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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031902
UUCD1 version UUC-DrM-00287
Ensembl Protein ID FBpp0072038
UniProt Accession O77459; KEN_DROME
Genbank Protein ID CAA10062.1; BAA32683.1; BAA32687.1; AAF47084.1; AAD55433.1
Protein Name Transcription factor Ken; Protein Ken and Barbie
Genbank Nucleotide ID AJ012576; AB010260; AB010261; AE013599; AF181647
Gene Name ken; CG5575
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0011236 FBtr0072129 FBpp0072038
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.50e-09 38.1 33 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgk 64
           aD ++v++ +++ +ahk+vLaa+S+  ++l+ +++l++   + +v + dv +++f+ ll+FlY+g+
   Q: 33   ADLTIVCEnKVKLHAHKLVLAAASPLIRNLLeDTHLSDC--STTVYFPDVNATYFKFLLDFLYSGQ 96
           688999999**********************55555566..79999*******************8 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.
 Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.
Protein Sequence
(Fasta)
MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR 60
NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031902|E3,BTB_Other|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
GCACAGTCAA AAAAAAAGGC TCCGAGTGAA CGGACGTGCG CGCGCGCAAA CTGAAAGTGT 60
AAGCACAAAC AGAGCGAAGC AAAGCAAGGC AAAAGCAAAA GCAGAAGCTG AAATCGAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031902|E3,BTB_Other|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007620--P:copulation
GO:0045497--P:female analia development
GO:0030540--P:female genitalia development
GO:0007320--P:insemination
GO:0045496--P:male analia development
GO:0030539--P:male genitalia development
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006909--P:phagocytosis
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG dme:Dmel_CG5575
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001625 Ailuropoda melanoleuca 41.51 2.00e-14 73.60
IUUC-Afl-008695 Aspergillus flavus 33.85 1.30e-02 33.10
IUUC-Aor-010003 Aspergillus oryzae 33.85 5.00e-03 34.30
IUUC-Csa-023942 Chlorocebus sabaeus 41.51 3.00e-14 73.20
IUUC-Cho-024599 Choloepus hoffmanni 41.35 9.00e-15 74.30
IUUC-Cin-025470 Ciona intestinalis 40.43 7.00e-15 75.50
IUUC-Dre-027466 Danio rerio 34.19 4.00e-15 75.90
IUUC-Eca-034377 Equus caballus 41.35 4.00e-15 75.90
IUUC-Fox-037766 Fusarium oxysporum 41.94 4.00e-01 29.60
IUUC-Gmo-039515 Gadus morhua 41.35 8.00e-15 73.90
IUUC-Ggo-044500 Gorilla gorilla 41.51 3.00e-14 73.20
IUUC-Hsa-046648 Homo sapiens 41.35 4.00e-15 75.90
IUUC-Laf-053636 Loxodonta africana 41.51 1.00e-14 74.30
IUUC-Mcc-055290 Macaca mulatta 41.35 4.00e-15 75.90
IUUC-Mmu-063292 Mus musculus 41.35 4.00e-15 75.90
IUUC-Mlu-067370 Myotis lucifugus 41.35 4.00e-15 75.90
IUUC-Nle-069870 Nomascus leucogenys 41.35 4.00e-15 75.90
IUUC-Ocu-073970 Oryctolagus cuniculus 41.35 4.00e-15 75.90
IUUC-Ola-087102 Oryzias latipes 41.35 3.00e-15 76.30
IUUC-Oga-088873 Otolemur garnettii 41.51 3.00e-14 73.20
IUUC-Ptr-090628 Pan troglodytes 41.35 4.00e-15 75.90
IUUC-Pno-094901 Phaeosphaeria nodorum 27.45 1.90e-02 32.00
IUUC-Pab-098012 Pongo abelii 41.35 4.00e-15 75.90
IUUC-Pca-100127 Procavia capensis 41.35 3.00e-15 76.30
IUUC-Sha-107259 Sarcophilus harrisii 41.51 2.00e-14 73.60
Created Date 25-Jun-2017

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