PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CCT4 ELA1 19536198 intact exp SAM2 ELA1 11805837 dip exp NRD1 ELA1 22028667 biogrid exp RPF2 ELA1 11805837 biogrid,intact,dip exp ELA1 NOG1 11805837 biogrid,intact,dip exp DEF1 ELA1 23993092 biogrid exp PET127 ELA1 11805837 biogrid,intact,dip exp EBP2 ELA1 11805837 biogrid,intact,dip exp ELA1 TSR2 i2d exp ELA1 RRP12 11805837 biogrid,intact,dip exp ELA1 LSP1 11805837 biogrid,intact,dip exp TYS1 ELA1 16429126 intact exp SSB2 ELA1 19536198 intact exp HSP82 ELA1 19536198 intact exp NOP7 ELA1 11805837 biogrid,intact,dip exp LEU2 ELA1 11805837 dip exp LOC1 ELA1 11805837 biogrid,intact,dip exp PAB1 ELA1 11805837 dip exp HEK2 ELA1 18805955 biogrid exp MSS116 ELA1 11805837 biogrid,intact,dip exp DSK2 ELA1 23993092 biogrid exp ELA1 NOP12 11805837 biogrid,intact,dip exp PWP1 ELA1 11805837 biogrid,intact,dip exp SSC1 ELA1 11805837 dip exp IMD4 ELA1 11805837 biogrid,intact,dip exp NOP1 ELA1 11805837 biogrid,intact,dip exp ELA1 ERB1 11805837 biogrid,intact,dip exp ECM10 ELA1 11805837 biogrid,intact,dip exp PIL1 ELA1 11805837 biogrid,intact,dip exp ELA1 YTM1 11805837 biogrid,intact,dip exp SSE2 ELA1 19536198 intact exp ELA1 TRE2 22940862 biogrid exp NAM7 ELA1 18087042 biogrid exp SBP1 ELA1 11805837 dip exp UTP22 ELA1 11805837 biogrid,intact,dip exp ELA1 KRE33 11805837 biogrid,intact,dip exp SSB1 ELA1 19536198 intact exp HSP60 ELA1 11805837 dip exp ELA1 HSP42 19536198 intact exp XRN1 ELA1 11805837 dip exp SSA2 ELA1 19536198 intact exp SAM1 ELA1 11805837 dip exp IMD3 ELA1 11805837 biogrid,intact,dip exp ELA1 YRA1 11805837, 23023127 biogrid,intact,dip exp, pred JSN1 ELA1 11283351, 23023127 i2d,mint,intact,dip exp, pred ELA1 PUF6 11805837, 23023127 biogrid,intact,dip exp, pred DLS1 ELA1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred CIC1 ELA1 11805837, 23023127 biogrid,intact,dip exp, pred TIS11 ELA1 11805837, 23023127 biogrid,intact,dip exp, pred ELA1 ELC1 23993092,10430890,10753924, 23023127 biogrid,intact,dip exp, pred ELA1 ATG17 11283351, 23023127 i2d,mint,intact,dip exp, pred ELA1 HRT1 19882662, 23023127 intact exp, pred ELA1 HAT1 11805837, 23023127 biogrid,mint,intact,dip exp, pred YAK1 ELA1 11805837, 23023127 biogrid,intact,dip exp, pred Uncharacterized protein YER077C ELA1 11805837, 23023127 biogrid,intact,dip exp, pred CUL3 ELA1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53861 - 11805837 - C 4 P53861 - 11805837 - C 17 P53861 - 11805837 - C 7 P53861 - 11805837 - C 5 P53861 Q12341 - 11805837 - X 2 P53861 - 11805837 - C 7 P53861 P47135 - 11283351 - X 2 P53861 Q06410 - 11283351 - X 2 P32606 P53861 affinity chromatography technology 11805837 physical association X 2 P53861 A0A024R7R0 pull down 23993092 direct interaction X 2 P53861 Q08208 affinity chromatography technology 11805837 physical association X 2 P53861 P53914 affinity chromatography technology 11805837 physical association X 2 P53861 P53252 affinity chromatography technology 11805837 physical association X 2 P53861 P53254 affinity chromatography technology 11805837 physical association X 2 P53861 P15646 affinity chromatography technology 11805837 physical association X 2 P53861 Q12024 affinity chromatography technology 11805837 physical association X 2 P53861 Q12754 affinity chromatography technology 11805837 physical association X 2 P53861 P40050 affinity chromatography technology 11805837 physical association X 2 P53861 Q02892 affinity chromatography technology 11805837 physical association X 2 P53861 P43586 affinity chromatography technology 11805837 physical association X 2 P53861 Q12341 affinity chromatography technology 11805837 physical association X 2 P36160 P53861 affinity chromatography technology 11805837 physical association X 2 P35732 P53861 affinity chromatography technology 23993092 physical association X 2 P35732 P53861 pull down 23993092 direct interaction X 2 P53861 Q08693 affinity chromatography technology 22940862 physical association X 2 P53861 Q03071 affinity chromatography technology 10753924 physical association X 2 P53861 Q03071 affinity chromatography technology 10753924 physical association X 2 P53861 Q03071 pull down 10430890 direct interaction X 2 P53861 Q03071 biochemical 10753924 association X 2 P53861 Q03071 affinity chromatography technology 23993092 physical association X 2 P53861 C9JQV6 pull down 23993092 direct interaction X 2 P53861 P40366 affinity chromatography technology 16554755 physical association X 2 P53861 Q04373 affinity chromatography technology 11805837 physical association X 2 P53861 Q04660 affinity chromatography technology 11805837 physical association X 2 P53861 P14680 affinity chromatography technology 11805837 physical association X 2 P53861 Q12230 affinity chromatography technology 11805837 physical association X 2 P53861 P15424 affinity chromatography technology 11805837 physical association X 2 P53861 P39987 affinity chromatography technology 11805837 physical association X 2 P53861 P38779 affinity chromatography technology 11805837 physical association X 2 P53861 P36049 affinity chromatography technology 11805837 physical association X 2 P53861 P21304 affinity chromatography technology 11805837 physical association X 2 P53861 P50094 affinity chromatography technology 11805837 physical association X 2 P53861 P47977 affinity chromatography technology 11805837 physical association X 2 P53861 P50095 affinity chromatography technology 11805837 physical association X 2 P53861 P53261 affinity chromatography technology 11805837 physical association X 2 P53861 Q12159 affinity chromatography technology 11805837 physical association X 2 P48510 P53861 pull down 23993092 direct interaction X 2 P53861 anti tag coimmunoprecipitation 11805837 - C 36 P32606 P53861 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P10659 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P19358 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P10080 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q12341 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P53914 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P43586 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q02892 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P15646 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q08208 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P40050 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P53252 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P53254 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q12754 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q12024 anti tag coimmunoprecipitation 11805837 physical association X 2 P36160 P53861 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 anti tag coimmunoprecipitation 11805837 - C 28 P53861 Q06410 two hybrid pooling approach 11283351 physical association X 2 P53861 P19882 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P22147 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P04147 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P47135 two hybrid pooling approach 11283351 physical association X 2 P53861 P36049 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P39987 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q04660 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P50095 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P50094 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P15424 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q04373 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P21304 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P47977 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P14680 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P53261 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P38779 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q12230 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q12159 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q03071 biochemical 10753924 direct interaction X 2 P53861 Q03071 nuclear magnetic resonance 10430890 direct interaction X 2 P53861 Q03071 cosedimentation in solution 10430890 direct interaction X 2 P53861 Q03071 coimmunoprecipitation 10753924 direct interaction X 2 P53861 Q03071 coimmunoprecipitation 10753924 direct interaction X 2 P04173 P53861 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 inferred by author 16554755 association C 4 P53861 anti tag coimmunoprecipitation 11805837 association C 4 P53861 pull down 19882662 association C 41 P53861 anti tag coimmunoprecipitation 11805837 association C 17 P53861 anti tag coimmunoprecipitation 11805837 association C 7 P53861 anti tag coimmunoprecipitation 11805837 association C 5 P53861 Q12341 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 P02829 tandem affinity purification 19536198 association X 2 P53861 Q12329 tandem affinity purification 19536198 association X 2 P53861 tandem affinity purification 16429126 association C 16 P53861 anti tag coimmunoprecipitation 11805837 association C 7 P53861 Q03071 anti tag coimmunoprecipitation 10753924 physical association X 2 P53861 Q03071 chromatography technology 10753924 physical association X 2 P53861 Q03071 anti tag coimmunoprecipitation 10753924 physical association X 2 P53861 Q03071 chromatography technology 10753924 physical association X 2 P53861 Q03071 circular dichroism 10753924 direct interaction X 2 P53861 Q03071 nuclear magnetic resonance 10753924 direct interaction X 2 P53861 Q06410 two hybrid fragment pooling approach 11283351 physical association X 2 P53861 P47135 two hybrid fragment pooling approach 11283351 physical association X 2 P53861 P40366 tandem affinity purification 16554755 physical association X 2 P53861 P32590 tandem affinity purification 19536198 association X 2 P53861 P11484 tandem affinity purification 19536198 association X 2 P53861 P10592 tandem affinity purification 19536198 association X 2 P53861 P40150 tandem affinity purification 19536198 association X 2 P53861 P39078 tandem affinity purification 19536198 association X 2 P53861 mass spectrometry studies of complexes 11805837 - C 29 P53861 mass spectrometry studies of complexes 11805837 - C 29 P53861 P47135 two hybrid 11283351 - X 2 P53861 Q06410 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality JSN1 ELA1 11283351,11283351,11283351 0018,0399,0398 HT ELA1 ELC1 10430890,10753924,10753924,10430890,10753924,10753924,10430890,10753924,10753924,10753924 0077,0077,0004,0096,0016,0091,0028,0401,0007,0019 LC ELA1 ATG17 11283351,11283351,11283351 0018,0399,0398 HT HSP82 ELA1 19536198 0676 HT PAB1 ELA1 11805837 0007 HT LEU2 ELA1 11805837 0007 HT SSC1 ELA1 11805837 0007 HT SBP1 ELA1 11805837 0007 HT SSA2 ELA1 19536198 0676 HT SAM1 ELA1 11805837 0007 HT SSB1 ELA1 19536198 0676 HT YAK1 ELA1 11805837,11805837 0004,0007 HT MSS116 ELA1 11805837,11805837 0004,0007 HT NOP1 ELA1 11805837,11805837 0004,0007 HT SAM2 ELA1 11805837 0007 HT HSP60 ELA1 11805837 0007 HT PWP1 ELA1 11805837,11805837 0004,0007 HT XRN1 ELA1 11805837 0007 HT SSE2 ELA1 19536198 0676 HT PET127 ELA1 11805837,11805837 0004,0007 HT DEF1 ELA1 23993092,23993092 0096,0004 LC EBP2 ELA1 11805837,11805837 0004,0007 HT RPF2 ELA1 11805837,11805837 0004,0007 HT TYS1 ELA1 16429126 0676 HT CIC1 ELA1 11805837,11805837 0004,0007 HT CCT4 ELA1 19536198 0676 HT ECM10 ELA1 11805837,11805837 0004,0007 HT MRX1 ELA1 11805837,11805837 0004,0007 HT SSB2 ELA1 19536198 0676 HT DLS1 ELA1 16554755,16554755,16554755 0363,0676,0004 HT LOC1 ELA1 11805837,11805837 0004,0007 HT TIS11 ELA1 11805837,11805837 0004,0007 HT DSK2 ELA1 23993092 0096 LC IMD4 ELA1 11805837,11805837 0004,0007 HT IMD3 ELA1 11805837,11805837 0004,0007 HT PIL1 ELA1 11805837,11805837 0004,0007 HT UTP22 ELA1 11805837,11805837 0004,0007 HT NOP7 ELA1 11805837,11805837 0004,0007 HT NRD1 ELA1 22028667 0004 LC ELA1 NAT10 11805837,11805837 0004,0007 HT ELA1 NOG1 11805837,11805837 0004,0007 HT ELA1 ELC1 10430890,23993092,10753924,10753924,10430890,10753924,10753924,10430890,10753924,10753924,10753924 0077,0004,0077,0004,0096,0016,0091,0028,0401,0007,0019 LC ELA1 PUF6 11805837,11805837 0004,0007 HT ELA1 ERB1 11805837,11805837 0004,0007 HT ELA1 NOP12 11805837,11805837 0004,0007 HT ELA1 HRT1 19882662 0096 LC ELA1 TRE2 22940862 0004 HT ELA1 YTM1 11805837,11805837 0004,0007 HT ELA1 YRA1 11805837,11805837 0004,0007 HT ELA1 LSP1 11805837,11805837 0004,0007 HT ELA1 HSP42 19536198 0676 HT ELA1 HAT1 11805837,11805837 0004,0007 HT ELA1 RRP12 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53861 P53617 ELA1 NRD1 0.126 22028667 Q12329 P53861 HSP42 ELA1 0.126 19536198 P53861 P10592 ELA1 SSA2 0.126 19536198 P53861 P10659 ELA1 SAM1 0.126 11805837 P53861 P04147 ELA1 PAB1 0.126 11805837 P53861 P35732 ELA1 DEF1 0.454 23993092 Q03071 P53861 ELC1 ELA1 0.953 10753924,10430890,23993092 P53861 P30771 ELA1 NAM7 0.126 18087042 P53861 P38199 ELA1 HEK2 0.126 18805955 Q96RL1 P53861 UIMC1 ELA1 0.309 23993092 P53861 P32590 ELA1 SSE2 0.126 19536198 P53861 P36160 ELA1 RPF2 0.236 11805837 P53861 P40150 ELA1 SSB2 0.126 19536198 P53861 P43586 ELA1 LOC1 0.236 11805837 P53861 P36421 ELA1 TYS1 0.126 16429126 P53861 P36049 ELA1 EBP2 0.236 11805837 P53861 P14680 ELA1 YAK1 0.236 11805837 P53861 P48510 ELA1 DSK2 0.309 23993092 P53861 P19358 ELA1 SAM2 0.126 11805837 Q06410 P53861 ATG17 ELA1 0.21 11283351 Q02892 P53861 NOG1 ELA1 0.236 11805837 P53861 P02829 ELA1 HSP82 0.126 19536198 P53861 P04173 ELA1 LEU2 0.126 11805837 P53861 P10080 ELA1 SBP1 0.126 11805837 P53861 P11484 ELA1 SSB1 0.126 19536198 P53861 P12398 ELA1 SSC1 0.126 11805837 P53861 P15424 ELA1 MSS116 0.21 11805837 P53861 P15646 ELA1 NOP1 0.236 11805837 P53861 P19882 ELA1 HSP60 0.126 11805837 P53861 P21304 ELA1 PWP1 0.236 11805837 P53861 P22147 ELA1 XRN1 0.126 11805837 P53861 P32606 ELA1 PET127 0.21 11805837 P53861 P38779 ELA1 CIC1 0.21 11805837 P53861 P39078 ELA1 CCT4 0.126 19536198 P53861 P39987 ELA1 ECM10 0.21 11805837 P53861 P40050 ELA1 P40050 0.21 11805837 P53861 P40366 ELA1 DLS1 0.332 16554755 P53861 P47135 ELA1 JSN1 0.21 11283351 P53861 P47977 ELA1 TIS11 0.21 11805837 P53861 P50094 ELA1 IMD4 0.21 11805837 P53861 P50095 ELA1 IMD3 0.21 11805837 P53861 P53252 ELA1 PIL1 0.236 11805837 P53861 P53254 ELA1 UTP22 0.21 11805837 P53861 P53261 ELA1 NOP7 0.236 11805837 P53914 P53861 KRE33 ELA1 0.236 11805837 Q04373 P53861 PUF6 ELA1 0.236 11805837 Q04660 P53861 ERB1 ELA1 0.236 11805837 Q08208 P53861 NOP12 ELA1 0.236 11805837 Q12024 P53861 YTM1 ELA1 0.21 11805837 Q12159 P53861 YRA1 ELA1 0.236 11805837 Q12230 P53861 LSP1 ELA1 0.236 11805837 Q12341 P53861 HAT1 ELA1 0.236 11805837 Q12754 P53861 RRP12 ELA1 0.21 11805837 P54252 P53861 ATXN3 ELA1 0.309 23993092 Q08273 P53861 HRT1 ELA1 0.21 19882662 Q08693 P53861 TRE2 ELA1 0.126 22940862