iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008744

Ensembl Protein ID

EED51039

UniProt Accession

B8NGT5; SCONB_ASPFN

Genbank Protein ID

EED51039.1

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit sconB; Sulfur controller B; Sulfur metabolite repression control protein B

Genbank Nucleotide ID

EQ963478

Gene Name

sconB; AFLA_138030

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_138030	EED51039	EED51039

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-55	181.0	417	453
UBD/Beta-Prp	1.70e-74	250.1	374	706

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH+++++cl+f+dt l+sGs D ++kvW++rtg ++ 
   Q: 417  GHQSGIRCLQFDDTKLISGSMDRSLKVWNWRTGECIS 453
           8**********66*********************975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           ++kgh  +v++ ++f  ++++latgs+d+tik+wd++tg  lr+l gh++++++++f+++   l++gs Dr +kvw+ +tg+c++t++gh   v  l+f++
   Q: 374  VFKGHTNGVMC-LQF--EDNILATGSYDATIKIWDTETGEELRTLRGHQSGIRCLQFDDT--KLISGSMDRSLKVWNWRTGECISTYTGHRGGVIGLHFDA 469
           56677777776.***..*******************************************..6************************************** PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..............fdsn 191
               l+s+s d+t+++w+ e ++ +  +l+gh+++vn v+v+ +++ ++s+s+D tvrlWdl t+ +lrt+ g h ++v+ +                   
   Q: 470  --TILASASVDKTVKIWNFEDKSTF--LLRGHTDWVNAVRVDTTSRTVFSASDDCTVRLWDLDTKACLRTFHG-HVGQVQQVVplprefefedhdaeC--- 562
           ..***********************..5********************************************9.*********999998866655551... PP
   S: 192  g............................................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiri 248
                                                        +++v+ +ld+t++lw+  tg+c+rt+ gh + v+ + ++  + r+vsg++D+ ++i
   Q: 563  DndnmsttsgdtesnslqatlglesnatetsvfgpsfdngrpappRYIVTSALDSTIRLWETTTGRCLRTFFGHLEGVWALGAD--TLRIVSGAEDRMVKI 661
           0555666667777788999999999999999999999999***************************************88888..*************** PP
   S: 249  Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkk 296
           Wd r+g++ +t+++h     +v+++++gd+ +++gsed++v+++++++
   Q: 662  WDPRTGKCERTFTGHS---GPVTCIGLGDSRFATGSEDCEVRMYSFRN 706
           **************88...55555666******************986 PP

Organism

Aspergillus flavus

Functional Description
(View)

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MQSDDRSVRE GSDSSQTFLM KMAQPTGELT HPSQQQQQQL LQQQSFRSIF GGASDTAEEI 60
DTETDSNHRR PHSFGAAATT PAKLANKNVA PFLVKHIPEQ YGPLGSRRTD KLEDLSSPNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGTCCG ACGACCGATC AGTGCGTGAA GGTAGCGACT CTTCGCAGAC TTTCTTGATG 60
AAAATGGCCC AACCGACCGG AGAACTTACA CATCCATCGC AACAACAACA ACAACAACTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

afv:AFLA_138030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	41.79	4.00e-133	466.00
IUUC-Acl-008078	Aspergillus clavatus	80.60	0.00e+00	1114.00
IUUC-Afu-008939	Aspergillus fumigatus	77.79	0.00e+00	1097.00
IUUC-Ani-009383	Aspergillus nidulans	81.89	0.00e+00	1076.00
IUUC-Ang-009570	Aspergillus niger	82.71	0.00e+00	1095.00
IUUC-Aor-010217	Aspergillus oryzae	99.01	0.00e+00	1330.00
IUUC-Ate-010336	Aspergillus terreus	84.33	0.00e+00	1113.00
IUUC-Bgr-012225	Blumeria graminis	57.35	0.00e+00	748.00
IUUC-Bci-013916	Botrytis cinerea	63.71	0.00e+00	840.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	52.58	0.00e+00	674.00
IUUC-Cne-026800	Cryptococcus neoformans	35.87	6.00e-123	433.00
IUUC-Dse-031413	Dothistroma septosporum	57.45	0.00e+00	718.00
IUUC-Fox-037683	Fusarium oxysporum	51.00	0.00e+00	651.00
IUUC-Fso-038092	Fusarium solani	57.10	0.00e+00	743.00
IUUC-Ggr-039842	Gaeumannomyces graminis	53.25	0.00e+00	702.00
IUUC-Kpa-049101	Komagataella pastoris	44.55	2.00e-160	557.00
IUUC-Lma-053200	Leptosphaeria maculans	55.94	0.00e+00	763.00
IUUC-Mor-057039	Magnaporthe oryzae	55.54	0.00e+00	708.00
IUUC-Mpo-057381	Magnaporthe poae	53.05	0.00e+00	695.00
IUUC-Mla-059099	Melampsora laricipopulina	40.43	4.00e-124	437.00
IUUC-Mvi-060426	Microbotryum violaceum	40.59	2.00e-54	205.00
IUUC-Nfi-068464	Neosartorya fischeri	79.79	0.00e+00	1073.00
IUUC-Ncr-068962	Neurospora crassa	51.03	0.00e+00	693.00
IUUC-Pno-095133	Phaeosphaeria nodorum	51.81	3.00e-158	549.00
IUUC-Pgr-103527	Puccinia graminis	39.70	4.00e-67	247.00
IUUC-Ptt-103819	Puccinia triticina	34.49	2.00e-54	204.00
IUUC-Pte-104035	Pyrenophora teres	56.45	0.00e+00	699.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	56.29	0.00e+00	704.00
IUUC-Sce-106343	Saccharomyces cerevisiae	40.56	5.00e-137	479.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	40.03	9.00e-122	428.00
IUUC-Spo-108115	Schizosaccharomyces pombe	40.89	2.00e-125	441.00
IUUC-Sre-115173	Sporisorium reilianum	39.81	6.00e-101	360.00
IUUC-Tre-122126	Trichoderma reesei	56.69	0.00e+00	742.00
IUUC-Tvi-122482	Trichoderma virens	57.52	0.00e+00	749.00
IUUC-Tme-127212	Tuber melanosporum	55.93	0.00e+00	749.00
IUUC-Uma-129406	Ustilago maydis	41.22	2.00e-101	361.00
IUUC-Vda-129799	Verticillium dahliae	56.21	0.00e+00	714.00
IUUC-Yli-134408	Yarrowia lipolytica	45.73	5.00e-169	585.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence