PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus YDJ1 DIA2 19536198,11805837 intact,dip exp SSF1 DIA2 11805837 biogrid,mint,intact,dip exp DIA2 RRP12 11805837 biogrid,mint,intact,dip exp CCT4 DIA2 19536198 intact exp HSP82 DIA2 19536198 intact exp PUF3 DIA2 23409723 biogrid exp POL31 DIA2 17452447 biogrid exp DIA2 YRA1 17452447 biogrid exp THI20 DIA2 11805837 dip exp SIS1 DIA2 19536198 intact exp GIM5 DIA2 19536198 intact exp ENP1 DIA2 11805837 biogrid,mint,intact,dip exp SSA2 DIA2 19536198 intact exp NMD3 DIA2 11805837 biogrid,mint,intact,dip exp KSP1 DIA2 11805837 dip exp HSP12 DIA2 19536198 intact exp DIA2 THI21 11805837 dip exp KRE33 DIA2 11805837 biogrid,mint,intact,dip exp DIA2 HSP42 19536198 intact exp DIA2 BMS1 11805837 biogrid,mint,intact,dip exp JJJ2 DIA2 19536198 intact exp DIA2 NIP7 11805837 biogrid,mint,intact,dip exp MCM4 DIA2 19913425 biogrid exp COF1 DIA2 11805837 biogrid,mint,intact,dip exp APJ1 DIA2 19536198 intact exp YAK1 DIA2 11805837 biogrid,mint,intact,dip exp NOP12 DIA2 11805837 biogrid,mint,intact,dip exp CDC6 DIA2 23129771 biogrid exp SEH1 DIA2 11805837 biogrid,mint,intact,dip exp TOM1 DIA2 22933573 biogrid exp SSE1 DIA2 19536198 intact exp DIA2 DBP10 11805837 biogrid,mint,intact,dip exp UTP10 DIA2 11805837 biogrid,mint,intact,dip exp DIA2 TIF6 11805837 biogrid,mint,intact,dip exp CCT8 DIA2 19536198,11805837 intact,dip exp FPR3 DIA2 11805837 biogrid,mint,intact,dip exp PAB1 DIA2 11805837 dip exp DJP1 DIA2 19536198 intact exp SSB1 DIA2 19536198 biogrid,intact exp CHC1 DIA2 11805837 dip exp SSC1 DIA2 11805837 dip exp SSB2 DIA2 19536198 intact exp PSA1 DIA2 11805837 dip exp PAC10 DIA2 19536198 intact exp ARX1 DIA2 i2d exp SSZ1 DIA2 19536198,11805837 biogrid,mint,intact,dip exp KRI1 DIA2 11805837 biogrid,mint,intact,dip exp SIR4 DIA2 22844255 biogrid exp HSP78 DIA2 19536198 intact exp XRN1 DIA2 11805837 dip exp CDC45 DIA2 21179020 intact exp SEC63 DIA2 19536198 intact exp YKE2 DIA2 19536198 intact exp ILS1 DIA2 11805837 biogrid,mint,intact,dip exp ALD6 DIA2 11805837 dip exp SPB1 DIA2 11805837 biogrid,mint,intact,dip exp HRT1 DIA2 14747994 biogrid exp CCT3 DIA2 19536198 intact exp DIA2 SSF2 11805837 biogrid,mint,intact,dip exp CKS1 DIA2 11805837 biogrid,intact,dip exp SSA3 DIA2 19536198 intact exp DED81 DIA2 11805837 biogrid,mint,intact,dip exp SSA1 DIA2 19536198 intact exp SLD5 DIA2 19913425,25342810, 23023127 biogrid exp, pred URB1 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred MCM5 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred LST4 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred MCM2 DIA2 19910927,11805837, 23023127 biogrid,mint,intact,dip exp, pred MCM3 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred SEA4 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred DIA2 CDC53 16751663,16421250,14747994,11805837, 23023127 biogrid,mint,intact,dip exp, pred CTF4 DIA2 19913425,20139071,19910927,11805837, 23023127 biogrid,mint,intact,dip exp, pred MRC1 DIA2 19913425,19910927, 23023127 biogrid,mint,intact exp, pred SLT2 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred SKP1 DIA2 19913425,16751663,19882662,19858292,16421250,14747994,11805837, 23023127 biogrid,mint,intact,dip exp, pred CIC1 DIA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08496 P11978 enzymatic study 22844255 direct interaction X 2 Q08496 P09119 affinity chromatography technology 23129771 physical association X 2 Q08496 P09119 affinity chromatography technology 23129771 physical association X 2 Q08496 Q03406 affinity chromatography technology 25342810 physical association X 2 Q08496 Q12159 affinity chromatography technology 17452447 physical association X 2 Q08496 Q12159 affinity chromatography technology 17452447 physical association X 2 Q08496 P46957 affinity chromatography technology 17452447 physical association X 2 Q08496 P25588 two hybrid 19910927 direct interaction X 2 Q08496 Q01454 two hybrid 19910927 direct interaction X 2 Q08496 P25588 affinity chromatography technology 19910927 physical association X 2 Q08496 Q01454 affinity chromatography technology 19910927 physical association X 2 Q08496 P25588 affinity chromatography technology 19910927 physical association X 2 Q08496 P25588 enzymatic study 19910927 direct interaction X 2 Q08496 Q01454 enzymatic study 19910927 direct interaction X 2 Q08496 P30665 affinity chromatography technology 19913425 physical association X 2 Q08496 Q03406 affinity chromatography technology 19913425 physical association X 2 Q08496 P25588 affinity chromatography technology 19913425 physical association X 2 Q08496 Q01454 affinity chromatography technology 19913425 physical association X 2 Q08496 P25588 two hybrid 19913425 direct interaction X 2 Q08496 Q01454 two hybrid 19913425 direct interaction X 2 Q08496 Q01454 two hybrid 20139071 direct interaction X 2 Q08496 Q01454 affinity chromatography technology 11805837 physical association X 2 Q08496 P42945 affinity chromatography technology 11805837 physical association X 2 Q08496 P24279 affinity chromatography technology 11805837 physical association X 2 Q08496 P38861 affinity chromatography technology 11805837 physical association X 2 Q08496 P38333 affinity chromatography technology 11805837 physical association X 2 Q08496 Q12153 affinity chromatography technology 11805837 physical association X 2 Q08496 Q00772 affinity chromatography technology 11805837 physical association X 2 Q08496 P38779 affinity chromatography technology 11805837 physical association X 2 Q08496 P38789 affinity chromatography technology 11805837 physical association X 2 P29469 Q08496 two hybrid 19910927 direct interaction X 2 P29469 Q08496 affinity chromatography technology 19910927 physical association X 2 P29469 Q08496 affinity chromatography technology 11805837 physical association X 2 P0CG63 Q08496 affinity chromatography technology 22933573 physical association X 2 P0CG63 Q08496 affinity chromatography technology 19858292 physical association X 2 Q08496 Q08273 pull down 14747994 direct interaction X 2 Q08496 P52286 pull down 14747994 direct interaction X 2 Q08496 Q12018 pull down 14747994 direct interaction X 2 Q08496 Q12018 affinity chromatography technology 16751663 physical association X 2 Q08496 P52286 affinity chromatography technology 16751663 physical association X 2 Q08496 Q03280 affinity chromatography technology 22933573 physical association X 2 Q08496 P52286 affinity chromatography technology 16421250 physical association X 2 Q08496 Q12018 affinity chromatography technology 16421250 physical association X 2 Q08496 P11484 affinity chromatography technology 19536198 physical association X 2 Q08496 P11484 affinity chromatography technology 19536198 physical association X 2 Q08496 P52286 affinity chromatography technology 19858292 physical association X 2 Q08496 P52286 two hybrid 19913425 direct interaction X 2 Q08496 P20486 affinity chromatography technology 11805837 physical association X 2 Q08496 P38788 affinity chromatography technology 11805837 physical association X 2 Q08496 P38164 affinity chromatography technology 11805837 physical association X 2 Q08496 Q08965 affinity chromatography technology 11805837 physical association X 2 Q08496 Q08962 affinity chromatography technology 11805837 physical association X 2 Q08496 Q12389 affinity chromatography technology 11805837 physical association X 2 Q08496 P42846 affinity chromatography technology 11805837 physical association X 2 Q08496 P29496 affinity chromatography technology 11805837 physical association X 2 Q08496 Q12018 affinity chromatography technology 11805837 physical association X 2 Q08496 P25582 affinity chromatography technology 11805837 physical association X 2 Q08496 P14680 affinity chromatography technology 11805837 physical association X 2 Q08496 P38707 affinity chromatography technology 11805837 physical association X 2 Q08496 P09436 affinity chromatography technology 11805837 physical association X 2 Q08496 P53914 affinity chromatography technology 11805837 physical association X 2 Q08496 P34239 affinity chromatography technology 11805837 physical association X 2 Q08496 Q03048 affinity chromatography technology 11805837 physical association X 2 Q08496 P38911 affinity chromatography technology 11805837 physical association X 2 Q08496 Q12522 affinity chromatography technology 11805837 physical association X 2 Q08496 P34241 affinity chromatography technology 11805837 physical association X 2 Q08496 P52286 affinity chromatography technology 11805837 physical association X 2 Q08496 Q12754 affinity chromatography technology 11805837 physical association X 2 Q08496 Q08208 affinity chromatography technology 11805837 physical association X 2 Q08496 P53011 affinity chromatography technology 11805837 physical association X 2 Q08496 anti tag coimmunoprecipitation 19910927 association C 3 Q08496 P40564 tandem affinity purification 19536198 association X 2 Q08496 P46997 tandem affinity purification 19536198 association X 2 Q08496 P25491 tandem affinity purification 19536198 association X 2 Q08496 P14906 tandem affinity purification 19536198 association X 2 Q08496 P09435 tandem affinity purification 19536198 association X 2 Q08496 P02829 tandem affinity purification 19536198 association X 2 Q08496 P52553 tandem affinity purification 19536198 association X 2 Q08496 P39077 tandem affinity purification 19536198 association X 2 Q08496 P33416 tandem affinity purification 19536198 association X 2 Q08496 Q12329 tandem affinity purification 19536198 association X 2 Q08496 P22943 tandem affinity purification 19536198 association X 2 Q08496 P25588 two hybrid 19910927 physical association X 2 Q08496 P25588 two hybrid 19910927 physical association X 2 Q08496 Q01454 two hybrid 19910927 physical association X 2 Q08496 P25588 two hybrid 19910927 physical association X 2 Q08496 P25588 anti tag coimmunoprecipitation 19910927 physical association X 2 Q08496 Q01454 anti tag coimmunoprecipitation 19910927 physical association X 2 Q08496 P25588 two hybrid 19910927 physical association X 2 Q08496 P25588 anti tag coimmunoprecipitation 19910927 physical association X 2 Q08496 P25588 anti tag coimmunoprecipitation 19910927 physical association X 2 Q08496 P25588 anti tag coimmunoprecipitation 19910927 physical association X 2 Q08496 P25588 coimmunoprecipitation 19910927 physical association X 2 Q08496 Q01454 two hybrid 19910927 physical association X 2 Q08496 P25588 two hybrid 19910927 physical association X 2 Q08496 pull down 19882662 association C 51 Q08496 tandem affinity purification 21179020 association C 18 Q08496 anti tag coimmunoprecipitation 11805837 association C 33 P29469 Q08496 two hybrid 19910927 physical association X 2 P29469 Q08496 two hybrid 19910927 physical association X 2 Q04493 Q08496 tandem affinity purification 19536198 association X 2 Q08496 P20486 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08496 P11484 tandem affinity purification 19536198 association X 2 Q08496 P25294 tandem affinity purification 19536198 association X 2 Q08496 P10591 tandem affinity purification 19536198 association X 2 Q08496 P11484 tandem affinity purification 19536198 association X 2 Q08496 P53940 tandem affinity purification 19536198 association X 2 Q08496 P38788 tandem affinity purification 19536198 association X 2 Q08496 P10592 tandem affinity purification 19536198 association X 2 Q08496 P40150 tandem affinity purification 19536198 association X 2 Q08496 P32589 tandem affinity purification 19536198 association X 2 Q08496 P39078 tandem affinity purification 19536198 association X 2 Q08496 P47079 tandem affinity purification 19536198 association X 2 Q08496 P48363 tandem affinity purification 19536198 association X 2 Q08496 mass spectrometry studies of complexes 11805837 - C 35 Q08496 mass spectrometry studies of complexes 11805837 - C 35 Q08496 Q06697 interaction detection method 14764870 - X 2 Q08496 P40351 interaction detection method 14764870 - X 2 Q08496 P32486 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SIR4 DIA2 22844255 0415 LC MRC1 DIA2 19913425,19913425,19910927,19910927,19910927,19910927,19910927 0004,0018,0019,0018,0007,0415,0004 LC MCM2 DIA2 19910927,19910927,19910927 0018,0007,0004 LC MCM4 DIA2 19910927 0018 LC SKP1 DIA2 19913425 0018 LC CTF4 DIA2 19913425,19913425,19910927,19910927,20139071,19910927,19910927 0004,0018,0018,0007,0018,0415,0004 LC HSP82 DIA2 19536198 0676 HT PAB1 DIA2 11805837 0007 HT CDC6 DIA2 23129771 0004 LC SSA3 DIA2 19536198 0676 HT ILS1 DIA2 11805837,11805837 0004,0007 HT UBI4 DIA2 19858292 0004 LC SSC1 DIA2 11805837 0007 HT SSA1 DIA2 19536198 0676 HT SSA2 DIA2 19536198 0676 HT SSB1 DIA2 19536198,19536198 0004,0676 HT YAK1 DIA2 11805837,11805837 0004,0007 HT SEC63 DIA2 19536198 0676 HT CKS1 DIA2 11805837,11805837 0004,0007 HT CHC1 DIA2 11805837 0007 HT XRN1 DIA2 11805837 0007 HT HSP12 DIA2 19536198 0676 HT MCM3 DIA2 11805837,11805837 0004,0007 HT SIS1 DIA2 19536198 0676 HT YDJ1 DIA2 19536198,11805837 0676,0007 HT SPB1 DIA2 11805837,11805837 0004,0007 HT MRC1 DIA2 19913425,19913425,19910927,19910927,19910927,19910927,19910927 0004,0018,0019,0018,0007,0415,0004 LC MCM2 DIA2 11805837,11805837,19910927,19910927,19910927 0004,0007,0018,0007,0004 HT,LC MCM5 DIA2 11805837,11805837 0004,0007 HT MCM4 DIA2 19913425 0004 LC SSE1 DIA2 19536198 0676 HT HSP78 DIA2 19536198 0676 HT LST4 DIA2 11805837,11805837 0004,0007 HT URB1 DIA2 11805837,11805837 0004,0007 HT SEA4 DIA2 11805837,11805837 0004,0007 HT ENP1 DIA2 11805837,11805837 0004,0007 HT KSP1 DIA2 11805837 0007 HT DED81 DIA2 11805837,11805837 0004,0007 HT CIC1 DIA2 11805837,11805837 0004,0007 HT SSZ1 DIA2 11805837,19536198,11805837 0004,0676,0007 HT SSF1 DIA2 11805837,11805837 0004,0007 HT WSS1 DIA2 26349035 0004 LC NMD3 DIA2 11805837,11805837 0004,0007 HT FPR3 DIA2 11805837,11805837 0004,0007 HT CCT3 DIA2 19536198 0676 HT CCT4 DIA2 19536198 0676 HT SSB2 DIA2 19536198 0676 HT DJP1 DIA2 19536198 0676 HT PSA1 DIA2 11805837 0007 HT KRI1 DIA2 11805837,11805837 0004,0007 HT UTP10 DIA2 11805837,11805837 0004,0007 HT POL31 DIA2 17452447 0004 LC JJJ2 DIA2 19536198 0676 HT CCT8 DIA2 19536198,11805837 0676,0007 HT PAC10 DIA2 19536198 0676 HT SKP1 DIA2 11805837,14747994,19882662,16751663,14747994,16421250,11805837,19858292 0004,0004,0096,0004,0096,0004,0007,0004 HT,LC YKE2 DIA2 19536198 0676 HT SEH1 DIA2 11805837,11805837 0004,0007 HT NAT10 DIA2 11805837,11805837 0004,0007 HT APJ1 DIA2 19536198 0676 HT ALD6 DIA2 11805837 0007 HT SLT2 DIA2 11805837,11805837 0004,0007 HT CTF4 DIA2 11805837,19913425,19913425,19910927,19910927,19910927,19910927,11805837 0004,0004,0018,0018,0007,0415,0004,0007 HT,LC COF1 DIA2 11805837,11805837 0004,0007 HT TOM1 DIA2 22933573 0004 LC SLD5 DIA2 25342810,19913425 0004,0004 LC GIM5 DIA2 19536198 0676 HT CDC45 DIA2 21179020 0676 HT NOP12 DIA2 11805837,11805837 0004,0007 HT THI20 DIA2 11805837 0007 HT HRT1 DIA2 14747994 0096 LC DIA2 NIP7 11805837,11805837 0004,0007 HT DIA2 BMS1 11805837,11805837 0004,0007 HT DIA2 THI21 11805837 0007 HT DIA2 CDC53 11805837,16751663,11805837,16421250,14747994 0004,0004,0007,0004,0096 HT,LC DIA2 SSF2 11805837,11805837 0004,0007 HT DIA2 YRA1 17452447 0004 LC DIA2 HSP42 19536198 0676 HT DIA2 DBP10 11805837,11805837 0004,0007 HT DIA2 TIF6 11805837,11805837 0004,0007 HT DIA2 RRP12 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08496 Q04493 DIA2 GIM5 0.126 19536198 Q08496 P10592 DIA2 SSA2 0.126 19536198 Q08496 P12398 DIA2 SSC1 0.126 11805837 Q08496 P11484 DIA2 SSB1 0.416 19536198 Q08496 P52286 DIA2 SKP1 0.787 16421250,19913425,19858292,16751663,11805837,19882662,14747994 Q08496 P25588 DIA2 MRC1 0.97 19910927,19913425 Q08496 P29469 DIA2 MCM2 0.832 11805837,19910927 Q08496 P30665 DIA2 MCM4 0.21 19913425 Q08496 P38333 DIA2 ENP1 0.236 11805837 Q08496 P38707 DIA2 DED81 0.236 11805837 Q08496 P38838 DIA2 WSS1 0.126 26349035 Q08496 P39078 DIA2 CCT4 0.126 19536198 Q08496 P33416 DIA2 HSP78 0.126 19536198 Q08496 P34239 DIA2 LST4 0.236 11805837 Q08496 P46997 DIA2 JJJ2 0.126 19536198 Q08496 P47079 DIA2 CCT8 0.21 11805837,19536198 Q12522 Q08496 TIF6 DIA2 0.236 11805837 Q08496 P14680 DIA2 YAK1 0.236 11805837 Q08496 P48363 DIA2 PAC10 0.126 19536198 Q08496 P42846 DIA2 KRI1 0.236 11805837 Q08496 P14906 DIA2 SEC63 0.126 19536198 Q08496 Q01454 DIA2 CTF4 0.959 19910927,20139071,19913425,11805837 Q08496 P52553 DIA2 YKE2 0.126 19536198 Q08496 Q03280 DIA2 TOM1 0.21 22933573 Q08496 P20486 DIA2 CKS1 0.309 11805837 Q08496 Q03406 DIA2 SLD5 0.21 19913425 Q08496 P53914 DIA2 KRE33 0.236 11805837 Q08496 P53940 DIA2 APJ1 0.126 19536198 Q08496 Q08032 DIA2 CDC45 0.126 21179020 Q08496 Q08208 DIA2 NOP12 0.236 11805837 Q08496 P02829 DIA2 HSP82 0.126 19536198 Q08496 P04147 DIA2 PAB1 0.126 11805837 Q08496 P09119 DIA2 CDC6 0.376 23129771 Q08496 P09435 DIA2 SSA3 0.126 19536198 Q08496 P09436 DIA2 ILS1 0.236 11805837 Q08496 P10591 DIA2 SSA1 0.126 19536198 Q08496 P11978 DIA2 SIR4 0.309 22844255 Q08496 P22147 DIA2 XRN1 0.126 11805837 Q08496 P22943 DIA2 HSP12 0.126 19536198 Q08496 P24279 DIA2 MCM3 0.236 11805837 Q08496 P25294 DIA2 SIS1 0.126 19536198 Q08496 P25491 DIA2 YDJ1 0.236 11805837,19536198 Q08496 P25582 DIA2 SPB1 0.21 11805837 Q08496 P29496 DIA2 MCM5 0.21 11805837 Q08496 P32589 DIA2 SSE1 0.126 19536198 Q08496 P34241 DIA2 URB1 0.21 11805837 Q08496 P38164 DIA2 SEA4 0.21 11805837 Q08496 P38691 DIA2 KSP1 0.126 11805837 Q08496 P38779 DIA2 CIC1 0.21 11805837 Q08496 P38788 DIA2 SSZ1 0.354 11805837,19536198 Q08496 P38789 DIA2 SSF1 0.21 11805837 Q08496 P38861 DIA2 NMD3 0.21 11805837 Q08496 P38911 DIA2 FPR3 0.21 11805837 Q08496 P39077 DIA2 CCT3 0.126 19536198 Q08496 P40150 DIA2 SSB2 0.126 19536198 Q08496 P40564 DIA2 DJP1 0.126 19536198 Q08496 P41940 DIA2 PSA1 0.126 11805837 Q08496 P42945 DIA2 UTP10 0.286 11805837 Q08496 P53011 DIA2 SEH1 0.236 11805837 Q08496 P54115 DIA2 ALD6 0.126 11805837 Q08496 Q00772 DIA2 SLT2 0.21 11805837 Q08496 Q03048 DIA2 COF1 0.21 11805837 Q08496 Q08224 DIA2 THI20 0.126 11805837 Q08962 Q08496 NIP7 DIA2 0.236 11805837 Q08965 Q08496 BMS1 DIA2 0.21 11805837 Q12018 Q08496 CDC53 DIA2 0.681 11805837,14747994,16421250,16751663 Q12153 Q08496 SSF2 DIA2 0.21 11805837 Q12329 Q08496 HSP42 DIA2 0.126 19536198 Q12389 Q08496 DBP10 DIA2 0.21 11805837 Q12754 Q08496 RRP12 DIA2 0.21 11805837 Q08496 P22137 DIA2 CHC1 0.126 11805837 Q08975 Q08496 THI21 DIA2 0.126 11805837