iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000006863.1	ENSSHAT00000007972.1	ENSSHAP00000007909.1
ENSSHAG00000006863.1	ENSSHAT00000007973.1	ENSSHAP00000007910.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-67	227.8	413	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k k+              a++p+
   Q: 413  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpippKAKQAlgdkivrdirpgaAFEPT 499
           9***************************99.333333.334799***************8777764333337788888899999***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde............. 129
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+ +                  +++++ e           +             
   Q: 500  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkklllpnnekfsvsngPETHSVPE-----------Deqeqgegsedewe 577
           *9999999999966599********************445557776666666555422222222...........13334444445466 PP
   S: 130  .....aeekkkkknk...........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeeleg 202
                +        k           ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++     ++qd+Les +++e+++g
   Q: 578  qvgprN--------KtsvtrqadfiqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSEKIH---TVQDALESLVARESVQG 654
           665552........223333444666***********9.688999999*******************88...****************8 PP
   S: 203  enkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG 288
               y++k k+++e +++++l+klP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G
   Q: 655  ----YTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISRELLSPGVKNKNfkgHRNYRLFAVVYHHG 738
           ....99999****************************9998886.***************999887766666666************** PP
   S: 289  .slssGHYvayvknekgk.WllfdDskVtevkeeevleetg.staYvlfYkr 337
            s+ +GHY+++v +   + Wl++dD+ V+++++ +v++ ++ +taY+l+Y+r
   Q: 739  nSATGGHYTTDVFQIGLNgWLRIDDQAVKVITQYQVVKPSAeRTAYLLYYRR 790
           **************87777*****************998778********98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

ICFFPPQYVF GDFTPDEFNQ FFVTPRSSVE LPPYNEAILC DTEAPEELHD GEEYQRIEFG 60
VTEVIEQDES LLNNTDYSIS STLNPQAPEF ILGCTTSKKN HDDIHSETNY NSIDCQFTSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATGTTTTT TTCCTCCTCA GTATGTTTTT GGAGATTTTA CTCCTGATGA GTTCAATCAG 60
TTTTTTGTGA CTCCTCGTTC TTCTGTTGAG GTAAGATCTT TGTTTTGTGT ATTAGTCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	30.85	8.00e-44	171.00
IUUC-Aml-001584	Ailuropoda melanoleuca	80.05	0.00e+00	1179.00
IUUC-Atr-002927	Amborella trichopoda	35.82	2.00e-60	226.00
IUUC-Apl-003988	Anas platyrhynchos	82.98	0.00e+00	1214.00
IUUC-Aca-004461	Anolis carolinensis	92.22	8.00e-161	559.00
IUUC-Aly-006038	Arabidopsis lyrata	34.96	6.00e-53	201.00
IUUC-Ath-007328	Arabidopsis thaliana	34.70	1.00e-51	197.00
IUUC-Ago-007717	Ashbya gossypii	27.91	1.00e-43	171.00
IUUC-Acl-008188	Aspergillus clavatus	35.38	5.00e-65	242.00
IUUC-Afl-008456	Aspergillus flavus	38.21	2.00e-50	192.00
IUUC-Afu-009067	Aspergillus fumigatus	36.90	3.00e-68	253.00
IUUC-Ani-009483	Aspergillus nidulans	34.50	1.00e-64	241.00
IUUC-Ang-009639	Aspergillus niger	35.37	9.00e-62	231.00
IUUC-Aor-010040	Aspergillus oryzae	35.59	2.00e-62	234.00
IUUC-Ate-010310	Aspergillus terreus	34.82	4.00e-65	242.00
IUUC-Ame-011012	Astyanax mexicanus	75.43	3.00e-165	575.00
IUUC-Bgr-012311	Blumeria graminis	34.49	9.00e-46	178.00
IUUC-Bta-013299	Bos taurus	78.74	0.00e+00	1131.00
IUUC-Bci-013783	Botrytis cinerea	37.53	2.00e-60	227.00
IUUC-Bdi-015039	Brachypodium distachyon	32.19	1.00e-49	190.00
IUUC-Bol-015806	Brassica oleracea	36.25	4.00e-62	232.00
IUUC-Bra-017076	Brassica rapa	36.25	3.00e-62	232.00
IUUC-Cja-018715	Callithrix jacchus	80.45	0.00e+00	1190.00
IUUC-Cfa-020194	Canis familiaris	81.34	0.00e+00	1207.00
IUUC-Cpo-022272	Cavia porcellus	69.18	0.00e+00	959.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	33.88	8.00e-34	138.00
IUUC-Csa-023310	Chlorocebus sabaeus	81.84	0.00e+00	1217.00
IUUC-Cho-024966	Choloepus hoffmanni	78.24	0.00e+00	833.00
IUUC-Cin-025616	Ciona intestinalis	47.13	7.00e-104	371.00
IUUC-Csv-026043	Ciona savignyi	46.57	2.00e-98	352.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	34.22	9.00e-47	182.00
IUUC-Cne-026962	Cryptococcus neoformans	35.42	2.00e-48	187.00
IUUC-Cme-027113	Cyanidioschyzon merolae	30.75	2.00e-37	150.00
IUUC-Dre-028072	Danio rerio	79.14	0.00e+00	725.00
IUUC-Dno-029489	Dasypus novemcinctus	81.31	0.00e+00	1237.00
IUUC-Dor-031068	Dipodomys ordii	70.35	2.00e-133	469.00
IUUC-Dse-031553	Dothistroma septosporum	36.43	6.00e-57	215.00
IUUC-Dme-031759	Drosophila melanogaster	41.10	2.00e-82	301.00
IUUC-Ete-032549	Echinops telfairi	70.74	0.00e+00	780.00
IUUC-Eca-033380	Equus caballus	80.20	0.00e+00	1208.00
IUUC-Eeu-034818	Erinaceus europaeus	78.59	0.00e+00	1143.00
IUUC-Fca-035535	Felis catus	79.08	0.00e+00	1088.00
IUUC-Fal-036627	Ficedula albicollis	78.06	0.00e+00	1137.00
IUUC-Fox-037904	Fusarium oxysporum	37.54	3.00e-55	210.00
IUUC-Fso-038170	Fusarium solani	33.87	2.00e-53	203.00
IUUC-Gmo-039499	Gadus morhua	68.68	0.00e+00	651.00
IUUC-Ggr-040042	Gaeumannomyces graminis	36.84	4.00e-61	229.00
IUUC-Gga-040571	Gallus gallus	82.98	0.00e+00	1198.00
IUUC-Gac-041345	Gasterosteus aculeatus	75.22	0.00e+00	653.00
IUUC-Gma-044407	Glycine max	35.48	3.00e-60	225.00
IUUC-Ggo-044652	Gorilla gorilla	80.85	0.00e+00	1229.00
IUUC-Hsa-045864	Homo sapiens	80.85	0.00e+00	1228.00
IUUC-Hvu-047071	Hordeum vulgare	32.41	6.00e-52	198.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	84.25	0.00e+00	932.00
IUUC-Kpa-049132	Komagataella pastoris	30.94	3.00e-46	179.00
IUUC-Lch-050040	Latimeria chalumnae	72.98	0.00e+00	965.00
IUUC-Lpe-050772	Leersia perrieri	28.31	5.00e-17	82.40
IUUC-Loc-052449	Lepisosteus oculatus	76.46	0.00e+00	707.00
IUUC-Lma-053248	Leptosphaeria maculans	35.90	1.00e-58	221.00
IUUC-Laf-054121	Loxodonta africana	80.58	0.00e+00	1204.00
IUUC-Mcc-055514	Macaca mulatta	81.59	0.00e+00	1211.00
IUUC-Meu-056873	Macropus eugenii	90.82	0.00e+00	1104.00
IUUC-Mor-057243	Magnaporthe oryzae	34.46	3.00e-58	220.00
IUUC-Mpo-057439	Magnaporthe poae	35.90	1.00e-59	224.00
IUUC-Mtr-058457	Medicago truncatula	34.70	3.00e-58	219.00
IUUC-Mla-058929	Melampsora laricipopulina	31.08	1.00e-55	211.00
IUUC-Mga-060157	Meleagris gallopavo	81.58	0.00e+00	1205.00
IUUC-Mvi-060442	Microbotryum violaceum	32.25	1.00e-53	205.00
IUUC-Mmr-061062	Microcebus murinus	80.68	0.00e+00	1224.00
IUUC-Mdo-062798	Monodelphis domestica	95.96	0.00e+00	1470.00
IUUC-Mmu-064050	Mus musculus	76.57	0.00e+00	1148.00
IUUC-Mac-065619	Musa acuminata	34.36	5.00e-55	207.00
IUUC-Mpu-066554	Mustela putorius furo	79.32	0.00e+00	1161.00
IUUC-Mlu-068003	Myotis lucifugus	80.93	0.00e+00	1195.00
IUUC-Nfi-068612	Neosartorya fischeri	36.41	1.00e-65	244.00
IUUC-Ncr-068878	Neurospora crassa	35.23	2.00e-51	197.00
IUUC-Nle-069661	Nomascus leucogenys	81.23	0.00e+00	1216.00
IUUC-Opr-070944	Ochotona princeps	76.59	7.00e-160	557.00
IUUC-Ont-071266	Oreochromis niloticus	77.83	0.00e+00	678.00
IUUC-Oan-073442	Ornithorhynchus anatinus	86.11	0.00e+00	1216.00
IUUC-Ocu-073788	Oryctolagus cuniculus	74.80	0.00e+00	1040.00
IUUC-Oba-075085	Oryza barthii	32.49	6.00e-36	144.00
IUUC-Obr-076663	Oryza brachyantha	32.74	1.00e-45	177.00
IUUC-Ogl-076937	Oryza glaberrima	29.38	2.00e-48	186.00
IUUC-Ogu-078909	Oryza glumaepatula	29.47	7.00e-46	178.00
IUUC-Oin-079617	Oryza indica	30.79	4.00e-48	186.00
IUUC-Olo-081043	Oryza longistaminata	25.54	4.00e-24	105.00
IUUC-Oni-082914	Oryza nivara	29.47	5.00e-46	179.00
IUUC-Oru-084878	Oryza rufipogon	29.47	5.00e-46	179.00
IUUC-Osa-085822	Oryza sativa	30.16	1.00e-50	193.00
IUUC-Ola-086931	Oryzias latipes	70.22	0.00e+00	648.00
IUUC-Oga-088443	Otolemur garnettii	79.92	0.00e+00	1207.00
IUUC-Oar-089325	Ovis aries	77.16	0.00e+00	1051.00
IUUC-Ptr-091584	Pan troglodytes	77.97	0.00e+00	1162.00
IUUC-Pan-092551	Papio anubis	79.47	0.00e+00	1179.00
IUUC-Psi-093366	Pelodiscus sinensis	82.67	0.00e+00	759.00
IUUC-Pno-095136	Phaeosphaeria nodorum	34.51	3.00e-52	200.00
IUUC-Ppa-095574	Physcomitrella patens	36.76	4.00e-60	225.00
IUUC-Pfo-097462	Poecilia formosa	77.25	0.00e+00	684.00
IUUC-Pab-098547	Pongo abelii	80.98	0.00e+00	1208.00
IUUC-Pop-099529	Populus trichocarpa	38.56	4.00e-63	235.00
IUUC-Pca-101066	Procavia capensis	72.34	0.00e+00	1059.00
IUUC-Ppe-102110	Prunus persica	36.48	5.00e-59	221.00
IUUC-Pva-103015	Pteropus vampyrus	76.10	0.00e+00	1118.00
IUUC-Ptt-103998	Puccinia triticina	33.33	1.00e-53	204.00
IUUC-Pte-104417	Pyrenophora teres	33.99	2.00e-56	214.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	35.71	1.00e-55	211.00
IUUC-Rno-105533	Rattus norvegicus	78.24	0.00e+00	1176.00
IUUC-Sce-106160	Saccharomyces cerevisiae	26.10	5.00e-40	159.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	36.95	2.00e-57	216.00
IUUC-Spo-108353	Schizosaccharomyces pombe	37.89	4.00e-65	242.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	36.90	4.00e-60	226.00
IUUC-Smo-108842	Selaginella moellendorffii	36.69	4.00e-38	151.00
IUUC-Sit-110781	Setaria italica	30.34	7.00e-55	208.00
IUUC-Sly-111797	Solanum lycopersicum	34.62	2.00e-56	213.00
IUUC-Stu-112188	Solanum tuberosum	35.88	3.00e-56	212.00
IUUC-Sbi-114862	Sorghum bicolor	32.04	3.00e-43	169.00
IUUC-Sre-115162	Sporisorium reilianum	33.75	4.00e-64	239.00
IUUC-Ssc-115505	Sus scrofa	89.64	1.00e-153	535.00
IUUC-Tgu-116535	Taeniopygia guttata	79.29	0.00e+00	1161.00
IUUC-Tru-117542	Takifugu rubripes	78.28	0.00e+00	712.00
IUUC-Tni-120200	Tetraodon nigroviridis	57.89	0.00e+00	808.00
IUUC-Tca-121548	Theobroma cacao	35.58	5.00e-46	178.00
IUUC-Tre-122124	Trichoderma reesei	34.63	4.00e-62	233.00
IUUC-Tvi-122457	Trichoderma virens	35.22	1.00e-52	201.00
IUUC-Tae-125646	Triticum aestivum	33.84	4.00e-54	206.00
IUUC-Tme-127180	Tuber melanosporum	39.13	1.00e-69	257.00
IUUC-Tbe-127530	Tupaia belangeri	67.23	0.00e+00	923.00
IUUC-Ttr-128549	Tursiops truncatus	73.02	0.00e+00	1061.00
IUUC-Uma-129381	Ustilago maydis	33.84	8.00e-64	238.00
IUUC-Vda-129889	Verticillium dahliae	33.42	9.00e-52	198.00
IUUC-Vpa-130100	Vicugna pacos	74.65	0.00e+00	1069.00
IUUC-Vvi-131366	Vitis vinifera	36.73	2.00e-64	240.00
IUUC-Xtr-132048	Xenopus tropicalis	64.94	0.00e+00	945.00
IUUC-Xma-133593	Xiphophorus maculatus	77.47	0.00e+00	679.00
IUUC-Yli-134338	Yarrowia lipolytica	28.57	2.00e-33	137.00
IUUC-Zma-135586	Zea mays	29.35	3.00e-50	192.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence