iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	15772280

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.00e-08	36.3	34	106
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.00e-09	36.6	141	171

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmele.es..ksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv +v   +++++ah  vLa++S+v+++ +++ ++  +   sk  ++i +v ++++++++kFlY+++l+e+e
   Q: 34   SDVEIVTSdNRRIPAHSGVLASASPVLMNIMKKPMRrYRgcGSKRVIKILGVPCDAVSVFIKFLYSSSLTEDE 106
           69999*999**************************9655555577777779******************9976 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eN++++l++A+l+d+pd++++ ++ i+++Fk
   Q: 141  ENVVDVLQLARLCDAPDVCLRSMRLIHSQFK 171
           9*****************************7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and vegetative development. Also negatively regulates ABA- and sugar-mediated inhibition of the germination. Essential for female and male gametophyte development.

Protein Sequence
(Fasta)

MEAVLVAMSV PATTEDDGFS LITDKLSYNL TPTSDVEIVT SDNRRIPAHS GVLASASPVL 60
MNIMKKPMRR YRGCGSKRVI KILGVPCDAV SVFIKFLYSS SLTEDEMERY GIHLLALSHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGCTATT CCCGTCACAT AAAAATGCCA AAAAAAGAAA AAAAAGAGTG ATAATCTAAG 60
TGAAAACAGA TCACGAGCGT GTTAGATAAG AATAGAGAGA CGCAAAAATA AAATAGATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR000197--Znf_TAZ

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF02135--zf-TAZ

SMART

SM00225--BTB
SM00551--ZnF_TAZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005516--F:calmodulin binding
GO:0004402--F:histone acetyltransferase activity
GO:0003712--F:transcription cofactor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0009734--P:auxin-activated signaling pathway
GO:0007623--P:circadian rhythm
GO:0009553--P:embryo sac development
GO:0009555--P:pollen development
GO:0051973--P:positive regulation of telomerase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009737--P:response to abscisic acid
GO:0009733--P:response to auxin
GO:0009743--P:response to carbohydrate
GO:0009409--P:response to cold
GO:0042542--P:response to hydrogen peroxide
GO:0009753--P:response to jasmonic acid
GO:0010167--P:response to nitrate
GO:0009751--P:response to salicylic acid
GO:0009651--P:response to salt stress
GO:0009611--P:response to wounding
GO:0010182--P:sugar mediated signaling pathway

KEGG

ath:AT3G48360

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005445	Arabidopsis lyrata	94.79	0.00e+00	683.00
IUUC-Afl-008411	Aspergillus flavus	34.88	1.10e+00	25.40
IUUC-Bci-013893	Botrytis cinerea	28.00	4.50e-01	28.50
IUUC-Bra-017712	Brassica rapa	80.98	7.00e-170	588.00
IUUC-Fso-038423	Fusarium solani	31.08	1.00e-03	36.20
IUUC-Gma-042705	Glycine max	58.21	4.00e-106	377.00
IUUC-Lpe-050852	Leersia perrieri	44.18	2.00e-67	248.00
IUUC-Mtr-057708	Medicago truncatula	61.21	2.00e-108	384.00
IUUC-Mac-065042	Musa acuminata	51.00	9.00e-87	312.00
IUUC-Obr-076222	Oryza brachyantha	42.48	5.00e-28	116.00
IUUC-Ogl-077499	Oryza glaberrima	44.08	5.00e-67	247.00
IUUC-Ogu-078525	Oryza glumaepatula	43.27	2.00e-67	248.00
IUUC-Oni-083076	Oryza nivara	43.95	7.00e-68	249.00
IUUC-Opu-083346	Oryza punctata	42.81	2.00e-64	238.00
IUUC-Osa-086271	Oryza sativa	44.54	7.00e-69	253.00
IUUC-Pte-104382	Pyrenophora teres	34.21	3.70e-02	32.30
IUUC-Pyt-104507	Pyrenophora triticirepentis	32.08	2.00e-02	33.10
IUUC-Sit-110089	Setaria italica	46.08	7.00e-74	270.00
IUUC-Sly-111857	Solanum lycopersicum	60.00	3.00e-113	400.00
IUUC-Sbi-114044	Sorghum bicolor	43.43	9.00e-66	243.00
IUUC-Tca-121566	Theobroma cacao	66.46	1.00e-118	418.00
IUUC-Tur-126296	Triticum urartu	47.62	7.00e-71	259.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence