iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-09	37.7	291	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e++ +g + lpC+H+fh++Cl  w       +++++CP+Cr
   Q: 291  CIICREEMVTGAKRLPCNHIFHTSCLRSW------FQRQQTCPTCR 330
           ********99999****************......**********8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV 60
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGAGG TGATCTGGGA AGATATATAT CTGTTTTCCG CATTGTTTTT TTAGAGAAGC 60
GCTTTACTTT TTACTGTGTC GTAGCTGTCC CTGGAATGAG GCGCTTACAC AGTTCATGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR032832--E3_lig_synoviolin/Hrd1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0016021--C:integral component of membrane
GO:0005654--C:nucleoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000344	Aegilops tauschii	37.28	6.00e-52	198.00
IUUC-Aml-001539	Ailuropoda melanoleuca	99.70	0.00e+00	706.00
IUUC-Atr-002892	Amborella trichopoda	44.48	9.00e-78	284.00
IUUC-Apl-004003	Anas platyrhynchos	95.76	2.00e-65	240.00
IUUC-Aca-004799	Anolis carolinensis	97.81	0.00e+00	661.00
IUUC-Aly-006352	Arabidopsis lyrata	44.41	5.00e-75	275.00
IUUC-Ath-006773	Arabidopsis thaliana	44.41	8.00e-75	274.00
IUUC-Ago-007894	Ashbya gossypii	25.16	3.00e-18	87.00
IUUC-Acl-008041	Aspergillus clavatus	30.53	1.00e-55	211.00
IUUC-Afl-008427	Aspergillus flavus	31.28	2.00e-50	193.00
IUUC-Afu-009023	Aspergillus fumigatus	31.11	3.00e-56	213.00
IUUC-Ani-009133	Aspergillus nidulans	31.50	1.00e-58	221.00
IUUC-Ang-009612	Aspergillus niger	34.30	9.00e-56	211.00
IUUC-Aor-010045	Aspergillus oryzae	30.94	9.00e-57	215.00
IUUC-Ate-010533	Aspergillus terreus	31.83	2.00e-56	213.00
IUUC-Ame-011083	Astyanax mexicanus	93.38	0.00e+00	629.00
IUUC-Bgr-012122	Blumeria graminis	28.54	2.00e-48	187.00
IUUC-Bta-013375	Bos taurus	100.00	0.00e+00	702.00
IUUC-Bci-013675	Botrytis cinerea	37.25	2.00e-23	104.00
IUUC-Bdi-015070	Brachypodium distachyon	42.69	5.00e-69	254.00
IUUC-Bol-015674	Brassica oleracea	43.50	7.00e-75	274.00
IUUC-Bra-017516	Brassica rapa	43.20	5.00e-73	268.00
IUUC-Cel-018422	Caenorhabditis elegans	57.70	2.00e-117	416.00
IUUC-Cja-019779	Callithrix jacchus	97.35	0.00e+00	672.00
IUUC-Cfa-020189	Canis familiaris	100.00	0.00e+00	702.00
IUUC-Cpo-022209	Cavia porcellus	99.70	0.00e+00	702.00
IUUC-Cre-022743	Chlamydomonas reinhardtii	39.24	2.00e-64	239.00
IUUC-Csa-023571	Chlorocebus sabaeus	100.00	0.00e+00	701.00
IUUC-Cho-024889	Choloepus hoffmanni	88.43	9.00e-178	616.00
IUUC-Csv-026160	Ciona savignyi	60.23	7.00e-122	431.00
IUUC-Cne-027002	Cryptococcus neoformans	40.62	3.00e-76	280.00
IUUC-Cme-027285	Cyanidioschyzon merolae	35.95	4.00e-51	196.00
IUUC-Dre-027999	Danio rerio	93.06	0.00e+00	636.00
IUUC-Dno-029250	Dasypus novemcinctus	99.70	0.00e+00	706.00
IUUC-Dor-030718	Dipodomys ordii	95.27	0.00e+00	669.00
IUUC-Dse-031498	Dothistroma septosporum	34.76	2.00e-27	117.00
IUUC-Dme-031969	Drosophila melanogaster	66.06	1.00e-142	500.00
IUUC-Ete-032592	Echinops telfairi	98.46	9.00e-32	130.00
IUUC-Eca-033258	Equus caballus	100.00	0.00e+00	706.00
IUUC-Fca-035980	Felis catus	99.70	0.00e+00	701.00
IUUC-Fal-037554	Ficedula albicollis	68.86	2.00e-99	355.00
IUUC-Fox-037902	Fusarium oxysporum	31.22	3.00e-52	199.00
IUUC-Fso-038418	Fusarium solani	30.71	2.00e-48	187.00
IUUC-Gmo-039288	Gadus morhua	90.55	0.00e+00	627.00
IUUC-Ggr-040076	Gaeumannomyces graminis	31.68	1.00e-50	194.00
IUUC-Gga-040347	Gallus gallus	92.31	3.00e-75	273.00
IUUC-Gac-042347	Gasterosteus aculeatus	92.43	0.00e+00	627.00
IUUC-Gma-044123	Glycine max	43.90	1.00e-74	273.00
IUUC-Ggo-044858	Gorilla gorilla	100.00	0.00e+00	705.00
IUUC-Hsa-046412	Homo sapiens	100.00	0.00e+00	706.00
IUUC-Hvu-047279	Hordeum vulgare	42.99	1.00e-69	256.00
IUUC-Itr-048924	Ictidomys tridecemlineatus	100.00	0.00e+00	701.00
IUUC-Kpa-049117	Komagataella pastoris	29.19	4.00e-31	129.00
IUUC-Lch-049533	Latimeria chalumnae	49.14	4.00e-73	269.00
IUUC-Lpe-051229	Leersia perrieri	32.38	2.00e-34	139.00
IUUC-Loc-052843	Lepisosteus oculatus	93.06	2.00e-121	427.00
IUUC-Lma-052997	Leptosphaeria maculans	33.07	2.00e-60	226.00
IUUC-Laf-053482	Loxodonta africana	100.00	0.00e+00	699.00
IUUC-Mcc-055075	Macaca mulatta	100.00	0.00e+00	707.00
IUUC-Meu-056683	Macropus eugenii	97.72	6.00e-151	527.00
IUUC-Mor-057082	Magnaporthe oryzae	31.34	7.00e-55	208.00
IUUC-Mpo-057573	Magnaporthe poae	30.64	2.00e-50	194.00
IUUC-Mtr-058601	Medicago truncatula	44.71	1.00e-79	290.00
IUUC-Mla-059168	Melampsora laricipopulina	40.95	6.00e-79	288.00
IUUC-Mga-059510	Meleagris gallopavo	98.80	6.00e-47	180.00
IUUC-Mvi-060515	Microbotryum violaceum	39.57	6.00e-66	245.00
IUUC-Mmr-060922	Microcebus murinus	100.00	0.00e+00	703.00
IUUC-Mdo-062491	Monodelphis domestica	98.52	0.00e+00	678.00
IUUC-Mmu-063770	Mus musculus	100.00	0.00e+00	702.00
IUUC-Mac-064789	Musa acuminata	43.50	9.00e-79	287.00
IUUC-Mpu-066107	Mustela putorius furo	99.41	0.00e+00	707.00
IUUC-Mlu-067918	Myotis lucifugus	97.75	0.00e+00	637.00
IUUC-Nfi-068389	Neosartorya fischeri	30.85	1.00e-55	211.00
IUUC-Ncr-068742	Neurospora crassa	32.08	5.00e-49	189.00
IUUC-Nle-069139	Nomascus leucogenys	100.00	0.00e+00	706.00
IUUC-Opr-070898	Ochotona princeps	99.52	3.00e-125	442.00
IUUC-Ont-071991	Oreochromis niloticus	91.08	0.00e+00	640.00
IUUC-Ocu-074065	Oryctolagus cuniculus	99.11	0.00e+00	698.00
IUUC-Oba-075221	Oryza barthii	41.49	1.00e-67	250.00
IUUC-Obr-076914	Oryza brachyantha	42.90	5.00e-64	238.00
IUUC-Ogu-078124	Oryza glumaepatula	41.49	1.00e-67	250.00
IUUC-Oin-080013	Oryza indica	39.82	4.00e-64	238.00
IUUC-Olo-080247	Oryza longistaminata	39.88	2.00e-60	226.00
IUUC-Ome-081769	Oryza meridionalis	42.09	3.00e-70	259.00
IUUC-Oni-082946	Oryza nivara	41.49	1.00e-67	250.00
IUUC-Opu-083268	Oryza punctata	36.13	6.00e-51	195.00
IUUC-Oru-085114	Oryza rufipogon	41.49	1.00e-67	250.00
IUUC-Osa-085829	Oryza sativa	42.09	2.00e-70	259.00
IUUC-Ola-087449	Oryzias latipes	92.70	0.00e+00	627.00
IUUC-Olu-087894	Ostreococcus lucimarinus	42.04	1.00e-73	270.00
IUUC-Oga-089036	Otolemur garnettii	100.00	0.00e+00	701.00
IUUC-Oar-089715	Ovis aries	100.00	0.00e+00	706.00
IUUC-Ptr-091000	Pan troglodytes	100.00	0.00e+00	700.00
IUUC-Pan-092187	Papio anubis	100.00	0.00e+00	706.00
IUUC-Psi-093377	Pelodiscus sinensis	97.04	0.00e+00	627.00
IUUC-Pma-094759	Petromyzon marinus	92.25	2.00e-79	289.00
IUUC-Pno-094883	Phaeosphaeria nodorum	32.62	9.00e-58	218.00
IUUC-Ppa-095684	Physcomitrella patens	44.51	4.00e-71	262.00
IUUC-Pfo-096861	Poecilia formosa	90.21	0.00e+00	634.00
IUUC-Pab-098030	Pongo abelii	100.00	0.00e+00	706.00
IUUC-Pop-099245	Populus trichocarpa	42.65	2.00e-80	293.00
IUUC-Pca-100191	Procavia capensis	96.49	0.00e+00	678.00
IUUC-Ppe-101829	Prunus persica	43.50	2.00e-79	289.00
IUUC-Pva-102689	Pteropus vampyrus	99.70	0.00e+00	707.00
IUUC-Pgr-103286	Puccinia graminis	37.82	2.00e-73	270.00
IUUC-Ptt-103919	Puccinia triticina	38.27	6.00e-72	265.00
IUUC-Pte-104372	Pyrenophora teres	33.50	1.00e-63	238.00
IUUC-Pyt-104456	Pyrenophora triticirepentis	33.25	1.00e-61	231.00
IUUC-Sce-106348	Saccharomyces cerevisiae	26.25	2.00e-24	107.00
IUUC-Sha-107300	Sarcophilus harrisii	97.01	6.00e-154	537.00
IUUC-Sja-107685	Schizosaccharomyces japonicus	27.79	5.00e-39	155.00
IUUC-Spo-108308	Schizosaccharomyces pombe	29.77	9.00e-39	155.00
IUUC-Ssl-108558	Sclerotinia sclerotiorum	37.25	1.00e-23	105.00
IUUC-Smo-109223	Selaginella moellendorffii	46.69	1.00e-75	276.00
IUUC-Sit-110276	Setaria italica	43.28	8.00e-71	261.00
IUUC-Sly-111819	Solanum lycopersicum	44.82	4.00e-72	265.00
IUUC-Stu-112048	Solanum tuberosum	44.76	1.00e-75	277.00
IUUC-Sbi-114027	Sorghum bicolor	42.39	1.00e-77	283.00
IUUC-Sre-115212	Sporisorium reilianum	36.76	4.00e-63	236.00
IUUC-Ssc-116323	Sus scrofa	99.70	0.00e+00	698.00
IUUC-Tgu-117156	Taeniopygia guttata	94.81	1.00e-39	153.00
IUUC-Tru-118045	Takifugu rubripes	89.85	0.00e+00	635.00
IUUC-Tsy-118823	Tarsius syrichta	86.52	1.00e-159	555.00
IUUC-Tni-120106	Tetraodon nigroviridis	90.51	1.00e-129	456.00
IUUC-Tca-121462	Theobroma cacao	45.51	3.00e-79	289.00
IUUC-Tre-122204	Trichoderma reesei	38.73	1.00e-26	115.00
IUUC-Tvi-122550	Trichoderma virens	30.77	2.00e-50	194.00
IUUC-Tae-125239	Triticum aestivum	43.28	7.00e-72	264.00
IUUC-Tur-126538	Triticum urartu	38.54	4.00e-50	192.00
IUUC-Tme-127197	Tuber melanosporum	40.73	2.00e-67	251.00
IUUC-Tbe-127385	Tupaia belangeri	90.13	0.00e+00	634.00
IUUC-Ttr-128795	Tursiops truncatus	100.00	0.00e+00	704.00
IUUC-Uma-129401	Ustilago maydis	35.31	2.00e-52	201.00
IUUC-Vda-129968	Verticillium dahliae	29.35	7.00e-42	165.00
IUUC-Vvi-130944	Vitis vinifera	46.22	3.00e-79	289.00
IUUC-Xtr-131884	Xenopus tropicalis	94.05	0.00e+00	652.00
IUUC-Xma-133488	Xiphophorus maculatus	90.50	0.00e+00	640.00
IUUC-Yli-134552	Yarrowia lipolytica	25.35	1.00e-35	144.00
IUUC-Zma-135530	Zea mays	42.25	3.00e-67	249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence