iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098068

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01346473

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000004206.2	ENSPPYT00000004982.2	ENSPPYP00000004792.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.60e-64	215.9	308	837
UBD/Alpha-Helix/UBA	1.00e-22	79.6	707	744

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
800	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 308  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 395
           7******************************.99999999********************67766666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 396  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 455
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 456  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekmalpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 541
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 542  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 629
           *******************997.*******************98888788888888888888888888888888888888777777777 PP
   S: 268  .................................................................................peekqke. 274
                                                                                            +     + 
   Q: 630  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----Ti 713
           7777777777777777777777777777777777666666666666666666666666666666665555555555555550.....05 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a ++H+G s+ +GHYv
   Q: 714  vsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYV 802
           555555555555566666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 803  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 837
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 707  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 744
           889999******************************97 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDPTTGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCCGTGT GTGGAGAAGC TGCTGCCGGT GTCATGGCGG AGCTGAGTGA GGAGGCGCTG 60
CTGTCAGTAT TACCGACGAT CCGGGTCCCT AAGGCTGGAG ACCGGGTCCA CAAAGACGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00627--UBA
PF00443--UCH

SMART

SM00165--UBA

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	90.34	0.00e+00	1470.00
IUUC-Atr-002580	Amborella trichopoda	42.13	5.00e-177	614.00
IUUC-Apl-003774	Anas platyrhynchos	84.60	0.00e+00	1364.00
IUUC-Aca-005368	Anolis carolinensis	79.63	0.00e+00	1338.00
IUUC-Aly-005727	Arabidopsis lyrata	42.48	3.00e-174	605.00
IUUC-Ath-006974	Arabidopsis thaliana	42.79	1.00e-174	607.00
IUUC-Ago-007890	Ashbya gossypii	27.84	8.00e-69	254.00
IUUC-Acl-008057	Aspergillus clavatus	31.79	4.00e-103	369.00
IUUC-Afl-008547	Aspergillus flavus	36.46	1.00e-99	357.00
IUUC-Afu-008805	Aspergillus fumigatus	37.88	1.00e-105	377.00
IUUC-Ani-009441	Aspergillus nidulans	31.78	1.00e-87	317.00
IUUC-Ang-009720	Aspergillus niger	31.87	7.00e-101	361.00
IUUC-Aor-010111	Aspergillus oryzae	32.10	1.00e-108	387.00
IUUC-Ate-010531	Aspergillus terreus	30.21	3.00e-86	312.00
IUUC-Ame-011893	Astyanax mexicanus	59.95	0.00e+00	853.00
IUUC-Bgr-012183	Blumeria graminis	31.48	1.00e-102	367.00
IUUC-Bta-013179	Bos taurus	90.55	0.00e+00	1469.00
IUUC-Bci-013858	Botrytis cinerea	32.95	5.00e-112	398.00
IUUC-Bdi-014904	Brachypodium distachyon	42.37	5.00e-169	588.00
IUUC-Bol-015536	Brassica oleracea	43.57	3.00e-180	625.00
IUUC-Bra-017939	Brassica rapa	43.55	3.00e-180	625.00
IUUC-Cel-018625	Caenorhabditis elegans	32.67	1.00e-113	404.00
IUUC-Cja-019063	Callithrix jacchus	90.35	0.00e+00	1466.00
IUUC-Cfa-020976	Canis familiaris	88.08	0.00e+00	1412.00
IUUC-Cpo-022265	Cavia porcellus	88.09	0.00e+00	1406.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	37.92	1.00e-98	353.00
IUUC-Csa-024177	Chlorocebus sabaeus	88.20	0.00e+00	1291.00
IUUC-Cho-024702	Choloepus hoffmanni	89.12	0.00e+00	991.00
IUUC-Cin-025411	Ciona intestinalis	44.52	0.00e+00	688.00
IUUC-Csv-026347	Ciona savignyi	41.39	0.00e+00	651.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	32.25	2.00e-94	340.00
IUUC-Cne-026831	Cryptococcus neoformans	33.64	6.00e-111	395.00
IUUC-Dre-027982	Danio rerio	62.54	0.00e+00	963.00
IUUC-Dno-029034	Dasypus novemcinctus	90.79	0.00e+00	1489.00
IUUC-Dor-030479	Dipodomys ordii	93.91	0.00e+00	717.00
IUUC-Dse-031467	Dothistroma septosporum	32.53	2.00e-105	376.00
IUUC-Dme-032075	Drosophila melanogaster	44.19	0.00e+00	682.00
IUUC-Ete-032865	Echinops telfairi	79.49	0.00e+00	1284.00
IUUC-Eca-034059	Equus caballus	91.11	0.00e+00	1489.00
IUUC-Eeu-035304	Erinaceus europaeus	85.02	0.00e+00	1320.00
IUUC-Fca-035515	Felis catus	90.91	0.00e+00	1475.00
IUUC-Fal-037271	Ficedula albicollis	80.93	0.00e+00	1259.00
IUUC-Fox-037745	Fusarium oxysporum	32.94	3.00e-110	392.00
IUUC-Fso-038158	Fusarium solani	33.88	2.00e-108	386.00
IUUC-Gmo-039071	Gadus morhua	60.54	0.00e+00	937.00
IUUC-Ggr-040098	Gaeumannomyces graminis	31.52	6.00e-98	352.00
IUUC-Gga-040635	Gallus gallus	84.40	0.00e+00	1428.00
IUUC-Gac-042528	Gasterosteus aculeatus	59.77	0.00e+00	951.00
IUUC-Gma-043614	Glycine max	42.14	2.00e-165	576.00
IUUC-Ggo-044602	Gorilla gorilla	92.09	0.00e+00	1491.00
IUUC-Hsa-045959	Homo sapiens	92.09	0.00e+00	1491.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	90.45	0.00e+00	1466.00
IUUC-Kpa-049156	Komagataella pastoris	31.41	6.00e-99	355.00
IUUC-Lch-049648	Latimeria chalumnae	75.44	0.00e+00	1215.00
IUUC-Loc-052520	Lepisosteus oculatus	57.50	0.00e+00	872.00
IUUC-Lma-053216	Leptosphaeria maculans	31.64	2.00e-101	364.00
IUUC-Laf-054327	Loxodonta africana	89.73	0.00e+00	1456.00
IUUC-Mcc-055443	Macaca mulatta	91.74	0.00e+00	1484.00
IUUC-Meu-056298	Macropus eugenii	82.50	0.00e+00	884.00
IUUC-Mor-057106	Magnaporthe oryzae	32.64	5.00e-110	392.00
IUUC-Mpo-057589	Magnaporthe poae	32.17	6.00e-102	365.00
IUUC-Mtr-058680	Medicago truncatula	43.14	2.00e-174	606.00
IUUC-Mla-058903	Melampsora laricipopulina	30.50	7.00e-97	348.00
IUUC-Mga-059669	Meleagris gallopavo	83.29	0.00e+00	1347.00
IUUC-Mvi-060476	Microbotryum violaceum	32.73	1.00e-110	394.00
IUUC-Mmr-060575	Microcebus murinus	90.79	0.00e+00	1472.00
IUUC-Mdo-062183	Monodelphis domestica	84.43	0.00e+00	1354.00
IUUC-Mmu-063592	Mus musculus	90.55	0.00e+00	1469.00
IUUC-Mac-065634	Musa acuminata	39.26	1.00e-163	570.00
IUUC-Mpu-066082	Mustela putorius furo	87.25	0.00e+00	1397.00
IUUC-Mlu-067345	Myotis lucifugus	88.59	0.00e+00	1440.00
IUUC-Nfi-068558	Neosartorya fischeri	33.04	2.00e-103	370.00
IUUC-Ncr-068960	Neurospora crassa	32.48	4.00e-96	345.00
IUUC-Nle-070173	Nomascus leucogenys	89.37	0.00e+00	1429.00
IUUC-Opr-070556	Ochotona princeps	89.37	0.00e+00	1456.00
IUUC-Ont-071502	Oreochromis niloticus	60.02	0.00e+00	944.00
IUUC-Ocu-074861	Oryctolagus cuniculus	87.60	0.00e+00	1405.00
IUUC-Obr-076292	Oryza brachyantha	43.06	4.00e-168	585.00
IUUC-Ogl-077065	Oryza glaberrima	42.82	5.00e-178	617.00
IUUC-Oin-080048	Oryza indica	42.36	4.00e-176	611.00
IUUC-Osa-085713	Oryza sativa	42.94	7.00e-179	620.00
IUUC-Ola-086951	Oryzias latipes	60.98	0.00e+00	940.00
IUUC-Olu-087822	Ostreococcus lucimarinus	38.75	8.00e-155	540.00
IUUC-Oga-088625	Otolemur garnettii	90.09	0.00e+00	1454.00
IUUC-Oar-089995	Ovis aries	88.00	0.00e+00	1445.00
IUUC-Ptr-090640	Pan troglodytes	89.26	0.00e+00	1466.00
IUUC-Pan-091974	Papio anubis	90.82	0.00e+00	1474.00
IUUC-Psi-093957	Pelodiscus sinensis	83.39	0.00e+00	1430.00
IUUC-Pma-094242	Petromyzon marinus	71.58	3.00e-160	557.00
IUUC-Pno-094835	Phaeosphaeria nodorum	32.34	2.00e-102	367.00
IUUC-Ppa-095901	Physcomitrella patens	45.24	0.00e+00	658.00
IUUC-Pfo-097148	Poecilia formosa	61.45	0.00e+00	956.00
IUUC-Pca-100738	Procavia capensis	97.84	0.00e+00	1137.00
IUUC-Pva-102154	Pteropus vampyrus	88.90	0.00e+00	1439.00
IUUC-Pgr-103343	Puccinia graminis	30.75	2.00e-83	303.00
IUUC-Pte-104306	Pyrenophora teres	29.71	1.00e-98	354.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	31.11	2.00e-102	366.00
IUUC-Rno-105801	Rattus norvegicus	90.55	0.00e+00	1469.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.49	5.00e-58	219.00
IUUC-Sha-107635	Sarcophilus harrisii	84.55	0.00e+00	1363.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	29.76	2.00e-88	320.00
IUUC-Spo-108144	Schizosaccharomyces pombe	29.75	4.00e-93	335.00
IUUC-Smo-108848	Selaginella moellendorffii	43.54	2.00e-176	612.00
IUUC-Sit-110728	Setaria italica	43.42	0.00e+00	642.00
IUUC-Sly-111523	Solanum lycopersicum	43.32	0.00e+00	635.00
IUUC-Sbi-114419	Sorghum bicolor	42.91	1.00e-180	626.00
IUUC-Sre-115225	Sporisorium reilianum	32.64	3.00e-102	366.00
IUUC-Ssc-115686	Sus scrofa	89.74	0.00e+00	1460.00
IUUC-Tgu-117346	Taeniopygia guttata	84.07	0.00e+00	1399.00
IUUC-Tru-118350	Takifugu rubripes	60.37	0.00e+00	967.00
IUUC-Tni-120658	Tetraodon nigroviridis	60.88	0.00e+00	955.00
IUUC-Tca-121585	Theobroma cacao	43.32	4.00e-172	598.00
IUUC-Tre-122043	Trichoderma reesei	31.97	3.00e-99	356.00
IUUC-Tvi-122303	Trichoderma virens	32.13	3.00e-105	376.00
IUUC-Tae-125686	Triticum aestivum	43.16	2.00e-175	609.00
IUUC-Tme-126909	Tuber melanosporum	33.14	1.00e-100	360.00
IUUC-Tbe-127261	Tupaia belangeri	91.18	0.00e+00	1039.00
IUUC-Uma-129599	Ustilago maydis	32.19	2.00e-106	380.00
IUUC-Vda-129688	Verticillium dahliae	31.24	8.00e-99	354.00
IUUC-Vvi-131116	Vitis vinifera	43.55	2.00e-166	579.00
IUUC-Xtr-131953	Xenopus tropicalis	72.98	0.00e+00	1189.00
IUUC-Xma-133837	Xiphophorus maculatus	61.57	0.00e+00	958.00
IUUC-Yli-134510	Yarrowia lipolytica	33.14	3.00e-111	395.00
IUUC-Zma-135786	Zea mays	42.79	2.00e-170	592.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence