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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046840
UUCD1 version UUC-HoS-00916
Ensembl Protein ID ENSP00000277540.2
UniProt Accession Q9BTV6; Q96AB7; DPH7_HUMAN
Genbank Protein ID BAC11411.1; AAH03123.2; AAH17335.1
Protein Name Diphthine methyltransferase; Diphthamide biosynthesis protein 7; WD repeat-containing protein 85
Genbank Nucleotide ID AK075115; AL365502; BC017335
Gene Name DPH7; C9orf112; WDR85
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000148399.12 ENST00000277540.6 ENSP00000277540.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-09 38.3 238 271
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrt 32
           Ht +v++++  +   ++l++Gs+D  i +WD+r 
   Q: 238  HTMGVCSIQSsPHreHILATGSYDEHILLWDTRN 271
           666788887663343779*************876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
 Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Protein Sequence
(Fasta)
MMGCFALQTV DTELTADSVE WCPLQGCRHL LACGTYQLRR PEDRPAGPQN KGGMEVKEPQ 60
VRLGRLFLYS FNDNNSIHPL VEVQRKDTSA ILDMKWCHIP VAGHALLGLA DASGSIQLLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046840|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCCGGAAGG AGTCGCGAGA GAGGCGGCCC GCGCTGACGG TGTCCCTGGG GCTCTGCGCT 60
CGTCCGGCCG GCCCCGGCCT CGCCGCCCCG CGCAGTACCC AGCCCGGCCC CGCCGACCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046840|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0061685--F:diphthine methylesterase activity
GO:0017183--P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine
KEGG hsa:92715
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000566 Aegilops tauschii 37.62 1.00e-32 133.00
IUUC-Aml-001799 Ailuropoda melanoleuca 67.68 0.00e+00 635.00
IUUC-Atr-002540 Amborella trichopoda 40.59 3.00e-36 144.00
IUUC-Apl-003582 Anas platyrhynchos 51.14 4.00e-107 381.00
IUUC-Aca-004275 Anolis carolinensis 52.88 3.00e-96 345.00
IUUC-Aly-005425 Arabidopsis lyrata 34.63 3.00e-45 176.00
IUUC-Ath-007434 Arabidopsis thaliana 34.83 4.00e-47 181.00
IUUC-Ago-007782 Ashbya gossypii 30.90 2.00e-13 70.10
IUUC-Ame-011276 Astyanax mexicanus 43.73 1.00e-58 219.00
IUUC-Bta-012985 Bos taurus 65.05 4.00e-163 567.00
IUUC-Bdi-014568 Brachypodium distachyon 33.33 2.00e-38 152.00
IUUC-Bol-016236 Brassica oleracea 33.23 3.00e-42 166.00
IUUC-Bra-017012 Brassica rapa 33.53 7.00e-41 160.00
IUUC-Cel-018435 Caenorhabditis elegans 30.32 7.00e-15 74.30
IUUC-Cja-018952 Callithrix jacchus 84.21 0.00e+00 758.00
IUUC-Cfa-021210 Canis familiaris 66.45 8.00e-172 596.00
IUUC-Cpo-022017 Cavia porcellus 60.80 7.00e-148 516.00
IUUC-Cre-022584 Chlamydomonas reinhardtii 43.70 1.00e-29 122.00
IUUC-Csa-023897 Chlorocebus sabaeus 93.28 0.00e+00 768.00
IUUC-Cho-024708 Choloepus hoffmanni 50.82 2.00e-58 218.00
IUUC-Cin-025485 Ciona intestinalis 39.77 2.00e-63 236.00
IUUC-Cne-026845 Cryptococcus neoformans 34.38 5.00e-45 174.00
IUUC-Cme-027194 Cyanidioschyzon merolae 26.80 4.00e-15 75.50
IUUC-Dre-028581 Danio rerio 46.34 8.00e-96 343.00
IUUC-Dno-029285 Dasypus novemcinctus 63.02 4.00e-162 564.00
IUUC-Dor-030566 Dipodomys ordii 65.34 1.00e-161 562.00
IUUC-Dme-031714 Drosophila melanogaster 37.90 2.00e-50 193.00
IUUC-Ete-032317 Echinops telfairi 56.49 6.00e-118 417.00
IUUC-Eca-033341 Equus caballus 81.62 3.00e-66 243.00
IUUC-Eeu-034890 Erinaceus europaeus 62.44 4.00e-159 554.00
IUUC-Fca-035966 Felis catus 65.58 2.00e-173 602.00
IUUC-Fal-037338 Ficedula albicollis 49.57 3.00e-115 408.00
IUUC-Gmo-039487 Gadus morhua 43.72 4.00e-90 324.00
IUUC-Gga-040691 Gallus gallus 48.07 6.00e-106 377.00
IUUC-Gac-041912 Gasterosteus aculeatus 48.33 5.00e-103 368.00
IUUC-Gma-042905 Glycine max 33.53 3.00e-42 165.00
IUUC-Ggo-045003 Gorilla gorilla 99.12 0.00e+00 929.00
IUUC-Hvu-047291 Hordeum vulgare 34.63 1.00e-41 163.00
IUUC-Itr-048072 Ictidomys tridecemlineatus 69.16 1.00e-171 596.00
IUUC-Kpa-049296 Komagataella pastoris 28.06 6.00e-18 85.10
IUUC-Lch-049627 Latimeria chalumnae 47.96 3.00e-115 409.00
IUUC-Lpe-051462 Leersia perrieri 33.93 2.00e-42 166.00
IUUC-Loc-052917 Lepisosteus oculatus 54.25 2.00e-96 346.00
IUUC-Laf-054268 Loxodonta africana 64.32 4.00e-156 544.00
IUUC-Mcc-055309 Macaca mulatta 92.92 0.00e+00 872.00
IUUC-Meu-055985 Macropus eugenii 66.24 3.00e-120 424.00
IUUC-Mtr-058767 Medicago truncatula 35.42 3.00e-44 172.00
IUUC-Mla-059032 Melampsora laricipopulina 34.34 3.00e-48 186.00
IUUC-Mga-059799 Meleagris gallopavo 50.27 5.00e-94 337.00
IUUC-Mvi-060258 Microbotryum violaceum 39.35 2.00e-49 189.00
IUUC-Mmr-061425 Microcebus murinus 70.82 2.00e-180 625.00
IUUC-Mdo-062620 Monodelphis domestica 52.93 1.00e-132 466.00
IUUC-Mmu-063473 Mus musculus 65.94 2.00e-170 592.00
IUUC-Mac-065376 Musa acuminata 32.63 8.00e-42 164.00
IUUC-Mpu-066124 Mustela putorius furo 65.37 7.00e-170 590.00
IUUC-Mlu-067844 Myotis lucifugus 59.34 6.00e-148 517.00
IUUC-Ont-071523 Oreochromis niloticus 48.26 6.00e-107 380.00
IUUC-Oan-072754 Ornithorhynchus anatinus 47.90 6.00e-93 334.00
IUUC-Ocu-074659 Oryctolagus cuniculus 66.03 6.00e-113 400.00
IUUC-Oba-075786 Oryza barthii 41.61 5.00e-32 130.00
IUUC-Obr-076077 Oryza brachyantha 32.74 4.00e-39 155.00
IUUC-Ogl-077449 Oryza glaberrima 35.52 2.00e-42 166.00
IUUC-Ogu-078217 Oryza glumaepatula 35.52 5.00e-42 164.00
IUUC-Oin-079292 Oryza indica 35.52 2.00e-42 166.00
IUUC-Olo-080599 Oryza longistaminata 41.61 3.00e-32 131.00
IUUC-Ome-081740 Oryza meridionalis 35.22 6.00e-42 164.00
IUUC-Oni-082582 Oryza nivara 35.52 4.00e-42 165.00
IUUC-Opu-083166 Oryza punctata 34.23 1.00e-41 163.00
IUUC-Oru-084514 Oryza rufipogon 34.78 6.00e-38 151.00
IUUC-Osa-086226 Oryza sativa 35.52 2.00e-42 166.00
IUUC-Olu-087798 Ostreococcus lucimarinus 37.58 2.00e-26 112.00
IUUC-Oga-088820 Otolemur garnettii 73.13 0.00e+00 654.00
IUUC-Oar-089825 Ovis aries 61.15 1.00e-150 526.00
IUUC-Pan-091766 Papio anubis 86.59 0.00e+00 794.00
IUUC-Psi-093167 Pelodiscus sinensis 53.32 1.00e-131 462.00
IUUC-Pno-095089 Phaeosphaeria nodorum 25.26 5.00e-12 65.50
IUUC-Ppa-095299 Physcomitrella patens 36.64 9.00e-48 184.00
IUUC-Pfo-096456 Poecilia formosa 44.57 4.00e-93 335.00
IUUC-Pab-097864 Pongo abelii 97.83 6.00e-164 569.00
IUUC-Pop-100043 Populus trichocarpa 37.36 4.00e-37 148.00
IUUC-Ppe-101556 Prunus persica 33.93 2.00e-46 179.00
IUUC-Pva-102281 Pteropus vampyrus 64.16 6.00e-163 566.00
IUUC-Pgr-103459 Puccinia graminis 36.97 1.00e-31 129.00
IUUC-Rno-105659 Rattus norvegicus 66.01 4.00e-174 604.00
IUUC-Sha-107077 Sarcophilus harrisii 51.07 5.00e-126 444.00
IUUC-Smo-108959 Selaginella moellendorffii 36.84 3.00e-51 195.00
IUUC-Sit-109789 Setaria italica 41.61 4.00e-33 135.00
IUUC-Sly-111376 Solanum lycopersicum 36.63 1.00e-33 136.00
IUUC-Stu-112698 Solanum tuberosum 32.93 9.00e-43 167.00
IUUC-Sbi-114197 Sorghum bicolor 31.63 1.00e-38 154.00
IUUC-Sre-115167 Sporisorium reilianum 43.32 4.00e-32 132.00
IUUC-Tgu-116657 Taeniopygia guttata 61.86 1.00e-74 272.00
IUUC-Tru-118578 Takifugu rubripes 44.27 7.00e-100 357.00
IUUC-Tca-121611 Theobroma cacao 34.51 2.00e-43 169.00
IUUC-Tae-123970 Triticum aestivum 34.13 4.00e-41 162.00
IUUC-Tur-126298 Triticum urartu 38.12 1.00e-33 136.00
IUUC-Ttr-128302 Tursiops truncatus 68.39 4.00e-129 454.00
IUUC-Uma-129644 Ustilago maydis 41.62 3.00e-32 133.00
IUUC-Vvi-131363 Vitis vinifera 33.63 5.00e-41 161.00
IUUC-Xtr-132976 Xenopus tropicalis 47.62 2.00e-108 386.00
IUUC-Xma-133286 Xiphophorus maculatus 44.79 1.00e-98 353.00
IUUC-Yli-134664 Yarrowia lipolytica 25.80 4.00e-19 89.00
Created Date 25-Jun-2017

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