iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108105

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 8; E2 ubiquitin-conjugating enzyme 8; Ubiquitin carrier protein 8; Ubiquitin-protein ligase 8

Genbank Nucleotide ID

CU329671

Gene Name

ubc8; SPBC211.07c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC211.07c	SPBC211.07c.1	SPBC211.07c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	7.70e-33	111.3	13	140

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 7    kelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspals 97
           ++l    ++ + +++v++ +++e+ v + Gp++tpY gg++k+++e+p++YP k+P++ f+++ifhPn++e  G+vCl++++  ++Wsp+ +
   Q: 13   MKL---LMSDYEVTLVND-NMQEFYVRFHGPSETPYSGGIWKVHVELPSEYPWKSPSIGFVNRIFHPNIDELsGSVCLDVIN--QTWSPMFD 98
           443...567778999999.9***************************************************99********9..******** PP
   S: 98   vesvl.lsiqsllaepnpesplneeaaellkknreeykkkvr 138
           + +++ + + +ll+ pn ++pln eaa ll +++++y  kvr
   Q: 99   MINIFeVFLPQLLRYPNASDPLNGEAAALLLREPNTYYAKVR 140
           *****889******************************9997 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MSSPRRRIET DVMKLLMSDY EVTLVNDNMQ EFYVRFHGPS ETPYSGGIWK VHVELPSEYP 60
WKSPSIGFVN RIFHPNIDEL SGSVCLDVIN QTWSPMFDMI NIFEVFLPQL LRYPNASDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGAAATTC CGCGTCTTCA TCATAGCCAA ACTTATGCTC AATTGCCTCG TTTGTAAATT 60
AAAATATATT TAACAATAAG AAGGACGATA AAGAGGGGAT TCTTCTATAC AATAAAATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPBC211.07c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	69.68	2.00e-64	236.00
IUUC-Aml-001260	Ailuropoda melanoleuca	63.70	1.00e-49	186.00
IUUC-Atr-002681	Amborella trichopoda	65.16	1.00e-63	233.00
IUUC-Apl-003547	Anas platyrhynchos	65.49	2.00e-43	166.00
IUUC-Aca-005224	Anolis carolinensis	65.22	2.00e-43	166.00
IUUC-Aly-005836	Arabidopsis lyrata	65.54	2.00e-61	226.00
IUUC-Ath-007534	Arabidopsis thaliana	64.86	5.00e-61	224.00
IUUC-Ago-007727	Ashbya gossypii	66.00	6.00e-60	221.00
IUUC-Acl-008119	Aspergillus clavatus	78.88	1.00e-75	273.00
IUUC-Afl-008412	Aspergillus flavus	81.25	6.00e-55	204.00
IUUC-Afu-008925	Aspergillus fumigatus	74.71	4.00e-71	258.00
IUUC-Ani-009294	Aspergillus nidulans	67.57	8.00e-66	240.00
IUUC-Ang-009805	Aspergillus niger	83.01	1.00e-75	273.00
IUUC-Aor-010201	Aspergillus oryzae	72.90	5.00e-64	234.00
IUUC-Ate-010441	Aspergillus terreus	75.18	3.00e-59	218.00
IUUC-Ame-010807	Astyanax mexicanus	59.43	4.00e-36	141.00
IUUC-Bta-012802	Bos taurus	63.70	1.00e-49	186.00
IUUC-Bdi-014713	Brachypodium distachyon	69.03	2.00e-65	239.00
IUUC-Bol-016385	Brassica oleracea	65.54	8.00e-61	224.00
IUUC-Bra-017669	Brassica rapa	65.56	1.00e-60	223.00
IUUC-Cel-018412	Caenorhabditis elegans	56.76	5.00e-52	195.00
IUUC-Cja-019571	Callithrix jacchus	46.48	5.00e-34	135.00
IUUC-Cfa-020811	Canis familiaris	63.70	1.00e-49	186.00
IUUC-Cpo-021889	Cavia porcellus	60.16	6.00e-45	171.00
IUUC-Cre-022956	Chlamydomonas reinhardtii	70.47	3.00e-63	232.00
IUUC-Csa-023289	Chlorocebus sabaeus	63.70	1.00e-49	186.00
IUUC-Cho-024517	Choloepus hoffmanni	41.48	5.00e-24	101.00
IUUC-Cin-025571	Ciona intestinalis	47.06	4.00e-35	138.00
IUUC-Cgl-026627	Colletotrichum gloeosporioides	79.69	1.00e-62	229.00
IUUC-Cne-027006	Cryptococcus neoformans	72.39	2.00e-61	226.00
IUUC-Cme-027171	Cyanidioschyzon merolae	70.39	5.00e-65	238.00
IUUC-Dre-027450	Danio rerio	63.70	1.00e-49	187.00
IUUC-Dno-029838	Dasypus novemcinctus	63.70	1.00e-49	186.00
IUUC-Dor-031119	Dipodomys ordii	63.70	1.00e-49	186.00
IUUC-Dse-031243	Dothistroma septosporum	81.05	1.00e-76	276.00
IUUC-Dme-031807	Drosophila melanogaster	62.58	7.00e-54	201.00
IUUC-Ete-032437	Echinops telfairi	62.00	4.00e-35	138.00
IUUC-Eca-034123	Equus caballus	64.00	3.00e-47	178.00
IUUC-Fca-035502	Felis catus	63.70	1.00e-49	186.00
IUUC-Fal-037054	Ficedula albicollis	65.22	4.00e-44	168.00
IUUC-Fox-037912	Fusarium oxysporum	84.85	4.00e-49	184.00
IUUC-Fso-038148	Fusarium solani	73.83	6.00e-63	231.00
IUUC-Gmo-038858	Gadus morhua	60.78	2.00e-54	202.00
IUUC-Ggr-039749	Gaeumannomyces graminis	77.69	2.00e-59	219.00
IUUC-Gga-040942	Gallus gallus	63.70	1.00e-49	186.00
IUUC-Gac-042079	Gasterosteus aculeatus	61.44	3.00e-55	205.00
IUUC-Gma-043183	Glycine max	62.64	3.00e-67	245.00
IUUC-Hsa-046545	Homo sapiens	63.70	1.00e-49	186.00
IUUC-Hvu-047260	Hordeum vulgare	69.39	2.00e-63	233.00
IUUC-Itr-048474	Ictidomys tridecemlineatus	63.70	1.00e-49	186.00
IUUC-Kpa-049144	Komagataella pastoris	82.95	1.00e-64	237.00
IUUC-Lch-050589	Latimeria chalumnae	60.31	6.00e-45	171.00
IUUC-Lpe-051335	Leersia perrieri	69.03	2.00e-65	239.00
IUUC-Loc-052829	Lepisosteus oculatus	63.70	2.00e-49	186.00
IUUC-Lma-052971	Leptosphaeria maculans	59.18	1.00e-59	220.00
IUUC-Laf-053526	Loxodonta africana	63.70	1.00e-49	187.00
IUUC-Mcc-055611	Macaca mulatta	63.70	1.00e-49	186.00
IUUC-Mor-057278	Magnaporthe oryzae	82.26	1.00e-61	226.00
IUUC-Mpo-057484	Magnaporthe poae	81.65	5.00e-54	201.00
IUUC-Mtr-058579	Medicago truncatula	70.86	7.00e-67	244.00
IUUC-Mla-058926	Melampsora laricipopulina	82.31	2.00e-74	268.00
IUUC-Mga-059801	Meleagris gallopavo	63.70	1.00e-49	186.00
IUUC-Mvi-060244	Microbotryum violaceum	83.33	2.00e-76	275.00
IUUC-Mmr-061205	Microcebus murinus	63.70	1.00e-49	186.00
IUUC-Mdo-062038	Monodelphis domestica	70.31	6.00e-25	103.00
IUUC-Mmu-063974	Mus musculus	63.70	1.00e-49	186.00
IUUC-Mac-064837	Musa acuminata	69.54	5.00e-64	234.00
IUUC-Mpu-066759	Mustela putorius furo	63.70	1.00e-49	186.00
IUUC-Mlu-067674	Myotis lucifugus	63.87	3.00e-44	168.00
IUUC-Nfi-068618	Neosartorya fischeri	81.88	5.00e-67	244.00
IUUC-Ncr-068712	Neurospora crassa	83.05	7.00e-59	217.00
IUUC-Nle-069926	Nomascus leucogenys	63.70	1.00e-49	186.00
IUUC-Opr-070598	Ochotona princeps	63.70	1.00e-49	186.00
IUUC-Ont-071893	Oreochromis niloticus	61.44	3.00e-55	205.00
IUUC-Oan-073273	Ornithorhynchus anatinus	65.22	4.00e-44	168.00
IUUC-Ocu-074357	Oryctolagus cuniculus	63.70	2.00e-49	185.00
IUUC-Oba-075055	Oryza barthii	69.03	2.00e-65	239.00
IUUC-Obr-076538	Oryza brachyantha	68.39	4.00e-65	238.00
IUUC-Ogl-077784	Oryza glaberrima	69.03	2.00e-65	239.00
IUUC-Ogu-078045	Oryza glumaepatula	69.03	2.00e-65	239.00
IUUC-Oin-079163	Oryza indica	69.03	2.00e-65	239.00
IUUC-Olo-080847	Oryza longistaminata	65.07	2.00e-55	206.00
IUUC-Ome-081586	Oryza meridionalis	64.07	3.00e-63	232.00
IUUC-Oni-082913	Oryza nivara	69.03	2.00e-65	239.00
IUUC-Opu-083651	Oryza punctata	69.03	2.00e-65	239.00
IUUC-Oru-084980	Oryza rufipogon	69.03	2.00e-65	239.00
IUUC-Osa-085334	Oryza sativa	71.43	8.00e-61	223.00
IUUC-Ola-087423	Oryzias latipes	61.44	3.00e-55	205.00
IUUC-Oga-088412	Otolemur garnettii	63.70	1.00e-49	186.00
IUUC-Oar-090282	Ovis aries	62.60	1.00e-44	170.00
IUUC-Ptr-090470	Pan troglodytes	63.70	1.00e-49	186.00
IUUC-Pan-092552	Papio anubis	63.70	1.00e-49	186.00
IUUC-Psi-093516	Pelodiscus sinensis	61.42	4.00e-45	172.00
IUUC-Pno-094800	Phaeosphaeria nodorum	70.92	2.00e-56	209.00
IUUC-Ppa-095962	Physcomitrella patens	72.19	1.00e-65	239.00
IUUC-Pfo-096105	Poecilia formosa	61.44	3.00e-55	205.00
IUUC-Pab-098112	Pongo abelii	63.70	1.00e-49	186.00
IUUC-Pop-099283	Populus trichocarpa	68.87	7.00e-65	237.00
IUUC-Pca-100436	Procavia capensis	48.95	8.00e-36	140.00
IUUC-Ppe-102031	Prunus persica	68.21	7.00e-65	237.00
IUUC-Pva-102776	Pteropus vampyrus	62.96	2.00e-48	182.00
IUUC-Pgr-103325	Puccinia graminis	80.74	6.00e-67	244.00
IUUC-Ptt-104010	Puccinia triticina	77.44	3.00e-61	225.00
IUUC-Pte-104024	Pyrenophora teres	75.15	1.00e-73	266.00
IUUC-Pyt-104715	Pyrenophora triticirepentis	84.21	4.00e-68	248.00
IUUC-Rno-105699	Rattus norvegicus	62.96	4.00e-49	185.00
IUUC-Sce-106165	Saccharomyces cerevisiae	70.00	4.00e-54	202.00
IUUC-Sha-106524	Sarcophilus harrisii	65.22	4.00e-44	168.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	77.18	2.00e-70	255.00
IUUC-Ssl-108543	Sclerotinia sclerotiorum	73.20	1.00e-62	229.00
IUUC-Smo-108956	Selaginella moellendorffii	64.09	1.00e-65	239.00
IUUC-Sit-110211	Setaria italica	69.03	2.00e-65	240.00
IUUC-Sly-111921	Solanum lycopersicum	71.71	1.00e-67	246.00
IUUC-Stu-112525	Solanum tuberosum	71.05	3.00e-67	245.00
IUUC-Sar-113572	Sorex araneus	44.35	1.00e-22	96.70
IUUC-Sbi-114111	Sorghum bicolor	69.03	2.00e-65	239.00
IUUC-Sre-115027	Sporisorium reilianum	80.39	3.00e-77	278.00
IUUC-Ssc-116221	Sus scrofa	63.20	3.00e-45	172.00
IUUC-Tgu-116965	Taeniopygia guttata	65.22	4.00e-44	168.00
IUUC-Tru-118743	Takifugu rubripes	61.44	1.00e-55	206.00
IUUC-Tni-120422	Tetraodon nigroviridis	63.70	3.00e-49	185.00
IUUC-Tca-121070	Theobroma cacao	68.42	4.00e-65	238.00
IUUC-Tre-122110	Trichoderma reesei	82.71	6.00e-65	237.00
IUUC-Tvi-122592	Trichoderma virens	73.15	3.00e-62	228.00
IUUC-Tae-125866	Triticum aestivum	68.39	4.00e-65	238.00
IUUC-Tur-126414	Triticum urartu	69.68	2.00e-64	235.00
IUUC-Tme-127020	Tuber melanosporum	68.89	3.00e-50	188.00
IUUC-Tbe-128053	Tupaia belangeri	48.70	1.00e-27	113.00
IUUC-Ttr-128734	Tursiops truncatus	63.70	1.00e-49	186.00
IUUC-Uma-129334	Ustilago maydis	80.39	3.00e-77	278.00
IUUC-Vda-129953	Verticillium dahliae	76.83	1.00e-71	260.00
IUUC-Vpa-130729	Vicugna pacos	65.22	4.00e-44	168.00
IUUC-Vvi-131633	Vitis vinifera	68.87	1.00e-65	240.00
IUUC-Xtr-132368	Xenopus tropicalis	63.70	1.00e-49	186.00
IUUC-Xma-133407	Xiphophorus maculatus	61.44	3.00e-55	205.00
IUUC-Yli-134339	Yarrowia lipolytica	82.12	1.00e-74	269.00
IUUC-Zma-135623	Zea mays	67.10	4.00e-64	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence