iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000004047.2	ENSNLET00000005177.2	ENSNLEP00000004923.2
ENSNLEG00000004047.2	ENSNLET00000005178.1	ENSNLEP00000004924.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-123	412.3	11	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 5    irlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveah 93
            rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ ++ + +  +++ +++Ae+a+e+l+eln+dv+++++
   Q: 11   ARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNKYVLFFSNIYMNRAEAAMEFLQELNSDVSGSFV 99
           59*************************************************************************************** PP
   S: 94   eesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlke 178
           ees+++l ++++ Ff++f+vVv+++  +++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf++l+e
   Q: 100  EESPENLLDNDPsFFCRFTVVVATQLAESTLLRLANVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFPELRE 188
           ***************************************************************************************** PP
   S: 179  tpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttins 252
           +++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t+i+s
   Q: 189  HFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTTQIPS 277
           *99999999998***********************************************9***************************** PP
   S: 253  .ikqllksfecdivtkskspfwv.................................................................. 274
            i++++++++c ++tk++++fw+                                                                  
   Q: 278  sIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqap 366
           ***************************************************************************************** PP
   S: 275  .........sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlv 336
                     +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  + +++
   Q: 367  esisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkLKSCL 455
           *********99********7777777888888**************9***********************************999**** PP
   S: 337  taaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 456  TGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 519
           ****....********************************************************9776 PP

Organism

Nomascus leucogenys

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MDAQQTKTNE ARLWGDHGQE ALESAHVCLI NATATGTEIL KNLVLPGIGS FTIIDGNQVS 60
GEDAGNKYVL FFSNIYMNRA EAAMEFLQEL NSDVSGSFVE ESPENLLDND PSFFCRFTVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCTC AGCAAACAAA AACAAATGAA GCCAGGTGCA GTGGCTTGTG CCTATAGTCC 60
CAGCAACTCT AGAGGCTGAG GCGAGAGGAA TGCTTGAACC CAGGAGTTCA AGACCAGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.14	1.00e-118	420.00
IUUC-Aml-002333	Ailuropoda melanoleuca	94.50	0.00e+00	1036.00
IUUC-Atr-002644	Amborella trichopoda	40.00	6.00e-109	387.00
IUUC-Apl-003446	Anas platyrhynchos	82.69	0.00e+00	901.00
IUUC-Aca-004450	Anolis carolinensis	78.67	0.00e+00	884.00
IUUC-Aly-006187	Arabidopsis lyrata	39.00	8.00e-119	420.00
IUUC-Ath-007600	Arabidopsis thaliana	39.58	4.00e-120	424.00
IUUC-Ago-007900	Ashbya gossypii	25.69	2.00e-37	150.00
IUUC-Acl-008333	Aspergillus clavatus	32.78	5.00e-72	265.00
IUUC-Afl-008529	Aspergillus flavus	34.68	2.00e-77	283.00
IUUC-Afu-009071	Aspergillus fumigatus	32.29	2.00e-73	269.00
IUUC-Ani-009443	Aspergillus nidulans	31.92	3.00e-69	256.00
IUUC-Ang-009669	Aspergillus niger	31.68	2.00e-73	270.00
IUUC-Aor-009914	Aspergillus oryzae	34.00	3.00e-74	272.00
IUUC-Ate-010450	Aspergillus terreus	32.97	6.00e-75	275.00
IUUC-Ame-011183	Astyanax mexicanus	69.64	0.00e+00	798.00
IUUC-Bgr-012111	Blumeria graminis	31.15	6.00e-57	215.00
IUUC-Bta-012583	Bos taurus	95.24	0.00e+00	1045.00
IUUC-Bci-013892	Botrytis cinerea	31.39	2.00e-56	213.00
IUUC-Bdi-014592	Brachypodium distachyon	41.92	6.00e-121	427.00
IUUC-Bol-016399	Brassica oleracea	38.30	3.00e-117	415.00
IUUC-Bra-017506	Brassica rapa	37.29	1.00e-112	400.00
IUUC-Cel-018456	Caenorhabditis elegans	34.94	6.00e-88	318.00
IUUC-Cja-020007	Callithrix jacchus	95.27	0.00e+00	1043.00
IUUC-Cfa-020324	Canis familiaris	95.05	0.00e+00	1040.00
IUUC-Cpo-022248	Cavia porcellus	64.27	1.00e-176	612.00
IUUC-Csa-023149	Chlorocebus sabaeus	99.33	0.00e+00	935.00
IUUC-Cho-024537	Choloepus hoffmanni	84.16	0.00e+00	792.00
IUUC-Cin-025763	Ciona intestinalis	48.28	4.00e-147	514.00
IUUC-Csv-026113	Ciona savignyi	45.03	1.00e-137	483.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.84	2.00e-56	213.00
IUUC-Cne-026884	Cryptococcus neoformans	28.52	8.00e-64	238.00
IUUC-Cme-027210	Cyanidioschyzon merolae	25.43	1.00e-13	71.60
IUUC-Dre-028140	Danio rerio	71.24	0.00e+00	816.00
IUUC-Dno-030033	Dasypus novemcinctus	94.22	0.00e+00	917.00
IUUC-Dor-030513	Dipodomys ordii	69.01	4.00e-116	411.00
IUUC-Dse-031536	Dothistroma septosporum	33.88	3.00e-77	282.00
IUUC-Dme-031683	Drosophila melanogaster	42.70	3.00e-119	421.00
IUUC-Ete-032420	Echinops telfairi	81.78	0.00e+00	872.00
IUUC-Eca-033992	Equus caballus	97.98	0.00e+00	917.00
IUUC-Eeu-034713	Erinaceus europaeus	80.31	2.00e-118	419.00
IUUC-Fca-036548	Felis catus	93.90	0.00e+00	1028.00
IUUC-Fal-037600	Ficedula albicollis	79.73	0.00e+00	870.00
IUUC-Fox-038037	Fusarium oxysporum	32.10	1.00e-67	250.00
IUUC-Fso-038387	Fusarium solani	32.79	1.00e-68	253.00
IUUC-Gmo-038562	Gadus morhua	69.07	0.00e+00	793.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.18	5.00e-64	238.00
IUUC-Gga-041129	Gallus gallus	82.67	0.00e+00	904.00
IUUC-Gac-042558	Gasterosteus aculeatus	70.21	0.00e+00	799.00
IUUC-Gma-043610	Glycine max	39.66	1.00e-113	403.00
IUUC-Ggo-045611	Gorilla gorilla	95.83	0.00e+00	1045.00
IUUC-Hsa-046563	Homo sapiens	96.38	0.00e+00	1050.00
IUUC-Hvu-047790	Hordeum vulgare	37.72	2.00e-77	282.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	95.43	0.00e+00	1045.00
IUUC-Kpa-049309	Komagataella pastoris	33.91	1.00e-75	276.00
IUUC-Lch-050038	Latimeria chalumnae	75.10	0.00e+00	825.00
IUUC-Lpe-051535	Leersia perrieri	40.53	4.00e-106	378.00
IUUC-Loc-051917	Lepisosteus oculatus	69.32	0.00e+00	778.00
IUUC-Lma-053112	Leptosphaeria maculans	34.24	2.00e-79	289.00
IUUC-Laf-053690	Loxodonta africana	93.37	0.00e+00	1037.00
IUUC-Mcc-055117	Macaca mulatta	95.84	0.00e+00	1048.00
IUUC-Meu-056761	Macropus eugenii	74.58	0.00e+00	789.00
IUUC-Mor-057230	Magnaporthe oryzae	31.44	8.00e-68	251.00
IUUC-Mpo-057514	Magnaporthe poae	31.63	3.00e-62	232.00
IUUC-Mtr-058551	Medicago truncatula	39.18	1.00e-110	393.00
IUUC-Mla-059183	Melampsora laricipopulina	34.95	5.00e-87	315.00
IUUC-Mga-060144	Meleagris gallopavo	83.43	0.00e+00	901.00
IUUC-Mvi-060221	Microbotryum violaceum	33.77	1.00e-73	270.00
IUUC-Mmr-061325	Microcebus murinus	94.89	0.00e+00	1045.00
IUUC-Mdo-062532	Monodelphis domestica	89.02	0.00e+00	986.00
IUUC-Mmu-063956	Mus musculus	94.86	0.00e+00	1040.00
IUUC-Mac-064521	Musa acuminata	39.62	9.00e-116	410.00
IUUC-Mpu-066716	Mustela putorius furo	93.91	0.00e+00	973.00
IUUC-Mlu-067459	Myotis lucifugus	93.73	0.00e+00	1028.00
IUUC-Nfi-068245	Neosartorya fischeri	32.66	8.00e-74	271.00
IUUC-Ncr-068910	Neurospora crassa	31.76	5.00e-68	251.00
IUUC-Opr-070552	Ochotona princeps	84.82	0.00e+00	842.00
IUUC-Ont-071426	Oreochromis niloticus	70.86	0.00e+00	815.00
IUUC-Oan-073389	Ornithorhynchus anatinus	84.04	0.00e+00	783.00
IUUC-Ocu-074911	Oryctolagus cuniculus	93.71	0.00e+00	1034.00
IUUC-Oba-075437	Oryza barthii	41.35	8.00e-111	394.00
IUUC-Obr-076684	Oryza brachyantha	41.73	2.00e-107	382.00
IUUC-Ogl-077170	Oryza glaberrima	41.35	8.00e-111	394.00
IUUC-Ogu-078844	Oryza glumaepatula	42.22	4.00e-104	371.00
IUUC-Oin-079105	Oryza indica	41.35	3.00e-110	392.00
IUUC-Olo-080943	Oryza longistaminata	40.53	1.00e-100	360.00
IUUC-Oni-082891	Oryza nivara	40.00	4.00e-106	378.00
IUUC-Opu-083457	Oryza punctata	41.35	2.00e-110	392.00
IUUC-Oru-084960	Oryza rufipogon	40.53	1.00e-100	359.00
IUUC-Osa-085358	Oryza sativa	41.54	5.00e-111	394.00
IUUC-Ola-086420	Oryzias latipes	71.31	9.00e-169	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.86	4.00e-56	212.00
IUUC-Oga-088810	Otolemur garnettii	93.33	0.00e+00	1026.00
IUUC-Oar-089196	Ovis aries	94.70	0.00e+00	1041.00
IUUC-Ptr-090617	Pan troglodytes	96.38	0.00e+00	1051.00
IUUC-Pan-092761	Papio anubis	96.38	0.00e+00	1052.00
IUUC-Psi-093191	Pelodiscus sinensis	85.71	0.00e+00	949.00
IUUC-Pma-094380	Petromyzon marinus	60.74	0.00e+00	633.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.87	2.00e-65	244.00
IUUC-Ppa-095875	Physcomitrella patens	39.35	2.00e-114	406.00
IUUC-Pfo-096467	Poecilia formosa	69.89	0.00e+00	798.00
IUUC-Pab-098255	Pongo abelii	95.40	0.00e+00	865.00
IUUC-Pop-099722	Populus trichocarpa	39.96	3.00e-118	418.00
IUUC-Pca-100807	Procavia capensis	75.47	1.00e-111	396.00
IUUC-Ppe-101280	Prunus persica	38.89	2.00e-116	412.00
IUUC-Pva-102333	Pteropus vampyrus	89.96	0.00e+00	975.00
IUUC-Pgr-103401	Puccinia graminis	31.40	5.00e-74	271.00
IUUC-Ptt-103889	Puccinia triticina	27.00	3.00e-55	209.00
IUUC-Pte-104355	Pyrenophora teres	34.85	1.00e-82	300.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.04	4.00e-83	301.00
IUUC-Rno-105810	Rattus norvegicus	94.48	0.00e+00	1037.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.56	5.00e-34	138.00
IUUC-Sha-106770	Sarcophilus harrisii	84.73	3.00e-141	493.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.77	5.00e-71	261.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.21	3.00e-75	276.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	30.13	9.00e-59	221.00
IUUC-Smo-109296	Selaginella moellendorffii	41.81	5.00e-118	417.00
IUUC-Sit-110157	Setaria italica	43.44	4.00e-127	448.00
IUUC-Sly-111105	Solanum lycopersicum	38.76	3.00e-115	408.00
IUUC-Stu-112469	Solanum tuberosum	39.29	4.00e-117	415.00
IUUC-Sar-113083	Sorex araneus	71.71	0.00e+00	731.00
IUUC-Sbi-113813	Sorghum bicolor	43.27	2.00e-126	445.00
IUUC-Sre-115058	Sporisorium reilianum	36.77	2.00e-76	280.00
IUUC-Tgu-116772	Taeniopygia guttata	78.52	0.00e+00	862.00
IUUC-Tru-118686	Takifugu rubripes	69.14	0.00e+00	801.00
IUUC-Tsy-119111	Tarsius syrichta	86.13	2.00e-139	488.00
IUUC-Tni-120231	Tetraodon nigroviridis	67.47	0.00e+00	722.00
IUUC-Tca-121491	Theobroma cacao	39.27	4.00e-110	391.00
IUUC-Tre-122103	Trichoderma reesei	34.25	9.00e-74	270.00
IUUC-Tvi-122672	Trichoderma virens	34.38	2.00e-66	246.00
IUUC-Tae-125679	Triticum aestivum	41.89	7.00e-121	427.00
IUUC-Tur-126487	Triticum urartu	41.00	6.00e-118	417.00
IUUC-Tme-127097	Tuber melanosporum	37.02	1.00e-84	307.00
IUUC-Ttr-128465	Tursiops truncatus	87.31	0.00e+00	947.00
IUUC-Uma-129645	Ustilago maydis	32.21	8.00e-82	297.00
IUUC-Vda-129989	Verticillium dahliae	28.79	3.00e-47	182.00
IUUC-Vpa-130529	Vicugna pacos	89.96	0.00e+00	981.00
IUUC-Vvi-131059	Vitis vinifera	40.04	1.00e-115	409.00
IUUC-Xtr-132002	Xenopus tropicalis	76.19	0.00e+00	870.00
IUUC-Xma-133930	Xiphophorus maculatus	70.29	0.00e+00	805.00
IUUC-Yli-134505	Yarrowia lipolytica	33.14	1.00e-76	280.00
IUUC-Zma-135895	Zea mays	43.08	2.00e-125	442.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence