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Tag Content
UUCD2 ID IUUC-Mdo-062741
UUCD1 version UUC-MoD-00271
Ensembl Protein ID ENSMODP00000026501.3
UniProt Accession F6UH62; F6UH62_MONDO
Protein Name Uncharacterized protein
Gene Name CUL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000021204.3 ENSMODT00000026975.3 ENSMODP00000026501.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 1.50e-230 767.2 37 665
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 37   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 125
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 126  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 213
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 214  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLACMYKL 302
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk++++++++e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 303  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 386
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 387  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 475
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 476  DMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 564
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 565  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 653
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 654  ENGHIFTVNDQF 665
           **********99 PP
   
Organism Monodelphis domestica
Protein Sequence
(Fasta)
MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN 60
AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mdo-062741|E3,Cullin|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNAGC CCGGCCGCCT TCGATGTGAC CTGGGCGCCC CAGAGCGCGA CCTGAAGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mdo-062741|E3,Cullin|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway
KEGG mdo:100015239
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000335 Aegilops tauschii 47.07 0.00e+00 686.00
IUUC-Aml-002278 Ailuropoda melanoleuca 99.09 0.00e+00 1556.00
IUUC-Atr-002616 Amborella trichopoda 52.36 0.00e+00 774.00
IUUC-Apl-004172 Anas platyrhynchos 99.87 0.00e+00 1520.00
IUUC-Aca-004309 Anolis carolinensis 99.87 0.00e+00 1567.00
IUUC-Aly-005566 Arabidopsis lyrata 51.64 0.00e+00 769.00
IUUC-Ath-007587 Arabidopsis thaliana 52.03 0.00e+00 774.00
IUUC-Ago-007795 Ashbya gossypii 25.29 1.00e-48 188.00
IUUC-Acl-008317 Aspergillus clavatus 36.48 4.00e-145 509.00
IUUC-Afl-008727 Aspergillus flavus 36.53 1.00e-144 507.00
IUUC-Afu-008879 Aspergillus fumigatus 37.96 6.00e-133 468.00
IUUC-Ani-009393 Aspergillus nidulans 35.55 5.00e-136 478.00
IUUC-Ang-009626 Aspergillus niger 36.44 2.00e-141 496.00
IUUC-Aor-010207 Aspergillus oryzae 36.53 1.00e-144 507.00
IUUC-Ate-010305 Aspergillus terreus 37.16 1.00e-140 493.00
IUUC-Ame-011805 Astyanax mexicanus 96.88 0.00e+00 1518.00
IUUC-Bgr-012098 Blumeria graminis 36.02 6.00e-121 428.00
IUUC-Bta-013445 Bos taurus 100.00 0.00e+00 1569.00
IUUC-Bci-013612 Botrytis cinerea 36.61 3.00e-139 489.00
IUUC-Bdi-014269 Brachypodium distachyon 52.55 0.00e+00 749.00
IUUC-Bol-015350 Brassica oleracea 52.16 0.00e+00 772.00
IUUC-Bra-016763 Brassica rapa 52.29 0.00e+00 775.00
IUUC-Cel-018641 Caenorhabditis elegans 48.53 0.00e+00 731.00
IUUC-Cja-019175 Callithrix jacchus 99.87 0.00e+00 1566.00
IUUC-Cfa-020905 Canis familiaris 99.60 0.00e+00 1526.00
IUUC-Cpo-021293 Cavia porcellus 97.91 0.00e+00 1531.00
IUUC-Cre-022776 Chlamydomonas reinhardtii 48.30 0.00e+00 700.00
IUUC-Csa-023800 Chlorocebus sabaeus 99.74 0.00e+00 1564.00
IUUC-Cho-024839 Choloepus hoffmanni 98.97 0.00e+00 1357.00
IUUC-Cin-025201 Ciona intestinalis 71.63 0.00e+00 1030.00
IUUC-Csv-026107 Ciona savignyi 71.24 0.00e+00 1096.00
IUUC-Cgl-026630 Colletotrichum gloeosporioides 35.43 1.00e-124 441.00
IUUC-Cne-027048 Cryptococcus neoformans 34.80 2.00e-117 416.00
IUUC-Cme-027254 Cyanidioschyzon merolae 31.00 3.00e-88 319.00
IUUC-Dre-028488 Danio rerio 97.53 0.00e+00 1531.00
IUUC-Dno-029784 Dasypus novemcinctus 99.87 0.00e+00 1566.00
IUUC-Dor-030682 Dipodomys ordii 92.63 0.00e+00 1368.00
IUUC-Dse-031326 Dothistroma septosporum 35.74 2.00e-128 453.00
IUUC-Dme-032112 Drosophila melanogaster 69.57 0.00e+00 1081.00
IUUC-Ete-032347 Echinops telfairi 81.46 0.00e+00 1197.00
IUUC-Eca-033560 Equus caballus 99.87 0.00e+00 1522.00
IUUC-Eeu-034502 Erinaceus europaeus 97.94 0.00e+00 1347.00
IUUC-Fca-035544 Felis catus 100.00 0.00e+00 1522.00
IUUC-Fal-036751 Ficedula albicollis 100.00 0.00e+00 1524.00
IUUC-Fox-037857 Fusarium oxysporum 36.92 1.00e-137 483.00
IUUC-Fso-038163 Fusarium solani 36.73 4.00e-141 495.00
IUUC-Gmo-039270 Gadus morhua 96.90 0.00e+00 1529.00
IUUC-Ggr-039999 Gaeumannomyces graminis 33.88 6.00e-128 451.00
IUUC-Gga-040329 Gallus gallus 99.87 0.00e+00 1568.00
IUUC-Gac-041510 Gasterosteus aculeatus 96.77 0.00e+00 1525.00
IUUC-Gma-043182 Glycine max 52.34 0.00e+00 748.00
IUUC-Ggo-044903 Gorilla gorilla 99.60 0.00e+00 1513.00
IUUC-Hsa-046000 Homo sapiens 99.74 0.00e+00 1564.00
IUUC-Hvu-047831 Hordeum vulgare 52.46 0.00e+00 701.00
IUUC-Itr-049067 Ictidomys tridecemlineatus 100.00 0.00e+00 942.00
IUUC-Kpa-049372 Komagataella pastoris 35.07 2.00e-115 410.00
IUUC-Lch-050458 Latimeria chalumnae 97.39 0.00e+00 1519.00
IUUC-Lpe-051396 Leersia perrieri 51.76 0.00e+00 758.00
IUUC-Loc-052186 Lepisosteus oculatus 98.83 0.00e+00 1554.00
IUUC-Lma-053030 Leptosphaeria maculans 38.55 4.00e-144 505.00
IUUC-Laf-053684 Loxodonta africana 100.00 0.00e+00 1522.00
IUUC-Mcc-055770 Macaca mulatta 99.74 0.00e+00 1564.00
IUUC-Meu-056852 Macropus eugenii 100.00 0.00e+00 764.00
IUUC-Mor-057273 Magnaporthe oryzae 34.76 3.00e-133 469.00
IUUC-Mpo-057403 Magnaporthe poae 34.00 1.00e-129 457.00
IUUC-Mtr-058317 Medicago truncatula 51.71 0.00e+00 753.00
IUUC-Mla-059055 Melampsora laricipopulina 37.40 2.00e-133 469.00
IUUC-Mga-060076 Meleagris gallopavo 98.26 0.00e+00 1491.00
IUUC-Mvi-060470 Microbotryum violaceum 33.64 9.00e-136 477.00
IUUC-Mmr-060976 Microcebus murinus 100.00 0.00e+00 1569.00
IUUC-Mmu-063905 Mus musculus 99.74 0.00e+00 1564.00
IUUC-Mac-064718 Musa acuminata 50.79 0.00e+00 732.00
IUUC-Mpu-066356 Mustela putorius furo 100.00 0.00e+00 1522.00
IUUC-Mlu-067768 Myotis lucifugus 99.47 0.00e+00 1519.00
IUUC-Nfi-068285 Neosartorya fischeri 37.20 2.00e-146 513.00
IUUC-Ncr-068883 Neurospora crassa 36.28 2.00e-138 486.00
IUUC-Nle-069638 Nomascus leucogenys 99.73 0.00e+00 1516.00
IUUC-Opr-070333 Ochotona princeps 90.90 0.00e+00 1272.00
IUUC-Ont-071601 Oreochromis niloticus 98.05 0.00e+00 1575.00
IUUC-Oan-073281 Ornithorhynchus anatinus 99.84 0.00e+00 1303.00
IUUC-Ocu-074504 Oryctolagus cuniculus 99.87 0.00e+00 1524.00
IUUC-Oba-075332 Oryza barthii 52.31 0.00e+00 750.00
IUUC-Obr-076435 Oryza brachyantha 53.12 0.00e+00 715.00
IUUC-Ogl-077655 Oryza glaberrima 52.29 0.00e+00 761.00
IUUC-Ogu-078458 Oryza glumaepatula 52.31 0.00e+00 751.00
IUUC-Oin-079567 Oryza indica 52.16 0.00e+00 758.00
IUUC-Olo-080930 Oryza longistaminata 53.02 0.00e+00 758.00
IUUC-Ome-081353 Oryza meridionalis 52.29 0.00e+00 759.00
IUUC-Oni-082378 Oryza nivara 52.29 0.00e+00 761.00
IUUC-Opu-084055 Oryza punctata 52.16 0.00e+00 760.00
IUUC-Oru-084202 Oryza rufipogon 52.31 0.00e+00 751.00
IUUC-Osa-085290 Oryza sativa 52.29 0.00e+00 761.00
IUUC-Ola-087562 Oryzias latipes 97.79 0.00e+00 1539.00
IUUC-Olu-087866 Ostreococcus lucimarinus 37.79 2.00e-139 489.00
IUUC-Oga-088833 Otolemur garnettii 100.00 0.00e+00 1522.00
IUUC-Oar-089958 Ovis aries 100.00 0.00e+00 1522.00
IUUC-Ptr-091013 Pan troglodytes 99.74 0.00e+00 1564.00
IUUC-Pan-091796 Papio anubis 99.07 0.00e+00 1509.00
IUUC-Psi-093564 Pelodiscus sinensis 98.26 0.00e+00 1488.00
IUUC-Pno-094939 Phaeosphaeria nodorum 38.22 1.00e-138 487.00
IUUC-Ppa-095920 Physcomitrella patens 52.68 0.00e+00 766.00
IUUC-Pfo-097498 Poecilia formosa 93.64 0.00e+00 1521.00
IUUC-Pab-098164 Pongo abelii 99.74 0.00e+00 1564.00
IUUC-Pop-099497 Populus trichocarpa 53.21 0.00e+00 789.00
IUUC-Pca-100702 Procavia capensis 91.80 0.00e+00 1395.00
IUUC-Ppe-101971 Prunus persica 51.83 0.00e+00 737.00
IUUC-Pva-103129 Pteropus vampyrus 99.87 0.00e+00 1569.00
IUUC-Pgr-103684 Puccinia graminis 36.44 2.00e-110 394.00
IUUC-Ptt-103961 Puccinia triticina 36.62 2.00e-109 390.00
IUUC-Pte-104325 Pyrenophora teres 38.06 8.00e-136 478.00
IUUC-Pyt-104746 Pyrenophora triticirepentis 37.09 1.00e-133 471.00
IUUC-Rno-105935 Rattus norvegicus 99.87 0.00e+00 1521.00
IUUC-Sce-106354 Saccharomyces cerevisiae 26.88 8.00e-53 202.00
IUUC-Sha-106569 Sarcophilus harrisii 99.42 0.00e+00 1387.00
IUUC-Sja-107676 Schizosaccharomyces japonicus 38.51 2.00e-154 539.00
IUUC-Spo-108135 Schizosaccharomyces pombe 37.48 1.00e-138 487.00
IUUC-Smo-109555 Selaginella moellendorffii 53.49 0.00e+00 790.00
IUUC-Sit-110763 Setaria italica 52.94 0.00e+00 764.00
IUUC-Sly-111090 Solanum lycopersicum 51.97 0.00e+00 765.00
IUUC-Stu-112351 Solanum tuberosum 52.11 0.00e+00 767.00
IUUC-Sar-113144 Sorex araneus 100.00 0.00e+00 1119.00
IUUC-Sbi-114690 Sorghum bicolor 52.16 0.00e+00 764.00
IUUC-Sre-115005 Sporisorium reilianum 38.04 2.00e-135 476.00
IUUC-Ssc-116053 Sus scrofa 99.82 0.00e+00 1144.00
IUUC-Tgu-116523 Taeniopygia guttata 100.00 0.00e+00 1522.00
IUUC-Tru-118189 Takifugu rubripes 93.88 0.00e+00 1444.00
IUUC-Tsy-118962 Tarsius syrichta 93.67 0.00e+00 1390.00
IUUC-Tni-120614 Tetraodon nigroviridis 57.22 0.00e+00 879.00
IUUC-Tca-121282 Theobroma cacao 52.68 0.00e+00 769.00
IUUC-Tre-122201 Trichoderma reesei 35.88 4.00e-134 472.00
IUUC-Tvi-122321 Trichoderma virens 36.36 6.00e-135 474.00
IUUC-Tae-124292 Triticum aestivum 51.90 0.00e+00 744.00
IUUC-Tur-126800 Triticum urartu 51.63 0.00e+00 741.00
IUUC-Tme-127053 Tuber melanosporum 40.48 2.00e-156 546.00
IUUC-Tbe-127427 Tupaia belangeri 85.21 0.00e+00 1165.00
IUUC-Ttr-128662 Tursiops truncatus 98.12 0.00e+00 1482.00
IUUC-Uma-129597 Ustilago maydis 38.54 8.00e-135 474.00
IUUC-Vda-129726 Verticillium dahliae 35.26 7.00e-134 471.00
IUUC-Vpa-130809 Vicugna pacos 100.00 0.00e+00 746.00
IUUC-Vvi-131630 Vitis vinifera 52.55 0.00e+00 759.00
IUUC-Xtr-131887 Xenopus tropicalis 98.70 0.00e+00 1550.00
IUUC-Xma-133517 Xiphophorus maculatus 97.92 0.00e+00 1542.00
IUUC-Yli-134576 Yarrowia lipolytica 33.46 3.00e-111 395.00
IUUC-Zma-135030 Zea mays 52.60 0.00e+00 771.00
Created Date 25-Jun-2017

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