iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-119820

UUCD1 version

UUC-TeN-00460

Ensembl Protein ID

ENSTNIP00000016276.1

UniProt Accession

H3D6Y5; H3D6Y5_TETNG

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000013286.1	ENSTNIT00000016488.1	ENSTNIP00000016276.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-42	141.2	341	376
UBD/Beta-Prp	1.90e-48	165.4	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s  +llvsGs D+ +k+WD+r+++
   Q: 341  HTGWVTAVKWapSHeHLLVSGSLDNLVKLWDTRSCK 376
           ***********7557999*************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ ++  +d + s+s+d tir+wd etg     tl+g++ v nc++++p ++ l+sGs+Dr +rlWd +t++ 
   Q: 246  TRTPLMTLSGHNEAVSSVLWCD-SDEVCSASWDHTIRLWDAETGAMKT-TLTGTK-VFNCISYSPLCRRLASGSADRHIRLWDPRTKDG 331
           67899*****************.99*********************98.999987.99**************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+ +++ ++    lvsgsld+ vklwd +  +  ++ l +h+d v +v+ + ++ +++sg++D+ ++ +
   Q: 332  SLVLlslTS-HTGWVTAVKWAPSHeHLLVSGSLDNLVKLWDTRsCKAPLYDLAAHEDKVFCVDWT-ENGLMLSGGADNKLYTY 412
           444444387.***********99956689**************54566*****************.88899******998876 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQVRFFT ENKRYVIDDV PFSIPAGSEV QDLSNVVNKL LEAKNASHSK VDFDFLVRGQ 60
FLRVPLSAHM EAEGISTEEV VEIEYVERIT APEPEECMMH DDWISSIVGD AEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCAGT TACAAGTGAG ATTTTTCACT GAGAACAAAA GGTGAGGTAT TTTTGAATCG 60
CTAATTAAAC ATTCGTGACC TGGAAAAGAC TGGTAAACTT TGCTAAACGT ACACTAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.89	3.00e-59	222.00
IUUC-Aml-001997	Ailuropoda melanoleuca	76.72	4.00e-179	620.00
IUUC-Atr-002544	Amborella trichopoda	35.24	1.00e-59	223.00
IUUC-Apl-003981	Anas platyrhynchos	75.73	4.00e-169	587.00
IUUC-Aca-004370	Anolis carolinensis	75.84	0.00e+00	642.00
IUUC-Aly-006455	Arabidopsis lyrata	35.46	2.00e-59	223.00
IUUC-Ath-006669	Arabidopsis thaliana	35.14	5.00e-55	208.00
IUUC-Ago-007864	Ashbya gossypii	30.68	3.00e-41	162.00
IUUC-Acl-008177	Aspergillus clavatus	27.99	6.00e-34	138.00
IUUC-Afl-008617	Aspergillus flavus	29.78	7.00e-36	144.00
IUUC-Afu-008752	Aspergillus fumigatus	26.54	5.00e-31	128.00
IUUC-Ani-009136	Aspergillus nidulans	29.56	8.00e-34	137.00
IUUC-Ang-009701	Aspergillus niger	27.21	5.00e-32	132.00
IUUC-Aor-009884	Aspergillus oryzae	29.30	7.00e-35	141.00
IUUC-Ame-011432	Astyanax mexicanus	79.20	0.00e+00	664.00
IUUC-Bgr-012218	Blumeria graminis	28.57	3.00e-34	139.00
IUUC-Bta-012829	Bos taurus	76.01	0.00e+00	641.00
IUUC-Bci-013953	Botrytis cinerea	27.41	2.00e-35	143.00
IUUC-Bdi-014351	Brachypodium distachyon	35.93	7.00e-57	214.00
IUUC-Bol-016190	Brassica oleracea	34.29	5.00e-55	208.00
IUUC-Bra-018095	Brassica rapa	34.55	8.00e-56	211.00
IUUC-Cel-018569	Caenorhabditis elegans	32.70	6.00e-50	191.00
IUUC-Cja-019468	Callithrix jacchus	75.53	1.00e-179	622.00
IUUC-Cfa-020471	Canis familiaris	75.77	1.00e-179	622.00
IUUC-Cpo-022260	Cavia porcellus	75.30	0.00e+00	629.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	32.91	2.00e-41	162.00
IUUC-Csa-023989	Chlorocebus sabaeus	75.53	4.00e-180	624.00
IUUC-Cho-024426	Choloepus hoffmanni	74.29	4.00e-134	471.00
IUUC-Cin-025789	Ciona intestinalis	43.17	1.00e-96	346.00
IUUC-Cne-027063	Cryptococcus neoformans	26.52	1.00e-16	80.90
IUUC-Dre-027907	Danio rerio	81.56	0.00e+00	687.00
IUUC-Dno-029225	Dasypus novemcinctus	75.30	0.00e+00	637.00
IUUC-Dor-031082	Dipodomys ordii	63.42	3.00e-137	481.00
IUUC-Dse-031308	Dothistroma septosporum	26.34	4.00e-34	139.00
IUUC-Dme-032189	Drosophila melanogaster	42.34	2.00e-92	332.00
IUUC-Ete-032247	Echinops telfairi	72.68	9.00e-171	592.00
IUUC-Eca-034285	Equus caballus	76.48	0.00e+00	642.00
IUUC-Eeu-035322	Erinaceus europaeus	69.10	3.00e-157	547.00
IUUC-Fca-036114	Felis catus	75.77	0.00e+00	641.00
IUUC-Fal-036891	Ficedula albicollis	78.53	5.00e-160	556.00
IUUC-Fox-037965	Fusarium oxysporum	25.37	1.00e-34	140.00
IUUC-Fso-038244	Fusarium solani	25.58	3.00e-33	135.00
IUUC-Gmo-039040	Gadus morhua	82.74	0.00e+00	704.00
IUUC-Gga-040610	Gallus gallus	74.94	0.00e+00	652.00
IUUC-Gac-042117	Gasterosteus aculeatus	87.94	0.00e+00	724.00
IUUC-Gma-043146	Glycine max	36.54	2.00e-64	239.00
IUUC-Ggo-045179	Gorilla gorilla	75.30	2.00e-178	618.00
IUUC-Hsa-046114	Homo sapiens	76.01	4.00e-180	623.00
IUUC-Hvu-047331	Hordeum vulgare	34.27	1.00e-54	206.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	76.01	0.00e+00	640.00
IUUC-Kpa-049304	Komagataella pastoris	29.78	1.00e-42	166.00
IUUC-Lch-050655	Latimeria chalumnae	71.98	3.00e-136	477.00
IUUC-Lpe-051675	Leersia perrieri	35.15	3.00e-60	226.00
IUUC-Loc-052868	Lepisosteus oculatus	80.05	0.00e+00	660.00
IUUC-Lma-053258	Leptosphaeria maculans	26.55	7.00e-34	139.00
IUUC-Laf-053993	Loxodonta africana	76.01	0.00e+00	637.00
IUUC-Mcc-055128	Macaca mulatta	62.71	5.00e-139	486.00
IUUC-Meu-056501	Macropus eugenii	67.83	4.00e-144	503.00
IUUC-Mor-057114	Magnaporthe oryzae	25.49	2.00e-26	113.00
IUUC-Mtr-058367	Medicago truncatula	35.49	4.00e-59	221.00
IUUC-Mla-059107	Melampsora laricipopulina	26.29	1.00e-29	124.00
IUUC-Mga-059745	Meleagris gallopavo	73.40	0.00e+00	629.00
IUUC-Mvi-060362	Microbotryum violaceum	28.32	3.00e-33	135.00
IUUC-Mdo-062257	Monodelphis domestica	75.06	0.00e+00	662.00
IUUC-Mmu-063546	Mus musculus	75.77	0.00e+00	635.00
IUUC-Mac-065540	Musa acuminata	34.44	2.00e-59	223.00
IUUC-Mpu-066284	Mustela putorius furo	76.48	0.00e+00	643.00
IUUC-Mlu-067241	Myotis lucifugus	76.25	0.00e+00	639.00
IUUC-Nfi-068260	Neosartorya fischeri	26.33	3.00e-32	132.00
IUUC-Ncr-068719	Neurospora crassa	26.72	3.00e-28	119.00
IUUC-Nle-068981	Nomascus leucogenys	75.77	6.00e-176	609.00
IUUC-Opr-071218	Ochotona princeps	69.35	3.00e-163	567.00
IUUC-Ont-071646	Oreochromis niloticus	88.84	0.00e+00	744.00
IUUC-Oan-073453	Ornithorhynchus anatinus	76.83	0.00e+00	682.00
IUUC-Ocu-074008	Oryctolagus cuniculus	75.77	0.00e+00	640.00
IUUC-Oba-075712	Oryza barthii	31.43	2.00e-43	169.00
IUUC-Obr-076721	Oryza brachyantha	35.48	3.00e-60	225.00
IUUC-Ogl-077229	Oryza glaberrima	35.70	6.00e-60	224.00
IUUC-Ogu-078977	Oryza glumaepatula	30.84	1.00e-43	170.00
IUUC-Oin-079683	Oryza indica	35.65	2.00e-60	226.00
IUUC-Olo-080291	Oryza longistaminata	31.76	2.00e-28	119.00
IUUC-Ome-081834	Oryza meridionalis	36.28	3.00e-61	229.00
IUUC-Oni-082507	Oryza nivara	34.45	2.00e-55	209.00
IUUC-Opu-083396	Oryza punctata	35.17	3.00e-60	225.00
IUUC-Oru-085220	Oryza rufipogon	34.69	2.00e-55	209.00
IUUC-Osa-085767	Oryza sativa	35.65	2.00e-60	226.00
IUUC-Ola-087420	Oryzias latipes	87.94	0.00e+00	721.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.51	5.00e-38	151.00
IUUC-Oga-088264	Otolemur garnettii	75.77	5.00e-180	623.00
IUUC-Oar-089335	Ovis aries	75.53	0.00e+00	637.00
IUUC-Ptr-091320	Pan troglodytes	76.01	4.00e-180	623.00
IUUC-Pan-092833	Papio anubis	75.77	1.00e-179	622.00
IUUC-Psi-093504	Pelodiscus sinensis	75.41	0.00e+00	655.00
IUUC-Pma-094189	Petromyzon marinus	65.62	7.00e-163	566.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.91	3.00e-33	135.00
IUUC-Ppa-095429	Physcomitrella patens	36.64	6.00e-68	251.00
IUUC-Pfo-096337	Poecilia formosa	86.76	0.00e+00	744.00
IUUC-Pab-097571	Pongo abelii	76.25	3.00e-180	624.00
IUUC-Pop-099977	Populus trichocarpa	35.82	2.00e-64	239.00
IUUC-Pca-100394	Procavia capensis	72.73	4.00e-161	560.00
IUUC-Ppe-101848	Prunus persica	36.30	1.00e-62	233.00
IUUC-Pva-102921	Pteropus vampyrus	73.68	7.00e-92	330.00
IUUC-Pgr-103637	Puccinia graminis	28.60	4.00e-37	149.00
IUUC-Ptt-103781	Puccinia triticina	29.12	1.00e-36	147.00
IUUC-Pte-104135	Pyrenophora teres	27.96	2.00e-33	137.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.59	6.00e-32	131.00
IUUC-Rno-105114	Rattus norvegicus	76.25	0.00e+00	635.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.99	2.00e-43	169.00
IUUC-Sha-107122	Sarcophilus harrisii	75.43	0.00e+00	630.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	33.02	1.00e-49	190.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.72	6.00e-39	154.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.88	9.00e-36	144.00
IUUC-Smo-108720	Selaginella moellendorffii	33.41	5.00e-58	218.00
IUUC-Sit-110311	Setaria italica	36.06	2.00e-57	216.00
IUUC-Sly-111178	Solanum lycopersicum	35.98	4.00e-60	225.00
IUUC-Stu-112778	Solanum tuberosum	36.28	1.00e-63	236.00
IUUC-Sar-113596	Sorex araneus	63.61	1.00e-141	496.00
IUUC-Sbi-114193	Sorghum bicolor	37.44	2.00e-60	226.00
IUUC-Sre-115002	Sporisorium reilianum	26.72	1.00e-12	67.80
IUUC-Ssc-116066	Sus scrofa	75.77	0.00e+00	636.00
IUUC-Tgu-117048	Taeniopygia guttata	76.78	2.00e-169	588.00
IUUC-Tsy-119573	Tarsius syrichta	47.48	5.00e-103	367.00
IUUC-Tca-121605	Theobroma cacao	35.34	4.00e-60	225.00
IUUC-Tre-121947	Trichoderma reesei	27.35	5.00e-35	141.00
IUUC-Tvi-122481	Trichoderma virens	27.56	8.00e-36	144.00
IUUC-Tae-125861	Triticum aestivum	34.12	2.00e-59	222.00
IUUC-Tur-126586	Triticum urartu	34.53	1.00e-56	213.00
IUUC-Tme-126900	Tuber melanosporum	30.50	4.00e-46	178.00
IUUC-Tbe-127736	Tupaia belangeri	56.78	2.00e-122	431.00
IUUC-Ttr-129041	Tursiops truncatus	66.27	6.00e-156	543.00
IUUC-Vpa-130260	Vicugna pacos	76.25	0.00e+00	641.00
IUUC-Vvi-131009	Vitis vinifera	36.02	3.00e-60	225.00
IUUC-Xtr-132083	Xenopus tropicalis	74.76	0.00e+00	633.00
IUUC-Xma-133094	Xiphophorus maculatus	85.11	0.00e+00	731.00
IUUC-Yli-134531	Yarrowia lipolytica	25.72	2.00e-21	96.70
IUUC-Zma-135509	Zea mays	35.71	7.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence