooling approach 11283351 physical association X 2 Q12495 Q04199 two hybrid fragment pooling approach 11283351 physical association X 2 Q12495 Q04199 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 Q12495 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16429126 physical association X 2 P13712 Q04199 inferred by author 16429126 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 P13712 Q04199 tandem affinity purification 16554755 physical association X 2 Q04199 mass spectrometry studies of complexes 11805837 - C 3 Q04199 mass spectrometry studies of complexes 11805837 - C 3 Q04199 confirmational text mining - - C 3 P26793 Q04199 interaction detection method 11743205 - X 2 P26793 Q04199 interaction detection method 11743205 - X 2 Q12191 Q04199 two hybrid 11283351 - X 2 Q12495 Q04199 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality MSI1 CAC2 8743889 0045 LC SBA1 CAC2 21777812 0018 LC TKL2 CAC2 17634282 0018 HT ECM15 CAC2 17634282 0018 HT YAP3 CAC2 17634282 0018 HT SSB2 CAC2 23332755 0401 LC SLD3 CAC2 17634282 0018 HT LEE1 CAC2 17634282 0018 HT CAC2 LUC7 17634282 0018 HT CAC2 BUG1 11283351,11283351,11283351 0018,0399,0398 HT CAC2 Q12259 17634282 0018 HT CAC2 RLF2 8743889,11731480,11731480,11283351,17634282,11283351,11283351,17321547 0045,0004,0019,0398,0018,0018,0399,0018 LC,HT HHF1|HHF2 CAC2 24209620,21256037,21256037,23034810,21444721 0007,0676,0004,0096,0004 LC GAL10 CAC2 11805837 0007 HT SSA1 CAC2 19536198 0676 HT SSB1 CAC2 19536198 0676 HT MSI1 CAC2 16554755,16554755,21256037,16429126,18662540,17200106,16429126,16429126,16554755 0363,0004,0676,0676,0004,0004,0363,0004,0676 HT,LC POL30 CAC2 16157874 0004 LC CRM1 CAC2 26673895,26673895 0096,0004 LC ASF1 CAC2 11756556,23034810 0004,0096 LC SSE1 CAC2 19536198 0676 HT TSA1 CAC2 11805837 0007 HT SPT10 CAC2 25228766 0004 HT STM1 CAC2 16554755,16554755 0676,0004 HT SSB2 CAC2 23332755 0401 LC RTT106 CAC2 21179020,19683497,16157874,21444721 0676,0004,0004,0004 HT,LC FET5 CAC2 16554755,16554755,16554755 0363,0676,0004 HT NET1 CAC2 20489023,20489023 0007,0004 HT RNR4 CAC2 11805837 0007 HT VPS75 CAC2 21256037 0676 LC HHT1|HHT2 CAC2 24209620,21256037,21256037,23034810,20188666,18662540,24573675,21444721 0007,0676,0004,0096,0004,0004,0004,0004 LC CAC2 RTT109 21256037 0676 LC CAC2 HSP42 19536198 0676 HT CAC2 RLF2 11805837,21179020,16554755,16554755,21256037,11731480,11731480,16429126,11805837,18662540,16554755,17200106 0004,0676,0363,0676,0676,0004,0019,0676,0007,0004,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04199 P61830 CAC2 HHT2 0.867 26804921,23034810,18662540,20188666,24209620,24573675,21256037,21444721 Q12191 Q04199 BUG1 CAC2 0.21 11283351 Q04199 P02309 CAC2 HHF2 0.659 24209620,21256037,23034810,21444721 Q04199 P11484 CAC2 SSB1 0.126 19536198 Q04199 P13712 CAC2 MSI1 0.623 16429126,8743889,18662540,16554755 Q04199 P15873 CAC2 POL30 0.376 16157874,26804921 Q04199 P30822 CAC2 CRM1 0.236 26673895 Q04199 P43561 CAC2 FET5 0.332 16554755 Q12495 Q04199 RLF2 CAC2 0.88 11731480,16429126,8743889,18662540,16554755,11805837,11283351,21179020,17321547,17634282 Q04199 P28707 CAC2 SBA1 0.183 21777812 Q04199 P32447 CAC2 ASF1 0.309 23034810 Q04199 P32589 CAC2 SSE1 0.126 19536198 Q04199 P39015 CAC2 STM1 0.236 16554755 Q04199 P34760 CAC2 TSA1 0.126 11805837 Q04199 P40150 CAC2 SSB2 0.126 23332755 Q04199 P47035 CAC2 NET1 0.286 20489023 Q04199 P53849 CAC2 GIS2 0.126 21232131 Q12259 Q04199 Q12259 CAC2 0.183 17634282 Q07508 Q04199 LUC7 CAC2 0.183 17634282 Q04636 Q04199 POB3 CAC2 0.21 26804921 Q04199 P32558 CAC2 SPT16 0.21 26804921 Q04199 P10591 CAC2 SSA1 0.126 19536198 Q04199 P04397 CAC2 GAL10 0.126 11805837 Q04199 P35195 CAC2 ECM15 0.183 17634282 Q04199 P33315 CAC2 TKL2 0.183 17634282 Q04199 Q02799 CAC2 LEE1 0.183 17634282 Q04199 P40161 CAC2 RTT106 0.569 21179020,19683497,21444721,16157874 Q04199 P38749 CAC2 YAP3 0.183 17634282 Q04199 P53135 CAC2 SLD3 0.183 17634282 Q04199 P49723 CAC2 RNR4 0.126 11805837 Q12329 Q04199 HSP42 CAC2 0.126 19536198 Q9Y294 Q04199 ASF1A CAC2 0.454 16980972