iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007279

UUCD1 version

UUC-ArT-01359

Ensembl Protein ID

AT4G14220.1

UniProt Accession

Q4TU14; O23280; Q8GXY4; Q9ZT43; RHF1A_ARATH

Genbank Protein ID

AAY57608.1; CAB46003.1; CAB78464.1; AEE83395.1; BAC42605.1; AAC69855.1

Protein Name

E3 ubiquitin-protein ligase RHF1A; RING-H2 finger F1a; RING-H2 zinc finger protein RHF1a; RING-type E3 ubiquitin transferase RHF1A

Genbank Nucleotide ID

DQ059122; Z97335; AL161538; CP002687; AK117968; AF079181

Gene Name

RHF1A; At4g14220; dl3150w; FCAALL.146

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G14220	AT4G14220.1	AT4G14220.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16339806

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.60e-07	31.1	46	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCle+f  +d+  v++C+H +h++C+  w      s+++  CP+C
   Q: 46   CSICLEPFtlQDPSTVTSCKHEYHLQCIIEW------SQRSKECPIC 86
           ********99998999***************......********** PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression. Mediates the proteasomal degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophyte development. Functions in association with RHF2A (PubMed:18552199). Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro (PubMed:15644464).

Protein Sequence
(Fasta)

MSNFTYTSAF NLSDNSPFNP AIGSSSSSSS ALVVASDDDN NTDDACSICL EPFTLQDPST 60
VTSCKHEYHL QCIIEWSQRS KECPICWQLF VLRDPASQEL LAAVEKERLL KTRNISSSSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCAAACAA ATCAATCTCA CACCTCTTCT TCTTCTTCTT CTTCTTCTTC TTCTTCAACC 60
TCTTAAATCT CAAAATCTCA ATCATCAAGC TTCTCCTTCT TCTTCTTCTT TCCATCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016020--C:membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009561--P:megagametogenesis
GO:0055046--P:microgametogenesis
GO:0010498--P:proteasomal protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051726--P:regulation of cell cycle

KEGG

ath:AT4G14220

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002655	Amborella trichopoda	72.46	9.00e-29	120.00
IUUC-Aly-005899	Arabidopsis lyrata	89.22	4.00e-128	450.00
IUUC-Bol-015999	Brassica oleracea	63.36	7.00e-93	332.00
IUUC-Bra-017518	Brassica rapa	61.16	4.00e-83	300.00
IUUC-Gma-042977	Glycine max	46.93	3.00e-56	211.00
IUUC-Mtr-058591	Medicago truncatula	66.67	3.00e-27	115.00
IUUC-Ppa-095686	Physcomitrella patens	72.46	3.00e-28	118.00
IUUC-Pop-099767	Populus trichocarpa	48.27	1.00e-66	246.00
IUUC-Ppe-101316	Prunus persica	58.41	7.00e-31	127.00
IUUC-Smo-109592	Selaginella moellendorffii	64.20	3.00e-28	115.00
IUUC-Sit-110350	Setaria italica	69.70	2.00e-26	112.00
IUUC-Stu-112150	Solanum tuberosum	72.00	4.00e-32	131.00
IUUC-Sbi-113905	Sorghum bicolor	69.70	5.00e-27	114.00
IUUC-Tca-121560	Theobroma cacao	73.68	9.00e-33	134.00
IUUC-Tur-126169	Triticum urartu	59.74	5.00e-24	104.00
IUUC-Vvi-131270	Vitis vinifera	46.27	9.00e-59	219.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence