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Tag Content
UUCD2 ID IUUC-Bta-013310
UUCD1 version UUC-BoT-00014
Ensembl Protein ID ENSBTAP00000011540.4
UniProt Accession A1A4R8; CDC23_BOVIN
Genbank Protein ID AAI26844.1
Protein Name Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; Cyclosome subunit 8
Genbank Nucleotide ID BC126843
Gene Name CDC23; ANAPC8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000008759.4 ENSBTAT00000011540.4 ENSBTAP00000011540.4
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 99.13 0.00e+00 1185.00 IUUC-Hsa-045713
E3 adaptor/Cullin RING/APC_C/APC_C 32.73 1.00e-65 245.00 IUUC-Sce-106199
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MAASSSIVSV APTASSVPVL PSSCDFSNLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF 60
SLPALPLSEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY 120
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Protein Fasta Sequence


>IUUC-Bta-013310|E3,APC_C|Bos taurus
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Nucleotide Sequence
(Fasta)
GACAGGAAAA TGGCTGCGAG CTCCTCTATA GTGTCGGTGG CCCCGACGGC TTCCTCGGTG 60
CCGGTCCTGC CATCCAGCTG CGATTTCTCA AATTTGCGGG AAATTAAAAA GCAGCTGCTA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013310|E3,APC_C|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR007192--APC8
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF04049--ANAPC8
PF13414--TPR_11
PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0051301--P:cell division
GO:0007080--P:mitotic metaphase plate congression
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG bta:512651
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000540 Aegilops tauschii 48.76 1.00e-103 370.00
IUUC-Aml-002139 Ailuropoda melanoleuca 99.48 0.00e+00 1154.00
IUUC-Atr-002658 Amborella trichopoda 48.03 1.00e-122 433.00
IUUC-Apl-004020 Anas platyrhynchos 95.78 0.00e+00 1040.00
IUUC-Aca-005101 Anolis carolinensis 92.15 0.00e+00 1073.00
IUUC-Aly-006437 Arabidopsis lyrata 46.87 1.00e-116 413.00
IUUC-Ath-006712 Arabidopsis thaliana 46.87 8.00e-115 407.00
IUUC-Ago-007953 Ashbya gossypii 34.32 1.00e-69 257.00
IUUC-Acl-008166 Aspergillus clavatus 36.33 3.00e-89 322.00
IUUC-Afl-008420 Aspergillus flavus 36.04 6.00e-91 328.00
IUUC-Afu-009028 Aspergillus fumigatus 36.56 2.00e-88 320.00
IUUC-Ani-009390 Aspergillus nidulans 35.97 9.00e-92 331.00
IUUC-Ang-009704 Aspergillus niger 37.57 1.00e-89 323.00
IUUC-Aor-009990 Aspergillus oryzae 36.22 5.00e-91 328.00
IUUC-Ate-010510 Aspergillus terreus 35.94 1.00e-89 323.00
IUUC-Ame-011724 Astyanax mexicanus 68.27 0.00e+00 786.00
IUUC-Bgr-012007 Blumeria graminis 35.45 7.00e-80 291.00
IUUC-Bci-013833 Botrytis cinerea 37.27 7.00e-84 305.00
IUUC-Bdi-014957 Brachypodium distachyon 46.61 1.00e-117 416.00
IUUC-Bol-016105 Brassica oleracea 47.04 1.00e-119 423.00
IUUC-Bra-017168 Brassica rapa 46.32 9.00e-110 390.00
IUUC-Cel-018142 Caenorhabditis elegans 37.08 4.00e-81 295.00
IUUC-Cja-019339 Callithrix jacchus 97.75 0.00e+00 1149.00
IUUC-Cfa-020690 Canis familiaris 99.48 0.00e+00 1154.00
IUUC-Cpo-021859 Cavia porcellus 96.48 0.00e+00 1171.00
IUUC-Cre-022698 Chlamydomonas reinhardtii 41.83 9.00e-76 277.00
IUUC-Csa-024176 Chlorocebus sabaeus 98.10 0.00e+00 1185.00
IUUC-Cho-024903 Choloepus hoffmanni 97.44 0.00e+00 983.00
IUUC-Cin-025468 Ciona intestinalis 45.57 6.00e-129 454.00
IUUC-Csv-026223 Ciona savignyi 44.37 1.00e-137 483.00
IUUC-Cgl-026453 Colletotrichum gloeosporioides 36.90 7.00e-82 298.00
IUUC-Cne-027038 Cryptococcus neoformans 36.19 3.00e-81 296.00
IUUC-Cme-027161 Cyanidioschyzon merolae 37.24 5.00e-72 265.00
IUUC-Dre-027972 Danio rerio 80.49 0.00e+00 936.00
IUUC-Dno-029164 Dasypus novemcinctus 98.62 0.00e+00 1154.00
IUUC-Dor-030344 Dipodomys ordii 87.89 0.00e+00 1003.00
IUUC-Dse-031277 Dothistroma septosporum 43.83 5.00e-54 204.00
IUUC-Dme-031895 Drosophila melanogaster 49.17 8.00e-145 507.00
IUUC-Ete-032942 Echinops telfairi 94.81 0.00e+00 1021.00
IUUC-Eca-034355 Equus caballus 98.95 0.00e+00 1150.00
IUUC-Eeu-035313 Erinaceus europaeus 96.07 3.00e-179 621.00
IUUC-Fca-035799 Felis catus 99.30 0.00e+00 1149.00
IUUC-Fal-037373 Ficedula albicollis 93.19 0.00e+00 1076.00
IUUC-Fox-037722 Fusarium oxysporum 34.46 4.00e-78 285.00
IUUC-Fso-038295 Fusarium solani 34.10 3.00e-72 266.00
IUUC-Gmo-039241 Gadus morhua 79.83 0.00e+00 929.00
IUUC-Ggr-039994 Gaeumannomyces graminis 41.31 3.00e-74 273.00
IUUC-Gga-040280 Gallus gallus 92.70 0.00e+00 1070.00
IUUC-Gac-042265 Gasterosteus aculeatus 80.56 0.00e+00 949.00
IUUC-Gma-043161 Glycine max 45.67 6.00e-116 411.00
IUUC-Ggo-044898 Gorilla gorilla 90.71 0.00e+00 1046.00
IUUC-Hsa-045713 Homo sapiens 98.44 0.00e+00 1152.00
IUUC-Hvu-047296 Hordeum vulgare 51.40 1.00e-103 370.00
IUUC-Itr-048205 Ictidomys tridecemlineatus 98.27 0.00e+00 1150.00
IUUC-Kpa-049344 Komagataella pastoris 38.51 3.00e-72 265.00
IUUC-Lch-049878 Latimeria chalumnae 86.01 0.00e+00 971.00
IUUC-Lpe-050917 Leersia perrieri 51.76 2.00e-118 419.00
IUUC-Loc-052893 Lepisosteus oculatus 59.62 4.00e-180 624.00
IUUC-Lma-053031 Leptosphaeria maculans 37.37 2.00e-87 316.00
IUUC-Laf-053888 Loxodonta africana 98.78 0.00e+00 1149.00
IUUC-Mcc-055617 Macaca mulatta 93.25 0.00e+00 1079.00
IUUC-Meu-056377 Macropus eugenii 91.97 0.00e+00 1052.00
IUUC-Mor-057030 Magnaporthe oryzae 36.06 4.00e-79 289.00
IUUC-Mpo-057558 Magnaporthe poae 40.88 1.00e-74 273.00
IUUC-Mtr-058778 Medicago truncatula 46.17 1.00e-116 413.00
IUUC-Mla-058861 Melampsora laricipopulina 36.40 9.00e-72 264.00
IUUC-Mga-059809 Meleagris gallopavo 91.61 0.00e+00 1044.00
IUUC-Mvi-060381 Microbotryum violaceum 37.88 6.00e-80 291.00
IUUC-Mmr-060669 Microcebus murinus 93.60 0.00e+00 1077.00
IUUC-Mdo-062293 Monodelphis domestica 95.64 0.00e+00 1106.00
IUUC-Mmu-064261 Mus musculus 97.38 0.00e+00 1130.00
IUUC-Mac-065082 Musa acuminata 51.06 4.00e-119 421.00
IUUC-Mpu-066465 Mustela putorius furo 86.28 0.00e+00 981.00
IUUC-Mlu-067770 Myotis lucifugus 98.27 0.00e+00 1186.00
IUUC-Nfi-068311 Neosartorya fischeri 40.89 3.00e-86 312.00
IUUC-Ncr-068653 Neurospora crassa 37.45 5.00e-81 295.00
IUUC-Nle-069036 Nomascus leucogenys 98.27 0.00e+00 1153.00
IUUC-Opr-070229 Ochotona princeps 95.57 0.00e+00 806.00
IUUC-Ont-072218 Oreochromis niloticus 80.80 0.00e+00 967.00
IUUC-Oan-073467 Ornithorhynchus anatinus 86.15 2.00e-29 120.00
IUUC-Ocu-073869 Oryctolagus cuniculus 98.10 0.00e+00 1151.00
IUUC-Oba-075863 Oryza barthii 50.35 2.00e-115 409.00
IUUC-Obr-076071 Oryza brachyantha 51.06 2.00e-116 412.00
IUUC-Ogl-077026 Oryza glaberrima 50.90 2.00e-108 385.00
IUUC-Ogu-078601 Oryza glumaepatula 45.42 8.00e-116 410.00
IUUC-Oin-079443 Oryza indica 50.35 3.00e-115 409.00
IUUC-Olo-080836 Oryza longistaminata 51.23 1.00e-112 400.00
IUUC-Ome-081640 Oryza meridionalis 46.30 1.00e-113 403.00
IUUC-Oni-083014 Oryza nivara 50.35 3.00e-115 409.00
IUUC-Opu-083788 Oryza punctata 50.59 2.00e-115 409.00
IUUC-Oru-085205 Oryza rufipogon 50.35 3.00e-115 409.00
IUUC-Osa-085809 Oryza sativa 50.35 2.00e-115 409.00
IUUC-Ola-087272 Oryzias latipes 79.20 0.00e+00 926.00
IUUC-Olu-087775 Ostreococcus lucimarinus 43.63 7.00e-102 364.00
IUUC-Oga-088234 Otolemur garnettii 99.13 0.00e+00 1150.00
IUUC-Oar-089533 Ovis aries 100.00 0.00e+00 1194.00
IUUC-Ptr-090956 Pan troglodytes 98.44 0.00e+00 1152.00
IUUC-Pan-091781 Papio anubis 98.27 0.00e+00 1152.00
IUUC-Psi-093533 Pelodiscus sinensis 93.04 0.00e+00 1112.00
IUUC-Pma-094153 Petromyzon marinus 71.28 0.00e+00 832.00
IUUC-Pno-095099 Phaeosphaeria nodorum 36.49 5.00e-77 282.00
IUUC-Ppa-095917 Physcomitrella patens 49.36 2.00e-123 436.00
IUUC-Pfo-096378 Poecilia formosa 80.45 0.00e+00 961.00
IUUC-Pab-098457 Pongo abelii 98.27 0.00e+00 1186.00
IUUC-Pop-099359 Populus trichocarpa 45.88 2.00e-114 405.00
IUUC-Pca-100406 Procavia capensis 98.84 3.00e-156 545.00
IUUC-Ppe-101636 Prunus persica 46.08 3.00e-116 412.00
IUUC-Pva-103102 Pteropus vampyrus 97.82 0.00e+00 1177.00
IUUC-Pgr-103324 Puccinia graminis 36.33 2.00e-83 303.00
IUUC-Ptt-103755 Puccinia triticina 39.49 3.00e-79 289.00
IUUC-Pte-104290 Pyrenophora teres 37.88 4.00e-89 322.00
IUUC-Pyt-104739 Pyrenophora triticirepentis 37.55 4.00e-89 322.00
IUUC-Rno-105205 Rattus norvegicus 97.61 0.00e+00 1076.00
IUUC-Sce-106199 Saccharomyces cerevisiae 34.83 3.00e-59 223.00
IUUC-Sha-107218 Sarcophilus harrisii 95.64 0.00e+00 1104.00
IUUC-Sja-107667 Schizosaccharomyces japonicus 38.60 1.00e-98 353.00
IUUC-Spo-108380 Schizosaccharomyces pombe 42.09 2.00e-98 353.00
IUUC-Smo-109350 Selaginella moellendorffii 47.73 2.00e-118 419.00
IUUC-Sit-110418 Setaria italica 46.20 9.00e-120 424.00
IUUC-Sly-111724 Solanum lycopersicum 47.00 1.00e-115 410.00
IUUC-Stu-112247 Solanum tuberosum 49.75 4.00e-106 378.00
IUUC-Sar-113502 Sorex araneus 86.33 0.00e+00 985.00
IUUC-Sbi-113784 Sorghum bicolor 42.86 3.00e-121 428.00
IUUC-Sre-115116 Sporisorium reilianum 33.41 2.00e-57 217.00
IUUC-Ssc-115914 Sus scrofa 99.48 0.00e+00 1192.00
IUUC-Tgu-117390 Taeniopygia guttata 93.19 0.00e+00 1072.00
IUUC-Tru-118703 Takifugu rubripes 78.66 0.00e+00 944.00
IUUC-Tsy-118972 Tarsius syrichta 95.11 0.00e+00 766.00
IUUC-Tni-119710 Tetraodon nigroviridis 79.76 0.00e+00 935.00
IUUC-Tca-121327 Theobroma cacao 47.62 1.00e-115 410.00
IUUC-Tre-121974 Trichoderma reesei 37.10 7.00e-73 268.00
IUUC-Tvi-122260 Trichoderma virens 34.47 2.00e-72 266.00
IUUC-Tae-124866 Triticum aestivum 48.08 5.00e-69 254.00
IUUC-Tme-127161 Tuber melanosporum 37.94 7.00e-101 360.00
IUUC-Tbe-127932 Tupaia belangeri 97.80 0.00e+00 887.00
IUUC-Ttr-129091 Tursiops truncatus 99.83 0.00e+00 1190.00
IUUC-Uma-129376 Ustilago maydis 34.46 3.00e-58 219.00
IUUC-Vda-129821 Verticillium dahliae 33.22 2.00e-76 280.00
IUUC-Vpa-130644 Vicugna pacos 99.48 0.00e+00 1188.00
IUUC-Vvi-130971 Vitis vinifera 46.88 8.00e-116 410.00
IUUC-Xtr-132050 Xenopus tropicalis 89.97 0.00e+00 1060.00
IUUC-Xma-133078 Xiphophorus maculatus 80.28 0.00e+00 941.00
IUUC-Yli-134413 Yarrowia lipolytica 38.76 2.00e-85 309.00
IUUC-Zma-135224 Zea mays 46.00 1.00e-119 423.00
Created Date 25-Jun-2017

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