• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Sce-106441
Ensembl Protein ID YOR124C
UniProt Accession Q01476; D6W2I2; Q99357; UBP2_YEAST
Genbank Protein ID AAA35190.1; CAA64043.1; CAA62120.1; CAA99323.1; DAA10898.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 2; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Genbank Nucleotide ID M94916; X94335; X90518; Z75032; BK006948
Gene Name UBP2; YOR124C; O3281; YOR3281C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOR124C YOR124C YOR124C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/UCH UCH 15933713; 17028178
DUB/USP USP 15933713; 17028178
Classification
Family E-value Score Start End
DUB/UCH 3.60e-143 475.5 433 1272
DUB/USP 1.10e-51 174.5 736 1257
Active Site
Position(s) Description Evidence
745 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1209 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/UCH

   S: 2    nsqvkewleLesdPglftllvedfgvkrdi..qveelysLdpenlgly...........................qepvegllllFkine.......... 62
    ns+ + +L+++P++++l+v++++++rdi ++e+l+sLdpen+gly qe++e++ll+Fkin+
   Q: 433 NSNEQTHSPLDAEPHFINLSVSHYYTDRDIirNYESLSSLDPENIGLYfdaltyianrkgayqliaycgkqdiigQEALENALLMFKINPkecniselne 532
    55667777******************************************************************************************** PP
   S: 63 .......kressrksqvtsndl.........................................evvdediiktif......................... 89
    k+e+s+ksqvtsn+l e+vdediikt++
   Q: 533 atllsiyKYETSNKSQVTSNHLtnlknalrllakytksdklkfyvdhepyralsqaydtlsidESVDEDIIKTAYsvkindspglkldcdralytiaisk 632
    **************************************************************************************************** PP
   S: 90 ....................................................fakq............................................ 93
    ++++
   Q: 633 rsldlfnflteecpqfsnyygpekldyqealkllqvnenasdetilkifkqkWFDEnvyepdqflilraaltkisiernstlitnflltgtidpnslppe 732
    *******9999999999999999999999999999999999999999999998888******************************************** PP
   S: 94 .......vigNsCat................................................................yAllsvllnc........... 111
    +igN+C++ yA+++++++c
   Q: 733 nwptginNIGNTCYLnsllqyyfsiaplrryvleyqktvenfndhlsnsghirriggreisrgeversiqfiyqlrnlfYAMVHTRERCvtpskelayla 832
    **************************************************************************************************** PP
   S: 112 ..................................................edkl.ldlGttlsrlk.estkaespenk.....................a 138
    ed+l +d+Gt+++r+k es++ae++en+ a
   Q: 833 fapsnvevefevegnkvvdqtgvlsdskkettddafttkikdtslidlemEDGLnGDVGTDANRKKnESNDAEVSENEdttgltsptrvakissdqlenA 932
    **************************************************************************************************** PP
   S: 139 lalgnqq.vlecihnslariesrseperqdedneqy..tkeaf.......................hfvsyvningr....................... 189
    l++g+qq v+eci+n+l++ies+sep+r+dedneqy +k++f ++++++ni+++
   Q: 933 LEMGRQQdVTECIGNVLFQIESGSEPIRYDEDNEQYdlVKQLFygttkqsivplsatnkvrtkverFLSLLINIGDHpkdiydafdsyfkdeyltmeeyg 1032
    **************************************************************************************************** PP
   S: 190 ......................lyeldglkpf......................Pldlgkkketeelkdklkvv.................r.aflerik 227
    +y++++l+pf Pl+l+kkketee+k+klkv+ + afle+ik
   Q: 1033 dvirtvavttfptilqvqiqrvYYDRERLMPFksieplpfkeviymdryadtenPLLLAKKKETEEMKQKLKVMknrqrellsrddsgltrKdAFLESIK 1132
    *****************************************************************************************96379****** PP
   S: 228 llesdeirfnllaivadrrviktlrlnvlkidkeLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetis 327
    llesd+i++++l+i+a+++viktlr+nv++id+eL+kL++di+s+eeki++q+dd+ke+++++++++i+R+e+++++++i+ikd++r+gi+rk+++etis
   Q: 1133 LLESDTIKKTPLKIEAANDVIKTLRNNVQNIDNELMKLYNDINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYGHYWIYIKDRNRNGIWRKYNDETIS 1232
    **************************************************************************************************** PP
   S: 328 evre...fgvnegrlakq.....rkqgrekkirplkrkrk 359
    ev+e f++neg++a++ +kqg+e++i+plkr++k
   Q: 1233 EVQEeevFNFNEGNTATPyflvyVKQGQEGDIEPLKRILK 1272
    *************************************987 PP
   


   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp....................kepkgellkslqklfeelwkskkkavsprellkalkke 80
    tG++N+gNtCY+NS+LQ ++i +lr+++le +++++++ n+ e++ +++ +l++lf ++++++++ v+p++ l+ l+ +
   Q: 736 TGINNIGNTCYLNSLLQYYFSIAPLRRYVLE-YQKTVENFNDhlsnsghirriggreisrgeVERSIQFIYQLRNLFYAMVHTRERCVTPSKELAYLAFA 834
    7******************************.88888888878888888888888888888888888**************9999988888844444333 PP
   S: 81 aeefs...gyeqqDaqEflaflldqleeelkk..........................eknkpkeeeeeedkselsde...................... 129
    ++++ + e + + + + +l d+ +e+ + +n +k+e+++++ se +
   Q: 835 PSNVEvefEVEGNKVVDQTGVLSDSKKETTDDafttkikdtslidlemedglngdvgtDANRKKNESNDAEVSE---Nedttgltsptrvakissdqlen 931
    33333224333444444444444444444422222333334444444466666665543444444444444333...145599999************** PP
   S: 130 ...........................aeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkkeslqdcLesftkeeele 201
    ++++++++ +l+++lF g++k++i+ l+ n+ ++ e fl+l +++ ++ + ++ d+++s++k e l+
   Q: 932 alemgrqqdvtecignvlfqiesgsepIRYDEDNEQYDLVKQLFYGTTKQSIVPLSATNKVrTKVERFLSLLINIGDHPK----DIYDAFDSYFKDEYLT 1027
    **********************999998899999999****************988777776**************9996....8**************9 PP
   S: 202 genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................peekqke........ 274
    +++ ++ +++ ++++P +L ++++R+ +++e+ ++ k + + f++ + ++++ + + +
   Q: 1028 M---------EEYGDVIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRYADTenplllakkketeemkqklK-----Vmknrqrel 1113
    4.........5677899**************************************99*****999978888877776655555550.....055555555 PP
   S: 275 ............................................................................kkkYeLiavvvHsGslssGHYvay 298
    ++ Y+L++v +H G++s GHY+ y
   Q: 1114 lsrddsgltrkdaflesikllesdtikktplkieaandviktlrnnvqnidnelmklyndinsleekishqfddfkEYGYSLFSVFIHRGEASYGHYWIY 1213
    6666666666666666666666666666777777777777777777777888888888888888888899999999************************ PP
   S: 299 vknekgk..WllfdDskVtevkeeevleetg...staYvlfYkr 337
    +k+++++ W +++D++++ev+eeev ++++ +t+Y l+Y +
   Q: 1214 IKDRNRNgiWRKYNDETISEVQEEEVFNFNEgntATPYFLVYVK 1257
    ***888899*******************999***********87 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion.
Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion.
Protein Sequence
(Fasta)
MPNEDNELQK AIENHHNQLL NQDKENADRN GSVIEDLPLY GTSINQQSTP GDVDDGKHLL 60
YPDIATNLPL KTSDRLLDDI LCDTIFLNST DPKVMQKGLQ SRGILKESML SYSTFRSSIR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sce-106441|DUB,UCH;DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCGAACG AAGATAATGA ACTTCAAAAA GCAATTGAGA ACCATCATAA TCAACTACTA 60
AACCAGGATA AAGAAAATGC TGACAGAAAT GGGTCTGTTA TAGAAGACCT CCCATTATAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106441|DUB,UCH;DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR025305--UCH_repeat_domain
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF13446--RPT
PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010992--P:ubiquitin homeostasis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG sce:YOR124C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007865 Ashbya gossypii 45.76 0.00e+00 702.00
IUUC-Acl-008164 Aspergillus clavatus 30.26 6.00e-91 327.00
IUUC-Afl-008717 Aspergillus flavus 28.88 3.00e-79 288.00
IUUC-Afu-008871 Aspergillus fumigatus 29.56 1.00e-88 319.00
IUUC-Ani-009503 Aspergillus nidulans 38.73 1.00e-52 200.00
IUUC-Ang-009577 Aspergillus niger 31.15 3.00e-93 334.00
IUUC-Aor-009928 Aspergillus oryzae 27.46 1.00e-56 213.00
IUUC-Ate-010275 Aspergillus terreus 30.19 3.00e-93 334.00
IUUC-Ame-011910 Astyanax mexicanus 32.65 2.00e-10 60.50
IUUC-Bgr-011993 Blumeria graminis 25.86 7.00e-59 220.00
IUUC-Bci-013999 Botrytis cinerea 33.92 2.00e-45 176.00
IUUC-Cel-018346 Caenorhabditis elegans 27.35 3.00e-09 55.80
IUUC-Cho-024343 Choloepus hoffmanni 39.39 3.00e-09 55.50
IUUC-Cin-025302 Ciona intestinalis 36.17 1.00e-09 56.20
IUUC-Cgl-026575 Colletotrichum gloeosporioides 22.93 3.00e-28 119.00
IUUC-Cne-026803 Cryptococcus neoformans 25.56 6.00e-15 75.10
IUUC-Cme-027167 Cyanidioschyzon merolae 23.62 2.00e-14 73.20
IUUC-Dno-029559 Dasypus novemcinctus 32.46 4.00e-10 58.20
IUUC-Dor-030955 Dipodomys ordii 30.70 1.00e-09 56.60
IUUC-Dse-031290 Dothistroma septosporum 24.86 3.00e-45 175.00
IUUC-Ete-032828 Echinops telfairi 30.26 6.00e-11 61.20
IUUC-Fox-037752 Fusarium oxysporum 25.83 3.00e-19 89.40
IUUC-Fso-038114 Fusarium solani 22.47 6.00e-17 81.60
IUUC-Gmo-039593 Gadus morhua 35.85 5.00e-11 61.60
IUUC-Ggr-039843 Gaeumannomyces graminis 28.43 2.00e-10 60.10
IUUC-Itr-048276 Ictidomys tridecemlineatus 31.58 1.00e-10 59.70
IUUC-Kpa-049349 Komagataella pastoris 36.93 0.00e+00 638.00
IUUC-Lma-053078 Leptosphaeria maculans 22.63 1.00e-46 180.00
IUUC-Meu-056416 Macropus eugenii 33.33 1.00e-11 63.50
IUUC-Mor-057281 Magnaporthe oryzae 23.45 7.00e-13 68.20
IUUC-Mpo-057451 Magnaporthe poae 23.53 2.00e-12 66.60
IUUC-Mla-058944 Melampsora laricipopulina 33.16 2.00e-44 172.00
IUUC-Mdo-061955 Monodelphis domestica 26.22 4.00e-13 69.30
IUUC-Mlu-067487 Myotis lucifugus 31.58 6.00e-11 61.20
IUUC-Nfi-068458 Neosartorya fischeri 29.79 1.00e-93 336.00
IUUC-Ncr-068739 Neurospora crassa 24.92 5.00e-24 105.00
IUUC-Opr-070214 Ochotona princeps 39.39 4.00e-09 55.50
IUUC-Ptr-091630 Pan troglodytes 32.46 7.00e-11 60.80
IUUC-Pan-092882 Papio anubis 31.58 2.00e-10 59.30
IUUC-Pno-095093 Phaeosphaeria nodorum 26.13 8.00e-24 103.00
IUUC-Pca-100901 Procavia capensis 31.90 6.00e-11 61.20
IUUC-Pva-102226 Pteropus vampyrus 31.96 4.00e-10 58.90
IUUC-Pgr-103515 Puccinia graminis 34.16 5.00e-27 114.00
IUUC-Pte-104300 Pyrenophora teres 23.43 3.00e-47 182.00
IUUC-Pyt-104434 Pyrenophora triticirepentis 23.87 6.00e-44 171.00
IUUC-Sja-107936 Schizosaccharomyces japonicus 29.45 4.00e-81 294.00
IUUC-Spo-108381 Schizosaccharomyces pombe 32.38 7.00e-49 187.00
IUUC-Ssl-108532 Sclerotinia sclerotiorum 33.62 3.00e-47 182.00
IUUC-Sar-113097 Sorex araneus 32.65 8.00e-10 57.80
IUUC-Sre-115145 Sporisorium reilianum 27.36 3.00e-59 222.00
IUUC-Ssc-115463 Sus scrofa 31.58 4.00e-11 61.60
IUUC-Tru-118135 Takifugu rubripes 32.65 5.00e-11 61.60
IUUC-Tsy-118971 Tarsius syrichta 30.19 5.00e-10 58.20
IUUC-Tre-122145 Trichoderma reesei 23.40 2.00e-17 83.20
IUUC-Tvi-122548 Trichoderma virens 24.80 1.00e-17 84.30
IUUC-Tme-126928 Tuber melanosporum 41.57 1.00e-63 236.00
IUUC-Tbe-127549 Tupaia belangeri 32.65 1.00e-09 57.00
IUUC-Ttr-128887 Tursiops truncatus 31.58 1.00e-10 60.80
IUUC-Uma-129338 Ustilago maydis 28.14 2.00e-63 236.00
IUUC-Vda-129742 Verticillium dahliae 42.50 1.00e-14 73.90
IUUC-Vpa-130614 Vicugna pacos 30.70 1.00e-10 60.10
IUUC-Yli-134560 Yarrowia lipolytica 33.33 1.00e-127 449.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved