iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007768

Ensembl Protein ID

AAS50961

UniProt Accession

Q75D34; ATG21_ASHGO

Genbank Protein ID

AAS50961.2

Protein Name

Autophagy-related protein 21

Genbank Nucleotide ID

AE016815

Gene Name

ATG21; ABR189W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ABR189W	AAS50961	AAS50961

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.90e-10	37.4	222	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDlrtgvll 36
           H++ v cl+  +d ++++++sd gt ++++++ + + l
   Q: 222  HKGNVACLCIsNDgKMVATASDKGTiVRIFSTGDENTL 259
           999********999***********8889987666655 PP

Organism

Ashbya gossypii

Functional Description
(View)

Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).

Protein Sequence
(Fasta)

MKVLRFNQDA SCFSAVSRPH SMTIYNCDPF GKCFELENSV VTSESCDTEC LTKAQGDQCS 60
NFVTEMLFAT SLIAVVNRDQ GLQKARKLRI VNTKRKTTIC ELTFPHEVVD IVMNRKRMCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGTGT TACGGTTCAA CCAGGATGCA AGTTGTTTTT CTGCTGTGAG TCGACCCCAT 60
TCTATGACTA TCTACAATTG CGACCCGTTT GGTAAGTGTT TTGAGCTCGA GAATAGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0000329--C:fungal-type vacuole membrane
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032258--P:CVT pathway
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006497--P:protein lipidation
GO:0034497--P:protein localization to pre-autophagosomal structure
GO:0016050--P:vesicle organization

KEGG

ago:AGOS_ABR189W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001842	Ailuropoda melanoleuca	27.32	4.00e-27	113.00
IUUC-Apl-003390	Anas platyrhynchos	27.89	3.00e-27	114.00
IUUC-Bdi-014719	Brachypodium distachyon	27.96	3.00e-20	90.90
IUUC-Cel-018503	Caenorhabditis elegans	26.10	3.00e-26	110.00
IUUC-Cja-018829	Callithrix jacchus	27.04	1.00e-24	105.00
IUUC-Cfa-020858	Canis familiaris	27.32	5.00e-27	113.00
IUUC-Cho-024328	Choloepus hoffmanni	28.12	6.00e-27	112.00
IUUC-Csv-025920	Ciona savignyi	29.41	5.00e-29	119.00
IUUC-Dno-030057	Dasypus novemcinctus	28.17	2.00e-27	114.00
IUUC-Dor-030472	Dipodomys ordii	26.48	4.00e-23	100.00
IUUC-Ete-032362	Echinops telfairi	27.41	6.00e-24	102.00
IUUC-Eca-034362	Equus caballus	27.89	2.00e-27	114.00
IUUC-Fca-036230	Felis catus	27.89	3.00e-27	114.00
IUUC-Fal-036782	Ficedula albicollis	27.89	7.00e-27	112.00
IUUC-Gmo-039706	Gadus morhua	26.36	3.00e-24	103.00
IUUC-Gma-043639	Glycine max	23.66	1.00e-21	94.70
IUUC-Hsa-046782	Homo sapiens	27.32	1.00e-24	105.00
IUUC-Hvu-047374	Hordeum vulgare	27.60	2.00e-20	91.30
IUUC-Itr-048693	Ictidomys tridecemlineatus	27.04	1.00e-24	105.00
IUUC-Lch-050413	Latimeria chalumnae	27.56	5.00e-27	113.00
IUUC-Lpe-051251	Leersia perrieri	27.30	2.00e-19	87.80
IUUC-Mtr-057850	Medicago truncatula	26.07	4.00e-21	93.60
IUUC-Mga-059795	Meleagris gallopavo	27.89	3.00e-27	114.00
IUUC-Mmr-061096	Microcebus murinus	28.17	7.00e-27	112.00
IUUC-Mdo-061815	Monodelphis domestica	27.61	1.00e-26	112.00
IUUC-Mlu-068016	Myotis lucifugus	28.17	1.00e-27	115.00
IUUC-Oan-073084	Ornithorhynchus anatinus	27.89	2.00e-27	114.00
IUUC-Oba-075529	Oryza barthii	26.64	1.00e-18	86.70
IUUC-Ogl-077403	Oryza glaberrima	26.64	6.00e-19	86.70
IUUC-Ogu-078223	Oryza glumaepatula	26.64	5.00e-19	86.70
IUUC-Oin-079580	Oryza indica	26.64	6.00e-19	86.70
IUUC-Ome-081736	Oryza meridionalis	25.74	7.00e-18	83.20
IUUC-Oni-082413	Oryza nivara	26.64	5.00e-19	86.70
IUUC-Opu-083356	Oryza punctata	26.97	2.00e-19	88.20
IUUC-Oru-084972	Oryza rufipogon	26.64	6.00e-19	86.70
IUUC-Osa-085644	Oryza sativa	26.64	6.00e-19	86.70
IUUC-Oga-088894	Otolemur garnettii	27.32	6.00e-25	106.00
IUUC-Oar-089850	Ovis aries	27.35	1.00e-27	115.00
IUUC-Ptr-090456	Pan troglodytes	27.32	1.00e-24	105.00
IUUC-Psi-094095	Pelodiscus sinensis	27.89	1.00e-27	115.00
IUUC-Pfo-096987	Poecilia formosa	27.02	1.00e-28	118.00
IUUC-Pab-097754	Pongo abelii	27.32	2.00e-24	104.00
IUUC-Pop-099760	Populus trichocarpa	25.43	3.00e-27	114.00
IUUC-Pva-103047	Pteropus vampyrus	27.84	1.00e-26	112.00
IUUC-Sce-106431	Saccharomyces cerevisiae	44.18	2.00e-113	400.00
IUUC-Sha-106581	Sarcophilus harrisii	27.56	8.00e-27	112.00
IUUC-Stu-111954	Solanum tuberosum	24.27	4.00e-22	96.70
IUUC-Sbi-114057	Sorghum bicolor	26.97	8.00e-19	85.90
IUUC-Tgu-116951	Taeniopygia guttata	27.89	2.00e-27	114.00
IUUC-Tru-117889	Takifugu rubripes	27.64	2.00e-27	114.00
IUUC-Tca-121459	Theobroma cacao	22.44	2.00e-15	75.10
IUUC-Tae-124634	Triticum aestivum	28.39	6.00e-20	90.10
IUUC-Xma-133370	Xiphophorus maculatus	27.02	1.00e-28	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence