iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049648

Ensembl Protein ID

ENSLACP00000007334.2

UniProt Accession

H3ACG3; H3ACG3_LATCH

Genbank Protein ID

ENSLACP00000007334

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01153733

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000006506.2	ENSLACT00000007394.2	ENSLACP00000007334.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.40e-58	196.5	326	832
UBD/Alpha-Helix/UBA	5.30e-19	68.0	702	739

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
795	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q++++ip++   +   + ek+ +++p++p++++ ++++kl   l                    +k+++  + 
   Q: 326  TGIRNLGNSCYLNSVMQVIFSIPDFHLKYVG-NLEKIFQNAPSDPTQDFNTQVAKLGYGLlcgdyskpatdledeeqtseQKGEQAGIV 413
           7*************************99999.89999999********************89999999888888877554488888*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             +++s  ++ F++ ++++i cl 
   Q: 414  PRMFKALVGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSSNPNEAFRFLVEERINCLV 473
           **************************************.............................7889999*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            ++ cLe+++++e++ +   ++++   +k+ a+k+
   Q: 474  SQKVKYTQRVDYIMQLPVPMEAAVNKEelleyearkrqaeeekqllpelvrakvPFSACLEAYAEPEHVAD---FWSTALLAKSVAVKT 559
           *******************9998888899****************************************97...88888999999**** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   s                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISHLRGSglqpgeeelpdiapplvtpdepkapvldesvitqlaemgfpv 647
           *******************997.*******************98888888888888888888888888888888888888888777777 PP
   S: 268  ...................................................................peekqke............... 274
                                                                              +     +               
   Q: 648  eacrkavyytgnsgveaamnwvmthiddpdfanpmvlpgssgpgststladpppedsvstivsmgfsR-----Dqafkalratsnsler 731
           77777777777777777777777777777777777777777766666666666555555555555550.....0555555555555556 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
                                                        +Y+++a ++H+G s+ +GHYv+++k+ +g+W+ f+D+kV ++  
   Q: 732  avdwifshiddldteatmdisegrsaaesvsesvpagpkvrdgAGRYQMFAFISHMGtSTMCGHYVCHIKK-EGRWVIFNDQKVCAS-- 817
           66666666666666666666777777777777888888888889***************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 818  EKPPK---DLGYIYFYQR 832
           78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++a +aLra++n+le+Av++++++
   Q: 702  EDSVSTIVSMGFSRDQAFKALRATSNSLERAVDWIFSH 739
           8999********************************97 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MAAELSEALL SVLPTIRIPK AGDRVHKDEC AFSFDTPESD GGLYICMNTF LGFGKQYVER 60
HYRKTGQKVY LHLKRTCKPK LDDNSSGSGD PPRKKPTRLA IGIEGGFDLD LEKFEYDEEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTATAAAC ACCTATTTTC TTGAAGGTTC ACAGAGGTTA TAACTAAAAA AATACCTTAA 60
ATACTACTTT TTGTCTTGTT AAGCCCGTAT GCTAGAAATT TAACTTCTGA GCTTTAATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.21	0.00e+00	661.00
IUUC-Aml-002104	Ailuropoda melanoleuca	81.46	0.00e+00	1381.00
IUUC-Atr-002580	Amborella trichopoda	44.19	0.00e+00	674.00
IUUC-Apl-003774	Anas platyrhynchos	80.74	0.00e+00	1374.00
IUUC-Aca-005368	Anolis carolinensis	83.03	0.00e+00	1452.00
IUUC-Aly-005727	Arabidopsis lyrata	48.44	0.00e+00	756.00
IUUC-Ath-006974	Arabidopsis thaliana	48.56	0.00e+00	754.00
IUUC-Ago-007890	Ashbya gossypii	27.94	7.00e-78	285.00
IUUC-Acl-008057	Aspergillus clavatus	34.99	7.00e-124	437.00
IUUC-Afl-008547	Aspergillus flavus	37.25	4.00e-118	418.00
IUUC-Afu-008805	Aspergillus fumigatus	33.97	2.00e-111	396.00
IUUC-Ani-009441	Aspergillus nidulans	33.29	9.00e-94	337.00
IUUC-Ang-009720	Aspergillus niger	34.40	4.00e-116	412.00
IUUC-Aor-010111	Aspergillus oryzae	34.77	4.00e-126	445.00
IUUC-Ate-010531	Aspergillus terreus	32.30	6.00e-100	358.00
IUUC-Ame-011893	Astyanax mexicanus	68.85	0.00e+00	1031.00
IUUC-Bgr-012183	Blumeria graminis	34.41	3.00e-123	436.00
IUUC-Bta-013179	Bos taurus	81.89	0.00e+00	1393.00
IUUC-Bci-013858	Botrytis cinerea	34.83	8.00e-128	451.00
IUUC-Bdi-014904	Brachypodium distachyon	47.43	0.00e+00	722.00
IUUC-Bol-015536	Brassica oleracea	48.63	0.00e+00	767.00
IUUC-Bra-017939	Brassica rapa	48.98	0.00e+00	775.00
IUUC-Cel-018625	Caenorhabditis elegans	35.10	7.00e-128	451.00
IUUC-Cja-019063	Callithrix jacchus	79.60	0.00e+00	1363.00
IUUC-Cfa-020976	Canis familiaris	84.67	0.00e+00	1413.00
IUUC-Cpo-022265	Cavia porcellus	84.57	0.00e+00	1410.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.98	5.00e-120	424.00
IUUC-Csa-024177	Chlorocebus sabaeus	83.27	0.00e+00	1279.00
IUUC-Cho-024702	Choloepus hoffmanni	75.04	0.00e+00	827.00
IUUC-Cin-025411	Ciona intestinalis	52.63	0.00e+00	847.00
IUUC-Csv-026347	Ciona savignyi	48.28	0.00e+00	805.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.48	8.00e-112	397.00
IUUC-Cne-026831	Cryptococcus neoformans	35.85	3.00e-129	455.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.98	9.00e-56	212.00
IUUC-Dre-027982	Danio rerio	66.51	0.00e+00	1110.00
IUUC-Dno-029034	Dasypus novemcinctus	82.01	0.00e+00	1406.00
IUUC-Dor-030479	Dipodomys ordii	83.06	7.00e-174	604.00
IUUC-Dse-031467	Dothistroma septosporum	34.45	6.00e-125	441.00
IUUC-Dme-032075	Drosophila melanogaster	49.88	0.00e+00	820.00
IUUC-Ete-032865	Echinops telfairi	74.07	0.00e+00	1247.00
IUUC-Eca-034059	Equus caballus	82.00	0.00e+00	1400.00
IUUC-Eeu-035304	Erinaceus europaeus	77.51	0.00e+00	1269.00
IUUC-Fca-035515	Felis catus	81.89	0.00e+00	1392.00
IUUC-Fal-037271	Ficedula albicollis	83.74	0.00e+00	1363.00
IUUC-Fox-037745	Fusarium oxysporum	33.93	3.00e-125	442.00
IUUC-Fso-038158	Fusarium solani	34.89	2.00e-123	436.00
IUUC-Gmo-039071	Gadus morhua	65.18	0.00e+00	1097.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.57	2.00e-119	423.00
IUUC-Gga-040635	Gallus gallus	81.85	0.00e+00	1456.00
IUUC-Gac-042528	Gasterosteus aculeatus	66.19	0.00e+00	1117.00
IUUC-Gma-043614	Glycine max	46.62	0.00e+00	720.00
IUUC-Ggo-044602	Gorilla gorilla	81.89	0.00e+00	1394.00
IUUC-Hsa-045959	Homo sapiens	81.89	0.00e+00	1394.00
IUUC-Hvu-047563	Hordeum vulgare	48.41	1.00e-174	605.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	80.97	0.00e+00	1392.00
IUUC-Kpa-049156	Komagataella pastoris	32.87	1.00e-113	403.00
IUUC-Lpe-051523	Leersia perrieri	47.69	0.00e+00	735.00
IUUC-Lma-053216	Leptosphaeria maculans	35.04	1.00e-115	411.00
IUUC-Laf-054327	Loxodonta africana	81.42	0.00e+00	1386.00
IUUC-Mcc-055443	Macaca mulatta	81.66	0.00e+00	1386.00
IUUC-Meu-056298	Macropus eugenii	82.47	0.00e+00	954.00
IUUC-Mor-057106	Magnaporthe oryzae	35.16	1.00e-127	450.00
IUUC-Mpo-057589	Magnaporthe poae	34.39	7.00e-122	431.00
IUUC-Mtr-058680	Medicago truncatula	48.98	0.00e+00	750.00
IUUC-Mla-058903	Melampsora laricipopulina	31.54	5.00e-115	408.00
IUUC-Mga-059669	Meleagris gallopavo	80.68	0.00e+00	1369.00
IUUC-Mvi-060476	Microbotryum violaceum	34.43	1.00e-118	421.00
IUUC-Mmr-060575	Microcebus murinus	81.78	0.00e+00	1390.00
IUUC-Mdo-062183	Monodelphis domestica	82.87	0.00e+00	1386.00
IUUC-Mmu-063592	Mus musculus	82.25	0.00e+00	1398.00
IUUC-Mac-065446	Musa acuminata	43.62	0.00e+00	689.00
IUUC-Mpu-066082	Mustela putorius furo	83.82	0.00e+00	1399.00
IUUC-Mlu-067345	Myotis lucifugus	79.48	0.00e+00	1365.00
IUUC-Nfi-068558	Neosartorya fischeri	35.46	4.00e-122	432.00
IUUC-Ncr-068960	Neurospora crassa	34.01	6.00e-111	395.00
IUUC-Nle-070173	Nomascus leucogenys	84.31	0.00e+00	1409.00
IUUC-Opr-070556	Ochotona princeps	81.54	0.00e+00	1403.00
IUUC-Ont-071502	Oreochromis niloticus	67.86	0.00e+00	1121.00
IUUC-Ocu-074861	Oryctolagus cuniculus	84.31	0.00e+00	1422.00
IUUC-Oba-075109	Oryza barthii	47.77	0.00e+00	738.00
IUUC-Obr-076292	Oryza brachyantha	49.22	0.00e+00	733.00
IUUC-Ogl-077065	Oryza glaberrima	49.10	0.00e+00	766.00
IUUC-Ogu-078776	Oryza glumaepatula	47.77	0.00e+00	749.00
IUUC-Oin-080048	Oryza indica	48.62	0.00e+00	756.00
IUUC-Olo-080711	Oryza longistaminata	46.05	0.00e+00	679.00
IUUC-Ome-081506	Oryza meridionalis	46.91	0.00e+00	691.00
IUUC-Oni-082320	Oryza nivara	46.82	0.00e+00	735.00
IUUC-Opu-083801	Oryza punctata	47.77	0.00e+00	728.00
IUUC-Oru-085139	Oryza rufipogon	46.94	0.00e+00	735.00
IUUC-Osa-085713	Oryza sativa	49.22	0.00e+00	769.00
IUUC-Ola-086951	Oryzias latipes	66.24	0.00e+00	1090.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.44	1.00e-176	613.00
IUUC-Oga-088625	Otolemur garnettii	80.38	0.00e+00	1379.00
IUUC-Oar-089995	Ovis aries	79.72	0.00e+00	1374.00
IUUC-Ptr-090640	Pan troglodytes	79.64	0.00e+00	1384.00
IUUC-Pan-091974	Papio anubis	80.07	0.00e+00	1370.00
IUUC-Psi-093957	Pelodiscus sinensis	81.26	0.00e+00	1474.00
IUUC-Pma-094242	Petromyzon marinus	73.42	3.00e-172	597.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.98	7.00e-107	381.00
IUUC-Ppa-095901	Physcomitrella patens	48.76	0.00e+00	786.00
IUUC-Pfo-097148	Poecilia formosa	68.26	0.00e+00	1121.00
IUUC-Pab-098068	Pongo abelii	75.62	0.00e+00	1233.00
IUUC-Pop-098943	Populus trichocarpa	47.90	0.00e+00	733.00
IUUC-Pca-100738	Procavia capensis	82.30	0.00e+00	964.00
IUUC-Ppe-101315	Prunus persica	47.79	0.00e+00	742.00
IUUC-Pva-102154	Pteropus vampyrus	80.99	0.00e+00	1375.00
IUUC-Pgr-103343	Puccinia graminis	32.95	2.00e-103	369.00
IUUC-Ptt-103928	Puccinia triticina	29.47	5.00e-101	362.00
IUUC-Pte-104306	Pyrenophora teres	34.40	3.00e-103	369.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.01	2.00e-105	376.00
IUUC-Rno-105801	Rattus norvegicus	82.01	0.00e+00	1397.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.60	4.00e-72	266.00
IUUC-Sha-107635	Sarcophilus harrisii	84.43	0.00e+00	1406.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.54	6.00e-102	365.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.26	3.00e-111	395.00
IUUC-Smo-108848	Selaginella moellendorffii	48.07	0.00e+00	750.00
IUUC-Sit-110728	Setaria italica	48.62	0.00e+00	786.00
IUUC-Sly-111523	Solanum lycopersicum	48.21	0.00e+00	786.00
IUUC-Sbi-114419	Sorghum bicolor	47.91	0.00e+00	765.00
IUUC-Sre-115225	Sporisorium reilianum	34.79	7.00e-122	431.00
IUUC-Ssc-115686	Sus scrofa	80.38	0.00e+00	1383.00
IUUC-Tgu-117346	Taeniopygia guttata	81.99	0.00e+00	1434.00
IUUC-Tru-118350	Takifugu rubripes	62.93	0.00e+00	1101.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.39	0.00e+00	1091.00
IUUC-Tca-121585	Theobroma cacao	48.62	0.00e+00	742.00
IUUC-Tre-122043	Trichoderma reesei	34.21	7.00e-119	421.00
IUUC-Tvi-122303	Trichoderma virens	35.13	3.00e-122	432.00
IUUC-Tae-125686	Triticum aestivum	47.41	0.00e+00	741.00
IUUC-Tur-126732	Triticum urartu	44.98	0.00e+00	701.00
IUUC-Tme-126909	Tuber melanosporum	34.84	3.00e-118	419.00
IUUC-Tbe-127261	Tupaia belangeri	76.29	0.00e+00	863.00
IUUC-Uma-129599	Ustilago maydis	34.16	2.00e-126	446.00
IUUC-Vda-129688	Verticillium dahliae	33.97	2.00e-116	413.00
IUUC-Vvi-131116	Vitis vinifera	47.21	0.00e+00	713.00
IUUC-Xtr-131953	Xenopus tropicalis	76.31	0.00e+00	1288.00
IUUC-Xma-133837	Xiphophorus maculatus	68.38	0.00e+00	1123.00
IUUC-Yli-134510	Yarrowia lipolytica	36.11	8.00e-127	447.00
IUUC-Zma-135786	Zea mays	47.19	0.00e+00	731.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence