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Tag Content
UUCD2 ID IUUC-Ocu-074008
UUCD1 version UUC-OrC-00114
Ensembl Protein ID ENSOCUP00000002575.2
UniProt Accession G1SIQ9; G1SIQ9_RABIT
Genbank Protein ID ENSOCUP00000002575
Protein Name Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Genbank Nucleotide ID AAGW02042233
Gene Name WDR12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000002961.2 ENSOCUT00000002962.2 ENSOCUP00000002575.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.30e-43 143.8 255 290
UBD/Beta-Prp 3.90e-47 160.9 246 412
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ ++++ +sd   ++s+s+D+ti+vWD+ +g l
   Q: 255  GHKEAISSVLWSDaEEICSASWDHTIRVWDVESGSL 290
           8**********999*****************99976 PP
   

   UBD/Beta-Prp
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   + + s+s+d tirvwd+e+g+  + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPIVTLSGHKEAISSVLWSD-AEEICSASWDHTIRVWDVESGSLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.99**********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+ ++++++  ++l+sgsld+ vklwd++  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTTIKWSPTHeQQLISGSLDNIVKLWDIRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           666644366.************9889*****************54566****************9.999********998765 PP
   
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAQLQTRFYT ENKKYAVDDV PFSIPAASEI ADLSNIINKL LEAKNEFHKH VEFDFLIKGQ 60
FLRMPLVKHM ELENISSEEV VELEYVEKYT APQPEQCMFH DDWISSVKGA EEWILTGSYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074008|E3,WD_repeat;UBD,Beta-Prp|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGCAGC TCCAGACACG CTTCTACACG GAAAACAAGA AGTAAGTAGG CGCCCTTCTC 60
TCCTCTCCGG GCTCTCGCCC GACGACCCCT TCCTTCGTTA CGGCGTTGTG GATCCCTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074008|E3,WD_repeat;UBD,Beta-Prp|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
KEGG ocu:100353524
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000532 Aegilops tauschii 33.25 6.00e-57 214.00
IUUC-Aml-001997 Ailuropoda melanoleuca 97.56 0.00e+00 753.00
IUUC-Atr-002544 Amborella trichopoda 33.10 2.00e-55 209.00
IUUC-Apl-003981 Anas platyrhynchos 86.97 0.00e+00 647.00
IUUC-Aca-004370 Anolis carolinensis 84.24 0.00e+00 699.00
IUUC-Aly-006455 Arabidopsis lyrata 33.89 9.00e-59 220.00
IUUC-Ath-006669 Arabidopsis thaliana 33.33 2.00e-54 206.00
IUUC-Ago-007864 Ashbya gossypii 30.16 5.00e-38 151.00
IUUC-Acl-008177 Aspergillus clavatus 27.98 2.00e-36 146.00
IUUC-Afl-008617 Aspergillus flavus 28.97 8.00e-36 144.00
IUUC-Afu-008752 Aspergillus fumigatus 27.80 2.00e-32 134.00
IUUC-Ani-009136 Aspergillus nidulans 29.23 7.00e-35 141.00
IUUC-Ang-009701 Aspergillus niger 27.95 3.00e-33 136.00
IUUC-Aor-009884 Aspergillus oryzae 29.23 2.00e-35 143.00
IUUC-Ame-011432 Astyanax mexicanus 76.60 0.00e+00 657.00
IUUC-Bgr-012218 Blumeria graminis 27.88 1.00e-31 130.00
IUUC-Bta-012829 Bos taurus 96.22 0.00e+00 775.00
IUUC-Bci-013953 Botrytis cinerea 29.27 3.00e-35 142.00
IUUC-Bdi-014351 Brachypodium distachyon 36.02 2.00e-56 213.00
IUUC-Bol-016514 Brassica oleracea 33.57 4.00e-53 202.00
IUUC-Bra-017876 Brassica rapa 33.50 1.00e-55 210.00
IUUC-Cel-018569 Caenorhabditis elegans 31.31 1.00e-48 187.00
IUUC-Cja-019468 Callithrix jacchus 96.69 0.00e+00 758.00
IUUC-Cfa-020471 Canis familiaris 95.98 0.00e+00 748.00
IUUC-Cpo-022260 Cavia porcellus 96.22 0.00e+00 758.00
IUUC-Cre-022614 Chlamydomonas reinhardtii 30.96 9.00e-39 154.00
IUUC-Csa-023989 Chlorocebus sabaeus 96.45 0.00e+00 761.00
IUUC-Cho-024426 Choloepus hoffmanni 92.70 2.00e-159 555.00
IUUC-Cin-025789 Ciona intestinalis 42.69 5.00e-96 344.00
IUUC-Cne-027063 Cryptococcus neoformans 24.07 1.00e-21 97.40
IUUC-Dre-027907 Danio rerio 77.07 0.00e+00 667.00
IUUC-Dno-029225 Dasypus novemcinctus 95.51 0.00e+00 768.00
IUUC-Dor-031082 Dipodomys ordii 78.25 2.00e-168 584.00
IUUC-Dse-031308 Dothistroma septosporum 27.79 5.00e-36 145.00
IUUC-Dme-032189 Drosophila melanogaster 41.50 2.00e-93 336.00
IUUC-Ete-032247 Echinops telfairi 88.65 0.00e+00 707.00
IUUC-Eca-034285 Equus caballus 96.45 0.00e+00 775.00
IUUC-Eeu-035322 Erinaceus europaeus 85.43 0.00e+00 645.00
IUUC-Fca-036114 Felis catus 96.45 0.00e+00 773.00
IUUC-Fal-036891 Ficedula albicollis 85.88 3.00e-173 600.00
IUUC-Fox-037965 Fusarium oxysporum 25.16 4.00e-34 139.00
IUUC-Fso-038244 Fusarium solani 26.64 4.00e-34 139.00
IUUC-Gmo-039040 Gadus morhua 75.65 0.00e+00 671.00
IUUC-Ggr-040093 Gaeumannomyces graminis 24.09 2.00e-09 57.40
IUUC-Gga-040610 Gallus gallus 84.16 0.00e+00 712.00
IUUC-Gac-042117 Gasterosteus aculeatus 74.94 0.00e+00 651.00
IUUC-Gma-043146 Glycine max 36.93 7.00e-66 244.00
IUUC-Ggo-045179 Gorilla gorilla 96.45 0.00e+00 756.00
IUUC-Hsa-046114 Homo sapiens 96.69 0.00e+00 757.00
IUUC-Hvu-047331 Hordeum vulgare 33.85 2.00e-52 199.00
IUUC-Itr-048275 Ictidomys tridecemlineatus 96.22 0.00e+00 771.00
IUUC-Kpa-049304 Komagataella pastoris 29.56 9.00e-42 164.00
IUUC-Lch-050655 Latimeria chalumnae 78.21 6.00e-145 506.00
IUUC-Lpe-051675 Leersia perrieri 35.32 8.00e-59 221.00
IUUC-Loc-052868 Lepisosteus oculatus 80.85 0.00e+00 671.00
IUUC-Lma-053258 Leptosphaeria maculans 26.35 2.00e-31 132.00
IUUC-Laf-053993 Loxodonta africana 95.51 0.00e+00 773.00
IUUC-Mcc-055128 Macaca mulatta 79.43 4.00e-173 600.00
IUUC-Meu-056501 Macropus eugenii 77.75 9.00e-161 559.00
IUUC-Mor-057114 Magnaporthe oryzae 25.78 1.00e-25 110.00
IUUC-Mtr-058367 Medicago truncatula 35.97 6.00e-60 224.00
IUUC-Mla-059107 Melampsora laricipopulina 27.00 1.00e-28 120.00
IUUC-Mga-059745 Meleagris gallopavo 82.12 0.00e+00 686.00
IUUC-Mvi-060362 Microbotryum violaceum 29.35 2.00e-35 143.00
IUUC-Mdo-062257 Monodelphis domestica 85.68 0.00e+00 721.00
IUUC-Mmu-063546 Mus musculus 94.33 0.00e+00 763.00
IUUC-Mac-065540 Musa acuminata 34.20 2.00e-54 206.00
IUUC-Mpu-066284 Mustela putorius furo 97.40 0.00e+00 781.00
IUUC-Mlu-067241 Myotis lucifugus 95.98 0.00e+00 773.00
IUUC-Nfi-068260 Neosartorya fischeri 27.07 2.00e-34 140.00
IUUC-Ncr-068719 Neurospora crassa 26.32 2.00e-26 113.00
IUUC-Nle-068981 Nomascus leucogenys 96.45 0.00e+00 737.00
IUUC-Opr-071218 Ochotona princeps 89.70 0.00e+00 682.00
IUUC-Ont-071646 Oreochromis niloticus 77.11 0.00e+00 669.00
IUUC-Oan-073453 Ornithorhynchus anatinus 89.13 0.00e+00 757.00
IUUC-Oba-075712 Oryza barthii 31.01 5.00e-42 165.00
IUUC-Obr-076721 Oryza brachyantha 34.76 2.00e-58 219.00
IUUC-Ogl-077229 Oryza glaberrima 34.84 1.00e-57 217.00
IUUC-Ogu-078977 Oryza glumaepatula 31.01 2.00e-42 166.00
IUUC-Oin-079683 Oryza indica 34.84 5.00e-58 218.00
IUUC-Olo-080291 Oryza longistaminata 30.98 1.00e-28 119.00
IUUC-Ome-081834 Oryza meridionalis 35.08 6.00e-59 221.00
IUUC-Oni-082507 Oryza nivara 33.73 5.00e-54 204.00
IUUC-Opu-083396 Oryza punctata 34.84 5.00e-59 221.00
IUUC-Oru-085220 Oryza rufipogon 33.97 1.00e-53 203.00
IUUC-Osa-085767 Oryza sativa 34.84 5.00e-58 218.00
IUUC-Ola-087420 Oryzias latipes 77.78 0.00e+00 674.00
IUUC-Olu-087740 Ostreococcus lucimarinus 27.40 2.00e-36 146.00
IUUC-Oga-088264 Otolemur garnettii 95.51 0.00e+00 752.00
IUUC-Oar-089335 Ovis aries 95.74 0.00e+00 771.00
IUUC-Ptr-091320 Pan troglodytes 96.69 0.00e+00 757.00
IUUC-Pan-092833 Papio anubis 95.98 0.00e+00 756.00
IUUC-Psi-093504 Pelodiscus sinensis 86.76 0.00e+00 731.00
IUUC-Pma-094189 Petromyzon marinus 68.40 2.00e-170 592.00
IUUC-Pno-094929 Phaeosphaeria nodorum 26.17 1.00e-32 134.00
IUUC-Ppa-095429 Physcomitrella patens 35.14 6.00e-64 238.00
IUUC-Pfo-096337 Poecilia formosa 75.41 0.00e+00 672.00
IUUC-Pab-097571 Pongo abelii 96.22 0.00e+00 756.00
IUUC-Pop-099977 Populus trichocarpa 35.58 2.00e-63 236.00
IUUC-Pca-100394 Procavia capensis 89.73 0.00e+00 672.00
IUUC-Ppe-101848 Prunus persica 35.34 7.00e-60 224.00
IUUC-Pva-102921 Pteropus vampyrus 96.76 1.00e-116 412.00
IUUC-Pgr-103637 Puccinia graminis 28.39 3.00e-34 139.00
IUUC-Ptt-103781 Puccinia triticina 28.39 3.00e-34 139.00
IUUC-Pte-104135 Pyrenophora teres 25.59 3.00e-32 134.00
IUUC-Pyt-104609 Pyrenophora triticirepentis 25.49 2.00e-31 130.00
IUUC-Rno-105114 Rattus norvegicus 93.85 0.00e+00 761.00
IUUC-Sce-106401 Saccharomyces cerevisiae 29.52 5.00e-39 155.00
IUUC-Sha-107122 Sarcophilus harrisii 85.64 0.00e+00 689.00
IUUC-Sja-107766 Schizosaccharomyces japonicus 32.24 1.00e-48 187.00
IUUC-Spo-108134 Schizosaccharomyces pombe 28.67 3.00e-38 152.00
IUUC-Ssl-108398 Sclerotinia sclerotiorum 28.81 2.00e-36 146.00
IUUC-Smo-108720 Selaginella moellendorffii 33.57 2.00e-57 216.00
IUUC-Sit-110311 Setaria italica 36.06 1.00e-56 213.00
IUUC-Sly-111023 Solanum lycopersicum 32.52 5.00e-54 205.00
IUUC-Stu-112778 Solanum tuberosum 35.32 7.00e-60 224.00
IUUC-Sar-113596 Sorex araneus 78.25 1.00e-174 605.00
IUUC-Sbi-114193 Sorghum bicolor 35.48 9.00e-58 217.00
IUUC-Sre-115002 Sporisorium reilianum 25.43 4.00e-11 62.80
IUUC-Ssc-116066 Sus scrofa 96.45 0.00e+00 773.00
IUUC-Tgu-117048 Taeniopygia guttata 84.84 0.00e+00 637.00
IUUC-Tsy-119573 Tarsius syrichta 62.92 3.00e-131 461.00
IUUC-Tni-119820 Tetraodon nigroviridis 75.77 0.00e+00 670.00
IUUC-Tca-121605 Theobroma cacao 36.06 2.00e-61 229.00
IUUC-Tre-121947 Trichoderma reesei 26.07 3.00e-33 135.00
IUUC-Tvi-122481 Trichoderma virens 26.50 5.00e-35 142.00
IUUC-Tae-125861 Triticum aestivum 33.49 5.00e-57 214.00
IUUC-Tur-126586 Triticum urartu 34.10 1.00e-54 206.00
IUUC-Tme-126900 Tuber melanosporum 32.39 5.00e-49 188.00
IUUC-Tbe-127736 Tupaia belangeri 74.87 2.00e-155 541.00
IUUC-Ttr-129041 Tursiops truncatus 84.16 0.00e+00 661.00
IUUC-Uma-129628 Ustilago maydis 24.29 9.00e-11 61.60
IUUC-Vpa-130260 Vicugna pacos 96.93 0.00e+00 779.00
IUUC-Vvi-131009 Vitis vinifera 35.00 1.00e-59 224.00
IUUC-Xtr-132083 Xenopus tropicalis 80.61 0.00e+00 674.00
IUUC-Xma-133094 Xiphophorus maculatus 74.70 0.00e+00 666.00
IUUC-Yli-134531 Yarrowia lipolytica 22.84 1.00e-18 87.80
IUUC-Zma-135509 Zea mays 34.05 2.00e-58 219.00
Created Date 25-Jun-2017

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