iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000006752.3	ENSMMUT00000061735.1	ENSMMUP00000052160.1
ENSMMUG00000006752.3	ENSMMUT00000009450.3	ENSMMUP00000008883.3
ENSMMUG00000006752.3	ENSMMUT00000039287.2	ENSMMUP00000032374.2
ENSMMUG00000006752.3	ENSMMUT00000009451.3	ENSMMUP00000008884.3
ENSMMUG00000006752.3	ENSMMUT00000067360.1	ENSMMUP00000045720.1
ENSMMUG00000006752.3	ENSMMUT00000074485.1	ENSMMUP00000052683.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.30e-126	424.3	13	529

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedv....gksKAevaaealkeln 85
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ ++ ++f  +      +k++Ae+a+e+l+eln
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNKYFFLIQVKcfvfKKNRAEAAMEFLQELN 101
           ************************************************************9888775433789**************** PP
   S: 86   pdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqkt 170
           +dv+++++ees+++l ++++ Ff++f+vVv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   ++++++
   Q: 102  SDVSGSFVEESPENLLDNDPsFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLD 190
           ***************************************************************************************** PP
   S: 171  iPfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavka 244
           +Pf++l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a
   Q: 191  KPFPELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTA 279
           *********99999999998***********************************************9********************* PP
   S: 245  fakttins.ikqllksfecdivtkskspfwv.......................................................... 274
           +++t+i+s i++++++++c ++tk++++fw+                                                          
   Q: 280  LNTTQIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakl 368
           ***************************************************************************************** PP
   S: 275  .................sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddd 330
                             +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d
   Q: 369  lqsigqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEED 457
           *****************99********7777777888888**************9********************************** PP
   S: 331  s..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +  + +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  IgkLKSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 529
           *999********....********************************************************9776 PP

Organism

Macaca mulatta

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNKYFFLIQV KCFVFKKNRA EAAMEFLQEL NSDVSGSFVE ESPENLLDND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGGCGCTC AGTGCGCCTG CGCGCTTGTG GAGCTGGTGG CGGCGGTCCG CTGGGGCTCC 60
GCTGTTCTCC GCGCTGCGGG CGCGGCCATG GCGCAGCCGG GGAAGCTGCT CAAGGAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.21	2.00e-122	432.00
IUUC-Aml-002333	Ailuropoda melanoleuca	96.10	0.00e+00	1076.00
IUUC-Atr-002644	Amborella trichopoda	40.26	4.00e-111	395.00
IUUC-Apl-003446	Anas platyrhynchos	82.22	0.00e+00	898.00
IUUC-Aca-004450	Anolis carolinensis	78.44	0.00e+00	897.00
IUUC-Aly-006187	Arabidopsis lyrata	39.52	2.00e-121	429.00
IUUC-Ath-007600	Arabidopsis thaliana	40.07	1.00e-122	433.00
IUUC-Ago-007900	Ashbya gossypii	26.59	2.00e-39	156.00
IUUC-Acl-008333	Aspergillus clavatus	33.57	2.00e-76	279.00
IUUC-Afl-008529	Aspergillus flavus	35.59	3.00e-82	299.00
IUUC-Afu-009071	Aspergillus fumigatus	32.92	2.00e-77	283.00
IUUC-Ani-009443	Aspergillus nidulans	32.56	9.00e-74	271.00
IUUC-Ang-009669	Aspergillus niger	32.56	1.00e-77	283.00
IUUC-Aor-009914	Aspergillus oryzae	34.92	6.00e-79	288.00
IUUC-Ate-010450	Aspergillus terreus	33.75	3.00e-79	289.00
IUUC-Ame-011183	Astyanax mexicanus	70.73	0.00e+00	818.00
IUUC-Bgr-012111	Blumeria graminis	32.14	1.00e-60	227.00
IUUC-Bta-012583	Bos taurus	95.91	0.00e+00	1074.00
IUUC-Bci-013892	Botrytis cinerea	32.18	1.00e-60	227.00
IUUC-Bdi-014592	Brachypodium distachyon	42.99	5.00e-125	441.00
IUUC-Bol-016399	Brassica oleracea	39.20	2.00e-118	419.00
IUUC-Bra-017506	Brassica rapa	38.15	6.00e-115	407.00
IUUC-Cel-018456	Caenorhabditis elegans	34.98	6.00e-89	321.00
IUUC-Cja-020007	Callithrix jacchus	96.12	0.00e+00	1075.00
IUUC-Cfa-020324	Canis familiaris	95.91	0.00e+00	1071.00
IUUC-Cpo-022248	Cavia porcellus	66.24	0.00e+00	649.00
IUUC-Csa-023149	Chlorocebus sabaeus	99.78	0.00e+00	965.00
IUUC-Cho-024537	Choloepus hoffmanni	85.62	0.00e+00	793.00
IUUC-Cin-025763	Ciona intestinalis	48.41	2.00e-150	525.00
IUUC-Csv-026113	Ciona savignyi	45.70	4.00e-142	498.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.90	4.00e-60	225.00
IUUC-Cne-026884	Cryptococcus neoformans	28.75	2.00e-66	246.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.89	7.00e-15	75.50
IUUC-Dre-028140	Danio rerio	71.56	0.00e+00	834.00
IUUC-Dno-030033	Dasypus novemcinctus	95.39	0.00e+00	942.00
IUUC-Dor-030513	Dipodomys ordii	69.01	8.00e-116	410.00
IUUC-Dse-031536	Dothistroma septosporum	34.51	5.00e-81	295.00
IUUC-Dme-031683	Drosophila melanogaster	43.39	4.00e-122	431.00
IUUC-Ete-032420	Echinops telfairi	81.15	0.00e+00	865.00
IUUC-Eca-033992	Equus caballus	98.43	0.00e+00	922.00
IUUC-Eeu-034713	Erinaceus europaeus	80.31	2.00e-118	419.00
IUUC-Fca-036548	Felis catus	94.80	0.00e+00	1060.00
IUUC-Fal-037600	Ficedula albicollis	79.09	0.00e+00	867.00
IUUC-Fox-038037	Fusarium oxysporum	33.09	4.00e-73	269.00
IUUC-Fso-038387	Fusarium solani	33.92	7.00e-75	274.00
IUUC-Gmo-038562	Gadus morhua	70.30	0.00e+00	805.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.21	2.00e-67	249.00
IUUC-Gga-041129	Gallus gallus	82.56	0.00e+00	922.00
IUUC-Gac-042558	Gasterosteus aculeatus	71.03	0.00e+00	815.00
IUUC-Gma-043610	Glycine max	40.30	3.00e-116	412.00
IUUC-Ggo-045611	Gorilla gorilla	96.49	0.00e+00	1075.00
IUUC-Hsa-046563	Homo sapiens	97.03	0.00e+00	1078.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	4.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	96.10	0.00e+00	1074.00
IUUC-Kpa-049309	Komagataella pastoris	34.84	7.00e-79	287.00
IUUC-Lch-050038	Latimeria chalumnae	74.58	0.00e+00	836.00
IUUC-Lpe-051535	Leersia perrieri	41.12	2.00e-110	392.00
IUUC-Loc-051917	Lepisosteus oculatus	69.41	0.00e+00	796.00
IUUC-Lma-053112	Leptosphaeria maculans	34.97	1.00e-83	304.00
IUUC-Laf-053690	Loxodonta africana	94.61	0.00e+00	1065.00
IUUC-Meu-056761	Macropus eugenii	76.01	0.00e+00	813.00
IUUC-Mor-057230	Magnaporthe oryzae	33.04	2.00e-72	266.00
IUUC-Mpo-057514	Magnaporthe poae	32.68	1.00e-65	244.00
IUUC-Mtr-058551	Medicago truncatula	39.64	6.00e-113	401.00
IUUC-Mla-059183	Melampsora laricipopulina	35.30	1.00e-90	327.00
IUUC-Mga-060144	Meleagris gallopavo	81.20	0.00e+00	894.00
IUUC-Mvi-060221	Microbotryum violaceum	34.81	1.00e-77	283.00
IUUC-Mmr-061325	Microcebus murinus	94.98	0.00e+00	1067.00
IUUC-Mdo-062532	Monodelphis domestica	89.57	0.00e+00	1006.00
IUUC-Mmu-063956	Mus musculus	95.35	0.00e+00	1069.00
IUUC-Mac-064521	Musa acuminata	40.45	1.00e-118	420.00
IUUC-Mpu-066716	Mustela putorius furo	94.86	0.00e+00	1003.00
IUUC-Mlu-067459	Myotis lucifugus	93.70	0.00e+00	1046.00
IUUC-Nfi-068245	Neosartorya fischeri	33.27	1.00e-77	284.00
IUUC-Ncr-068910	Neurospora crassa	33.03	5.00e-73	268.00
IUUC-Nle-070034	Nomascus leucogenys	95.84	0.00e+00	1048.00
IUUC-Opr-070552	Ochotona princeps	85.54	0.00e+00	874.00
IUUC-Ont-071426	Oreochromis niloticus	71.67	0.00e+00	832.00
IUUC-Oan-073389	Ornithorhynchus anatinus	84.04	0.00e+00	781.00
IUUC-Ocu-074911	Oryctolagus cuniculus	94.42	0.00e+00	1065.00
IUUC-Oba-075437	Oryza barthii	42.61	8.00e-116	410.00
IUUC-Obr-076684	Oryza brachyantha	42.99	1.00e-111	396.00
IUUC-Ogl-077170	Oryza glaberrima	42.61	8.00e-116	410.00
IUUC-Ogu-078844	Oryza glumaepatula	43.37	4.00e-109	388.00
IUUC-Oin-079105	Oryza indica	42.61	3.00e-115	408.00
IUUC-Olo-080943	Oryza longistaminata	40.32	1.00e-105	377.00
IUUC-Oni-082891	Oryza nivara	39.96	4.00e-111	395.00
IUUC-Opu-083457	Oryza punctata	42.61	3.00e-115	408.00
IUUC-Oru-084960	Oryza rufipogon	40.32	1.00e-105	376.00
IUUC-Osa-085358	Oryza sativa	42.80	5.00e-116	411.00
IUUC-Ola-086420	Oryzias latipes	71.31	2.00e-168	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.72	8.00e-60	224.00
IUUC-Oga-088810	Otolemur garnettii	94.42	0.00e+00	1060.00
IUUC-Oar-089196	Ovis aries	95.38	0.00e+00	1069.00
IUUC-Ptr-090617	Pan troglodytes	97.03	0.00e+00	1079.00
IUUC-Pan-092761	Papio anubis	97.21	0.00e+00	1084.00
IUUC-Psi-093191	Pelodiscus sinensis	84.84	0.00e+00	943.00
IUUC-Pma-094380	Petromyzon marinus	60.36	0.00e+00	645.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.08	4.00e-70	260.00
IUUC-Ppa-095875	Physcomitrella patens	39.55	6.00e-116	411.00
IUUC-Pfo-096467	Poecilia formosa	70.92	0.00e+00	815.00
IUUC-Pab-098255	Pongo abelii	96.43	0.00e+00	897.00
IUUC-Pop-099722	Populus trichocarpa	40.07	1.00e-120	427.00
IUUC-Pca-100807	Procavia capensis	74.72	1.00e-111	396.00
IUUC-Ppe-101280	Prunus persica	39.37	3.00e-118	419.00
IUUC-Pva-102333	Pteropus vampyrus	90.94	0.00e+00	1007.00
IUUC-Pgr-103401	Puccinia graminis	31.38	1.00e-76	280.00
IUUC-Ptt-103889	Puccinia triticina	27.30	2.00e-53	203.00
IUUC-Pte-104355	Pyrenophora teres	35.58	2.00e-86	313.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.75	9.00e-88	317.00
IUUC-Rno-105810	Rattus norvegicus	95.35	0.00e+00	1066.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.06	1.00e-37	150.00
IUUC-Sha-106770	Sarcophilus harrisii	86.41	2.00e-148	518.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.40	7.00e-76	278.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.26	3.00e-79	289.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.41	2.00e-62	233.00
IUUC-Smo-109296	Selaginella moellendorffii	41.54	3.00e-119	422.00
IUUC-Sit-110157	Setaria italica	44.07	6.00e-132	464.00
IUUC-Sly-111105	Solanum lycopersicum	38.92	8.00e-117	414.00
IUUC-Stu-112469	Solanum tuberosum	39.42	1.00e-118	420.00
IUUC-Sar-113083	Sorex araneus	71.35	0.00e+00	731.00
IUUC-Sbi-113813	Sorghum bicolor	44.07	6.00e-131	461.00
IUUC-Sre-115058	Sporisorium reilianum	37.53	4.00e-81	295.00
IUUC-Tgu-116772	Taeniopygia guttata	79.43	0.00e+00	878.00
IUUC-Tru-118686	Takifugu rubripes	69.79	0.00e+00	815.00
IUUC-Tsy-119111	Tarsius syrichta	88.50	3.00e-149	521.00
IUUC-Tni-120231	Tetraodon nigroviridis	64.80	0.00e+00	733.00
IUUC-Tca-121491	Theobroma cacao	39.56	7.00e-112	397.00
IUUC-Tre-122103	Trichoderma reesei	35.95	6.00e-78	285.00
IUUC-Tvi-122672	Trichoderma virens	35.65	1.00e-70	260.00
IUUC-Tae-125679	Triticum aestivum	42.80	1.00e-124	440.00
IUUC-Tur-126487	Triticum urartu	41.10	4.00e-118	418.00
IUUC-Tme-127097	Tuber melanosporum	38.63	2.00e-90	326.00
IUUC-Ttr-128465	Tursiops truncatus	88.35	0.00e+00	980.00
IUUC-Uma-129645	Ustilago maydis	32.67	1.00e-85	310.00
IUUC-Vda-129989	Verticillium dahliae	29.57	6.00e-51	195.00
IUUC-Vpa-130529	Vicugna pacos	90.94	0.00e+00	1013.00
IUUC-Vvi-131059	Vitis vinifera	40.11	5.00e-117	414.00
IUUC-Xtr-132002	Xenopus tropicalis	77.02	0.00e+00	887.00
IUUC-Xma-133930	Xiphophorus maculatus	71.32	0.00e+00	820.00
IUUC-Yli-134505	Yarrowia lipolytica	34.03	1.00e-81	297.00
IUUC-Zma-135895	Zea mays	44.13	9.00e-130	457.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence