iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046279

UUCD1 version

UUC-HoS-00084

Ensembl Protein ID

ENSP00000216225.8

UniProt Accession

P62877; B2RDY1; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254; RBX1_HUMAN

Genbank Protein ID

AAD30146.1; AAD29715.1; CAG30446.1; BAG38078.1; CAB62925.1; EAW60403.1; AAH01466.1; AAH17370.2; AAM21718.1

Protein Name

E3 ubiquitin-protein ligase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Regulator of cullins 1; E3 ubiquitin-protein ligase RBX1, N-terminally processed

Genbank Nucleotide ID

AF142059; AF140598; CR456560; AK315722; AL080242; CH471095; BC001466; BC017370; AY099360

Gene Name

RBX1; RNF75; ROC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100387.8	ENST00000216225.8	ENSP00000216225.8

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12565873; 18826954; 20427290; 19424503; 17132228; 18279656

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.70e-08	36.5	42	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+++++d +++                  + C+H+fh++C+ +w       ++++ CPl+
   Q: 42   CAICRNHIMD-LCIecqanqasatseectvawGVCNHAFHFHCISRW------LKTRQVCPLD 97
           ********66.55333444444433333333488*************......********97 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Protein Sequence
(Fasta)

MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ 60
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH 108

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Nucleotide Sequence
(Fasta)

GTGCGCTGCT GCGCAGGCGC GGTGGTCGGA CGACAGACCG TGTGTTTCCA AAATGGCGGC 60
AGCGATGGAT GTGGATACCC CGAGCGGCAC CAACAGCGGC GCGGGCAAGA AGCGCTTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030891--C:VCB complex
GO:0097602--F:cullin family protein binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0070911--P:global genome nucleotide-excision repair
GO:0000165--P:MAPK cascade
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0006293--P:nucleotide-excision repair, preincision complex stabilization
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0045116--P:protein neddylation
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0010265--P:SCF complex assembly
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0016032--P:viral process
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:9978

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001798	Ailuropoda melanoleuca	100.00	1.00e-61	227.00
IUUC-Atr-002900	Amborella trichopoda	90.82	4.00e-51	192.00
IUUC-Apl-003762	Anas platyrhynchos	100.00	9.00e-43	164.00
IUUC-Aca-005328	Anolis carolinensis	99.07	7.00e-61	224.00
IUUC-Aly-005923	Arabidopsis lyrata	96.59	2.00e-48	183.00
IUUC-Ath-007535	Arabidopsis thaliana	94.38	1.00e-46	177.00
IUUC-Ago-007991	Ashbya gossypii	59.26	4.00e-37	145.00
IUUC-Acl-008332	Aspergillus clavatus	93.33	1.00e-48	184.00
IUUC-Afl-008537	Aspergillus flavus	94.19	2.00e-46	177.00
IUUC-Afu-008985	Aspergillus fumigatus	93.33	1.00e-48	184.00
IUUC-Ani-009342	Aspergillus nidulans	91.40	2.00e-49	187.00
IUUC-Ang-009778	Aspergillus niger	94.19	2.00e-46	177.00
IUUC-Aor-009918	Aspergillus oryzae	94.19	2.00e-46	177.00
IUUC-Ame-010814	Astyanax mexicanus	100.00	1.00e-29	120.00
IUUC-Bgr-012224	Blumeria graminis	93.33	6.00e-49	185.00
IUUC-Bta-012426	Bos taurus	100.00	1.00e-61	227.00
IUUC-Bci-013839	Botrytis cinerea	97.70	3.00e-48	183.00
IUUC-Bdi-014575	Brachypodium distachyon	95.60	2.00e-49	187.00
IUUC-Bol-015671	Brassica oleracea	97.75	2.00e-49	187.00
IUUC-Bra-017034	Brassica rapa	97.75	2.00e-49	187.00
IUUC-Cel-018195	Caenorhabditis elegans	79.28	3.00e-47	179.00
IUUC-Cja-018788	Callithrix jacchus	100.00	2.00e-59	219.00
IUUC-Cpo-021365	Cavia porcellus	100.00	1.00e-61	227.00
IUUC-Cre-022904	Chlamydomonas reinhardtii	54.64	2.00e-26	110.00
IUUC-Csa-024198	Chlorocebus sabaeus	100.00	1.00e-61	227.00
IUUC-Cho-024344	Choloepus hoffmanni	100.00	2.00e-29	119.00
IUUC-Cin-025449	Ciona intestinalis	92.23	6.00e-53	198.00
IUUC-Cgl-026522	Colletotrichum gloeosporioides	90.62	4.00e-50	189.00
IUUC-Cne-027067	Cryptococcus neoformans	69.57	2.00e-34	137.00
IUUC-Cme-027268	Cyanidioschyzon merolae	62.62	7.00e-37	145.00
IUUC-Dre-027434	Danio rerio	98.15	2.00e-60	223.00
IUUC-Dno-029252	Dasypus novemcinctus	99.05	1.00e-58	217.00
IUUC-Dor-030861	Dipodomys ordii	76.92	6.00e-42	161.00
IUUC-Dse-031355	Dothistroma septosporum	93.41	4.00e-49	186.00
IUUC-Dme-031585	Drosophila melanogaster	91.09	9.00e-52	194.00
IUUC-Ete-032747	Echinops telfairi	58.33	4.00e-26	109.00
IUUC-Eca-033758	Equus caballus	100.00	1.00e-61	227.00
IUUC-Fca-035586	Felis catus	100.00	1.00e-61	227.00
IUUC-Fal-037097	Ficedula albicollis	98.77	2.00e-44	170.00
IUUC-Fox-037881	Fusarium oxysporum	95.06	2.00e-43	166.00
IUUC-Fso-038373	Fusarium solani	87.63	3.00e-49	186.00
IUUC-Gmo-039457	Gadus morhua	99.04	5.00e-58	215.00
IUUC-Ggr-039970	Gaeumannomyces graminis	95.40	4.00e-47	179.00
IUUC-Gga-040328	Gallus gallus	100.00	1.00e-61	227.00
IUUC-Gac-041578	Gasterosteus aculeatus	98.15	2.00e-60	223.00
IUUC-Gma-042692	Glycine max	97.73	7.00e-49	185.00
IUUC-Ggo-045249	Gorilla gorilla	75.00	6.00e-41	157.00
IUUC-Hvu-047597	Hordeum vulgare	97.75	4.00e-49	186.00
IUUC-Itr-048174	Ictidomys tridecemlineatus	100.00	1.00e-61	227.00
IUUC-Kpa-049330	Komagataella pastoris	64.29	6.00e-37	145.00
IUUC-Lch-049667	Latimeria chalumnae	97.22	6.00e-60	221.00
IUUC-Lma-053052	Leptosphaeria maculans	97.75	4.00e-49	186.00
IUUC-Laf-053827	Loxodonta africana	97.22	1.00e-59	220.00
IUUC-Mcc-055208	Macaca mulatta	100.00	1.00e-61	227.00
IUUC-Meu-056143	Macropus eugenii	100.00	9.00e-46	174.00
IUUC-Mor-057158	Magnaporthe oryzae	96.55	1.00e-47	181.00
IUUC-Mpo-057409	Magnaporthe poae	95.40	4.00e-47	179.00
IUUC-Mtr-058375	Medicago truncatula	78.63	3.00e-50	189.00
IUUC-Mla-059071	Melampsora laricipopulina	72.00	5.00e-47	179.00
IUUC-Mga-059797	Meleagris gallopavo	100.00	1.00e-61	227.00
IUUC-Mvi-060401	Microbotryum violaceum	76.92	8.00e-49	185.00
IUUC-Mmr-061077	Microcebus murinus	100.00	1.00e-61	227.00
IUUC-Mdo-062218	Monodelphis domestica	100.00	1.00e-61	227.00
IUUC-Mmu-064224	Mus musculus	100.00	1.00e-61	227.00
IUUC-Mac-064505	Musa acuminata	97.73	1.00e-48	184.00
IUUC-Mpu-066572	Mustela putorius furo	100.00	1.00e-61	227.00
IUUC-Mlu-067821	Myotis lucifugus	100.00	1.00e-61	227.00
IUUC-Nfi-068412	Neosartorya fischeri	93.33	1.00e-48	184.00
IUUC-Nle-069309	Nomascus leucogenys	100.00	1.00e-61	227.00
IUUC-Opr-070307	Ochotona princeps	100.00	1.00e-61	227.00
IUUC-Ont-071677	Oreochromis niloticus	98.15	7.00e-59	218.00
IUUC-Oan-072926	Ornithorhynchus anatinus	100.00	3.00e-44	169.00
IUUC-Oba-075405	Oryza barthii	97.75	3.00e-49	186.00
IUUC-Obr-076843	Oryza brachyantha	97.75	1.00e-49	188.00
IUUC-Ogl-077608	Oryza glaberrima	97.75	3.00e-49	186.00
IUUC-Ogu-078316	Oryza glumaepatula	97.75	2.00e-49	186.00
IUUC-Oin-079918	Oryza indica	65.38	7.00e-43	166.00
IUUC-Olo-080968	Oryza longistaminata	96.23	2.00e-26	109.00
IUUC-Ome-081246	Oryza meridionalis	96.59	2.00e-48	184.00
IUUC-Oni-082133	Oryza nivara	96.51	4.00e-47	179.00
IUUC-Opu-084035	Oryza punctata	90.00	1.00e-50	190.00
IUUC-Oru-084941	Oryza rufipogon	97.75	3.00e-49	186.00
IUUC-Osa-085800	Oryza sativa	97.75	3.00e-49	186.00
IUUC-Ola-087352	Oryzias latipes	97.22	4.00e-60	222.00
IUUC-Olu-087676	Ostreococcus lucimarinus	53.49	1.00e-25	107.00
IUUC-Oga-088880	Otolemur garnettii	100.00	1.00e-61	227.00
IUUC-Oar-089286	Ovis aries	100.00	1.00e-61	227.00
IUUC-Ptr-091402	Pan troglodytes	100.00	1.00e-61	227.00
IUUC-Pan-091687	Papio anubis	97.22	3.00e-59	219.00
IUUC-Psi-093640	Pelodiscus sinensis	97.22	9.00e-60	221.00
IUUC-Pma-094723	Petromyzon marinus	98.80	6.00e-46	174.00
IUUC-Pno-094822	Phaeosphaeria nodorum	90.72	2.00e-50	190.00
IUUC-Ppa-095730	Physcomitrella patens	96.63	6.00e-49	185.00
IUUC-Pfo-096055	Poecilia formosa	99.07	6.00e-61	224.00
IUUC-Pab-098577	Pongo abelii	100.00	1.00e-61	227.00
IUUC-Pop-099697	Populus trichocarpa	82.73	1.00e-50	191.00
IUUC-Pca-100719	Procavia capensis	100.00	1.00e-61	227.00
IUUC-Ppe-101429	Prunus persica	83.33	1.00e-51	194.00
IUUC-Pva-102885	Pteropus vampyrus	74.07	2.00e-41	160.00
IUUC-Pgr-103470	Puccinia graminis	80.36	6.00e-50	188.00
IUUC-Ptt-103909	Puccinia triticina	74.07	4.00e-30	123.00
IUUC-Pte-104144	Pyrenophora teres	92.55	2.00e-46	176.00
IUUC-Pyt-104533	Pyrenophora triticirepentis	91.67	1.00e-49	187.00
IUUC-Rno-105912	Rattus norvegicus	100.00	1.00e-61	227.00
IUUC-Sce-106407	Saccharomyces cerevisiae	66.29	2.00e-34	137.00
IUUC-Sha-107549	Sarcophilus harrisii	100.00	1.00e-61	227.00
IUUC-Sja-108003	Schizosaccharomyces japonicus	82.24	4.00e-48	182.00
IUUC-Spo-108091	Schizosaccharomyces pombe	74.07	1.00e-44	171.00
IUUC-Ssl-108634	Sclerotinia sclerotiorum	97.70	2.00e-48	183.00
IUUC-Smo-109681	Selaginella moellendorffii	97.73	1.00e-48	184.00
IUUC-Sit-110419	Setaria italica	95.51	2.00e-48	183.00
IUUC-Sly-110933	Solanum lycopersicum	85.19	5.00e-51	192.00
IUUC-Stu-112567	Solanum tuberosum	88.89	1.00e-50	191.00
IUUC-Sar-113409	Sorex araneus	75.00	1.00e-41	161.00
IUUC-Sbi-113799	Sorghum bicolor	93.62	1.00e-49	187.00
IUUC-Sre-115142	Sporisorium reilianum	81.90	4.00e-48	182.00
IUUC-Tgu-116923	Taeniopygia guttata	98.73	5.00e-43	164.00
IUUC-Tru-117710	Takifugu rubripes	93.52	7.00e-57	211.00
IUUC-Tsy-119641	Tarsius syrichta	100.00	6.00e-26	108.00
IUUC-Tni-119934	Tetraodon nigroviridis	97.22	2.00e-60	223.00
IUUC-Tca-121820	Theobroma cacao	96.63	6.00e-49	185.00
IUUC-Tre-122212	Trichoderma reesei	95.06	8.00e-44	168.00
IUUC-Tvi-122357	Trichoderma virens	86.67	5.00e-50	189.00
IUUC-Tae-125834	Triticum aestivum	91.67	8.00e-50	188.00
IUUC-Tur-125958	Triticum urartu	97.73	1.00e-48	183.00
IUUC-Tme-126940	Tuber melanosporum	83.17	3.00e-48	182.00
IUUC-Tbe-127918	Tupaia belangeri	100.00	9.00e-46	174.00
IUUC-Ttr-128306	Tursiops truncatus	100.00	9.00e-46	174.00
IUUC-Uma-129482	Ustilago maydis	77.14	7.00e-46	174.00
IUUC-Vda-129917	Verticillium dahliae	86.92	5.00e-52	195.00
IUUC-Vpa-130142	Vicugna pacos	97.12	2.00e-55	206.00
IUUC-Vvi-130957	Vitis vinifera	97.73	6.00e-49	185.00
IUUC-Xma-133061	Xiphophorus maculatus	99.07	6.00e-61	224.00
IUUC-Yli-134542	Yarrowia lipolytica	59.65	4.00e-37	146.00
IUUC-Zma-135160	Zea mays	97.75	2.00e-49	186.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence